fluorouracil and Cardiomyopathy, Dilated
fluorouracil has been researched along with Cardiomyopathy, Dilated in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"This article presents a patient affected with epidermoid carcinoma of the soft palate who developed a dilated myocardiopathy with aortic embolism and fatal left cardiac failure after treatment with cisplatin (100 mg/m2, day 1) and 5-fluorouracil (1 g/m2/day i." | 3.67 | Lethal cardiac toxicity after cisplatin and 5-fluorouracil chemotherapy. Report of a case with necropsy study. ( Almenarez, J; Blázquez, J; Diaz-Rubio, E; Fariña, J; Furió, V; Martin, M, 1989) |
"Malignant glucagonoma is an exceptional pancreatic endocrine tumour, with frequent dermatologic symptoms, diabetes and degradation of the general health status." | 1.36 | [Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency]. ( de Mestier, L; Dove, P; Hammel, P; Hentic, O; Lévy, P; Ruszniewski, P, 2010) |
"5-fluorouracil (5-FU) is an antimetabolite that acts during the S phase of the cell cycle." | 1.35 | Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene. ( Harold, L; Rajebi, MR; Saif, MW; Shahrokni, A, 2009) |
Research
Studies (11)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (18.18) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (27.27) | 29.6817 |
2010's | 6 (54.55) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Bakhshi, S | 2 |
Louis, AR | 1 |
Chang, RY | 1 |
Lee, MY | 1 |
Kan, CB | 1 |
Hsu, WP | 1 |
Hsiao, PC | 1 |
Shahrokni, A | 1 |
Rajebi, MR | 1 |
Harold, L | 1 |
Saif, MW | 1 |
Dalzell, JR | 1 |
Samuel, LM | 1 |
de Mestier, L | 1 |
Hammel, P | 1 |
Hentic, O | 1 |
Dove, P | 1 |
Lévy, P | 1 |
Ruszniewski, P | 1 |
Radhakrishnan, V | 1 |
Shipman, KE | 1 |
Arnold, I | 1 |
Pagani, O | 1 |
Sessa, C | 1 |
Nolè, F | 1 |
Munzone, E | 1 |
Crivellari, D | 1 |
Lombardi, D | 1 |
Thürlimann, B | 1 |
Hess, D | 1 |
Graffeo, R | 1 |
Ruggeri, M | 1 |
Longhi, S | 1 |
Goldhirsch, A | 1 |
Martin, M | 1 |
Diaz-Rubio, E | 1 |
Furió, V | 1 |
Blázquez, J | 1 |
Almenarez, J | 1 |
Fariña, J | 1 |
Coronel, B | 1 |
Madonna, O | 1 |
Mercatello, A | 1 |
Caillette, A | 1 |
Moskovtchenko, JF | 1 |
Reviews
1 review available for fluorouracil and Cardiomyopathy, Dilated
Article | Year |
---|---|
The spectrum of 5-fluorouracil cardiotoxicity.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arr | 2009 |
Trials
1 trial available for fluorouracil and Cardiomyopathy, Dilated
Article | Year |
---|---|
Dose-finding study of weekly docetaxel, anthracyclines plus fluoropyrimidines as first-line treatment in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cardiom | 2005 |
Other Studies
9 other studies available for fluorouracil and Cardiomyopathy, Dilated
Article | Year |
---|---|
In reply: the philosophy of "treatment intent".
Topics: Antimetabolites, Antineoplastic; Cardiomyopathy, Dilated; Fluorouracil; Humans; Male | 2013 |
The philosophy of "treatment intent".
Topics: Antimetabolites, Antineoplastic; Cardiomyopathy, Dilated; Fluorouracil; Humans; Male | 2013 |
Oxaliplatin-induced acquired long QT syndrome with torsades de pointes and myocardial injury in a patient with dilated cardiomyopathy and rectal cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathy, Dilated | 2013 |
Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cardiomyopathy, Dilated; Deoxycytidine; Dihydrouracil | 2009 |
[Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathy, Dilated; Dacarbazine; Female; | 2010 |
5-Fluorouracil-induced acute dilated cardiomyopathy in a pediatric patient.
Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Pro | 2011 |
Case of epirubicin-induced cardiomyopathy in familial cardiomyopathy.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma, Ductal, Breast; Cardiac | 2011 |
Lethal cardiac toxicity after cisplatin and 5-fluorouracil chemotherapy. Report of a case with necropsy study.
Topics: Aortic Diseases; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cisplatin; Embolism; Fluorouraci | 1989 |
Myocardiotoxicity of 5 fluorouracil.
Topics: Adult; Cardiomyopathy, Dilated; Fluorouracil; Humans; Laryngeal Neoplasms; Male | 1988 |