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fluorouracil and Chromoblastomycosis

fluorouracil has been researched along with Chromoblastomycosis in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Chromoblastomycosis: Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. The extremity may become swollen and, at its distal portion, covered with various nodular, tumorous, verrucous lesions that resemble cauliflower. In rare instances, the disease may begin on the hand or wrist and involve the entire upper extremity. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p362)

Research Excerpts

ExcerptRelevanceReference
"Ajoene and 5-fluorouracil (5-FU) are compounds that have shown in-vitro activity against Cladophialophora carrionii, an important etiologic agent of chromoblastomycosis."9.10Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study. ( Apitz-Castro, R; Pérez-Blanco, M; Valles, RH; Zeppenfeldt, GF, 2003)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pérez-Blanco, M2
Valles, RH1
Zeppenfeldt, GF1
Apitz-Castro, R1
Hernández Valles, R1
García-Humbría, L1
Yegres, F1
De Clercq, D1
De Vroey, C1

Trials

1 trial available for fluorouracil and Chromoblastomycosis

ArticleYear
Ajoene and 5-fluorouracil in the topical treatment of Cladophialophora carrionii chromoblastomycosis in humans: a comparative open study.
    Medical mycology, 2003, Volume: 41, Issue:6

    Topics: Administration, Topical; Adult; Antifungal Agents; Ascomycota; Chromoblastomycosis; Disulfides; Fluo

2003

Other Studies

2 other studies available for fluorouracil and Chromoblastomycosis

ArticleYear
Chromoblastomycosis in children and adolescents in the endemic area of the Falcón State, Venezuela.
    Medical mycology, 2006, Volume: 44, Issue:5

    Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Antifungal Agents; Ascomycota; Chi

2006
Treatment of a Zairian case of chromomycosis with oral 5-fluorocytosine and 5-fluorouracil ointment in association.
    International journal of dermatology, 1987, Volume: 26, Issue:5

    Topics: Aged; Chromoblastomycosis; Drug Combinations; Flucytosine; Fluorouracil; Humans; Male

1987