fluorouracil has been researched along with Central Nervous System Neoplasm in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Median time from breast cancer diagnosis to the development of CNS metastasis was 48 (18-165) months." | 6.73 | Capecitabine therapy of central nervous system metastases from breast cancer. ( Abrey, LE; Deangelis, LM; Ekenel, M; Hormigo, AM; Peak, S, 2007) |
| "Median time from breast cancer diagnosis to the development of CNS metastasis was 48 (18-165) months." | 2.73 | Capecitabine therapy of central nervous system metastases from breast cancer. ( Abrey, LE; Deangelis, LM; Ekenel, M; Hormigo, AM; Peak, S, 2007) |
| "However, the presence of metastases separate from the pituitary in the central nervous system or at a distance is necessary to designate pituitary tumors as carcinomas, i." | 1.30 | The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors. ( Besser, GM; Grossman, AB; Kaltsas, GA; Monson, JP; Mukherjee, JJ; Plowman, PN, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krop, IE | 1 |
| Lin, NU | 1 |
| Blackwell, K | 1 |
| Guardino, E | 1 |
| Huober, J | 1 |
| Lu, M | 1 |
| Miles, D | 1 |
| Samant, M | 1 |
| Welslau, M | 1 |
| Diéras, V | 1 |
| Foglietta, J | 1 |
| Metro, G | 1 |
| Crinò, L | 1 |
| Gori, S | 1 |
| Pestalozzi, BC | 1 |
| Francis, P | 1 |
| Quinaux, E | 1 |
| Dolci, S | 1 |
| Azambuja, E | 1 |
| Gelber, RD | 1 |
| Viale, G | 1 |
| Balil, A | 1 |
| Andersson, M | 1 |
| Nordenskjöld, B | 1 |
| Gnant, M | 1 |
| Gutierrez, J | 1 |
| Láng, I | 1 |
| Crown, JP | 1 |
| Piccart-Gebhart, M | 1 |
| Abali, H | 1 |
| Celik, I | 1 |
| Ekenel, M | 1 |
| Hormigo, AM | 1 |
| Peak, S | 1 |
| Deangelis, LM | 1 |
| Abrey, LE | 1 |
| Jardines, L | 1 |
| Callans, LS | 1 |
| Torosian, MH | 1 |
| Kaltsas, GA | 1 |
| Mukherjee, JJ | 1 |
| Plowman, PN | 1 |
| Monson, JP | 1 |
| Grossman, AB | 1 |
| Besser, GM | 1 |
1 review available for fluorouracil and Central Nervous System Neoplasm
| Article | Year |
|---|---|
Recurrent breast cancer: presentation, diagnosis, and treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Bone Neoplasms; Breast | 1993 |
3 trials available for fluorouracil and Central Nervous System Neoplasm
| Article | Year |
|---|---|
Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA.
Topics: Ado-Trastuzumab Emtansine; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antime | 2015 |
Is risk of central nervous system (CNS) relapse related to adjuvant taxane treatment in node-positive breast cancer? Results of the CNS substudy in the intergroup Phase III BIG 02-98 Trial.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Central N | 2008 |
Capecitabine therapy of central nervous system metastases from breast cancer.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma; Central Nervous S | 2007 |
3 other studies available for fluorouracil and Central Nervous System Neoplasm
| Article | Year |
|---|---|
Letter to the editor concerning 'Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA'.
Topics: Antibodies, Monoclonal, Humanized; Breast Neoplasms; Central Nervous System Neoplasms; Deoxycytidine | 2015 |
High incidence of central nervous system involvement in patients with breast cancer treated with epirubicin and docetaxel.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; | 2002 |
The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined C | 1998 |