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fluorouracil and Cardiomyopathy, Dilated

fluorouracil has been researched along with Cardiomyopathy, Dilated in 11 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.

Research Excerpts

ExcerptRelevanceReference
"This article presents a patient affected with epidermoid carcinoma of the soft palate who developed a dilated myocardiopathy with aortic embolism and fatal left cardiac failure after treatment with cisplatin (100 mg/m2, day 1) and 5-fluorouracil (1 g/m2/day i."3.67Lethal cardiac toxicity after cisplatin and 5-fluorouracil chemotherapy. Report of a case with necropsy study. ( Almenarez, J; Blázquez, J; Diaz-Rubio, E; Fariña, J; Furió, V; Martin, M, 1989)
"Malignant glucagonoma is an exceptional pancreatic endocrine tumour, with frequent dermatologic symptoms, diabetes and degradation of the general health status."1.36[Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency]. ( de Mestier, L; Dove, P; Hammel, P; Hentic, O; Lévy, P; Ruszniewski, P, 2010)
"5-fluorouracil (5-FU) is an antimetabolite that acts during the S phase of the cell cycle."1.35Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene. ( Harold, L; Rajebi, MR; Saif, MW; Shahrokni, A, 2009)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19902 (18.18)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's6 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bakhshi, S2
Louis, AR1
Chang, RY1
Lee, MY1
Kan, CB1
Hsu, WP1
Hsiao, PC1
Shahrokni, A1
Rajebi, MR1
Harold, L1
Saif, MW1
Dalzell, JR1
Samuel, LM1
de Mestier, L1
Hammel, P1
Hentic, O1
Dove, P1
Lévy, P1
Ruszniewski, P1
Radhakrishnan, V1
Shipman, KE1
Arnold, I1
Pagani, O1
Sessa, C1
Nolè, F1
Munzone, E1
Crivellari, D1
Lombardi, D1
Thürlimann, B1
Hess, D1
Graffeo, R1
Ruggeri, M1
Longhi, S1
Goldhirsch, A1
Martin, M1
Diaz-Rubio, E1
Furió, V1
Blázquez, J1
Almenarez, J1
Fariña, J1
Coronel, B1
Madonna, O1
Mercatello, A1
Caillette, A1
Moskovtchenko, JF1

Reviews

1 review available for fluorouracil and Cardiomyopathy, Dilated

ArticleYear
The spectrum of 5-fluorouracil cardiotoxicity.
    Anti-cancer drugs, 2009, Volume: 20, Issue:1

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arr

2009

Trials

1 trial available for fluorouracil and Cardiomyopathy, Dilated

ArticleYear
Dose-finding study of weekly docetaxel, anthracyclines plus fluoropyrimidines as first-line treatment in advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cardiom

2005

Other Studies

9 other studies available for fluorouracil and Cardiomyopathy, Dilated

ArticleYear
In reply: the philosophy of "treatment intent".
    Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:4

    Topics: Antimetabolites, Antineoplastic; Cardiomyopathy, Dilated; Fluorouracil; Humans; Male

2013
The philosophy of "treatment intent".
    Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:4

    Topics: Antimetabolites, Antineoplastic; Cardiomyopathy, Dilated; Fluorouracil; Humans; Male

2013
Oxaliplatin-induced acquired long QT syndrome with torsades de pointes and myocardial injury in a patient with dilated cardiomyopathy and rectal cancer.
    Journal of the Chinese Medical Association : JCMA, 2013, Volume: 76, Issue:8

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathy, Dilated

2013
Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene.
    JOP : Journal of the pancreas, 2009, Mar-09, Volume: 10, Issue:2

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Cardiomyopathy, Dilated; Deoxycytidine; Dihydrouracil

2009
[Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency].
    Gastroenterologie clinique et biologique, 2010, Volume: 34, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathy, Dilated; Dacarbazine; Female;

2010
5-Fluorouracil-induced acute dilated cardiomyopathy in a pediatric patient.
    Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:4

    Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Pro

2011
Case of epirubicin-induced cardiomyopathy in familial cardiomyopathy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jun-20, Volume: 29, Issue:18

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma, Ductal, Breast; Cardiac

2011
Lethal cardiac toxicity after cisplatin and 5-fluorouracil chemotherapy. Report of a case with necropsy study.
    American journal of clinical oncology, 1989, Volume: 12, Issue:3

    Topics: Aortic Diseases; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cisplatin; Embolism; Fluorouraci

1989
Myocardiotoxicity of 5 fluorouracil.
    Intensive care medicine, 1988, Volume: 14, Issue:4

    Topics: Adult; Cardiomyopathy, Dilated; Fluorouracil; Humans; Laryngeal Neoplasms; Male

1988
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