fluorouracil has been researched along with Cell Transformation, Neoplastic in 99 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Globally, breast cancer in women is the leading cause of cancer death." | 5.43 | Apoptotic activity of 5-fluorouracil in breast cancer cells transformed by low doses of ionizing α-particle radiation. ( Calaf, GM; Ponce-Cusi, R, 2016) |
| "However, the role of KLF8 in colorectal cancer remains unknown." | 5.42 | Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil. ( Bai, Y; Chen, C; Chen, Y; Cheng, T; Liu, S; Luo, X; Peng, Y; Shi, X; Wang, J; Wu, Y; Yan, Q; Zhang, M; Zhang, W; Zhang, Y; Zhao, J, 2015) |
| "Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out." | 3.85 | The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy. ( Ishchenko, IY; Kabakov, AV; Kazakov, OV; Konenkov, VI; Michurina, SV; Poveshchenko, AF; Raiter, TV; Strunkin, DN, 2017) |
| " siRNA targeting of choline kinase-α (Chk-α), an enzyme significantly up-regulated in aggressive breast cancer cells, was combined with the prodrug enzyme bacterial cytosine deaminase (bCD) that converts the nontoxic prodrug 5-fluorocytosine (5-FC) to cytotoxic 5-fluorouracil (5-FU)." | 3.76 | Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy. ( Artemov, D; Bhujwalla, ZM; Chen, Z; Li, C; Penet, MF; Takagi, T; Wildes, F; Winnard, PT, 2010) |
| "Squamous cell carcinoma is the most common malignant change." | 2.78 | Characteristics and treatment outcomes of patients with malignant transformation arising from mature cystic teratoma of the ovary: experience at a single institution. ( Khemapech, N; Oranratanaphan, S, 2013) |
| "Condylomata acuminata are benign epitheliomas which are caused by the human papilloma virus." | 2.36 | [Condylomata acuminata]. ( Gschnait, F; Luger, A, 1981) |
| "Liver fibrosis is characterized by the progressive accumulation of extracellular matrix (ECM) and is a strong predictor of hepatocellular carcinoma (HCC) development and progression." | 1.46 | A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells. ( Fukumitsu, K; Ishii, T; Katayama, H; Kawai, T; Kita, S; Kojima, H; Minami, T; Miyauchi, Y; Ogiso, S; Sasaki, N; Uemoto, S; Yamaoka, R; Yasuchika, K; Yasuda, K; Yoshitoshi-Uebayashi, EY, 2017) |
| "Globally, breast cancer in women is the leading cause of cancer death." | 1.43 | Apoptotic activity of 5-fluorouracil in breast cancer cells transformed by low doses of ionizing α-particle radiation. ( Calaf, GM; Ponce-Cusi, R, 2016) |
| "Oral squamous cell carcinoma (OSCC), one of the most deadliest malignancies in the world, is caused primarily by areca nut chewing in Southeast Asia." | 1.43 | Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline. ( Chang, YC; Chou, MY; Lee, SS; Peng, CY; Wang, TY; Yu, CC, 2016) |
| "However, the role of KLF8 in colorectal cancer remains unknown." | 1.42 | Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil. ( Bai, Y; Chen, C; Chen, Y; Cheng, T; Liu, S; Luo, X; Peng, Y; Shi, X; Wang, J; Wu, Y; Yan, Q; Zhang, M; Zhang, W; Zhang, Y; Zhao, J, 2015) |
| "However, the role of CSCs in colorectal cancer metastasis is unclear." | 1.36 | A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. ( Cheung, LW; Chow, AK; Chu, AC; Lam, CS; Lan, HY; Lan, XR; Law, WL; Ng, L; Pang, R; Poon, JT; Poon, RT; Tan, VP; Wong, BC; Yau, TC, 2010) |
| "As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis." | 1.36 | LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. ( Chae, HS; Kang, JH; Kim, JO; Lee, SK; Shin, JY, 2010) |
| "Finally, RhoB inhibits melanoma metastasis to the lung in a mouse model." | 1.32 | Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. ( Cheng, J; Djeu, JY; Jiang, K; Sebti, S; Sun, J; Wei, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (36.36) | 18.7374 |
| 1990's | 7 (7.07) | 18.2507 |
| 2000's | 10 (10.10) | 29.6817 |
| 2010's | 39 (39.39) | 24.3611 |
| 2020's | 7 (7.07) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, TC | 1 |
| Zhou, ZH | 1 |
| Ju, WT | 1 |
| Liang, SY | 1 |
| Tang, X | 1 |
| Zhu, DW | 1 |
| Zhang, ZY | 1 |
| Zhong, LP | 1 |
| Gong, W | 1 |
| Guo, Y | 1 |
| Yuan, H | 1 |
| Chai, R | 1 |
| Wan, Z | 1 |
| Zheng, B | 1 |
| Hu, X | 2 |
| Chen, B | 1 |
| Gao, S | 1 |
| Dai, Q | 1 |
| Yu, P | 1 |
| Tu, S | 1 |
| Okuyama, H | 1 |
| Nogami, W | 1 |
| Sato, Y | 1 |
| Yoshida, H | 1 |
| Tona, Y | 1 |
| Tanaka, Y | 1 |
| Chung, HH | 1 |
| Lee, CT | 1 |
| Hu, JM | 1 |
| Chou, YC | 1 |
| Lin, YW | 1 |
| Shih, YL | 1 |
| Gilchrest, BA | 1 |
| Zhou, H | 2 |
| Li, N | 1 |
| Li, G | 1 |
| Sun, X | 1 |
| Ge, F | 1 |
| Jiang, J | 2 |
| Yao, J | 1 |
| Huang, D | 1 |
| Yang, L | 1 |
| Meyer, FB | 1 |
| Goebel, S | 1 |
| Spangel, SB | 1 |
| Leovsky, C | 1 |
| Hoelzer, D | 1 |
| Thierbach, R | 1 |
| Sun, L | 1 |
| Jiang, C | 1 |
| Xu, C | 1 |
| Xue, H | 1 |
| Gu, L | 1 |
| Liu, Y | 1 |
| Xu, Q | 1 |
| Miyauchi, Y | 1 |
| Yasuchika, K | 1 |
| Fukumitsu, K | 1 |
| Ishii, T | 1 |
| Ogiso, S | 1 |
| Minami, T | 1 |
| Kojima, H | 1 |
| Yamaoka, R | 1 |
| Katayama, H | 1 |
| Kawai, T | 1 |
| Yoshitoshi-Uebayashi, EY | 1 |
| Kita, S | 1 |
| Yasuda, K | 1 |
| Sasaki, N | 1 |
| Uemoto, S | 1 |
| Al-Haseni, A | 1 |
| Chitgopeker, P | 1 |
| Ho, JD | 1 |
| Goldberg, LJ | 1 |
| Sahni, D | 1 |
| Radyk, MD | 1 |
| Burclaff, J | 1 |
| Willet, SG | 1 |
| Mills, JC | 1 |
| Schelhaas, S | 1 |
| Wachsmuth, L | 1 |
| Hermann, S | 1 |
| Rieder, N | 1 |
| Heller, A | 1 |
| Heinzmann, K | 1 |
| Honess, DJ | 1 |
| Smith, DM | 1 |
| Fricke, IB | 1 |
| Just, N | 1 |
| Doblas, S | 1 |
| Sinkus, R | 1 |
| Döring, C | 1 |
| Schäfers, KP | 1 |
| Griffiths, JR | 1 |
| Faber, C | 1 |
| Schneider, R | 1 |
| Aboagye, EO | 1 |
| Jacobs, AH | 1 |
| Zhang, W | 4 |
| Lu, Y | 1 |
| Li, X | 6 |
| Zhang, J | 2 |
| Lin, W | 1 |
| Zheng, L | 1 |
| Jafek, JL | 1 |
| Shakya, A | 1 |
| Tai, PY | 1 |
| Ibarra, A | 1 |
| Kim, H | 1 |
| Maddox, J | 1 |
| Chumley, J | 1 |
| Spangrude, GJ | 1 |
| Miles, RR | 1 |
| Kelley, TW | 1 |
| Tantin, D | 1 |
| Park, JS | 1 |
| Chang, DY | 1 |
| Kim, JH | 1 |
| Jung, JH | 1 |
| Park, J | 1 |
| Kim, SH | 1 |
| Lee, YD | 1 |
| Kim, SS | 1 |
| Suh-Kim, H | 1 |
| Kuznietsova, HM | 1 |
| Ogloblya, OV | 1 |
| Rybalchenko, VK | 1 |
| Lo, AK | 1 |
| Lo, KW | 1 |
| Ko, CW | 1 |
| Young, LS | 1 |
| Dawson, CW | 1 |
| Kabadere, S | 1 |
| Kus, G | 1 |
| Uyar, R | 1 |
| Oztopcu-Vatan, P | 1 |
| Kucerova, L | 1 |
| Feketeova, L | 1 |
| Kozovska, Z | 1 |
| Poturnajova, M | 1 |
| Matuskova, M | 1 |
| Nencka, R | 1 |
| Babal, P | 1 |
| Oranratanaphan, S | 1 |
| Khemapech, N | 1 |
| Puissant, A | 1 |
| Fenouille, N | 1 |
| Alexe, G | 1 |
| Pikman, Y | 1 |
| Bassil, CF | 1 |
| Mehta, S | 1 |
| Du, J | 1 |
| Kazi, JU | 1 |
| Luciano, F | 1 |
| Rönnstrand, L | 1 |
| Kung, AL | 1 |
| Aster, JC | 1 |
| Galinsky, I | 1 |
| Stone, RM | 1 |
| DeAngelo, DJ | 1 |
| Hemann, MT | 1 |
| Stegmaier, K | 1 |
| Alomar, A | 1 |
| Xiao, J | 1 |
| Peng, F | 1 |
| Yu, C | 1 |
| Wang, M | 1 |
| Li, Z | 1 |
| Sun, C | 1 |
| Chen, X | 1 |
| Zhao, B | 1 |
| Shang, D | 1 |
| Zhong, M | 1 |
| Deng, C | 1 |
| Jia, X | 2 |
| Chi, JY | 1 |
| Hsiao, YW | 1 |
| Li, CF | 1 |
| Lo, YC | 1 |
| Lin, ZY | 1 |
| Hong, JY | 1 |
| Liu, YM | 1 |
| Han, X | 1 |
| Wang, SM | 1 |
| Chen, BK | 1 |
| Tsai, KK | 1 |
| Wang, JM | 1 |
| Shi, X | 1 |
| Luo, X | 1 |
| Yan, Q | 1 |
| Wu, Y | 1 |
| Zhang, M | 1 |
| Zhao, J | 2 |
| Peng, Y | 1 |
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Chen, C | 2 |
| Cheng, T | 1 |
| Liu, S | 1 |
| Bai, Y | 1 |
| Wang, J | 1 |
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| Zhou, X | 1 |
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| Liu, L | 1 |
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| Li, L | 2 |
| Ji, Q | 1 |
| Liu, H | 1 |
| Kazakov, OV | 1 |
| Kabakov, AV | 1 |
| Ishchenko, IY | 1 |
| Poveshchenko, AF | 1 |
| Raiter, TV | 1 |
| Strunkin, DN | 1 |
| Michurina, SV | 1 |
| Konenkov, VI | 1 |
| Huang, Y | 1 |
| McHenry, KT | 1 |
| Kim, MM | 1 |
| Zeng, W | 1 |
| Lopez-Pajares, V | 1 |
| Dibble, CC | 1 |
| Mizgerd, JP | 1 |
| Yuan, ZM | 1 |
| Ajani, JA | 1 |
| Wang, X | 1 |
| Izzo, JG | 1 |
| Crane, CH | 1 |
| Eng, C | 1 |
| Skibber, JM | 1 |
| Das, P | 1 |
| Rashid, A | 1 |
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| Paolino, D | 1 |
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| Celia, C | 1 |
| Citraro, R | 1 |
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| Fresta, M | 1 |
| Pang, R | 1 |
| Law, WL | 1 |
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| Poon, JT | 1 |
| Lam, CS | 1 |
| Chow, AK | 1 |
| Ng, L | 1 |
| Cheung, LW | 1 |
| Lan, XR | 1 |
| Lan, HY | 1 |
| Tan, VP | 1 |
| Yau, TC | 1 |
| Poon, RT | 1 |
| Wong, BC | 1 |
| Shin, JY | 1 |
| Kim, JO | 1 |
| Lee, SK | 1 |
| Chae, HS | 1 |
| Kang, JH | 1 |
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| Saxena, A | 1 |
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| Artemov, D | 1 |
| Bhujwalla, ZM | 1 |
| Papageorgis, P | 1 |
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| Buckley, NE | 1 |
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| Lantuas, D | 1 |
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| De Thé, H | 1 |
| Soliman, H | 1 |
| Nunes, M | 1 |
| Lardier, G | 1 |
| Calvet, L | 1 |
| Demers, B | 1 |
| Prévost, G | 1 |
| Vrignaud, P | 1 |
| Roman-Roman, S | 1 |
| Duchamp, O | 1 |
| Berthet, C | 1 |
| Lee, I | 1 |
| Lee, SJ | 1 |
| Kang, WK | 1 |
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| Chang, EY | 1 |
| Tsai, SH | 1 |
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| Hee, SW | 1 |
| Tsai, YC | 1 |
| Tsai, JS | 1 |
| Chen, HJ | 1 |
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| Lin, SY | 1 |
| Chuang, LM | 1 |
| Jia, L | 1 |
| Shi, M | 1 |
| Ye, X | 1 |
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| Wang, E | 1 |
| Li, F | 1 |
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| Tevethia, MJ | 1 |
| Carnesecchi, S | 1 |
| Langley, K | 1 |
| Exinger, F | 1 |
| Gosse, F | 1 |
| Raul, F | 1 |
| Jiang, K | 2 |
| Delarue, FL | 1 |
| Sebti, SM | 1 |
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| Hamill, RL | 1 |
| Dainer, P | 1 |
| Sun, J | 1 |
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| Wei, S | 1 |
| Sebti, S | 1 |
| Ambrosini-Spaltro, A | 1 |
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| Frezza, GP | 1 |
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9 reviews available for fluorouracil and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Actinic Keratoses: Reconciling the Biology of Field Cancerization with Treatment Paradigms.
Topics: Administration, Cutaneous; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Transformation, Neo | 2021 |
Actinic keratosis: new concepts and therapeutic approaches for an ancestral condition.
Topics: Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cryotherapy; Electrocoagulation; Fluorour | 2014 |
[Condylomata acuminata].
Topics: Adult; Cell Transformation, Neoplastic; Colchicine; Condylomata Acuminata; Cryosurgery; Electrocoagu | 1981 |
Tretinoin. A review of its pharmacological properties and clinical efficacy in the topical treatment of photodamaged skin.
Topics: Administration, Topical; Animals; Cell Transformation, Neoplastic; Clinical Trials as Topic; Drug Th | 1995 |
[Treatment possibilities of laryngeal cancer. Surgery--radiotherapy--chemotherapy].
Topics: Antineoplastic Agents; Cell Transformation, Neoplastic; Chemotherapy, Cancer, Regional Perfusion; Co | 1975 |
Growth and death of diploid and transformed human fibroblasts.
Topics: Animals; Biological Clocks; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cu | 1975 |
Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Cytidine; Deoxycytidine; Deo | 1985 |
Lysogenic induction.
Topics: Animals; Bacteria; Bacteriolysis; Bacteriophages; Cell Transformation, Neoplastic; Chromosomes; Coli | 1973 |
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.
Topics: Animals; Antineoplastic Agents; Arginase; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Divisi | 1970 |
1 trial available for fluorouracil and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Characteristics and treatment outcomes of patients with malignant transformation arising from mature cystic teratoma of the ovary: experience at a single institution.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Antineoplastic Combined Chemotherapy Protocol | 2013 |
89 other studies available for fluorouracil and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Mechanism of sensitivity to cisplatin, docetaxel, and 5-fluorouracil chemoagents and potential erbB2 alternatives in oral cancer with growth differentiation factor 15 overexpression.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 9; Cell Line, Tumor; Cel | 2022 |
Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
Topics: Cancer-Associated Fibroblasts; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2023 |
Characterization of CD44-positive Cancer Stem-like Cells in COLO 201 Cells.
Topics: Animals; Biomarkers; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Cell Transformation, Neopla | 2020 |
NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Transformation, Ne | 2020 |
Loganetin and 5-fluorouracil synergistically inhibit the carcinogenesis of gastric cancer cells via down-regulation of the Wnt/β-catenin pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; beta Catenin; Biomarkers; Cell Line, Tumor; Cell Surviva | 2020 |
Metformin alters therapeutic effects in the BALB/c tumor therapy model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BALB 3T3 Cells; Carcinogens; Cell Survival; | 2021 |
Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway.
Topics: Adult; Aged; Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Movement; | 2017 |
A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells.
Topics: Animals; Biopsy; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line, Tumor; Cell Prolifer | 2017 |
Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach.
Topics: Administration, Cutaneous; Aged; Antimetabolites, Antineoplastic; Bandages; Biopsy; Cell Transformat | 2018 |
Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Lineage; Cell Proliferation; Cell Transdifferentiat | 2018 |
Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Artifacts; Biological Transport; Cell Trans | 2018 |
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Topics: Active Transport, Cell Nucleus; Adult; Aged; Animals; beta Karyopherins; Carrier Proteins; Cell Line | 2019 |
Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
Topics: Animals; Bone Marrow; Bone Marrow Failure Disorders; CDX2 Transcription Factor; Cell Transformation, | 2019 |
Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells.
Topics: Adolescent; Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplast | 2013 |
Impact of dihydropyrrol derivative on the normal colonic mucosa of DMH-induced colon cancer rats compared with 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Cell Transformation, Neoplastic; | 2013 |
Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Car | 2013 |
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis.
Topics: Analysis of Variance; Animals; Apoptosis; Cell Transformation, Neoplastic; DNA Primers; Dose-Respons | 2014 |
In vivo 5FU-exposed human medullary thyroid carcinoma cells contain a chemoresistant CD133+ tumor-initiating cell subset.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents; Apoptosis; Carcinoma, Medullary; Carcinoma, Neur | 2014 |
SYK is a critical regulator of FLT3 in acute myeloid leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Proliferation; Cell Tra | 2014 |
microRNA-137 modulates pancreatic cancer cells tumor growth, invasion and sensitivity to chemotherapy.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Down-Regulation; Female; | 2014 |
Dormancy activation mechanism of oral cavity cancer stem cells.
Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell T | 2015 |
Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers.
Topics: Animals; Antineoplastic Agents; Apoptosis; C-Reactive Protein; CCAAT-Enhancer-Binding Protein-delta; | 2015 |
Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Cell Transformat | 2015 |
Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Adult; Animals; Cadherins; Cell Line, Tumor; Cell Movement; Ce | 2016 |
Apoptotic activity of 5-fluorouracil in breast cancer cells transformed by low doses of ionizing α-particle radiation.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Caspase 3; Cell Lin | 2016 |
Stem cell function and stress response are controlled by protein synthesis.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cytosine; Female | 2016 |
Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline.
Topics: 3' Untranslated Regions; Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Arecoline; | 2016 |
Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways.
Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Co | 2016 |
The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinogens; Cell Transform | 2017 |
Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation.
Topics: Animals; Arsenic; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytoplasm; DNA Damage; Extracel | 2008 |
Molecular biomarkers correlate with disease-free survival in patients with anal canal carcinoma treated with chemoradiation.
Topics: Anal Canal; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Biomarkers, Tumor; Carci | 2010 |
Novel PEG-coated niosomes based on bola-surfactant as drug carriers for 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Aza Compounds; Capsules; Cell Transformation, Neoplastic; Chemical P | 2009 |
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma; Cell Migration Assays; Cell Transformation, Neopla | 2010 |
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Cell | 2010 |
Secondary cytoreduction and perioperative intraperitoneal chemotherapy after initial debulking of pseudomyxoma peritonei: a study of timing and the impact of malignant dedifferentiation.
Topics: Adult; Antineoplastic Agents; Cell Differentiation; Cell Transformation, Neoplastic; Disease Progres | 2010 |
Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy.
Topics: Animals; Bacteria; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplasti | 2010 |
Smad4 inactivation promotes malignancy and drug resistance of colon cancer.
Topics: Cell Hypoxia; Cell Movement; Cell Transformation, Neoplastic; Colonic Neoplasms; Drug Resistance, Ne | 2011 |
[Isolation and identification of side population cells in human lung adenocarcinoma cell line A549].
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; ATP-Binding Cassette Transporters; Cell Cycle; Cell | 2011 |
CD133(-) cells, derived from a single human colon cancer cell line, are more resistant to 5-fluorouracil (FU) than CD133(+) cells, dependent on the β1-integrin signaling.
Topics: AC133 Antigen; Adenocarcinoma; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, | 2012 |
BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers.
Topics: Antineoplastic Agents; Base Sequence; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Cell Prolif | 2012 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.
Topics: Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Camptot | 2012 |
Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo.
Topics: Animals; Autophagy; Biomarkers, Tumor; Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Transforma | 2012 |
Prostaglandin reductase 2 modulates ROS-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients.
Topics: 15-Oxoprostaglandin 13-Reductase; Alcohol Dehydrogenase; Animals; Caspase 3; Cell Death; Cell Line, | 2012 |
Enrichment of Oct3/4-positive cells from a human bronchial epithelial cell line.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Differentiation; Cell Line; Cell Proliferati | 2013 |
Simian virus 40 large T antigen and two independent T-antigen segments sensitize cells to apoptosis following genotoxic damage.
Topics: Animals; Antigens, Polyomavirus Transforming; Apoptosis; Cell Line; Cell Transformation, Neoplastic; | 2002 |
Geraniol, a component of plant essential oils, sensitizes human colon cancer cells to 5-fluorouracil treatment.
Topics: Acyclic Monoterpenes; Antimetabolites, Antineoplastic; Biological Transport; Caco-2 Cells; Cell Deat | 2002 |
EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation.
Topics: Animals; Anoikis; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Transformation, | 2004 |
Rectal adenocarcinoma with germ-cell differentiation: report of a case.
Topics: Adenocarcinoma; Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin | 2003 |
Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Transformation, Neoplastic; Down-Regulation; Female; | 2004 |
Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Cell Transformation, Neopl | 2006 |
[Biodistribution of (99m)Tc-labeled anti-VEGF mAb 5-FU loaded polylactic acid nanoparticles in human gastric carcinoma xenografts].
Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Fluorour | 2007 |
Combined effects of 5-fluorouracil and interferon on proliferation of human neoplastic cells in culture.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical; Fibroblasts; Fluo | 1982 |
Therapeutic effect dependent on timing of combination treatment with chemotherapy and allogeneic lymphoid cell transfer in rats.
Topics: Animals; Cell Transformation, Neoplastic; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; | 1980 |
Transforming activities of methotrexate, hydroxyurea and 5-fluorouracil in different cell systems.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Do | 1983 |
Castration--chemotherapy treatment of prostate cancer model.
Topics: Animals; Carmustine; Castration; Cell Transformation, Neoplastic; Cisplatin; Cyclophosphamide; Disea | 1981 |
[Use of 5-fluorouracil in the radiation therapy of cervical cancer].
Topics: Adult; Aged; Cell Cycle; Cell Transformation, Neoplastic; Female; Fluorouracil; Humans; Lymphatic Me | 1980 |
Influence of cisplatinum and 5-fluorouracil on the oral mucosa.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, Neoplastic; Cisplatin; Fluorour | 1994 |
[Effect of a cisplatin-5-fluorouracil combination chemotherapy on malignant transformation of the epithelium of mouth mucosa].
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Di | 1994 |
ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.
Topics: Animals; Base Sequence; Bone Marrow; Cell Transformation, Neoplastic; Fluorouracil; Fusion Proteins, | 1993 |
HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; DNA Damage; DNA Rep | 2000 |
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Neoplast | 1976 |
Isolation of variant cells from SV-40 transformed human diploid fibroblasts.
Topics: Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Contact Inhibition; Fibroblasts; | 1975 |
Selective killing of transformed baby hamster kidney (BHK) cells.
Topics: Antibiotics, Antineoplastic; Caffeine; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cy | 1975 |
Evidence for an increase in presumed somatic mutation during the ageing of human cells in culture.
Topics: Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Fluorouracil; Genetic Vari | 1979 |
Comparison of RNA metabolism in G1-arrested and stimulated nontransformed and chemically transformed mouse embryo cells in culture.
Topics: Amanitins; Animals; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Embryo, Mamma | 1979 |
Changes in cell age cohort composition of tumors and normal tissues by radiation and chemotherapy.
Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Fluorouracil; Hydroxyurea; Mice; Splenic Ne | 1976 |
Uterine mullerian adenosarcoma following adenomyoma in a woman on tamoxifen therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltr | 1992 |
Activation and cytotoxicity of 5'-deoxy-5-fluorouridine in c-H-ras transformed NIH 3T3 cells.
Topics: Animals; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationsh | 1991 |
[Colorectal carcinogenesis, tumor progression and chemoresistance].
Topics: Camptothecin; Cell Transformation, Neoplastic; Colorectal Neoplasms; Drug Resistance; Fluorouracil; | 1990 |
Transformation of single myeloid precursor cells by the malignant histiocytosis sarcoma virus (MHSV): generation of growth-factor-independent myeloid colonies and permanent cell lines.
Topics: Animals; Bone Marrow Cells; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Fluo | 1988 |
Potentiation of 5-fluorouracil, chromomycin A3, and bleomycin by amphotericin B or polymyxin B in transformed fibroblastic cells.
Topics: Amphotericin B; Animals; Bleomycin; Cell Transformation, Neoplastic; Chromomycins; Drug Synergism; F | 1973 |
[The effects of cytostatic agents on short-term cultures (3H-uridine incorporation) and tissue cultures (cell counts) from human tumors (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Cyta | 1974 |
Potentiation of bleomycin by an antifungal polyene, pentamycin, in transformed animal cells.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Bleomycin; Cell Transformation, Neoplastic; Cultu | 1974 |
Induction of guinea pig leukemia-like virus from cultured guinea pigs cells.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Transformation, Neoplastic; Cells, Cultured; Centr | 1974 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; | 1969 |
[Isolation and study of a conditional mutant of Rous virus with thermosensitive transforming capacity].
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Culture Techniques; D | 1970 |
[Effect of 5-fluorouracil on protein metabolism of tumors and normal tissues in culture].
Topics: Adenocarcinoma; Animals; Autoradiography; Carcinoma, Basal Cell; Cell Line; Cell Transformation, Neo | 1970 |
The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant.
Topics: Agar; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo | 1971 |
Chemical induction of focus-forming virus from nonproducer cells transformed by murine sarcoma virus.
Topics: Amines; Animals; Antigens, Viral; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Clo | 1971 |
Characteristics of a conditional mutant of Rous sarcoma virus defective in ability to transform cells at high temperature.
Topics: Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chick E | 1972 |
Effect of various inhibitors on the expression of polyoma virus-induced surface antigen in BHK21 cells.
Topics: Amino Acids; Animals; Antigens, Viral; Autoradiography; Bromodeoxyuridine; Carbon Radioisotopes; Cel | 1973 |
Activation of virus production in vaccinia virus transformed cells by methotrexate.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Complement Fixa | 1973 |
Effect of methotrexate on cells chronically infected with vaccinia virus.
Topics: Cell Count; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Drug Resista | 1973 |
Chromosome patterns of nontransformed variants from chemically transformed Balb-3T3 cells.
Topics: Animals; Benz(a)Anthracenes; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome | 1974 |
[Clinical and experimental studies on radiotherapy of inoperable tumors following partial synchronization].
Topics: Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; DNA, Neoplasm; Fluorouracil; Head and Nec | 1974 |
[Villous tumors of the jejunum and ileum].
Topics: Adenocarcinoma; Cell Transformation, Neoplastic; Female; Fluorouracil; Humans; Ileum; Intestinal Neo | 1971 |
[Radiotherapy of synchronized tumors; 1st results].
Topics: Aged; Cell Division; Cell Transformation, Neoplastic; Female; Fluorouracil; Head; Head and Neck Neop | 1970 |
Inhibition by 5-fluorouracil of the early stages of chemical carcinogenesis in mouse skin.
Topics: Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Depression, Chemical; Female; Fluorour | 1969 |