fluorouracil has been researched along with Cheilitis in 14 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cheilitis: Inflammation of the lips. It is of various etiologies and degrees of pathology.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty patients with actinic cheilitis were treated with one of four modalities: topical fluorouracil, chemical peel with trichloroacetic acid, lip shave, or carbon dioxide laser ablation of the vermilion." | 5.06 | Actinic cheilitis. A prospective study comparing four treatment methods. ( Robinson, JK, 1989) |
| "Laser therapy appears the best option among nonsurgical approaches for actinic cheilitis, and PDT showed higher efficacy when sequentially combined with 5% imiquimod." | 5.05 | Treatments of actinic cheilitis: A systematic review of the literature. ( Cornacchia, L; Lai, M; Longo, C; Pampena, R; Pellacani, G; Peris, K, 2020) |
| "Actinic cheilitis is a common premalignant condition, significant for symptoms and potential development into invasive squamous cell carcinoma." | 2.40 | Actinic cheilitis. A treatment review. ( Curlin, MU; Dufresne, RG, 1997) |
| "Actinic cheilitis is a premalignant condition that may be symptomatic; it occurs predominantly on the lower lip and is caused by chronic exposure to sunlight." | 1.27 | Actinic cheilitis: treatment with the carbon dioxide laser. ( Roenigk, RK; Stanley, RJ, 1988) |
| "Histologic characteristics of squamous cell carcinoma include loss of cell organization and orientation, loss of intercellular bridges, presence of nuclear atypia and mitotic figures, and premature cell keratinization." | 1.27 | Skin lesions from sun exposure: a treatment guide. ( Gibson, LE; Perry, HO, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, M | 1 |
| Pampena, R | 1 |
| Cornacchia, L | 1 |
| Pellacani, G | 1 |
| Peris, K | 1 |
| Longo, C | 1 |
| Cohen, PR | 1 |
| Shah, AY | 1 |
| Doherty, SD | 1 |
| Rosen, T | 1 |
| Jadotte, YT | 1 |
| Schwartz, RA | 1 |
| Miki, I | 1 |
| Nakamura, T | 1 |
| Kuwahara, A | 1 |
| Yamamori, M | 1 |
| Nishiguchi, K | 1 |
| Tamura, T | 1 |
| Okuno, T | 1 |
| Omatsu, H | 1 |
| Mizuno, S | 1 |
| Hirai, M | 1 |
| Azuma, T | 1 |
| Sakaeda, T | 1 |
| Levine, N | 1 |
| Chiaffitelli, C | 1 |
| Suarez Halty, L | 1 |
| Dufresne, RG | 1 |
| Curlin, MU | 1 |
| Wright, K | 1 |
| Dufresne, R | 1 |
| Epstein, E | 1 |
| Robinson, JK | 1 |
| Braunstein, BL | 1 |
| Stanley, RJ | 1 |
| Roenigk, RK | 1 |
| Gibson, LE | 1 |
| Perry, HO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial[NCT04219358] | Phase 1 | 49 participants (Actual) | Interventional | 2019-03-23 | Terminated (stopped due to Study terminated because of COVID19 pandemics.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluorouracil and Cheilitis
| Article | Year |
|---|---|
Treatments of actinic cheilitis: A systematic review of the literature.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cheilitis; Combined Modality Therapy; Dermabrasion; D | 2020 |
Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.
Topics: Administration, Cutaneous; Aged; Angioedema; Antimetabolites, Antineoplastic; Cheilitis; Fluorouraci | 2018 |
Actinic cheilitis: a treatment review.
Topics: Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Caustics; Cheilitis; Cryosurgery; | 2010 |
Actinic cheilitis. A treatment review.
Topics: Cheilitis; Cryosurgery; Electrocoagulation; Fluorouracil; Humans; Laser Therapy; Precancerous Condit | 1997 |
1 trial available for fluorouracil and Cheilitis
| Article | Year |
|---|---|
Actinic cheilitis. A prospective study comparing four treatment methods.
Topics: Aged; Cheilitis; Chemexfoliation; Female; Fluorouracil; Humans; Laser Therapy; Lip; Male; Middle Age | 1989 |
9 other studies available for fluorouracil and Cheilitis
| Article | Year |
|---|---|
Solar cheilosis: an ominous precursor part II. Therapeutic perspectives.
Topics: Administration, Topical; Aminoquinolines; Biopsy; Carcinoma, Squamous Cell; Cheilitis; Combined Moda | 2012 |
THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.
Topics: 3' Untranslated Regions; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; Carcino | 2012 |
Lower lip exhibits shiny, white, nonhealing lesions. Patient was heavy smoker in past, and has spent much time outdoors.
Topics: Administration, Topical; Cheilitis; Fluorouracil; Humans; Immunosuppressive Agents; Male; Middle Age | 2005 |
[Experience on topical 5-fluoruracil- (5-FU) in cutaneous carcinomatosis. I. Test on the efficiency of topical 5-FU].
Topics: Carcinoma, Basal Cell; Cheilitis; Facial Dermatoses; Female; Fluorouracil; Hand Dermatoses; Humans; | 1966 |
Actinic cheilitis.
Topics: Cheilitis; Fluorouracil; Humans; Sunlight | 1998 |
Treatment of lip keratoses (actinic cheilitis) with topical fluorouracil.
Topics: Administration, Topical; Adult; Aged; Cheilitis; Female; Fluorouracil; Humans; Keratosis; Lip Neopla | 1977 |
Herpes simplex complicating topical 5-fluorouracil therapy.
Topics: Administration, Topical; Cheilitis; Female; Fluorouracil; Herpes Labialis; Humans; Middle Aged; Simp | 1985 |
Actinic cheilitis: treatment with the carbon dioxide laser.
Topics: Administration, Topical; Aged; Carbon Dioxide; Cheilitis; Fluorouracil; Humans; Laser Therapy; Male; | 1988 |
Skin lesions from sun exposure: a treatment guide.
Topics: Acute Disease; Adult; Aged; Carcinoma, Squamous Cell; Cheilitis; Chronic Disease; Fluorouracil; Huma | 1985 |