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fluorouracil and Carcinoma, Thymic

fluorouracil has been researched along with Carcinoma, Thymic in 8 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"To predict tumor sensitivity to 5-fluorouracil (5-FU) in thymoma, we investigated the mRNA levels of thymidylate synthase (TS), the key enzyme that catalyzes the methylation of deoxyuridine monophosphate, and correlates with the resistance of 5-FU and dihydropyrimidine dehydrogenase (DPD), which degrades 5-FU in thymoma."3.72Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma. ( Fujii, Y; Fukai, I; Kaji, M; Kiriyama, M; Sasaki, H; Yamakawa, Y; Yano, M, 2003)
"Thymic carcinoma is a rare anterior mediastinal neoplasm."1.32Concurrent chemoradiotherapy for unresectable thymic carcinoma. ( Chen, YY; Eng, HL; Huang, CH; Tang, Y, 2004)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leelakanok, N1
Geary, SM1
Salem, AK1
Heine, A1
Schmiedel, A1
Menschik, T1
Held, SA1
Erdmann, C1
Brossart, P1
Rajan, A1
Giaccone, G1
Sasaki, H1
Fukai, I1
Kiriyama, M1
Kaji, M1
Yano, M1
Yamakawa, Y1
Fujii, Y1
Chen, YY1
Huang, CH1
Tang, Y1
Eng, HL1
Tampellini, M1
Alabiso, I1
Sculli, CM1
Barberis, M1
Giachino, D1
Berruti, A1
Dogliotti, L1
Donovan, PJ1
Foley, JF1
Sagara, N1
Kurooka, K1
Mori, K1
Kayama, H1
Haeno, Y1
Hara, S1
Yasutomi, M1

Reviews

1 review available for fluorouracil and Carcinoma, Thymic

ArticleYear
Chemotherapy for thymic tumors: induction, consolidation, palliation.
    Thoracic surgery clinics, 2011, Volume: 21, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Clinical Trials as Topic; C

2011

Other Studies

7 other studies available for fluorouracil and Carcinoma, Thymic

ArticleYear
Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Delayed-Action Preparations; Drug Carri

2018
Regression of liver metastases after treatment with oxaliplatin/capecitabine and development of a progressive multifocal leukoencephalopathy in a patient with advanced thymoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-20, Volume: 31, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; L

2013
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma.
    Surgery today, 2003, Volume: 33, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP);

2003
Concurrent chemoradiotherapy for unresectable thymic carcinoma.
    Chang Gung medical journal, 2004, Volume: 27, Issue:7

    Topics: Aged; Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Fe

2004
Stage IB malignant thymoma in a Lynch syndrome patient with multiple cancers: response to incidental administration of oxaliplatin and 5-fluorouracil.
    Journal of chemotherapy (Florence, Italy), 2006, Volume: 18, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms, Hereditary Nonpolyposis; Femal

2006
Chemotherapy in invasive thymomas: five case reports.
    Journal of surgical oncology, 1986, Volume: 33, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dacarbazine; Doxorubicin; Female;

1986
[A case of non-resectable thymoma which responded to the administration of adriamycin, vindesine and 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Middle Ag

1986