fluorouracil has been researched along with Cardiovascular Diseases in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) represents the backbone of systemic therapy regimens of colorectal cancer." | 7.91 | 5-Fluorouracil-related Cardiotoxicity; Findings From Five Randomized Studies of 5-Fluorouracil-based Regimens in Metastatic Colorectal Cancer. ( Abdel-Rahman, O, 2019) |
| "Patients with metastatic gastric, gastro-oesophageal junction, or distal oesophageal adenocarcinoma were randomized 1:1:1 to CX (cisplatin 80 mg/m(2) IV Q3W; capecitabine 1000 mg/m(2) P." | 5.17 | Phase II randomized, double-blind, placebo-controlled study of AMG 386 (trebananib) in combination with cisplatin and capecitabine in patients with metastatic gastro-oesophageal cancer. ( Adewoye, AH; Bampton, CL; Bass, MB; Bodoky, G; Eatock, MM; Nanayakkara, N; Strickland, AH; Sun, YN; Swieboda-Sadlej, A; Tebbutt, NC; Valladares-Ayerbes, M; Van Cutsem, E; Zhong, ZD, 2013) |
| "5-Fluorouracil (5-FU) represents the backbone of systemic therapy regimens of colorectal cancer." | 3.91 | 5-Fluorouracil-related Cardiotoxicity; Findings From Five Randomized Studies of 5-Fluorouracil-based Regimens in Metastatic Colorectal Cancer. ( Abdel-Rahman, O, 2019) |
| "Many trials of anticancer agents have been conducted, excluding patients with heart diseases." | 2.66 | Cardiotoxicities of 5-Fluorouracil and Other Fluoropyrimidines. ( Hiraide, M; Shiga, T, 2020) |
| " This review summarizes the current state of knowledge of FIC with special regard to proposed pathogenetic models (coronary vasospasm, endothelium and cardiomyocytes damage, toxic metabolites, dihydropyrimidine dehydrogenase deficiency); risk and predictive factors; efficacy and usefulness in detection of laboratory markers, electrocardiographic changes and cardiac imaging; and specific treatment, including a novel agent, uridine triacetate." | 2.58 | Fluoropyrimidine-induced cardiotoxicity. ( Aglietta, M; Bonzano, A; Cagnazzo, C; Depetris, I; Filippi, R; Leone, F; Marino, D, 2018) |
| "Many types of cancer are now curable or, if not cured, becoming a chronic illness." | 2.49 | Cancer survivorship: cardiotoxic therapy in the adult cancer patient; cardiac outcomes with recommendations for patient management. ( Carver, JR; Liu, J; Manrique, C; Steingart, RM; Yadav, N, 2013) |
| "Of raltitrexed-treated patients, 13 (5%) experienced CV toxicities and 1 (< 0." | 1.51 | Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience. ( Braconi, C; Chau, I; Cunningham, D; Forster, M; Gerlinger, M; Kalaitzaki, E; Khan, K; Rane, JK; Rao, S; Starling, N; Valeri, N; Watkins, D, 2019) |
| "8mg/kg) in different dosing schedules." | 1.40 | Adverse effects on cardiovascular status and lipid levels of albino Wistar rats treated with cisplatin and oxaliplatin in combination with 5 Fluorouracil. ( Bano, N; Hassan, S; Mirza, T; Najam, R, 2014) |
| " We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided." | 1.36 | Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina. ( Pavlakis, N; Stewart, T; Ward, M, 2010) |
| "The patient, who had unresectable colon cancer metastases to the liver and lung, was referred to us for chemotherapy from an affiliated hospital; he had no cardiac history." | 1.33 | 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine. ( Hatakeyama, K; Muneoka, K; Shirai, Y; Wakai, T; Yokoyama, N, 2005) |
| "Currently, a large population of breast cancer survivors is at increased risk of death from CVDs and second cancers, especially when treated with RT at a young age." | 1.33 | Cause-specific mortality in long-term survivors of breast cancer: A 25-year follow-up study. ( Aleman, BM; Hooning, MJ; Klijn, JG; Kuenen, MA; van Leeuwen, FE; van Rosmalen, AJ, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 13 (68.42) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Shiga, T | 1 |
| Hiraide, M | 1 |
| Depetris, I | 1 |
| Marino, D | 1 |
| Bonzano, A | 1 |
| Cagnazzo, C | 1 |
| Filippi, R | 1 |
| Aglietta, M | 1 |
| Leone, F | 1 |
| Khan, K | 1 |
| Rane, JK | 1 |
| Cunningham, D | 1 |
| Rao, S | 1 |
| Watkins, D | 1 |
| Starling, N | 1 |
| Kalaitzaki, E | 1 |
| Forster, M | 1 |
| Braconi, C | 1 |
| Valeri, N | 1 |
| Gerlinger, M | 1 |
| Chau, I | 1 |
| Abdel-Rahman, O | 1 |
| Di Biasi, B | 1 |
| Prochilo, T | 1 |
| Sabatini, T | 1 |
| Zaniboni, A | 1 |
| Steingart, RM | 1 |
| Yadav, N | 1 |
| Manrique, C | 1 |
| Carver, JR | 1 |
| Liu, J | 1 |
| Najam, R | 1 |
| Bano, N | 1 |
| Mirza, T | 1 |
| Hassan, S | 1 |
| Boekel, NB | 1 |
| Schaapveld, M | 1 |
| Gietema, JA | 1 |
| Russell, NS | 1 |
| Poortmans, P | 1 |
| Theuws, JC | 1 |
| Schinagl, DA | 1 |
| Rietveld, DH | 1 |
| Versteegh, MI | 1 |
| Visser, O | 1 |
| Rutgers, EJ | 1 |
| Aleman, BM | 2 |
| van Leeuwen, FE | 2 |
| Salepci, T | 1 |
| Seker, M | 1 |
| Uyarel, H | 1 |
| Gumus, M | 1 |
| Bilici, A | 1 |
| Ustaalioğlu, BB | 1 |
| Oztürk, A | 1 |
| Sonmez, B | 1 |
| Orcun, A | 1 |
| Ozates, M | 1 |
| Irmak, R | 1 |
| Yaylaci, M | 1 |
| Stewart, T | 1 |
| Pavlakis, N | 1 |
| Ward, M | 1 |
| Yusuf, SW | 1 |
| Koca, D | 1 |
| Salman, T | 1 |
| Unek, IT | 1 |
| Oztop, I | 1 |
| Ellidokuz, H | 1 |
| Eren, M | 1 |
| Yilmaz, U | 1 |
| Romano, S | 1 |
| Fratini, S | 1 |
| Ricevuto, E | 1 |
| Procaccini, V | 1 |
| Stifano, G | 1 |
| Mancini, M | 1 |
| Di Mauro, M | 1 |
| Ficorella, C | 1 |
| Penco, M | 1 |
| Eatock, MM | 1 |
| Tebbutt, NC | 1 |
| Bampton, CL | 1 |
| Strickland, AH | 1 |
| Valladares-Ayerbes, M | 1 |
| Swieboda-Sadlej, A | 1 |
| Van Cutsem, E | 1 |
| Nanayakkara, N | 1 |
| Sun, YN | 1 |
| Zhong, ZD | 1 |
| Bass, MB | 1 |
| Adewoye, AH | 1 |
| Bodoky, G | 1 |
| Muneoka, K | 1 |
| Shirai, Y | 1 |
| Yokoyama, N | 1 |
| Wakai, T | 1 |
| Hatakeyama, K | 1 |
| Hooning, MJ | 1 |
| van Rosmalen, AJ | 1 |
| Kuenen, MA | 1 |
| Klijn, JG | 1 |
| Bleiberg, H | 1 |
| Di Leo, A | 1 |
| Gradishar, W | 1 |
| Vokes, E | 1 |
| Schilsky, R | 1 |
| Weichselbaum, R | 1 |
| Panje, W | 1 |
| Orlova, PN | 1 |
| Gol'dman, BG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients Who Receiving Radical Concurrent Chemoradiotherapy and Immunotherapy: a Prospective, Randomized Controlled, Multicenter P[NCT04980716] | Phase 3 | 524 participants (Anticipated) | Interventional | 2021-06-01 | Recruiting | ||
| Early Detection of Late Anthracycline Induced Cardiotoxicity in Survivors of Childhood Malignancy[NCT04852965] | 208 participants (Anticipated) | Observational | 2021-10-20 | Recruiting | |||
| A Randomized, Double Blind, Multi-Center, Phase 2 Study to Estimate the Efficacy and Evaluate the Safety and Tolerability of Cisplatin & Capecitabine (CX) in Combination With AMG 386 or Placebo in Subjects With Metastatic Gastric, Gastroesophageal Junctio[NCT00583674] | Phase 2 | 171 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluorouracil and Cardiovascular Diseases
| Article | Year |
|---|---|
Cardiotoxicities of 5-Fluorouracil and Other Fluoropyrimidines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cardiotoxicity; Cardiovascula | 2020 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Hu | 2018 |
Chemotherapeutic options for colorectal cancer patients with cardiovascular diseases.
Topics: Antineoplastic Agents; Cardiovascular Diseases; Colorectal Neoplasms; Fluorouracil; Global Health; H | 2013 |
Cancer survivorship: cardiotoxic therapy in the adult cancer patient; cardiac outcomes with recommendations for patient management.
Topics: Anthracyclines; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carboplatin; Cardiovascula | 2013 |
1 trial available for fluorouracil and Cardiovascular Diseases
| Article | Year |
|---|---|
Phase II randomized, double-blind, placebo-controlled study of AMG 386 (trebananib) in combination with cisplatin and capecitabine in patients with metastatic gastro-oesophageal cancer.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Pro | 2013 |
14 other studies available for fluorouracil and Cardiovascular Diseases
| Article | Year |
|---|---|
Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cardio | 2019 |
5-Fluorouracil-related Cardiotoxicity; Findings From Five Randomized Studies of 5-Fluorouracil-based Regimens in Metastatic Colorectal Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cardiotoxicity; Cardiovascular Diseases | 2019 |
Adverse effects on cardiovascular status and lipid levels of albino Wistar rats treated with cisplatin and oxaliplatin in combination with 5 Fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aorta; Biomarkers; Cardiovascular Diseases; | 2014 |
Cardiovascular Disease Risk in a Large, Population-Based Cohort of Breast Cancer Survivors.
Topics: Age Factors; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, | 2016 |
5-Fluorouracil induces arterial vasoconstrictions but does not increase angiotensin II levels.
Topics: Adult; Aged; Angiotensin II; Brachial Artery; Cardiovascular Diseases; Colonic Neoplasms; Female; Fl | 2010 |
Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina.
Topics: Aged; Aged, 80 and over; Angina, Unstable; Capecitabine; Cardiotoxins; Cardiovascular Diseases; Coro | 2010 |
Chemotherapy for older patients with colorectal cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Cardiovascular Diseases; Colorectal Neoplasms; | 2011 |
Clinical and electrocardiography changes in patients treated with capecitabine.
Topics: Capecitabine; Cardiovascular Diseases; Deoxycytidine; Electrocardiography; Female; Fluorouracil; Hum | 2011 |
Serial measurements of NT-proBNP are predictive of not-high-dose anthracycline cardiotoxicity in breast cancer patients.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; | 2011 |
5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.
Topics: Aged; Antimetabolites, Antineoplastic; beta-Alanine; Cardiovascular Diseases; Colonic Neoplasms; Dru | 2005 |
Cause-specific mortality in long-term survivors of breast cancer: A 25-year follow-up study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiovascular Diseas | 2006 |
Mortality associated with irinotecan plus bolus fluorouracil/leucovorin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cardiovascular Diseases; Colorectal Ne | 2002 |
Vascular events in patients receiving high-dose infusional 5-fluorouracil-based chemotherapy: the University of Chicago experience.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cardiovascular Diseases; Electrocardiog | 1991 |
[The state of the cardiovascular system during long-term perfusion chemotherapy of cancer of the mammary glands].
Topics: Adult; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Cancer, Regional Perfusion; Electroc | 1969 |