Compounds > fluorouracil
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fluorouracil and Carcinoma, Bronchial

fluorouracil has been researched along with Carcinoma, Bronchial in 47 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Twenty-seven patients with colorectal adenocarcinoma, (12) non-small cell bronchogenic carcinoma, (11) gastric adenocarcinoma (3), and adenocarcinoma of unknown primary lesion (1) were treated with the combination of thymidine (TdR), 5-fluorouracil (FU), and N-phosphonacetyl-L-aspartic acid (PALA)."3.67Sequential administration of thymidine, 5-fluorouracil, and PALA. A phase I-II study. ( Bedikian, A; Benvenuto, JA; Bodey, GP; Chiuten, DF; Freireich, EJ; Loo, TL; Miller, A; Valdivieso, M, 1985)
"Thirty patients with an advanced bronchogenic carcinoma were treated with a combination of adriamycin and 5-fluorouracil; in eight the size of the tumour or its metastases was reduced by over 50%, and eight further patients experienced useful relief of symptoms."3.65Treatment of advanced bronchogenic carcinoma with adriamycin and 5-fluorouracil. ( Anderson, G; Bugaighis, A; Rees, GJ, 1975)
"Etoposide has been added to this regimen, and 32 stage IIIM0 non-small cell lung cancer patients have been treated with the 3-drug regimen resulting in a 73% clinical partial remission rate."1.27Phase II trial of therapy with etoposide, 5-fluorouracil by continuous infusion, cisplatin, and simultaneous split-course radiation in stage III non-small cell bronchogenic carcinoma. ( Bonomi, P; Faber, LP; Kittle, CF; Lee, MS; Pincus, M; Reddy, S; Rowland, KM; Taylor, SG; Warren, W, 1988)
"Oat cell carcinoma is the one variety of primary lung cancer which is sufficiently responsive to a variety of drugs and drug combinations that a very high rate of response and significant prolongation of survival can be consistently achieved."1.26Chemotherapy for lung cancer. ( Golbey, RB, 1978)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199043 (91.49)18.7374
1990's3 (6.38)18.2507
2000's1 (2.13)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
REITEMEIER, RJ1
MOERTEL, CG1
BLACKBURN, CM1
GOLLIN, FF4
ANSFIELD, FJ5
VERMUND, H4
KARNOFSKY, DA1
ARONOVITCH, M1
BOUCHARD, J1
GROSZMAN, M1
MEAKINSS, JF1
HAZEL, J1
JALIL, A1
RIEHL, JL1
BROWN, WJ1
LAMY, P1
ANTHOINE, D1
DUC, M1
VAILLANT, G1
CERVONI, P1
Dimitriadis, K1
Boutis, L1
Tavantzis, J1
Mouratidou, D1
Bouchoris, N1
Koukourikos, S1
Hatzigogos, K1
Safarini, S1
Anderson, G3
Deeley, TJ1
Smith, C1
Jani, J1
Düker, D1
Bretel, JJ1
Arriagada, R1
Le Chevalier, T1
Baldeyrou, P1
Grunenwald, D1
Le Péchoux, C1
Pellae-Cosset, B1
Ruffié, P1
Doddoli, C1
Thomas, P1
Reynaud-Gaubert, M1
Giudicelli, R1
Papazian, L1
Fuentes, P1
Lanzotti, VJ1
Thomas, DR1
Holoye, PY1
Boyle, LE1
Smith, TL1
Samuels, ML1
Golbey, RB1
Livingston, RB1
Karrer, K3
Pridun, N3
Denck, H2
Thomas, G1
Stewart-Jones, J1
Zwintz, E2
Rees, GJ1
Bugaighis, A1
Robinet, G1
Richard, P1
Rouhart, F1
Mocquard, Y1
Goas, JY1
André, N1
Gouva, S1
Clavier, J1
Broder, LE1
Sridhar, KS1
Selawry, OS1
Charyulu, KN1
Rao, RK1
Saldana, MJ1
Lenz, C1
Bonomi, P2
Rowland, KM1
Taylor, SG2
Pincus, M1
Reddy, S2
Lee, MS2
Faber, LP2
Warren, W2
Kittle, CF1
Wang, ZT1
Rowland, K1
Chiuten, DF1
Miller, A1
Valdivieso, M1
Loo, TL1
Bedikian, A1
Bodey, GP1
Benvenuto, JA1
Freireich, EJ1
Holsti, LR1
Bonadonna, G1
Tancini, G1
Bajetta, E1
Perevodchikova, NI1
Bychkov, MB1
Kirsch, WM1
Schulz, D1
Van Buskirk, JJ1
Young, HE1
Elias, EG1
Carr, DT1
Childs, DS1
Lee, RE1
Dana, M1
Israel, L1
Depierre, A1
Chahinian, P1
Haller, JD1
Bron, KM1
Wholey, MH1
Poller, S1
Enerson, DM1
Shnider, BI2
Cohen, JL1
Krant, MJ1
Matias, PI1
Horton, J1
Baxter, D1
Wieme, RJ1
Van Hove, WZ1
Van der Straeten, ME1
Fazio, M1
Minetto, E1
Cavallero, P1
Sartoris, S1
Gottlieb, JA1
Serpick, AA1
Dorigoni, A1
Peris, GC1
Scarponi, F1
Alcozer, G1
Wirtanen, GW1
Freckman, HA1
Mendez, FL1
Maurer, ER1
Fry, HL1

Reviews

1 review available for fluorouracil and Carcinoma, Bronchial

ArticleYear
Chemotherapy of solid tumors. Recent advances.
    Postgraduate medicine, 1976, Volume: 59, Issue:2

    Topics: Adult; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Bronchogenic; Carcinom

1976

Trials

6 trials available for fluorouracil and Carcinoma, Bronchial

ArticleYear
[Chemotherapy of the non-small cell bronchogenic carcinoma].
    Onkologie, 1983, Volume: 6, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents; Bleomycin; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell;

1983
Comparison of radiotherapy alone and radiotherapy with chemotherapy using adriamycin and 5-fluorouracil in bronchogenic carcinoma.
    Thorax, 1981, Volume: 36, Issue:3

    Topics: Carcinoma, Bronchogenic; Doxorubicin; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Middle Age

1981
[Optimization of combined radiotherapy and chemotherapy in treatment of non-small cell lung carcinoma].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 1997, Volume: 1, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Non

1997
A phase II clinical trial evaluating the use of two sequential, four-drug combination chemotherapy regimens in ambulatory bronchogenic adenocarcinoma patients.
    American journal of clinical oncology, 1992, Volume: 15, Issue:6

    Topics: Adenocarcinoma; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchog

1992
Radiotherapy plus 5-FU compared to radiotherapy alone for inoperable and unresectable bronchogenic carcinoma.
    Cancer, 1972, Volume: 29, Issue:2

    Topics: Adenocarcinoma; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Clinical Trials as Top

1972
Combination chemotherapy for 418 cases of advanced cancer.
    Cancer, 1971, Volume: 27, Issue:5

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Squamous Cel

1971

Other Studies

40 other studies available for fluorouracil and Carcinoma, Bronchial

ArticleYear
VINCRISTINE (NSC-67574) THERAPY OF ADULT PATIENTS WITH SOLID TUMORS.
    Cancer chemotherapy reports, 1964, Volume: 34

    Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoid Tumor; Carcinoma, Bronchogenic; Carcinoma, Squamous

1964
COMBINED CHEMOTHERAPY AND RADIATION THERAPY IN ADVANCED MALIGNANCIES.
    Geriatrics, 1964, Volume: 19

    Topics: Carcinoma, Bronchogenic; Cyclophosphamide; Female; Fluorouracil; Head and Neck Neoplasms; Humans; La

1964
NONSURGICAL TREATMENT OF PULMONARY CANCER.
    Modern treatment, 1964, Volume: 1

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agen

1964
ALKYLATING AGENTS, ANTI-METABOLITES, ALKALOIDS AND X-RAYS IN THE TREATMENT OF INOPERABLE BRONCHOGENIC CARCINOMA.
    Medical services journal, Canada, 1964, Volume: 20

    Topics: Alkaloids; Alkylating Agents; Antimetabolites; Antineoplastic Agents; Carcinoma; Carcinoma, Bronchog

1964
CLINICAL STUDIES OF COMBINED CHEMOTHERAPY AND IRRADIATION IN INOPERABLE BRONCHOGENIC CARCINOMA.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1964, Volume: 92

    Topics: Adenocarcinoma; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclophosphamide; Fluo

1964
[TREATMENT OF INOPERABLE BRONCHIAL CANCER WITH A COMBINATION OF CHEMOTHERAPY AND IRRADIATION].
    Deutsche medizinische Wochenschrift (1946), 1964, Nov-06, Volume: 89

    Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide; Fluorouracil; Humans; Idoxuridine; L

1964
ACUTE CEREBELLAR SYNDROME SECONDARY TO 5-FLUOROURACIL THERAPY.
    Neurology, 1964, Volume: 14

    Topics: Abdominal Neoplasms; Adenocarcinoma; Bone Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Carcinoma,

1964
[PRELIMINARY RESULTS OF PRIMARY BRONCHOGENIC CARCINOMAS TREATED WITH COBALT-THERAPY ASSOCIATED WITH 5-FLUORO-URACIL. (APROPOS OF 50 CASES)].
    Annales medicales de Nancy, 1965, Volume: 4

    Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Cobalt; Fluorouracil; Humans; Neoplasms; Radiotherapy,

1965
Continued studies of combined chemotherapy and irradiation in inoperable bronchogenic carcinoma.
    Cancer chemotherapy reports, 1967, Volume: 51, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Cyclophosphamide; Female; Fluorouracil;

1967
Investigations into sister chromatid exchange in patients under cytostatic therapy.
    Human genetics, 1981, Volume: 58, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Child; Child, Preschool; Cr

1981
[Postoperative complications after radiochemotherapy or chemotherapy for bronchial cancers].
    Revue des maladies respiratoires, 2000, Volume: 17, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bronchial Fistula; Carcinoma, Bronchoge

2000
Bleomycin (NSC-125066) followed by cyclophosphamide (NSC-26271), vincristine (NSC-67574), methotrexate (NSC-740), and 5-fllorouracil (NSC-19893) for non-oat cell bronchogenic carcinoma.
    Cancer treatment reports, 1976, Volume: 60, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Agents; Bleomycin; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell;

1976
Chemotherapy for lung cancer.
    Postgraduate medicine, 1978, Volume: 63, Issue:2

    Topics: Bleomycin; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cyclophosphamide; Cytarabine; Dactinomyci

1978
[After care in bronchial carcinoma. Results of postoperative polychemotherapy].
    Fortschritte der Medizin, 1976, Mar-04, Volume: 94, Issue:7

    Topics: Aftercare; Aged; Antineoplastic Agents; Austria; Carcinoma, Bronchogenic; Cyclophosphamide; Fluorour

1976
Treatment of advanced bronchogenic carcinoma with adriamycin, 5-fluorouracil and methotrexate.
    British journal of diseases of the chest, 1977, Volume: 71, Issue:3

    Topics: Carcinoma, Bronchogenic; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leuco

1977
[How could the results of surgical treatment of bronchogenic carcinoma be improved? (authors transl)].
    Wiener klinische Wochenschrift, 1978, Apr-14, Volume: 90, Issue:8

    Topics: Angiography; Carcinoma, Bronchogenic; Cyclophosphamide; Drug Therapy, Combination; Female; Fluoroura

1978
[Chemotherapy of bronchial carcinomas (author's transl)].
    Zeitschrift fur Erkrankungen der Atmungsorgane, 1975, Volume: 142, Issue:2

    Topics: Antineoplastic Agents; Bronchial Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide; Drug Therapy,

1975
Treatment of advanced bronchogenic carcinoma with adriamycin and 5-fluorouracil.
    British journal of diseases of the chest, 1975, Volume: 69

    Topics: Alopecia; Carcinoma, Bronchogenic; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Hum

1975
[Inoperable brain metastases from bronchogenic cancers. Value of combined chemotherapy with cisplatin and 5 fluorouracil].
    Revue neurologique, 1992, Volume: 148, Issue:6-7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Bronchogeni

1992
Phase II trial of therapy with etoposide, 5-fluorouracil by continuous infusion, cisplatin, and simultaneous split-course radiation in stage III non-small cell bronchogenic carcinoma.
    NCI monographs : a publication of the National Cancer Institute, 1988, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell L

1988
[Intra-arterial drug infusion via the bronchial artery in the treatment of bronchogenic carcinoma].
    Zhonghua fang she xue za zhi Chinese journal of radiology, 1988, Volume: 22, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bronchial Arteries; Carcinoma, Bronchog

1988
Phase II trial of etoposide, cisplatin, continuous infusion 5-fluorouracil, and simultaneous split-course radiation therapy in stage III non-small-cell bronchogenic carcinoma.
    Seminars in oncology, 1986, Volume: 13, Issue:3 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Cisplatin; Combined Modalit

1986
Sequential administration of thymidine, 5-fluorouracil, and PALA. A phase I-II study.
    American journal of clinical oncology, 1985, Volume: 8, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carcinom

1985
Alternative approaches to radiotherapy alone and radiotherapy as a part of a combined therapeutic approach for lung cancer.
    Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2

    Topics: Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclophosphamide; Fluorouracil; Humans; Lung Neop

1973
Chemotherapy of lung cancer: the experience of the National Cancer Institute of Milan.
    Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2

    Topics: Adenocarcinoma; Bleomycin; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Doxorubicin; Fluoroura

1973
Chemotherapy for lung cancer at the Institute of Experimental and Clinical Oncology, Academy of Medical Sciences, USSR.
    Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2

    Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcino

1973
Effects of sodium warfarin and other carcinostatic agents on malignant cells: a study of drug synergy.
    Journal of medicine, 1974, Volume: 5, Issue:1

    Topics: Animals; Carbon Radioisotopes; Carcinoma, Bronchogenic; Carcinoma, Hepatocellular; Carcinoma, Squamo

1974
Heparin anticoagulation as adjuvant to chemotherapy in carcinoma of the lung.
    Journal of medicine, 1974, Volume: 5, Issue:1

    Topics: Aged; Antineoplastic Agents; Blood Coagulation; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Small

1974
Chemotherapeutic studies in bronchogenic carcinoma by the Austrian study group.
    Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2

    Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Austria; Carcinoma, Bronchogenic; Cyclophosphamide;

1973
Radiotherapy for bronchogenic carcinoma: actual difficulties and plans for the future.
    Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2

    Topics: Adenocarcinoma; Brain Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclophosphamide

1973
Selective bronchial artery catheterization for diagnostic and physiologic studies and chemotherapy for bronchogenic carcinoma.
    The Journal of thoracic and cardiovascular surgery, 1966, Volume: 51, Issue:1

    Topics: Adult; Aged; Angiography; Bronchial Arteries; Carcinoma, Bronchogenic; Catheterization; Fluorouracil

1966
The use of chemotherapy in lung cancer (controlled trials).
    The Medical annals of the District of Columbia, 1971, Volume: 40, Issue:8

    Topics: Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Dactinomycin; Drug Synergism; Female; Fluorouraci

1971
Radiation plus 5-fluorouracil (NSC-19893): clinical demonstration of an additive effect in bronchogenic carcinoma.
    Cancer chemotherapy reports, 1971, Volume: 55, Issue:3

    Topics: Adenocarcinoma; Aged; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Female; Fluorouracil; Human

1971
The influence of cytostatic treatment on serum LDH patterns of patients with bronchial carcinoma and its relation to tumor regression.
    Annals of the New York Academy of Sciences, 1968, Jun-14, Volume: 151, Issue:1

    Topics: Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Fluorouracil; Humans; Isoenzymes; L-Lactate Dehyd

1968
[Polychemotherapy of bronchial carcinoma].
    Minerva medica, 1970, Jun-09, Volume: 61, Issue:46

    Topics: Aged; Brain Neoplasms; Bronchial Neoplasms; Carcinoma, Bronchogenic; Cyclophosphamide; Fluorouracil;

1970
An evaluation of combination chemotherapy with procarbazine (NSC-77213) and 5-fluorouracil (NSC-19893) in advanced carcinoma of the lung.
    Cancer chemotherapy reports, 1970, Volume: 54, Issue:5

    Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Benzoates; Blood Cell Count; Carcinoma; Carcinoma, Bro

1970
[Polychemotherapeutic treatment of pulmonary neoplasms].
    Giornale di pneumologia, 1970, Volume: 14, Issue:3

    Topics: Carcinoma, Bronchogenic; Cyclophosphamide; Drug Synergism; Evaluation Studies as Topic; Fluorouracil

1970
[Internal cancer therapy: cooperative clinical studies. Principles, organization and first results of the Swiss chemotherapy group].
    Praxis, 1967, Dec-14, Volume: 56, Issue:50

    Topics: Adenocarcinoma; Androgens; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Car

1967
Bronchial artery infusion in bronchogenic carcinoma.
    Cancer chemotherapy reports, 1968, Volume: 52, Issue:2

    Topics: Angiography; Bronchial Arteries; Carcinoma, Bronchogenic; Catheterization; Fluorouracil; Humans; Met

1968
Chemotherapy for lung cancer by intra-aortic infusion.
    JAMA, 1966, Apr-04, Volume: 196, Issue:1

    Topics: Aorta; Carcinoma, Bronchogenic; Cyclophosphamide; Female; Fluorouracil; Humans; Injections, Intra-Ar

1966