fluorouracil has been researched along with Centriacinar Emphysema in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Structural changes were found in the experimental (5-fluorouracil) group compared to the controls, including abnormal alveolar duct, sac, and terminal bronchioles with emphysematous changes in most of the alveoli in addition to peribronchiolitis, perivasculitis, inflammatory cells infiltration and interstitial fibrosis." | 3.80 | The structural changes of the rat's lung induced by intraperitoneal injection of 5-fluorouracil. ( Al-Hamdany, MZ; Al-Hubaity, AY, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Hamdany, MZ | 1 |
| Al-Hubaity, AY | 1 |
1 other study available for fluorouracil and Centriacinar Emphysema
| Article | Year |
|---|---|
The structural changes of the rat's lung induced by intraperitoneal injection of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Case-Control Studies; Female; Fibrosis; Fluorouracil; Inje | 2014 |