fluorouracil has been researched along with Chest Pain in 25 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chest Pain: Pressure, burning, or numbness in the chest.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients with primary colorectal adenocarcinoma or anal squamous cell carcinoma were started on a 2-weeks-on, 1-week-off capecitabine dosing regimen in addition to other chemotherapeutic agents and/or radiation." | 7.78 | Capecitabine-induced chest pain relieved by diltiazem. ( Ambrosy, AP; Fisher, GA; Kunz, PL; Witteles, RM, 2012) |
| "5-Fluorouracil, a widely used drug in cancer treatment, is known to have cardiotoxic effects: chest pain with ECG changes, arrhythmias, arterial hypertension or hypotension, myocardial infarction, cardiogenic shock and sudden death have been described in the literature." | 7.72 | Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases. ( Alberti, A; Corrada, E; Ferrari, S; Mafrici, A; Marenna, B, 2003) |
| "A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed." | 7.71 | 5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report. ( Campbell, NP; McGlinchey, PG; Webb, ST, 2001) |
| "5-fluorouracil is a chemotherapeutic agent that plays an important role in the treatment of various cancers including head and neck and gastrointestinal malignancies." | 6.53 | Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review. ( Mahipal, A; Markey, KR; Saneeymehri, SS, 2016) |
| "Capecitabine is a chemotherapeutic prodrug that is metabolised to 5-fluorouracil." | 5.35 | Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. ( Curzen, NP; Ferchow, L; Hobson, A; Scott, PA, 2008) |
| "Coronary artery spasm has been postulated to be involved in the mechanism of this incident Patients may present with angina, myocardial infarction, arrhythmias and/or even sudden death." | 5.31 | A case of coronary spasm induced by 5-fluorouracil. ( Celik, S; Gorgulu, S; Tezel, T, 2002) |
| " Postulated mechanisms include direct myocardial ischemia, coronary spasm, or cardiotoxic impurities in fluorouracil formulation." | 4.79 | Fluorouracil cardiotoxicity. ( Anand, AJ, 1994) |
| "A9 years boy diagnosed with nasopharyngeal carcinoma was started on chemotherapy protocol including 5-fluorouracil." | 3.81 | Chemotherapy Induced Acute Pericarditis in a Child. ( Almoukirish, S; Jadoon, S; Khan, MA; Momenah, TS; Rahman, A, 2015) |
| "Five patients with primary colorectal adenocarcinoma or anal squamous cell carcinoma were started on a 2-weeks-on, 1-week-off capecitabine dosing regimen in addition to other chemotherapeutic agents and/or radiation." | 3.78 | Capecitabine-induced chest pain relieved by diltiazem. ( Ambrosy, AP; Fisher, GA; Kunz, PL; Witteles, RM, 2012) |
| "Capesitabine is a orally administered cytotoxic drug metabolized to 5-fluorouracil and is widely used in large intestine cancer and breast cancer therapy." | 3.75 | [Coronary artery disease attack caused by cytotoxic chemotherapy]. ( Eskola, M; Ilveskoski, E; Nikus, K; Tanner, M, 2009) |
| "5-Fluorouracil, a widely used drug in cancer treatment, is known to have cardiotoxic effects: chest pain with ECG changes, arrhythmias, arterial hypertension or hypotension, myocardial infarction, cardiogenic shock and sudden death have been described in the literature." | 3.72 | Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases. ( Alberti, A; Corrada, E; Ferrari, S; Mafrici, A; Marenna, B, 2003) |
| "A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed." | 3.71 | 5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report. ( Campbell, NP; McGlinchey, PG; Webb, ST, 2001) |
| "The most common cardiotoxic effects of 5-fluorouracil (5-FU) are chest pain and ischemic ECG abnormalities." | 3.68 | Failure of preventing 5-fluorouracil cardiotoxicity by prophylactic treatment with verapamil. ( Albertsson, M; Eskilsson, J, 1990) |
| "5-fluorouracil is a chemotherapeutic agent that plays an important role in the treatment of various cancers including head and neck and gastrointestinal malignancies." | 2.53 | Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review. ( Mahipal, A; Markey, KR; Saneeymehri, SS, 2016) |
| "Capecitabine is a chemotherapeutic prodrug that is metabolised to 5-fluorouracil." | 1.35 | Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. ( Curzen, NP; Ferchow, L; Hobson, A; Scott, PA, 2008) |
| " Coronary spasm is the most commonly suspected hypothesis, but further studies are warranted to seek for toxic inflammatory lesions of the myocardium (apoptosis, necrosis, fibrosis)." | 1.33 | Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease. ( Barel, C; Belkhiria, M; Bui-Xuan, B; Descotes, J; Lombard-Bohas, C; Tabib, A; Timour, Q; Tsibiribi, P, 2006) |
| "Coronary artery spasm has been postulated to be involved in the mechanism of this incident Patients may present with angina, myocardial infarction, arrhythmias and/or even sudden death." | 1.31 | A case of coronary spasm induced by 5-fluorouracil. ( Celik, S; Gorgulu, S; Tezel, T, 2002) |
| "Gestational trophoblastic neoplasm treated by large dosage of 5-fluorouracil and actinomycin could cause cardiotoxicity." | 1.29 | [Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies]. ( Qian, H; Wu, Y, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, SK | 1 |
| Das, AK | 1 |
| William, M | 1 |
| Saneeymehri, SS | 1 |
| Markey, KR | 1 |
| Mahipal, A | 1 |
| Ray, JC | 1 |
| Cho, P | 1 |
| Dragon, M | 1 |
| Graham, CG | 1 |
| Khan, MA | 1 |
| Rahman, A | 1 |
| Almoukirish, S | 1 |
| Jadoon, S | 1 |
| Momenah, TS | 1 |
| Ben-Yakov, M | 1 |
| Mattu, A | 1 |
| Brady, WJ | 1 |
| Dubbs, SB | 1 |
| Scott, PA | 1 |
| Ferchow, L | 1 |
| Hobson, A | 1 |
| Curzen, NP | 1 |
| Le Brun-Ly, V | 1 |
| Martin, J | 1 |
| Venat-Bouvet, L | 1 |
| Darodes, N | 1 |
| Labourey, JL | 1 |
| Genet, D | 1 |
| Tubiana-Mathieu, N | 1 |
| Ilveskoski, E | 1 |
| Nikus, K | 1 |
| Tanner, M | 1 |
| Eskola, M | 1 |
| Ambrosy, AP | 1 |
| Kunz, PL | 1 |
| Fisher, GA | 1 |
| Witteles, RM | 1 |
| Dalzell, JR | 1 |
| Abu-Arafeh, A | 1 |
| Campbell, RT | 1 |
| Luján, J | 1 |
| García De Burgos, F | 1 |
| Jordán, A | 1 |
| García, M | 1 |
| Reyes, F | 1 |
| Espinosa, MD | 1 |
| Gorgulu, S | 1 |
| Celik, S | 1 |
| Tezel, T | 1 |
| Mafrici, A | 1 |
| Alberti, A | 1 |
| Corrada, E | 1 |
| Ferrari, S | 1 |
| Marenna, B | 1 |
| Kuppens, IE | 1 |
| Boot, H | 1 |
| Beijnen, JH | 1 |
| Schellens, JH | 1 |
| Labadie, J | 1 |
| Gul, M | 1 |
| Duzenli, A | 1 |
| Bircan, M | 1 |
| Cander, B | 1 |
| Kocak, S | 1 |
| Ozdemir, K | 1 |
| Tsibiribi, P | 1 |
| Descotes, J | 1 |
| Lombard-Bohas, C | 1 |
| Barel, C | 1 |
| Bui-Xuan, B | 1 |
| Belkhiria, M | 1 |
| Tabib, A | 1 |
| Timour, Q | 1 |
| Wu, Y | 1 |
| Qian, H | 1 |
| Mizuno, Y | 1 |
| Hokamura, Y | 1 |
| Kimura, T | 1 |
| Kimura, Y | 1 |
| Kaikita, K | 1 |
| Yasue, H | 1 |
| Anand, AJ | 1 |
| Farooqi, IS | 1 |
| Aronson, JK | 1 |
| Schnetzler, B | 1 |
| Popova, N | 1 |
| Collao Lamb, C | 1 |
| Sappino, AP | 1 |
| McGlinchey, PG | 1 |
| Webb, ST | 1 |
| Campbell, NP | 1 |
| Jeremic, B | 1 |
| Jevremovic, S | 1 |
| Djuric, L | 1 |
| Mijatovic, L | 1 |
| Eskilsson, J | 2 |
| Albertsson, M | 2 |
| Mercke, C | 1 |
2 reviews available for fluorouracil and Chest Pain
| Article | Year |
|---|---|
Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Cardiotoxicity; Chest Pain; Co | 2016 |
Fluorouracil cardiotoxicity.
Topics: Chest Pain; Electrocardiography; Electrocardiography, Ambulatory; Female; Fluorouracil; Heart; Human | 1994 |
23 other studies available for fluorouracil and Chest Pain
| Article | Year |
|---|---|
5-Fluorouracil-induced acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Antimetabolites, Antineoplastic; Chest Pain; Coronary Angiography; El | 2019 |
A Case of 5-Fluorouracil-Induced Cardiac Arrest.
Topics: Antimetabolites, Antineoplastic; Chest Pain; Female; Fluorouracil; Heart Arrest; Humans; Middle Aged | 2016 |
Chemotherapy Induced Acute Pericarditis in a Child.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protoco | 2015 |
Prinzmetal angina (Coronary vasospasm) associated with 5-fluorouracil chemotherapy.
Topics: Administration, Sublingual; Antineoplastic Combined Chemotherapy Protocols; Chest Pain; Coronary Ang | 2017 |
Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Chest Pain; Colorectal Neoplasms; Coronary Vaso | 2008 |
Cardiac toxicity with capecitabine, vinorelbine and trastuzumab therapy: case report and review of fluoropyrimidine-related cardiotoxicity.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2009 |
[Coronary artery disease attack caused by cytotoxic chemotherapy].
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Chest Pain; Coronary Vasospas | 2009 |
Capecitabine-induced chest pain relieved by diltiazem.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Anus Neoplasms; Calcium Channel Blockers; Cap | 2012 |
Cardiotoxicity with 5-fluorouracil based agents: rechallenge cannot currently be safely advised.
Topics: Chest Pain; Colorectal Neoplasms; Deoxycytidine; Diltiazem; Female; Fluorouracil; Humans; Male | 2013 |
[Angina related to 5-Fluorouracil].
Topics: Adenocarcinoma; Aged; Angina, Unstable; Antimetabolites, Antineoplastic; Chest Pain; Electrocardiogr | 2002 |
A case of coronary spasm induced by 5-fluorouracil.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Chest Pain; Colonic Neoplasms; Coronary Angiography; | 2002 |
Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antimetabolites, Antineoplas | 2003 |
Capecitabine induces severe angina-like chest pain.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Chest Pain; Deoxycytidine; Female; Fluor | 2004 |
Cardiotoxicity resembling myocardial infarction that occurs during chemotherapy with 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Chest Pain; Colonic Neoplasms; Diagnosis, Differential; Electrocardiography; | 2005 |
Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.
Topics: Adult; Aged; Angina Pectoris; Antimetabolites, Antineoplastic; Cardiac Output, Low; Chest Pain; Fema | 2006 |
[Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiac Output, Low; Chest Pain; Dactinomycin | 1995 |
A case of 5-fluorouracil cardiotoxicity simulating acute myocardial infarction.
Topics: Aged; Breast Neoplasms; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diagnosis, Differentia | 1995 |
Iatrogenic chest pain: a case of 5-fluorouracil cardiotoxicity.
Topics: Acute Disease; Aged; Antimetabolites, Antineoplastic; Chest Pain; Fluorouracil; Humans; Male; Myocar | 1996 |
Coronary spasm induced by capecitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C | 2001 |
5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.
Topics: Aged; Antimetabolites, Antineoplastic; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diagnos | 2001 |
Cardiotoxicity during chemotherapy treatment with 5-fluorouracil and cisplatin.
Topics: Arrhythmias, Cardiac; Carcinoma, Squamous Cell; Chest Pain; Cisplatin; Electrocardiography; Esophage | 1990 |
Failure of preventing 5-fluorouracil cardiotoxicity by prophylactic treatment with verapamil.
Topics: Adult; Aged; Arrhythmias, Cardiac; Chest Pain; Female; Fluorouracil; Heart; Humans; Male; Middle Age | 1990 |
Adverse cardiac effects during induction chemotherapy treatment with cis-platin and 5-fluorouracil.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac | 1988 |