fluorouracil has been researched along with Chromoblastomycosis in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chromoblastomycosis: Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. The extremity may become swollen and, at its distal portion, covered with various nodular, tumorous, verrucous lesions that resemble cauliflower. In rare instances, the disease may begin on the hand or wrist and involve the entire upper extremity. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p362)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ajoene and 5-fluorouracil (5-FU) are compounds that have shown in-vitro activity against Cladophialophora carrionii, an important etiologic agent of chromoblastomycosis." | 9.10 | Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study. ( Apitz-Castro, R; Pérez-Blanco, M; Valles, RH; Zeppenfeldt, GF, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pérez-Blanco, M | 2 |
| Valles, RH | 1 |
| Zeppenfeldt, GF | 1 |
| Apitz-Castro, R | 1 |
| Hernández Valles, R | 1 |
| García-Humbría, L | 1 |
| Yegres, F | 1 |
| De Clercq, D | 1 |
| De Vroey, C | 1 |
1 trial available for fluorouracil and Chromoblastomycosis
| Article | Year |
|---|---|
Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study.
Topics: Administration, Topical; Adult; Antifungal Agents; Ascomycota; Chromoblastomycosis; Disulfides; Fluo | 2003 |
2 other studies available for fluorouracil and Chromoblastomycosis
| Article | Year |
|---|---|
Chromoblastomycosis in children and adolescents in the endemic area of the Falcón State, Venezuela.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Antifungal Agents; Ascomycota; Chi | 2006 |
Treatment of a Zairian case of chromomycosis with oral 5-fluorocytosine and 5-fluorouracil ointment in association.
Topics: Aged; Chromoblastomycosis; Drug Combinations; Flucytosine; Fluorouracil; Humans; Male | 1987 |