fluorouracil has been researched along with Central Nervous System Diseases in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer." | 5.33 | 5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma. ( Chua, YJ; Cunningham, D; Formica, V; Leary, A, 2006) |
| "Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer." | 1.33 | 5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma. ( Chua, YJ; Cunningham, D; Formica, V; Leary, A, 2006) |
| " Since toxicity is a prominent impediment, the possibility of therapeutic synergy may perhaps be explored at drastically reduced doses of PALA, combined with other modulating measures." | 1.27 | Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer. ( Camacho, FJ; Engstrom, PF; Green, MD; Greenwald, ES; Kaplan, BH; Muggia, FM; Wernz, JC, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, W | 1 |
| Ba, H | 1 |
| Huang, P | 1 |
| Zheng, A | 1 |
| Yang, X | 1 |
| Peddi, PF | 1 |
| Peddi, S | 1 |
| Santos, ES | 1 |
| Morgensztern, D | 1 |
| Formica, V | 1 |
| Leary, A | 1 |
| Cunningham, D | 1 |
| Chua, YJ | 1 |
| Davis, ST | 1 |
| Joyner, SS | 1 |
| Baccanari, DP | 1 |
| Spector, T | 1 |
| Saletti, P | 1 |
| Pagani, O | 1 |
| Sessa, C | 1 |
| Goldhirsch, A | 1 |
| Khandekar, JD | 1 |
| Oyer, D | 1 |
| Miller, HJ | 1 |
| Vick, NA | 1 |
| Kuzuhara, S | 1 |
| Muggia, FM | 1 |
| Camacho, FJ | 1 |
| Kaplan, BH | 1 |
| Green, MD | 1 |
| Greenwald, ES | 1 |
| Wernz, JC | 1 |
| Engstrom, PF | 1 |
| Hermann, J | 1 |
| Plenert, W | 1 |
2 reviews available for fluorouracil and Central Nervous System Diseases
| Article | Year |
|---|---|
Central nervous system toxicities of chemotherapeutic agents.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Cisplatin; Cytarabine; Fluorouracil; Humans; | 2014 |
[Generalized candida mycoses].
Topics: Amphotericin B; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Burns; Candida albicans; Candidi | 1974 |
8 other studies available for fluorouracil and Central Nervous System Diseases
| Article | Year |
|---|---|
Preparation and Properties of 5-Fluorouracil-Loaded Chitosan Microspheres for the Intranasal Administration.
Topics: Administration, Intranasal; Animals; Central Nervous System Diseases; Chitosan; Drug Carriers; Drug | 2018 |
Oxaliplatin (Eloxatin) for advanced colon cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseas | 2003 |
5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma.
Topics: Antineoplastic Agents; Blood-Brain Barrier; Capecitabine; Central Nervous System Diseases; Coma; Deo | 2006 |
5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs.
Topics: Animals; beta-Alanine; Central Nervous System Diseases; Dihydrouracil Dehydrogenase (NADP); Dogs; Do | 1994 |
Two cases of neurotoxicity possibly related to 5-fluorouracil and FA administration.
Topics: Adenocarcinoma; Central Nervous System Diseases; Colonic Neoplasms; Drug Interactions; Female; Fluor | 1996 |
Neurologic involvement in glucagonoma syndrome: response to combination chemotherapy with 5-fluorouracil and streptozotocin.
Topics: Adenoma, Islet Cell; Adult; Central Nervous System Diseases; Drug Therapy, Combination; Fluorouracil | 1979 |
[Central nervous system toxicity of carmofur, an antineoplastic drug].
Topics: Aged; Central Nervous System Diseases; Electroencephalography; Female; Fluorouracil; Humans; Male; T | 1986 |
Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Central Nervous System D | 1987 |