Page last updated: 2024-10-27

fluorouracil and Carditis

fluorouracil has been researched along with Carditis in 10 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity."7.83Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. ( Amraotkar, AR; DeFilippis, AP; Grubb, KJ; Pachika, A, 2016)
"5-Fluorouracil (5-FU) has a significant antineoplastic activity and has been used for the management of various malignant neoplasms."5.38Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. ( Çağdaş, M; Çalık, AN; Çeliker, E; Güzelburç, Ö; Velibey, Y, 2012)
"5-fluorouracil (5-FU) is one of the most common causes of cardiotoxicity associated with chemotherapy."5.125-FU Cardiotoxicity: Vasospasm, Myocarditis, and Sudden Death. ( Asnani, A; Lane, S; More, LA, 2021)
"Fulminant myocarditis is a rare but potentially life-threatening illness caused by 5-fluorouracil cardiotoxicity."3.83Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. ( Amraotkar, AR; DeFilippis, AP; Grubb, KJ; Pachika, A, 2016)
"5-fluorouracil (5FU) is a largely employed antimetabolite, responsible for several well-known toxicities like hand-foot syndrome, diarrhoea, mucositis or leucopenia."2.42[Cardiotoxicity of 5-fluorouracil]. ( Barry, S; Cohen, A; Debourdeau, P; Teixeira, L; Tournigand, C, 2004)
"5-Fluorouracil (5-FU) has a significant antineoplastic activity and has been used for the management of various malignant neoplasms."1.38Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. ( Çağdaş, M; Çalık, AN; Çeliker, E; Güzelburç, Ö; Velibey, Y, 2012)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
More, LA1
Lane, S1
Asnani, A1
Fradley, MG1
Barrett, CD1
Clark, JR1
Francis, SA1
Rateesh, S1
Shekar, K1
Naidoo, R1
Mittal, D1
Bhaskar, B1
Amraotkar, AR1
Pachika, A1
Grubb, KJ1
DeFilippis, AP1
Dalzell, JR1
Samuel, LM1
Çalık, AN1
Çeliker, E1
Velibey, Y1
Çağdaş, M1
Güzelburç, Ö1
Teixeira, L1
Barry, S1
Debourdeau, P1
Cohen, A1
Tournigand, C1
Antonelli, D1
Beker, B1
Barzilay, J1
Sasson, Z1
Morgan, CD1
Wang, B1
Thomas, G1
MacKenzie, B1
Platts, ME1
Levillain, R1

Reviews

3 reviews available for fluorouracil and Carditis

ArticleYear
5-FU Cardiotoxicity: Vasospasm, Myocarditis, and Sudden Death.
    Current cardiology reports, 2021, 02-03, Volume: 23, Issue:3

    Topics: Cardiotoxicity; Death, Sudden; Fluorouracil; Humans; Myocarditis; Prospective Studies

2021
The spectrum of 5-fluorouracil cardiotoxicity.
    Anti-cancer drugs, 2009, Volume: 20, Issue:1

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arr

2009
[Cardiotoxicity of 5-fluorouracil].
    Bulletin du cancer, 2004, Volume: 91 Suppl 3

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Coronary Thrombosis; Coronary Vessels; Deoxycytidine;

2004

Other Studies

7 other studies available for fluorouracil and Carditis

ArticleYear
Ventricular fibrillation cardiac arrest due to 5-fluorouracil cardiotoxicity.
    Texas Heart Institute journal, 2013, Volume: 40, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Coronary Angiography; Coronary Vasospasm; Defibrill

2013
Use of extracorporeal membrane oxygenation for mechanical circulatory support in a patient with 5-fluorouracil induced acute heart failure.
    Circulation. Heart failure, 2015, Volume: 8, Issue:2

    Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Cardiotoxicity; Colorectal Neoplasms; Extrac

2015
Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil.
    Texas Heart Institute journal, 2016, Volume: 43, Issue:2

    Topics: Acute Disease; Anus Neoplasms; Carcinoma, Squamous Cell; Coronary Angiography; Electrocardiography;

2016
Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:1

    Topics: Acute Disease; Adenocarcinoma; Antimetabolites, Antineoplastic; Colonic Neoplasms; Coronary Angiogra

2012
[Early cardiotoxicity of 5-fluorouracil].
    Giornale italiano di cardiologia, 1981, Volume: 11, Issue:11

    Topics: Adenocarcinoma; Colonic Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Myocarditis; Pericarditi

1981
5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation.
    The Canadian journal of cardiology, 1994, Volume: 10, Issue:8

    Topics: Acute Disease; Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Lip Ne

1994
[Experimental myocarditis; anatomical study of 210 rat hearts after ingestion of 5-fluorouracil].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1972, Nov-09, Volume: 166, Issue:2

    Topics: Animals; DNA Replication; Female; Fluorouracil; Humans; Male; Myocarditis; Myocardium; Rats

1972