fluorouracil and Carditis
fluorouracil has been researched along with Carditis in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity." | 7.83 | Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. ( Amraotkar, AR; DeFilippis, AP; Grubb, KJ; Pachika, A, 2016) |
| "5-Fluorouracil (5-FU) has a significant antineoplastic activity and has been used for the management of various malignant neoplasms." | 5.38 | Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. ( Çağdaş, M; Çalık, AN; Çeliker, E; Güzelburç, Ö; Velibey, Y, 2012) |
| "5-fluorouracil (5-FU) is one of the most common causes of cardiotoxicity associated with chemotherapy." | 5.12 | 5-FU Cardiotoxicity: Vasospasm, Myocarditis, and Sudden Death. ( Asnani, A; Lane, S; More, LA, 2021) |
| "Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity." | 3.83 | Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. ( Amraotkar, AR; DeFilippis, AP; Grubb, KJ; Pachika, A, 2016) |
| "5-fluorouracil (5FU) is a largely employed antimetabolite, responsible for several well-known toxicities like hand-foot syndrome, diarrhoea, mucositis or leucopenia." | 2.42 | [Cardiotoxicity of 5-fluorouracil]. ( Barry, S; Cohen, A; Debourdeau, P; Teixeira, L; Tournigand, C, 2004) |
| "5-Fluorouracil (5-FU) has a significant antineoplastic activity and has been used for the management of various malignant neoplasms." | 1.38 | Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. ( Çağdaş, M; Çalık, AN; Çeliker, E; Güzelburç, Ö; Velibey, Y, 2012) |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| More, LA | 1 |
| Lane, S | 1 |
| Asnani, A | 1 |
| Fradley, MG | 1 |
| Barrett, CD | 1 |
| Clark, JR | 1 |
| Francis, SA | 1 |
| Rateesh, S | 1 |
| Shekar, K | 1 |
| Naidoo, R | 1 |
| Mittal, D | 1 |
| Bhaskar, B | 1 |
| Amraotkar, AR | 1 |
| Pachika, A | 1 |
| Grubb, KJ | 1 |
| DeFilippis, AP | 1 |
| Dalzell, JR | 1 |
| Samuel, LM | 1 |
| Çalık, AN | 1 |
| Çeliker, E | 1 |
| Velibey, Y | 1 |
| Çağdaş, M | 1 |
| Güzelburç, Ö | 1 |
| Teixeira, L | 1 |
| Barry, S | 1 |
| Debourdeau, P | 1 |
| Cohen, A | 1 |
| Tournigand, C | 1 |
| Antonelli, D | 1 |
| Beker, B | 1 |
| Barzilay, J | 1 |
| Sasson, Z | 1 |
| Morgan, CD | 1 |
| Wang, B | 1 |
| Thomas, G | 1 |
| MacKenzie, B | 1 |
| Platts, ME | 1 |
| Levillain, R | 1 |
Reviews
3 reviews available for fluorouracil and Carditis
| Article | Year |
|---|---|
5-FU Cardiotoxicity: Vasospasm, Myocarditis, and Sudden Death.
Topics: Cardiotoxicity; Death, Sudden; Fluorouracil; Humans; Myocarditis; Prospective Studies | 2021 |
The spectrum of 5-fluorouracil cardiotoxicity.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arr | 2009 |
[Cardiotoxicity of 5-fluorouracil].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Coronary Thrombosis; Coronary Vessels; Deoxycytidine; | 2004 |
Other Studies
7 other studies available for fluorouracil and Carditis
| Article | Year |
|---|---|
Ventricular fibrillation cardiac arrest due to 5-fluorouracil cardiotoxicity.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Coronary Angiography; Coronary Vasospasm; Defibrill | 2013 |
Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Cardiotoxicity; Colorectal Neoplasms; Extrac | 2015 |
Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil.
Topics: Acute Disease; Anus Neoplasms; Carcinoma, Squamous Cell; Coronary Angiography; Electrocardiography; | 2016 |
Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis.
Topics: Acute Disease; Adenocarcinoma; Antimetabolites, Antineoplastic; Colonic Neoplasms; Coronary Angiogra | 2012 |
[Early cardiotoxicity of 5-fluorouracil].
Topics: Adenocarcinoma; Colonic Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Myocarditis; Pericarditi | 1981 |
5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation.
Topics: Acute Disease; Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Lip Ne | 1994 |
[Experimental myocarditis; anatomical study of 210 rat hearts after ingestion of 5-fluorouracil].
Topics: Animals; DNA Replication; Female; Fluorouracil; Humans; Male; Myocarditis; Myocardium; Rats | 1972 |