fluorouracil has been researched along with Chromosomal Breakage in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "MNi are formed as a consequence of chromosome breaks and aneuploidy." | 1.40 | Acute toxic and genotoxic activities of widely used cytostatic drugs in higher plants: Possible impact on the environment. ( Filipic, M; Knasmueller, S; Mišík, M; Nersesyan, A; Pichler, C; Rainer, B, 2014) |
| "It has long been believed that chromosomal breaks are always associated with double-strand breaks (DSBs)." | 1.39 | Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks. ( Adachi, N; Fujita, M; Harada, H; Hiraoka, M; Hirota, K; Kurosawa, A; Omura, M; Sasanuma, H; Takeda, S; Yamamoto, KN, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujita, M | 1 |
| Sasanuma, H | 1 |
| Yamamoto, KN | 1 |
| Harada, H | 1 |
| Kurosawa, A | 1 |
| Adachi, N | 1 |
| Omura, M | 1 |
| Hiraoka, M | 1 |
| Takeda, S | 1 |
| Hirota, K | 1 |
| Mišík, M | 1 |
| Pichler, C | 1 |
| Rainer, B | 1 |
| Filipic, M | 1 |
| Nersesyan, A | 1 |
| Knasmueller, S | 1 |
2 other studies available for fluorouracil and Chromosomal Breakage
| Article | Year |
|---|---|
Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks.
Topics: Animals; Antigens, Nuclear; Aphidicolin; Apoptosis; Cell Line, Tumor; Chickens; Chromosome Breakage; | 2013 |
Acute toxic and genotoxic activities of widely used cytostatic drugs in higher plants: Possible impact on the environment.
Topics: Allium; Aneuploidy; Chromosome Breakage; Cyclophosphamide; Cytostatic Agents; Etoposide; Fluorouraci | 2014 |