Page last updated: 2024-10-27

fluorouracil and Cardiovascular Abnormalities

fluorouracil has been researched along with Cardiovascular Abnormalities in 1 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Cardiovascular Abnormalities: Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Steenbruggen, TG1
Steggink, LC1
Seynaeve, CM1
van der Hoeven, JJM1
Hooning, MJ1
Jager, A1
Konings, IR1
Kroep, JR1
Smit, WM1
Tjan-Heijnen, VCG1
van der Wall, E1
Bins, AD1
Linn, SC1
Schaapveld, M1
Jacobse, JN1
van Leeuwen, FE1
Schröder, CP1
van Tinteren, H1
de Vries, EGE1
Sonke, GS1
Gietema, JA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
High-dose Chemotherapy With Hematopoietic Stem-cell Rescue for High-risk Breast Cancer: Long-term Follow-up of a Randomized Phase III Study[NCT03087409]885 participants (Actual)Observational2016-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for fluorouracil and Cardiovascular Abnormalities

ArticleYear
High-Dose Chemotherapy With Hematopoietic Stem Cell Transplant in Patients With High-Risk Breast Cancer and 4 or More Involved Axillary Lymph Nodes: 20-Year Follow-up of a Phase 3 Randomized Clinical Trial.
    JAMA oncology, 2020, 04-01, Volume: 6, Issue:4

    Topics: Adult; Axilla; Breast; Breast Neoplasms; Cardiovascular Abnormalities; Child; Cyclophosphamide; Dise

2020