fluorouracil has been researched along with Cardiac Output, Low in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Coronary spasm is the most commonly suspected hypothesis, but further studies are warranted to seek for toxic inflammatory lesions of the myocardium (apoptosis, necrosis, fibrosis)." | 1.33 | Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease. ( Barel, C; Belkhiria, M; Bui-Xuan, B; Descotes, J; Lombard-Bohas, C; Tabib, A; Timour, Q; Tsibiribi, P, 2006) |
| "Gestational trophoblastic neoplasm treated by large dosage of 5-fluorouracil and actinomycin could cause cardiotoxicity." | 1.29 | [Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies]. ( Qian, H; Wu, Y, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsibiribi, P | 1 |
| Descotes, J | 1 |
| Lombard-Bohas, C | 1 |
| Barel, C | 1 |
| Bui-Xuan, B | 1 |
| Belkhiria, M | 1 |
| Tabib, A | 1 |
| Timour, Q | 1 |
| Geisler, JP | 1 |
| Manahan, KJ | 1 |
| Rippy, JK | 1 |
| Wu, Y | 1 |
| Qian, H | 1 |
| Brillet, G | 1 |
| Deray, G | 1 |
| Baumelou, A | 1 |
| Jacobs, C | 1 |
4 other studies available for fluorouracil and Cardiac Output, Low
| Article | Year |
|---|---|
Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease.
Topics: Adult; Aged; Angina Pectoris; Antimetabolites, Antineoplastic; Cardiac Output, Low; Chest Pain; Fema | 2006 |
5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.
Topics: Acute Disease; Adult; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cardiac Output, Low | 2007 |
[Clinical analysis of 6 cases of gestational trophoblastic neoplasms complicated by cardiotoxicity after chemotherapies].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiac Output, Low; Chest Pain; Dactinomycin | 1995 |
Acute cardiac and renal failure after 5-FU and cisplatin treatment.
Topics: Acute Kidney Injury; Adult; Cardiac Output, Low; Cisplatin; Female; Fluorouracil; Humans; Uterine Ne | 1991 |