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fluorouracil and Carpal Tunnel Syndrome

fluorouracil has been researched along with Carpal Tunnel Syndrome in 1 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Carpal Tunnel Syndrome: Entrapment of the MEDIAN NERVE in the carpal tunnel, which is formed by the flexor retinaculum and the CARPAL BONES. This syndrome may be associated with repetitive occupational trauma (CUMULATIVE TRAUMA DISORDERS); wrist injuries; AMYLOID NEUROPATHIES; rheumatoid arthritis (see ARTHRITIS, RHEUMATOID); ACROMEGALY; PREGNANCY; and other conditions. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. (Joynt, Clinical Neurology, 1995, Ch51, p45)

Research Excerpts

ExcerptRelevanceReference
"We found eight patients with renal cell carcinoma who developed carpal tunnel syndrome (CTS) during treatment with IL-2, fluorouracil (5-FU), and alpha-interferon (alpha-IFN)."3.69Carpal tunnel syndrome associated with interleukin-2 therapy. ( Austin, SG; Forman, AD; Puduvalli, VK; Sella, A, 1996)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Puduvalli, VK1
Sella, A1
Austin, SG1
Forman, AD1

Other Studies

1 other study available for fluorouracil and Carpal Tunnel Syndrome

ArticleYear
Carpal tunnel syndrome associated with interleukin-2 therapy.
    Cancer, 1996, Mar-15, Volume: 77, Issue:6

    Topics: Adult; Carcinoma, Renal Cell; Carpal Tunnel Syndrome; Drug Therapy, Combination; Female; Fluorouraci

1996