Page last updated: 2024-10-27

fluorouracil and Centriacinar Emphysema

fluorouracil has been researched along with Centriacinar Emphysema in 1 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Structural changes were found in the experimental (5-fluorouracil) group compared to the controls, including abnormal alveolar duct, sac, and terminal bronchioles with emphysematous changes in most of the alveoli in addition to peribronchiolitis, perivasculitis, inflammatory cells infiltration and interstitial fibrosis."3.80The structural changes of the rat's lung induced by intraperitoneal injection of 5-fluorouracil. ( Al-Hamdany, MZ; Al-Hubaity, AY, 2014)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Al-Hamdany, MZ1
Al-Hubaity, AY1

Other Studies

1 other study available for fluorouracil and Centriacinar Emphysema

ArticleYear
The structural changes of the rat's lung induced by intraperitoneal injection of 5-fluorouracil.
    JPMA. The Journal of the Pakistan Medical Association, 2014, Volume: 64, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Case-Control Studies; Female; Fibrosis; Fluorouracil; Inje

2014