Page last updated: 2024-10-27

fluorouracil and Carcinoma, Ductal

fluorouracil has been researched along with Carcinoma, Ductal in 17 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.

Research Excerpts

ExcerptRelevanceReference
"We studied the usefulness of the oral 5-FU anti-cancer drug 1-hexylcarbamoyl-5-fluorouracil (HCFU) + cyclophosphamide (CPM) + tamoxifen (TAM) (HCT group) in comparison with CMF + TAM (CMFT group) in adjuvant therapy for breast cancer by a non-inferiority study based on a multi-institutional joint study."9.111-hexylcarbamoyl-5-fluorouracil + cyclophosphamide + tamoxifen versus CMF + tamoxifen in women with lymph node-positive breast cancer after primary surgery: a randomized controlled trial. ( Abe, R; Aoyama, H; Asaga, T; Awane, H; Danno, M; Ikeda, T; Kimura, M; Koyama, H; Mitsuyama, S; Nishi, T; Ogita, M; Sano, M; Takashima, S; Takatsuka, Y; Toi, M; Tominaga, T; Wada, T; Yoshida, M, 2004)
"We report an extremely long duration of chemotherapy with ixabepilone and capecitabine (42 cycles) in a patient with triple-negative metastatic breast cancer previously treated with anthracyclines and taxanes."7.76Long-lasting control of triple-negative metastatic breast cancer with the novel drug combination ixabepilone and capecitabine--case report. ( Bosković, L; Curić, Z; Lukić, B; Mise, BP; Tica, I; Vrdoljak, E, 2010)
"A 47-year-old woman with metastatic breast cancer developed acute pancreatitis while receiving capecitabine."7.72Capecitabine-induced pancreatitis. ( Jones, KL; Valero, V, 2003)
"Capecitabine has become a standard treatment option for metastatic breast cancer, as a single agent or in combination."6.50Breast cancer, DPYD mutations and capecitabine-related ileitis: description of two cases and a review of the literature. ( Aftimos, PG; Errihani, H; Mokrim, M; Piccart-Gebhart, M, 2014)
"We studied the usefulness of the oral 5-FU anti-cancer drug 1-hexylcarbamoyl-5-fluorouracil (HCFU) + cyclophosphamide (CPM) + tamoxifen (TAM) (HCT group) in comparison with CMF + TAM (CMFT group) in adjuvant therapy for breast cancer by a non-inferiority study based on a multi-institutional joint study."5.111-hexylcarbamoyl-5-fluorouracil + cyclophosphamide + tamoxifen versus CMF + tamoxifen in women with lymph node-positive breast cancer after primary surgery: a randomized controlled trial. ( Abe, R; Aoyama, H; Asaga, T; Awane, H; Danno, M; Ikeda, T; Kimura, M; Koyama, H; Mitsuyama, S; Nishi, T; Ogita, M; Sano, M; Takashima, S; Takatsuka, Y; Toi, M; Tominaga, T; Wada, T; Yoshida, M, 2004)
" A total of 283 women with metastatic breast cancer were initially enrolled in a randomised multicentre trial comparing docetaxel to sequential methotrexate-fluorouracil (MF) in advanced breast cancer after anthracycline failure."5.11Cyclin A as a marker for prognosis and chemotherapy response in advanced breast cancer. ( Ahlgren, J; Amini, RM; Blomqvist, C; Poikonen, P; Sjöström, J; Villman, K, 2005)
"We report an extremely long duration of chemotherapy with ixabepilone and capecitabine (42 cycles) in a patient with triple-negative metastatic breast cancer previously treated with anthracyclines and taxanes."3.76Long-lasting control of triple-negative metastatic breast cancer with the novel drug combination ixabepilone and capecitabine--case report. ( Bosković, L; Curić, Z; Lukić, B; Mise, BP; Tica, I; Vrdoljak, E, 2010)
"A 47-year-old woman with metastatic breast cancer developed acute pancreatitis while receiving capecitabine."3.72Capecitabine-induced pancreatitis. ( Jones, KL; Valero, V, 2003)
" A postmenopausal woman was treated for stage II breast cancer with a modified radical mastectomy and adjuvant cyclophosphamide, doxorubicin, and 5-flurouracil followed by tamoxifen for 5 years."3.72Raloxifene rebound regression. ( Dosik, M; Kaufman, R, 2004)
"Capecitabine has become a standard treatment option for metastatic breast cancer, as a single agent or in combination."2.50Breast cancer, DPYD mutations and capecitabine-related ileitis: description of two cases and a review of the literature. ( Aftimos, PG; Errihani, H; Mokrim, M; Piccart-Gebhart, M, 2014)
"The diagnosis was made as right breast cancer (T4c, N3c, M1, and stage IV)."1.35[A case of stage IV breast cancer responding to S-1 therapy after FEC and PTX therapies]. ( Aoyagi, H; Hamada, S; Kaneko, J; Katsuta, E; Maejima, S; Makinose, T; Okubo, K; Saguchi, M; Sato, T; Sekine, T; Someno, Y; Sugihara, K, 2009)
"This is the first study investigating neoadjuvant interstitial high-dose-rate (HDR) brachytherapy combined with chemotherapy in patients with breast cancer."1.33Neoadjuvant interstitial high-dose-rate (HDR) brachytherapy combined with systemic chemotherapy in patients with breast cancer. ( Baltas, D; Filipowicz, I; Hoffmann, G; Kolotas, C; Kontova, M; Kuner, RP; Kurek, R; Martin, T; Pollow, B; Roddiger, SJ; Rogge, B; Zamboglou, N, 2006)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's0 (0.00)18.2507
2000's12 (70.59)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mokrim, M1
Aftimos, PG1
Errihani, H1
Piccart-Gebhart, M1
Iguchi, T1
Uchida, J1
Nakamura, T1
Kawamura, M1
Wakasa, K1
Nakatani, T1
Aoyagi, H1
Kaneko, J1
Makinose, T1
Someno, Y1
Katsuta, E1
Saguchi, M1
Okubo, K1
Hamada, S1
Sekine, T1
Sato, T1
Sugihara, K1
Maejima, S1
Vrdoljak, E1
Mise, BP1
Lukić, B1
Curić, Z1
Bosković, L1
Tica, I1
Ferreira, A1
Vieira, C1
Rodrigues, A1
Pereira, D1
Rodrigues, H1
Dávila, C1
Bento, S1
Basu, S1
Baghel, NS1
Jones, KL1
Valero, V1
SILVA, AR1
SMART, CR1
ROCHLIN, DB1
van Kuilenburg, AB1
Meinsma, R1
Zonnenberg, BA1
Zoetekouw, L1
Baas, F1
Matsuda, K1
Tamaki, N1
van Gennip, AH1
Tominaga, T1
Kimura, M1
Asaga, T1
Yoshida, M1
Awane, H1
Koyama, H1
Takatsuka, Y1
Mitsuyama, S1
Ikeda, T1
Ogita, M1
Aoyama, H1
Sano, M1
Abe, R1
Nishi, T1
Wada, T1
Danno, M1
Toi, M1
Takashima, S1
Dosik, M1
Kaufman, R1
Poikonen, P1
Sjöström, J1
Amini, RM1
Villman, K1
Ahlgren, J1
Blomqvist, C1
Cho, JY1
Paik, YH1
Chang, YS1
Lee, SJ1
Lee, DK1
Song, SY1
Chung, JB1
Park, MS1
Yu, JS1
Yoon, DS1
Roddiger, SJ1
Kolotas, C1
Filipowicz, I1
Kurek, R1
Kuner, RP1
Martin, T1
Baltas, D1
Rogge, B1
Kontova, M1
Hoffmann, G1
Pollow, B1
Zamboglou, N1
Zorzi, D1
Abdalla, EK1
Pawlik, TM1
Brown, TD1
Vauthey, JN1
Cottu, PH1
Asselah, J1
Lae, M1
Pierga, JY1
Diéras, V1
Mignot, L1
Sigal-Zafrani, B1
Vincent-Salomon, A1
Puglisi, F1
Cardellino, GG1
Crivellari, D1
Di Loreto, C1
Magri, MD1
Minisini, AM1
Mansutti, M1
Andreetta, C1
Russo, S1
Lombardi, D1
Perin, T1
Damante, G1
Veronesi, A1

Reviews

1 review available for fluorouracil and Carcinoma, Ductal

ArticleYear
Breast cancer, DPYD mutations and capecitabine-related ileitis: description of two cases and a review of the literature.
    BMJ case reports, 2014, Apr-19, Volume: 2014

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neopla

2014

Trials

4 trials available for fluorouracil and Carcinoma, Ductal

ArticleYear
1-hexylcarbamoyl-5-fluorouracil + cyclophosphamide + tamoxifen versus CMF + tamoxifen in women with lymph node-positive breast cancer after primary surgery: a randomized controlled trial.
    Oncology reports, 2004, Volume: 12, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal; Ch

2004
Cyclin A as a marker for prognosis and chemotherapy response in advanced breast cancer.
    British journal of cancer, 2005, Sep-05, Volume: 93, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Duct

2005
Capecitabine combined with gemcitabine (CapGem) as first-line treatment in patients with advanced/metastatic biliary tract carcinoma.
    Cancer, 2005, Dec-15, Volume: 104, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Biopsy, Needle

2005
Thymidine phosphorylase expression is associated with time to progression in patients receiving low-dose, docetaxel-modulated capecitabine for metastatic breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:9

    Topics: Administration, Oral; Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Biomark

2008

Other Studies

12 other studies available for fluorouracil and Carcinoma, Ductal

ArticleYear
Effective combined chemotherapy for prostatic ductal adenocarcinoma: continuous venous infusion of 5-fluorouracil and low-dose consecutive cisplatin.
    BJU international, 2003, Volume: 92 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ductal; Cisplatin; Fluorouracil; Humans;

2003
[A case of stage IV breast cancer responding to S-1 therapy after FEC and PTX therapies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined C

2009
Long-lasting control of triple-negative metastatic breast cancer with the novel drug combination ixabepilone and capecitabine--case report.
    Onkologie, 2010, Volume: 33, Issue:1-2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; C

2010
Bevacizumab in the treatment of metastatic breast cancer: three case reports.
    Current opinion in oncology, 2011, Volume: 23 Suppl

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot

2011
Response to low-dose oral capecitabine monotherapy in an elderly frail patient with metastatic breast carcinoma and impaired renal function: documentation by fluorodeoxyglucose positron emission tomography.
    Japanese journal of radiology, 2011, Volume: 29, Issue:4

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcino

2011
Capecitabine-induced pancreatitis.
    Pharmacotherapy, 2003, Volume: 23, Issue:8

    Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal; Deoxycytidine; D

2003
CHEMOTHERAPY OF BREAST CANCER.
    Surgery, gynecology & obstetrics, 1965, Volume: 121

    Topics: Antineoplastic Agents; Biomedical Research; Breast Neoplasms; Carcinoma, Ductal; Cyclophosphamide; F

1965
Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-01, Volume: 9, Issue:12

    Topics: Amidohydrolases; Amino Acid Sequence; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neo

2003
Raloxifene rebound regression.
    Cancer investigation, 2004, Volume: 22, Issue:5

    Topics: Antineoplastic Agents; Bone Diseases, Metabolic; Breast Neoplasms; Carcinoma, Ductal; Cyclophosphami

2004
Neoadjuvant interstitial high-dose-rate (HDR) brachytherapy combined with systemic chemotherapy in patients with breast cancer.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2006, Volume: 182, Issue:1

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents,

2006
Subtotal hepatectomy following neoadjuvant chemotherapy for a previously unresectable hepatocellular carcinoma.
    Journal of hepato-biliary-pancreatic surgery, 2006, Volume: 13, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal; Carcinoma, Hepa

2006
Intratumoral heterogeneity of HER2/neu expression and its consequences for the management of advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot

2008