fluorouracil has been researched along with Carcinoma, Lewis Lung in 20 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three mouse cancer cell lines [CT26 mouse colon cancer cells, B16 melanoma cells and Lewis lung carcinoma (LLC)], 5 human carcinoma cell lines (human esophageal squamous cell carcinoma cell lines TE8 and HEC46 and the human pancreatic carcinoma cell lines PK-9, AsPC-1 and SUIT-2) and 5 chemotherapeutic agents [mitoxantrone (MIT), mitomycin C(MMC), 5-fluorouracil (5FU), camptothecin (CPT-11) and cisplatin (CDDP)] that are frequently used in a clinical setting for cancer treatment were utilized to investigate the surface expression level of calreticulin and HLA class I after exposure to chemotherapeutic agents." | 3.81 | The key role of calreticulin in immunomodulation induced by chemotherapeutic agents. ( Hirano, S; Kuroda, A; Kuwatani, T; Kyogoku, N; Maki, T; Miyauchi, K; Shichinohe, T; Takeuchi, S; Tsuchikawa, T; Wada, M; Yamamura, Y, 2015) |
| "5-Fluorouracil (5-Fu) is an effective anticarcinogenic agent, however, continuous use of 5-Fu may cause severe side effects." | 1.56 | Reduction of 5-fluorouracil-induced toxicity by Sarcodon aspratus polysaccharides in Lewis tumor-bearing mice. ( Chen, J; Chen, L; Chen, Y; Liu, JJ; Lu, YM; Mehmood, S; Pan, WJ; Wang, Y; Wu, QX; Yan, CC; Zhang, C; Zhang, WN, 2020) |
| ") Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma." | 1.43 | Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium. ( Ermolaeva, LA; Lopatina, KA; Razina, TG; Safonova, EA; Vychuzhanina, AV; Zueva, EP, 2016) |
| "Cancer cachexia is characterised by the loss of body mass and directly compromises immune response and the quality of life of cancer patients." | 1.38 | Improving cachectic symptoms and immune strength of tumour-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang. ( Chan, YL; Li, TL; Wang, H; Wu, CJ, 2012) |
| "The LD50 of pentamidine on cancer cells maintained in vitro is correlated with the endo-exonuclease enzyme activity." | 1.32 | The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer. ( Alaoui-Jamali, MA; Chow, TY; Griller, D; Yeh, C; Yuen, L, 2004) |
| " Repeated dosing of rMETase of tumor-bearing mice could be administered without acute immune-hypersensitivity." | 1.30 | Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase. ( Hoffman, RM; Hojo, K; Ide, N; Kasai, H; Maekawa, R; Maki, H; Shono, K; Sugita, K; Uchida, N; Wada, T; Yagi, S; Yoshida, H; Yoshioka, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, JJ | 1 |
| Chen, J | 1 |
| Wang, Y | 1 |
| Yan, CC | 1 |
| Zhang, C | 1 |
| Mehmood, S | 1 |
| Pan, WJ | 1 |
| Zhang, WN | 1 |
| Lu, YM | 1 |
| Wu, QX | 1 |
| Chen, L | 2 |
| Chen, Y | 1 |
| Wang, J | 1 |
| Zou, MJ | 1 |
| Sheng, YL | 1 |
| Zhou, XM | 1 |
| Zhang, XR | 1 |
| Yamamura, Y | 1 |
| Tsuchikawa, T | 1 |
| Miyauchi, K | 1 |
| Takeuchi, S | 1 |
| Wada, M | 1 |
| Kuwatani, T | 1 |
| Kyogoku, N | 1 |
| Kuroda, A | 1 |
| Maki, T | 1 |
| Shichinohe, T | 1 |
| Hirano, S | 1 |
| Aksinenko, SG | 1 |
| Suslov, NI | 1 |
| Povet'eva, TN | 1 |
| Nesterova, YV | 1 |
| Kharina, TG | 1 |
| Kravtsova, SS | 1 |
| Safonova, EA | 1 |
| Lopatina, KA | 1 |
| Vychuzhanina, AV | 1 |
| Ermolaeva, LA | 1 |
| Razina, TG | 1 |
| Zueva, EP | 1 |
| Ke, M | 1 |
| Wang, H | 2 |
| Zhou, Y | 1 |
| Li, J | 1 |
| Liu, Y | 1 |
| Zhang, M | 1 |
| Dou, J | 1 |
| Xi, T | 1 |
| Shen, B | 1 |
| Zhou, C | 1 |
| Matsumoto, K | 1 |
| Obara, N | 1 |
| Ema, M | 1 |
| Horie, M | 1 |
| Naka, A | 1 |
| Takahashi, S | 1 |
| Imagawa, S | 1 |
| Hwang, JA | 1 |
| Lee, EH | 1 |
| Kim, HW | 1 |
| Park, JB | 1 |
| Jeon, BH | 1 |
| Cho, CH | 1 |
| Schwartz, L | 1 |
| Abolhassani, M | 1 |
| Guais, A | 1 |
| Sanders, E | 1 |
| Steyaert, JM | 1 |
| Campion, F | 1 |
| Israël, M | 1 |
| Chan, YL | 1 |
| Li, TL | 1 |
| Wu, CJ | 1 |
| Rásó, E | 1 |
| Paku, S | 1 |
| Kopper, L | 1 |
| Tímár, J | 1 |
| McDonnell, CO | 1 |
| Holden, G | 1 |
| Sheridan, ME | 1 |
| Foley, D | 1 |
| Moriarty, M | 1 |
| Walsh, TN | 1 |
| Bouchier-Hayes, DJ | 1 |
| Wei, J | 1 |
| Blum, S | 1 |
| Unger, M | 1 |
| Jarmy, G | 1 |
| Lamparter, M | 1 |
| Geishauser, A | 1 |
| Vlastos, GA | 1 |
| Chan, G | 1 |
| Fischer, KD | 1 |
| Rattat, D | 1 |
| Debatin, KM | 1 |
| Hatzopoulos, AK | 1 |
| Beltinger, C | 1 |
| Chow, TY | 1 |
| Alaoui-Jamali, MA | 1 |
| Yeh, C | 1 |
| Yuen, L | 1 |
| Griller, D | 1 |
| Lee, CH | 1 |
| Wu, CL | 1 |
| Shiau, AL | 1 |
| Rashid, G | 1 |
| Ophir, R | 1 |
| Pecht, M | 1 |
| Lourie, S | 1 |
| Meshorer, A | 1 |
| Ben-Efraim, S | 1 |
| Trainin, N | 1 |
| Burstein, Y | 1 |
| Keisari, Y | 1 |
| Yoshioka, T | 3 |
| Wada, T | 2 |
| Uchida, N | 3 |
| Maki, H | 1 |
| Yoshida, H | 1 |
| Ide, N | 1 |
| Kasai, H | 2 |
| Hojo, K | 3 |
| Shono, K | 1 |
| Maekawa, R | 3 |
| Yagi, S | 1 |
| Hoffman, RM | 1 |
| Sugita, K | 3 |
| Teicher, BA | 1 |
| Ara, G | 1 |
| Chen, YN | 1 |
| Recht, A | 1 |
| Coleman, CN | 1 |
| Takeda, Y | 2 |
| Nishida, K | 1 |
20 other studies available for fluorouracil and Carcinoma, Lewis Lung
| Article | Year |
|---|---|
Reduction of 5-fluorouracil-induced toxicity by Sarcodon aspratus polysaccharides in Lewis tumor-bearing mice.
Topics: Animals; Basidiomycota; Carcinoma, Lewis Lung; Cell Line, Tumor; Disease Models, Animal; Drug Antago | 2020 |
Synthesis, physicochemical characterization and pharmacological investigation of indolacin-5-fluorouracil-1-ylmethyl ester.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Carbon-13 Magnetic R | 2016 |
The key role of calreticulin in immunomodulation induced by chemotherapeutic agents.
Topics: Animals; Antigens, Surface; Antineoplastic Agents; Apoptosis; Calreticulin; Camptothecin; Carcinoma, | 2015 |
Antitoxic Activity of Extract from Salix Viminalis Leaves under Conditions of 5-Fluorouracil Treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Bone Marrow; Carcinoma, Lewis Lung; Cyto | 2015 |
Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Lewis Lung; Drug Screening Assays, Antitumor; F | 2016 |
SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice.
Topics: A549 Cells; ADAM10 Protein; Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents; Ca | 2016 |
Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model.
Topics: Angiogenesis Inhibitors; Animals; Blotting, Western; Carcinoma, Lewis Lung; Cell Proliferation; Enzy | 2009 |
COMP-Ang1 potentiates the antitumor activity of 5-fluorouracil by improving tissue perfusion in murine Lewis lung carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferati | 2009 |
A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Citrate (pro-S)- | 2010 |
Improving cachectic symptoms and immune strength of tumour-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Cachexia; Carcinoma, Lewis Lu | 2012 |
Trace elements improve survival of DTIC-treated mice with overt liver metastases of Lewis lung carcinoma.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carcinoma, Lewis Lung; Dacarbazin | 2003 |
Improvement in efficacy of chemoradiotherapy by addition of an antiangiogenic agent in a murine tumor model.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineopla | 2004 |
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
Topics: Animals; Bone Neoplasms; Bystander Effect; Carcinoma, Lewis Lung; Cell Hypoxia; Cytosine Deaminase; | 2004 |
The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; | 2004 |
Hypoxia-induced cytosine deaminase gene expression for cancer therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Lewis Lung; Cell Line, Tumor; Cytosine Deaminas | 2007 |
Inhibition of murine Lewis lung carcinoma metastases by combined chemotherapy and intranasal THF-gamma 2 immunotherapy.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Carcinoma, Lewis Lung; Combined Modalit | 1996 |
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carbon-Sulfur Lyases; Carcinoma, | 1998 |
Interaction of tomudex with radiation in vitro and in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Lewis Lung; Carcinoma, Squamous Cell; Cell Surv | 1998 |
[Augmented antitumor efficacy of combination chemotherapy of nedaplatin with 5-fluorouracil in in vivo murine and human tumor model].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Lewis Lung; Carcinoma, Squamous | 1998 |
Sequence-dependent antitumour efficacy of combination chemotherapy of nedaplatin, a novel platinum complex, with 5-fluorouracil in an in vivo murine tumour model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Lewis Lung; Dose-Response Relati | 1998 |