fluorouracil has been researched along with Carcinoma, Ovarian Epithelial in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Carcinoma, Ovarian Epithelial: A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "MTT assays revealed that tumor cells from ascites of primary and type II EOC were more sensitive to paclitaxel (PTX) and carboplatin (CBDCA) than relapse (p = 0." | 3.79 | In vitro chemosensitivity assay of ascites in epithelial ovarian cancer. ( Chen, X; Dai, H; Qian, Z; Wang, Y; Xu, X; Zhao, Y, 2013) |
| "Elafin has been reported to be abundantly expressed in human epithelial ovarian carcinoma (EOC), however, its functions are poorly understood." | 1.38 | Elafin selectively regulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis. ( Hellström, I; Hellström, KE; Wei, H, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernández, LP | 1 |
| Sánchez-Martínez, R | 1 |
| Vargas, T | 1 |
| Herranz, J | 1 |
| Martín-Hernández, R | 1 |
| Mendiola, M | 1 |
| Hardisson, D | 1 |
| Reglero, G | 1 |
| Feliu, J | 1 |
| Redondo, A | 1 |
| Ramírez de Molina, A | 1 |
| Xu, X | 2 |
| Dai, H | 1 |
| Zhao, Y | 1 |
| Wang, Y | 1 |
| Qian, Z | 1 |
| Chen, X | 1 |
| Chen, J | 1 |
| Wang, J | 1 |
| Zhang, Y | 1 |
| Chen, D | 1 |
| Yang, C | 1 |
| Kai, C | 1 |
| Wang, X | 1 |
| Shi, F | 1 |
| Dou, J | 1 |
| Wei, H | 1 |
| Hellström, KE | 1 |
| Hellström, I | 1 |
4 other studies available for fluorouracil and Carcinoma, Ovarian Epithelial
| Article | Year |
|---|---|
The role of glycosyltransferase enzyme GCNT3 in colon and ovarian cancer prognosis and chemoresistance.
Topics: Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferatio | 2018 |
In vitro chemosensitivity assay of ascites in epithelial ovarian cancer.
Topics: Antineoplastic Agents; Ascites; Carboplatin; Carcinoma, Ovarian Epithelial; Coloring Agents; Deoxycy | 2013 |
Observation of ovarian cancer stem cell behavior and investigation of potential mechanisms of drug resistance in three-dimensional cell culture.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carboplatin; Carcinogenesis; Carcinoma, Ovarian Epithelia | 2014 |
Elafin selectively regulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Ovarian Epithelial; Caspase 3; Cell Line, Tumo | 2012 |