fluorouracil has been researched along with Cholestasis, Intrahepatic in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gerhardt, T | 1 |
| Rings, D | 1 |
| Höblinger, A | 1 |
| Heller, J | 1 |
| Sauerbruch, T | 1 |
| Schepke, M | 1 |
| Knox, JJ | 1 |
| Hedley, D | 1 |
| Oza, A | 1 |
| Feld, R | 1 |
| Siu, LL | 1 |
| Chen, E | 1 |
| Nematollahi, M | 1 |
| Pond, GR | 1 |
| Zhang, J | 1 |
| Moore, MJ | 1 |
| Brooks, AJ | 1 |
| Begg, EJ | 1 |
| Chapman, BA | 1 |
| Fitzharris, BM | 1 |
| Foitl, DR | 1 |
| Hyman, G | 1 |
| Lefkowitch, JH | 1 |
1 trial available for fluorouracil and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trial.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemot | 2005 |
3 other studies available for fluorouracil and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Combination of bilateral metal stenting and trans-stent photodynamic therapy for palliative treatment of hilar cholangiocarcinoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile D | 2010 |
Two cases of severe liver injury possibly related to 5-fluorouracil and calcium folinate.
Topics: Acute Disease; Aged; Antineoplastic Agents; Cholestasis, Intrahepatic; Colorectal Neoplasms; Fluorou | 2007 |
Jaundice and intrahepatic cholestasis following high-dose megestrol acetate for breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bilirubin; Breast Neoplasms; Cholestasis, Intr | 1989 |