fluorouracil has been researched along with Carcinosarcoma in 16 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Carcinosarcoma: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 7.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 3.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "To investigate the toxicities, biodistribution and anticancer effect of 5-fluorouracil controlled release implant (5-FUCI) on Walker 256 carcinosarcoma cells in Wistar rats." | 3.72 | Toxicities and therapeutic effect of 5-fluorouracil controlled release implant on tumor-bearing rats. ( Cao, J; Chen, JW; He, YC; Pan, DY; Qiao, JG, 2003) |
| "Esophageal carcinosarcoma is a rare malignant tumor." | 2.49 | [Esophageal carcinosarcoma treated with surgery and chemoradiotherapy-a report of 4 cases]. ( Fujiwara, H; Ichikawa, D; Ikoma, H; Komatsu, S; Konishi, H; Kubota, T; Kuriu, Y; Morimura, R; Murayama, Y; Nakanishi, M; Okamoto, K; Otsuji, E; Sakakura, C; Shimizu, H; Shiozaki, A; Takemoto, K, 2013) |
| "Esophageal carcinosarcoma is a rare malignant esophageal neoplasm consisting of both carcinomatous and sarcomatous elements, with an incidence of 0." | 1.40 | A case of metachronous development of esophageal squamous cell carcinoma in the patient with esophageal carcinosarcoma. ( Cha, RR; Ha, CY; Jung, WT; Kim, HJ; Kim, TH; Ko, GH; Oh, HW, 2014) |
| "Carcinosarcoma is a biphasic tumor composed of malignant epithelial and mesenchymal elements." | 1.32 | Primary sweat gland carcinosarcoma of the scrotal skin. ( Huang, WJ; Lin, TP; Murphy, GF; Pan, CC, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Lalonde, CS | 1 |
| Wang, L | 1 |
| Quigley, B | 1 |
| Patel, P | 1 |
| Maithel, SK | 1 |
| El-Rayes, BF | 1 |
| Akce, M | 1 |
| Kobayashi, R | 1 |
| Yamashita, H | 1 |
| Okuma, K | 1 |
| Shiraishi, K | 1 |
| Ohtomo, K | 1 |
| Nakagawa, K | 1 |
| Takemoto, K | 1 |
| Shiozaki, A | 1 |
| Fujiwara, H | 1 |
| Shimizu, H | 1 |
| Konishi, H | 1 |
| Komatsu, S | 1 |
| Kubota, T | 1 |
| Ichikawa, D | 1 |
| Okamoto, K | 1 |
| Morimura, R | 1 |
| Murayama, Y | 1 |
| Ikoma, H | 1 |
| Kuriu, Y | 1 |
| Nakanishi, M | 1 |
| Sakakura, C | 1 |
| Otsuji, E | 1 |
| Cha, RR | 1 |
| Jung, WT | 1 |
| Oh, HW | 1 |
| Kim, HJ | 2 |
| Ha, CY | 1 |
| Kim, TH | 1 |
| Ko, GH | 1 |
| Yamaguchi, K | 1 |
| Ono, K | 1 |
| Hitomi, S | 1 |
| Ito, M | 1 |
| Nodai, T | 1 |
| Goto, T | 1 |
| Harano, N | 1 |
| Watanabe, S | 1 |
| Inoue, H | 1 |
| Miyano, K | 1 |
| Uezono, Y | 1 |
| Matoba, M | 1 |
| Inenaga, K | 1 |
| He, YC | 1 |
| Chen, JW | 1 |
| Cao, J | 1 |
| Pan, DY | 1 |
| Qiao, JG | 1 |
| CARISSIMI, E | 1 |
| SANGIORGI, G | 1 |
| VARGIU, L | 1 |
| SULLIVAN, RD | 1 |
| ZUREK, WZ | 1 |
| Lin, TP | 1 |
| Pan, CC | 1 |
| Huang, WJ | 1 |
| Murphy, GF | 1 |
| Nitsche, M | 1 |
| Hermann, RM | 1 |
| Christiansen, H | 1 |
| Berger, J | 1 |
| Pradier, O | 1 |
| Kawano, S | 1 |
| Kusunoki, R | 1 |
| Aimi, M | 1 |
| Higashi, R | 1 |
| Ishii, Y | 1 |
| Fujishiro, H | 1 |
| Kobayashi, K | 1 |
| Okada, H | 1 |
| Shiratori, Y | 1 |
| Karayannopoulou, M | 1 |
| Kaldrymidou, E | 1 |
| Constantinidis, TC | 1 |
| Dessiris, A | 1 |
| Mundinger, F | 1 |
| Vogt, P | 1 |
| Jobski, C | 1 |
| Fischer, HU | 1 |
| Ostertag, C | 1 |
| Kreye, VA | 2 |
| Traldi, A | 1 |
| Morini, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Concurrent Radiotherapy and Weekly Chemotherapy of 5-fluorouracil and Cisplatin for Postoperative Locoregional Recurrence of Oesophageal Squamous Cell Carcinoma[NCT02325986] | Phase 2 | 46 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Carcinosarcoma
| Article | Year |
|---|---|
Neoadjuvant treatment of pancreatic carcinosarcoma: a case report and review of literature.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinosarcoma; Female; Fluorouracil | 2022 |
[Esophageal carcinosarcoma treated with surgery and chemoradiotherapy-a report of 4 cases].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinosarcoma; Chemoradiotherapy; Cisplatin; | 2013 |
14 other studies available for fluorouracil and Carcinosarcoma
| Article | Year |
|---|---|
Salvage radiation therapy and chemoradiation therapy for postoperative locoregional recurrence of esophageal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Carcinosarcom | 2014 |
A case of metachronous development of esophageal squamous cell carcinoma in the patient with esophageal carcinosarcoma.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Carcinosarcoma; Cisplatin; Drug Therapy, Combinatio | 2014 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C | 2016 |
Toxicities and therapeutic effect of 5-fluorouracil controlled release implant on tumor-bearing rats.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinosarcoma; Delayed-Action Preparations; Fluorouracil; | 2003 |
[Inhibitory effect of 5-fluorouracil on Walker carcinosarcoma transplant growth].
Topics: Animals; Antineoplastic Agents; Carcinosarcoma; Fluorouracil; Humans | 1958 |
PROTRACTED AMBULATORY INFUSION CANCER CHEMOTHERAPY BY THE WATKINS CHRONOMETRIC INFUSOR.
Topics: Adenoma; Antineoplastic Agents; Breast Neoplasms; Carcinosarcoma; Colonic Neoplasms; Dermatitis, Exf | 1964 |
Primary sweat gland carcinosarcoma of the scrotal skin.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinosarcoma; Chemotherap | 2004 |
Rationale for individualized therapy in Sinonasal Teratocarcinosarcoma (SNTC): case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinosarcoma; Cisplatin; Combined Modality | 2005 |
[A case of carcinosarcoma of the esophagus treated by the chemoradiotherapy].
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinosarcoma; Cisplatin; Combin | 2007 |
Adjuvant post-operative chemotherapy in bitches with mammary cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinosarcoma; Chemotherapy, Ad | 2001 |
[Clinical and experimental results of interstitial Brachy-Curie-therapy combined with radiation sensitizing agents in infiltrative growing brain neoplasms].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinosarcoma; Cytidine; Fluorouracil; Guanosine; Irid | 1972 |
[Comparative quantitative studies of dye incorporation by Yoshida- and DS- carcinosarcoma-ascitic tumor cells as a contribution to the problem of natural resistance to cytostatic substances].
Topics: Animals; Antineoplastic Agents; Carcinosarcoma; Cell Membrane Permeability; Coloring Agents; Fluorou | 1968 |
[Basic differences in the effect of cellular parameters on the incorporation of strongly and weakly incorporated pharmaco].
Topics: Adsorption; Animals; Antineoplastic Agents; Binding Sites; Carcinosarcoma; Cell Membrane Permeabilit | 1968 |
[The use of 5-fluorouracil in the therapy of some epithelial tumors].
Topics: Adenocarcinoma; Breast Neoplasms; Carcinosarcoma; Fluorouracil; Humans; Intestinal Neoplasms; Lung N | 1966 |