fluorouracil has been researched along with Cerebellar Diseases in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cerebellar Diseases: Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine is an oral fluoropyrimidine that was designed to allow selective activation in tumour tissues, thus reducing toxicity." | 5.36 | Capecitabine-induced cerebellar toxicity in a patient with metastatic colorectal cancer. ( Ahmad, A; Gounaris, I, 2010) |
| "Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity." | 3.65 | Oculomotor disturbances associated with 5-fluorouracil chemotherapy. ( Bixenman, WW; Nicholls, JV; Warwick, OH, 1977) |
| "Capecitabine is an oral fluoropyrimidine that was designed to allow selective activation in tumour tissues, thus reducing toxicity." | 1.36 | Capecitabine-induced cerebellar toxicity in a patient with metastatic colorectal cancer. ( Ahmad, A; Gounaris, I, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fine, JD | 1 |
| Dewan, A | 1 |
| Miller, JL | 1 |
| Gounaris, I | 1 |
| Ahmad, A | 1 |
| MOERTEL, CG | 1 |
| REITEMEIER, RJ | 1 |
| BOLTON, CF | 1 |
| SHORTER, RG | 1 |
| RIEHL, JL | 1 |
| BROWN, WJ | 1 |
| Recht, L | 1 |
| Bixenman, WW | 1 |
| Nicholls, JV | 1 |
| Warwick, OH | 1 |
6 other studies available for fluorouracil and Cerebellar Diseases
| Article | Year |
|---|---|
Occurrence of Acute Cerebellar Syndrome After Topical Application of Fluorouracil.
Topics: Acute Disease; Administration, Topical; Cerebellar Diseases; Fluorouracil; Humans; Immunosuppressive | 2017 |
Capecitabine-induced cerebellar toxicity in a patient with metastatic colorectal cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecit | 2010 |
CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY.
Topics: Ataxia; Cerebellar Ataxia; Cerebellar Diseases; Floxuridine; Fluorouracil; Gastrointestinal Neoplasm | 1964 |
ACUTE CEREBELLAR SYNDROME SECONDARY TO 5-FLUOROURACIL THERAPY.
Topics: Abdominal Neoplasms; Adenocarcinoma; Bone Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, | 1964 |
Early diagnosis and intravenous immune globulin therapy in paraneoplastic cerebellar degeneration.
Topics: Adult; Cerebellar Diseases; Diagnosis, Differential; Female; Fluorouracil; Humans; Immunoglobulins, | 1993 |
Oculomotor disturbances associated with 5-fluorouracil chemotherapy.
Topics: Adenocarcinoma; Adult; Brain Stem; Cerebellar Diseases; Colonic Neoplasms; Eye Movements; Female; Fl | 1977 |