Page last updated: 2024-10-27

fluorouracil and Cerebral Infarction

fluorouracil has been researched along with Cerebral Infarction in 6 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).

Research Excerpts

ExcerptRelevanceReference
" CASE REPORT We report the case of a patient who was diagnosed with stage IV colorectal cancer and who underwent chemotherapy with a high dose of 5-FU as part of the FOLFIRI (Folinic Acid, Fluorouracil, Irinotecan) treatment plan."9.41Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review. ( Gofir, A; Hutajulu, SH; Nugroho, DB; Yuwono, KA, 2023)
" CASE REPORT We report the case of a patient who was diagnosed with stage IV colorectal cancer and who underwent chemotherapy with a high dose of 5-FU as part of the FOLFIRI (Folinic Acid, Fluorouracil, Irinotecan) treatment plan."5.41Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review. ( Gofir, A; Hutajulu, SH; Nugroho, DB; Yuwono, KA, 2023)
"In a transient 90-min middle cerebral artery occlusion (MCAO) model of rats, a large ischemic lesion is formed where macrophage-like cells massively accumulate, many of which express a macrophage marker, Iba1, and an oligodendrocyte progenitor cell marker, NG2 chondroitin sulfate proteoglycan (NG2); therefore, the cells were termed BINCs (Brain Iba1(+)/NG2(+) Cells)."1.36Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain. ( Inoue, A; Kumon, Y; Matsumoto, H; Ohnishi, T; Ohue, S; Smirkin, A; Tagawa, M; Takahashi, H; Tanaka, J; Watanabe, H; Yano, H, 2010)
"Suspected pulmonary embolism was demonstrated by CT scan."1.31[Complicated antiphospholid antibody syndrome]. ( Eifrig, B; Hegewisch-Becker, S; Hossfeld, DK; Langer, F; Marx, G; Neuber, K, 2002)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Yuwono, KA1
Hutajulu, SH1
Gofir, A1
Nugroho, DB1
Kurniadi, I1
Yamada, D1
Wirya, AY1
Norimatsu, Y1
Kuzumi, A1
Ogaki, J1
Takahashi, N1
Sato, S1
Smirkin, A1
Matsumoto, H1
Takahashi, H1
Inoue, A1
Tagawa, M1
Ohue, S1
Watanabe, H1
Yano, H1
Kumon, Y1
Ohnishi, T1
Tanaka, J1
Katoh, K1
Sone, M1
Kuroda, T1
Nakasato, T1
Ehara, S1
Satoh, C1
Ohtsuka, K1
Higuchi, T1
El Amrani, M1
Heinzlef, O1
Debroucker, T1
Roullet, E1
Bousser, MG1
Amarenco, P1
Langer, F1
Eifrig, B1
Hegewisch-Becker, S1
Marx, G1
Neuber, K1
Hossfeld, DK1

Reviews

1 review available for fluorouracil and Cerebral Infarction

ArticleYear
Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review.
    The American journal of case reports, 2023, Apr-04, Volume: 24

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cerebral Infarction; Colorectal Neoplasms; Fluoroura

2023

Other Studies

5 other studies available for fluorouracil and Cerebral Infarction

ArticleYear
Trousseau syndrome associated with cutaneous squamous cell carcinoma.
    The Journal of dermatology, 2018, Volume: 45, Issue:8

    Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Atherosclerosis; Carcinoma, Squamous Cell; Carot

2018
Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:3

    Topics: Animals; Antigens; Bone Marrow Transplantation; Brain; Brain Ischemia; Bromodeoxyuridine; Calcium-Bi

2010
[A case of cerebral infarction caused by disseminated intravascular coagulation during hepatic arterial infusion chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:7

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cerebral Infarction; Colorectal Neoplasms; Dis

2005
Brain infarction following 5-fluorouracil and cisplatin therapy.
    Neurology, 1998, Volume: 51, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cerebral Infarction; Cisplatin; Fatal Outcome;

1998
[Complicated antiphospholid antibody syndrome].
    Deutsche medizinische Wochenschrift (1946), 2002, Jul-05, Volume: 127, Issue:27

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antiphospholipid Syndrome; Breast Neoplasms; Carcino

2002