fluorouracil has been researched along with Cholangitis, Sclerosing in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Novel neoadjuvant therapy protocols combined with demolitive surgery and liver transplantation seem to achieve successful results in terms of overall and disease-free survivals." | 1.37 | Neoadjuvant therapy protocol and liver transplantation in combination with pancreatoduodenectomy for the treatment of hilar cholangiocarcinoma occurring in a case of primary sclerosing cholangitis: case report with a more than 8-year disease-free survival ( Bassi, D; Boccagni, P; Boetto, R; Cillo, U; D'Amico, F; D'Amico, FE; Gringeri, E; Lodo, E; Polacco, M; Vitale, A; Zanus, G, 2011) |
| "Consequently, secondary biliary cirrhosis developed, requiring orthotopic liver transplantation." | 1.28 | [Ectasing cholangitis and secondary biliary cirrhosis following intra-arterial hepatic chemotherapy. Treatment by liver transplantation]. ( Chapuis, Y; Gaudric, M; Houssin, D; Louvel, A; Pitre, J; Vigouroux, C, 1991) |
| "A case of iatrogenic sclerosing cholangitis secondary to hepatic intra-arterial 5-fluorouracil (5FU) and Mitomycin C (MMC) chemotherapy is described." | 1.28 | Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy. ( Fukuzumi, S; Makuuchi, M; Moriya, Y; Terui, S, 1990) |
| "Excisions of metastatic liver cancer were performed in 36 patients and 23 had nonresectable metastatic liver cancer." | 1.28 | [Complications of intra-arterial infusion chemotherapy in patients with colorectal cancer with liver metastasis, with special reference to IA-5-FU induced sclerosing cholangitis]. ( Hojo, K; Moriya, Y; Sawada, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Welling, TH | 1 |
| Feng, M | 1 |
| Wan, S | 1 |
| Hwang, SY | 1 |
| Volk, ML | 1 |
| Lawrence, TS | 1 |
| Zalupski, MM | 1 |
| Sonnenday, CJ | 1 |
| Chen, Y | 1 |
| Schaeffer, DF | 1 |
| Yoshida, EM | 1 |
| Yri, OE | 1 |
| Vig, J | 1 |
| Hegstad, E | 1 |
| Hovde, O | 1 |
| Pignon, I | 1 |
| Jynge, P | 1 |
| Gringeri, E | 1 |
| Bassi, D | 1 |
| D'Amico, FE | 1 |
| Boetto, R | 1 |
| Polacco, M | 1 |
| Lodo, E | 1 |
| D'Amico, F | 1 |
| Vitale, A | 1 |
| Boccagni, P | 1 |
| Zanus, G | 1 |
| Cillo, U | 1 |
| Barnett, KT | 1 |
| Malafa, MP | 1 |
| Maruyama, S | 1 |
| Nishimoto, T | 1 |
| Kiriyama, K | 1 |
| Yabu, M | 1 |
| Kato, T | 1 |
| Yamamoto, S | 1 |
| Himeno, S | 1 |
| Alazmi, WM | 1 |
| McHenry, L | 1 |
| Watkins, JL | 1 |
| Fogel, EL | 1 |
| Schmidt, S | 1 |
| Sherman, S | 1 |
| Lehman, GL | 1 |
| Miyamoto, S | 1 |
| Umekita, N | 1 |
| Maeshiro, T | 1 |
| Awane, Y | 1 |
| Pitre, J | 1 |
| Houssin, D | 1 |
| Louvel, A | 1 |
| Vigouroux, C | 1 |
| Gaudric, M | 1 |
| Chapuis, Y | 1 |
| Fukuzumi, S | 1 |
| Moriya, Y | 2 |
| Makuuchi, M | 1 |
| Terui, S | 1 |
| Sawada, T | 1 |
| Hojo, K | 1 |
2 reviews available for fluorouracil and Cholangitis, Sclerosing
| Article | Year |
|---|---|
Complications of hepatic artery infusion: a review of 4580 reported cases.
Topics: Antimetabolites, Antineoplastic; Arterial Occlusive Diseases; Bone Marrow Diseases; Catheters, Indwe | 2001 |
[Complications of hepatic artery chemotherapy for liver metastases in colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Arterial Occlusive Diseases; Cholangitis, Sclerosing | 2003 |
10 other studies available for fluorouracil and Cholangitis, Sclerosing
| Article | Year |
|---|---|
Neoadjuvant stereotactic body radiation therapy, capecitabine, and liver transplantation for unresectable hilar cholangiocarcinoma.
Topics: Aged; Antineoplastic Agents; Capecitabine; Chemoradiotherapy; Cholangiocarcinoma; Cholangitis, Scler | 2014 |
Hepatoid adenocarcinoma of the colon in a patient with inflammatory bowel disease.
Topics: Adenocarcinoma; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; B | 2014 |
Mangafodipir as a cytoprotective adjunct to chemotherapy--a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cholangitis, Sclerosing; Col | 2009 |
Neoadjuvant therapy protocol and liver transplantation in combination with pancreatoduodenectomy for the treatment of hilar cholangiocarcinoma occurring in a case of primary sclerosing cholangitis: case report with a more than 8-year disease-free survival
Topics: Antimetabolites, Antineoplastic; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Brachytherapy; Chemo | 2011 |
[A case of sclerosing cholangitis trigered by 5-FU/leucovorine combination therapy and rapidly deteriorated].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cholangitis, Sclerosing; Colonic Neoplasms; Co | 2005 |
Chemotherapy-induced sclerosing cholangitis: long-term response to endoscopic therapy.
Topics: Adult; Aged; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Cholangiopancreat | 2006 |
[Sclerosing cholangitis-induced biliary cyst formation: complication of hepatic artery infusion chemotherapy].
Topics: Adenocarcinoma; Biliary Tract Diseases; Cholangitis, Sclerosing; Cysts; Fluorouracil; Hepatic Artery | 1995 |
[Ectasing cholangitis and secondary biliary cirrhosis following intra-arterial hepatic chemotherapy. Treatment by liver transplantation].
Topics: Adenocarcinoma; Adult; Cholangitis, Sclerosing; Female; Fluorouracil; Humans; Infusions, Intra-Arter | 1991 |
Serious chemical sclerosing cholangitis associated with hepatic arterial 5FU and MMC chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cholangiopancreatography, Endoscopic Retrogra | 1990 |
[Complications of intra-arterial infusion chemotherapy in patients with colorectal cancer with liver metastasis, with special reference to IA-5-FU induced sclerosing cholangitis].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Catheterization; Cholangitis, Sclerosin | 1989 |