Compounds > fluorouracil
Page last updated: 2024-10-27

fluorouracil and Carcinogenesis

fluorouracil has been researched along with Carcinogenesis in 72 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.

Research Excerpts

ExcerptRelevanceReference
"As EIF3D is oncogenic in colorectal cancer (CRC) and is associated with multidrug resistance, this study aims to investigate whether and how EIF3D regulates resistance to 5-fluorouracil (5-Fu) in CRC."8.31EIF3D promotes resistance to 5-fluorouracil in colorectal cancer through upregulating RUVBL1. ( Du, W; Li, C; Liang, Z; Lu, K; Yang, C, 2023)
" Here, we evaluated the anti-inflammatory Trimethylglycine and the Signal transducer and activator of transcription (STAT6) inhibitor AS1517499, as possible adjuvants to 5-FU in already established cancers, using a model of colitis-associated colon cancer (CAC)."7.96Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis. ( Beristain-Terrazas, DL; Callejas, BE; Chirino, YI; Delgado-Buenrostro, NL; García-Castillo, V; Gutierrez-Cirlos, EB; León-Cabrera, SA; Mendoza-Rodríguez, MG; Meraz-Ríos, MA; Pérez-Plasencia, C; Rodríguez-Sosa, M; Sánchez-Barrera, CÁ; Terrazas, LI; Vaca-Paniagua, F, 2020)
"5-Fluorouracil (5-FU)-based chemotherapy has always been the first-line treatment of colorectal cancer (CRC)."7.91The long non-coding RNA HOTAIRM1 suppresses cell progression via sponging endogenous miR-17-5p/ B-cell translocation gene 3 (BTG3) axis in 5-fluorouracil resistant colorectal cancer cells. ( Chen, J; Hou, J; Liu, C; Qin, A; Ren, T; Ren, W; Shan, F; Xiong, X, 2019)
"The efficacy of Fluorouracil (FU) in the treatment of colorectal cancer (CRC) is greatly limited by drug resistance."7.91ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield. ( Chen, Y; Hao, J; Li, F; Li, J; Liang, H; Luo, X; Ou, J; Peng, Y; Sun, W; Wang, L; Wu, S; Xie, G; Xie, X; Yang, W; Zha, L; Zhang, Y; Zhao, Y; Zhou, Q, 2019)
"To investigate expression of cell cycle-related and expression-elevated protein in tumor (CREPT) in colorectal cancer (CRC) and determine its prognostic value in response to 5-fluorouracil (5-FU)."7.88Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil. ( Chang, ZJ; Ding, LD; Jia, BQ; Kuang, YS; Li, J; Liu, HY; Liu, SH; Wang, XN; Wang, Y; Wang, YY; Yang, L; Zhu, BT, 2018)
"This study analyzes the anti-tumor effects of evodiamine on cellular growth, tumorigenesis, cell cycle and apoptosis induction of human urothelial cell carcinoma (UCC) cells."7.85Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells. ( Chin, CC; Huang, YC; Kuo, YH; Lee, YR; Li, JM; Shi, CS, 2017)
"Colorectal cancer has risen to the third occurring cancer in the world."5.91The Gut Microbiota Metabolite Urolithin B Prevents Colorectal Carcinogenesis by Remodeling Microbiota and PD-L1/HLA-B. ( Chen, J; Chen, Q; Jin, S; Song, H; Song, X; Wang, L; Wang, Z; Xing, W; Yang, H; Zhao, W, 2023)
" Although curcumin is known to have anti-tumor, hepatoprotective, and hypoglycemic-like actions, its low water solubility, oral absorption, and bioavailability impede its therapeutic uses."5.62Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. ( Abugomaa, A; Ayame, H; Elbadawy, M; Hayashi, K; Hayashi, SM; Hazama, S; Ishihara, Y; Kaneda, M; Nagano, H; Nakajima, M; Sasaki, K; Shibutani, M; Shinohara, Y; Suzuki, N; Takenouchi, H; Tsunedomi, R; Usui, T; Yamawaki, H, 2021)
"5-fluorouracil (5-FU) is a pyrimidine-like antimetabolite."5.51Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma. ( Liu, H; Liu, Q; Song, L, 2019)
"It is now widely accepted that therapeutic antibodies targeting epidermal growth factor receptor (EGFR) can have efficacy in KRAS wild-type advanced colorectal cancer (CRC) patients."5.22TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: a potential novel approach to the treatment of metastatic colorectal cancer. ( Brünner, N; Christensen, IJ; Glimelius, B; Guren, TK; Ikdahl, T; Kure, EH; Moreira, JM; Nielsen, HJ; Noer, J; Nordgaard, C; Pfeiffer, P; Sorbye, H; Tarpgaard, LS; Tveit, KM; Ørum-Madsen, MS, 2016)
"As EIF3D is oncogenic in colorectal cancer (CRC) and is associated with multidrug resistance, this study aims to investigate whether and how EIF3D regulates resistance to 5-fluorouracil (5-Fu) in CRC."4.31EIF3D promotes resistance to 5-fluorouracil in colorectal cancer through upregulating RUVBL1. ( Du, W; Li, C; Liang, Z; Lu, K; Yang, C, 2023)
" Here, we evaluated the anti-inflammatory Trimethylglycine and the Signal transducer and activator of transcription (STAT6) inhibitor AS1517499, as possible adjuvants to 5-FU in already established cancers, using a model of colitis-associated colon cancer (CAC)."3.96Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis. ( Beristain-Terrazas, DL; Callejas, BE; Chirino, YI; Delgado-Buenrostro, NL; García-Castillo, V; Gutierrez-Cirlos, EB; León-Cabrera, SA; Mendoza-Rodríguez, MG; Meraz-Ríos, MA; Pérez-Plasencia, C; Rodríguez-Sosa, M; Sánchez-Barrera, CÁ; Terrazas, LI; Vaca-Paniagua, F, 2020)
"The efficacy of Fluorouracil (FU) in the treatment of colorectal cancer (CRC) is greatly limited by drug resistance."3.91ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield. ( Chen, Y; Hao, J; Li, F; Li, J; Liang, H; Luo, X; Ou, J; Peng, Y; Sun, W; Wang, L; Wu, S; Xie, G; Xie, X; Yang, W; Zha, L; Zhang, Y; Zhao, Y; Zhou, Q, 2019)
"Clinically, one of the principal factors in the failure of advanced colorectal cancer (CRC) treatment is chemoresistance to 5-fluorouracil (5FU)-based chemotherapy."3.91miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells. ( Chen, X; He, B; Liu, X; Pan, B; Pan, Y; Qin, J; Sun, H; Sun, L; Wang, S; Xu, M; Xu, T; Xu, X; Zeng, K, 2019)
"5-Fluorouracil (5-FU)-based chemotherapy has always been the first-line treatment of colorectal cancer (CRC)."3.91The long non-coding RNA HOTAIRM1 suppresses cell progression via sponging endogenous miR-17-5p/ B-cell translocation gene 3 (BTG3) axis in 5-fluorouracil resistant colorectal cancer cells. ( Chen, J; Hou, J; Liu, C; Qin, A; Ren, T; Ren, W; Shan, F; Xiong, X, 2019)
"Patients with advanced colorectal cancer often are treated with systemic cytotoxic therapy using fluorouracil (5-FU), oxaliplatin, irinotecan, and FOLFOX or FOLFIRI combination protocols."3.91In vivo effects of chemotherapy on oncogenic pathways in colorectal cancer. ( Elmasry, M; Horst, D; Kirchner, T; Schmidt, EM; Schulz, GB; Spartalis, C, 2019)
"To investigate expression of cell cycle-related and expression-elevated protein in tumor (CREPT) in colorectal cancer (CRC) and determine its prognostic value in response to 5-fluorouracil (5-FU)."3.88Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil. ( Chang, ZJ; Ding, LD; Jia, BQ; Kuang, YS; Li, J; Liu, HY; Liu, SH; Wang, XN; Wang, Y; Wang, YY; Yang, L; Zhu, BT, 2018)
"Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out."3.85The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy. ( Ishchenko, IY; Kabakov, AV; Kazakov, OV; Konenkov, VI; Michurina, SV; Poveshchenko, AF; Raiter, TV; Strunkin, DN, 2017)
"This study analyzes the anti-tumor effects of evodiamine on cellular growth, tumorigenesis, cell cycle and apoptosis induction of human urothelial cell carcinoma (UCC) cells."3.85Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells. ( Chin, CC; Huang, YC; Kuo, YH; Lee, YR; Li, JM; Shi, CS, 2017)
" Additionally, functional studies indicated that over-expression of RAD51B promoted cell proliferation, aneuploidy, and drug resistance, while RAD51B knockdown led to G1 arrest and sensitized cells to 5-fluorouracil (5-FU)."3.83RAD51B as a potential biomarker for early detection and poor prognostic evaluation contributes to tumorigenesis of gastric cancer. ( Chen, X; Cheng, Y; Xi, Y; Yang, B, 2016)
"Treatment of MLH1-methylated colon cancer cell lines with the demethylating agent 5'-aza-2'-deoxycytidine induces the expression of MLH1 and sensitizes cancer cells to 5-fluorouracil."2.53The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer. ( Gao, D; Guo, M; Herman, JG, 2016)
"Colorectal cancer has risen to the third occurring cancer in the world."1.91The Gut Microbiota Metabolite Urolithin B Prevents Colorectal Carcinogenesis by Remodeling Microbiota and PD-L1/HLA-B. ( Chen, J; Chen, Q; Jin, S; Song, H; Song, X; Wang, L; Wang, Z; Xing, W; Yang, H; Zhao, W, 2023)
" Although curcumin is known to have anti-tumor, hepatoprotective, and hypoglycemic-like actions, its low water solubility, oral absorption, and bioavailability impede its therapeutic uses."1.62Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. ( Abugomaa, A; Ayame, H; Elbadawy, M; Hayashi, K; Hayashi, SM; Hazama, S; Ishihara, Y; Kaneda, M; Nagano, H; Nakajima, M; Sasaki, K; Shibutani, M; Shinohara, Y; Suzuki, N; Takenouchi, H; Tsunedomi, R; Usui, T; Yamawaki, H, 2021)
"Therefore, we examined five gastric cancer cell lines and isolated gastric oncospheres from three gastric cancer cell lines."1.62SNAIL regulates gastric carcinogenesis through CCN3 and NEFL. ( Chen, R; Masuo, K; Seno, H; Sugiyama, A; Takaishi, S; Yogo, A; Yokoyama, S; Yoshizawa, A, 2021)
"Anal cancer is a rare disease that has doubled in incidence over the last four decades."1.62Molecular and genomic characterisation of a panel of human anal cancer cell lines. ( Behrenbruch, CC; Bernardi, MP; Chittleborough, TJ; Di Costanzo, N; Guerra, GR; Hawkes, D; Haynes, NM; Heriot, AG; Kong, JC; Liu, DS; Lupat, R; Millen, RM; Mitchell, C; Ngan, SY; Phillips, WA; Ramsay, RG; Read, M; Roth, S; Sampurno, S; Sia, J; Teh, J; Tothill, RW; Xu, H; Yu, J, 2021)
" Particularly, the expression of tumour-suppressing gene Ccdc80 was induced by vactosertib and further induced by vactosertib in combination with nal-IRI/5-FU/LV."1.56Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models. ( An, H; Heo, JS; Hong, CP; Hong, E; Kang, JM; Kim, SJ; Lee, S; Ooshima, A; Park, J; Park, JO; Park, S; Park, SH, 2020)
"Colon cancer is one of the leading causes of cancer-related deaths and its five-year survival rate remains low in locally advanced or metastatic stages of colon cancer."1.56Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. ( Chen, CH; Cho, EC; Hsieh, YC; Liu, YR; Yang, PM, 2020)
"5-fluorouracil (5-FU) is a pyrimidine-like antimetabolite."1.51Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma. ( Liu, H; Liu, Q; Song, L, 2019)
"5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers."1.515-Fluorouracil treatment induces characteristic T>G mutations in human cancer. ( Besselink, N; Boymans, S; Christensen, S; Cuppen, E; Janssen, R; Kuijk, E; Martens, JWM; Priestley, P; Van der Roest, B; Van Hoeck, A; Yaspo, ML, 2019)
"Skin cancer is the most common type of cancer."1.48A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model. ( Ahn, JS; Cha-Molstad, H; Choi, TW; Han, HJ; Hong, JT; Hwang, J; Kim, BY; Kim, HJ; Kwon, YT; Lee, HG; Lee, KH; Lee, Y; Mun, J; Soung, NK, 2018)
"A total of 80 cases of colorectal cancer tissues were examined by immunohistochemistry for MTA3 protein expression."1.46MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway. ( Feng, M; Gao, T; Jiao, T; Li, Y; Liu, M; Sun, M; Zhang, Y; Zhou, H, 2017)
"Notably, REP1 is highly expressed in colon cancer tissues and cell lines, and silencing of REP1 sensitizes colon cancer cells to serum starvation- and 5-FU-induced apoptosis."1.46REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. ( Bae, DJ; Bae, YK; Cho, H; Chung, JY; Hibi, M; Hong, SM; Hong, SO; Kim, MG; Kim, SY; Kim, TW; Kim, YN; Lee, HJ; Oh, SJ; Rho, SB; Shim, J; Song, KH; Woo, SR, 2017)
" A strong antitumorigenic effect of FOXK1-shRNA was enhanced when combined with 5-FU treatment."1.43Knockdown of FOXK1 alone or in combination with apoptosis-inducing 5-FU inhibits cell growth in colorectal cancer. ( Ba, Y; Chen, Y; Li, A; Liu, S; Liu, X; Nan, Q; Peng, Y; Tang, W; Wang, J; Wu, M; Wu, Y; Xie, R; Zhang, P; Zhao, J, 2016)
"However, ovarian cancer cells with ectopic expression of cyclin A1 demonstrated slowdown of proliferation and senescence-associated β-galactosidase activity."1.43Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells. ( Berkowitz, RS; Huang, KC; Muto, MG; Ng, MC; Ng, SK; Ng, SW; Welch, WR; Yang, J, 2016)
"Finally, using a human colon cancer xenograft murine model, we found that the combined 5-FU and 10058-F4 treatment significantly decreased tumorigenicity in nude mice compared with 5-FU or 10058-F4 treatment alone."1.42The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells. ( Enoki, T; Hamano, K; Hosoyama, T; Kugimiya, N; Li, TS; Nishimoto, A; Ueno, K, 2015)
"The directed application of the normal nucleobase uracil to the squamous cells of the oral mucosa and palms and soles together with the delivery of the normal nucleobase adenine to the columnar cells of the GI tract may enable the safe delivery of higher 5FU dose intensity."1.42Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis. ( Albrecht, P; Ford, JP; Kamerow, H; Mandetta, D; Thompson, JT; Vanden Heuvel, JP, 2015)
"Its role in tumorigenesis is more controversial and both the presence and the absence of autophagy have been implicated."1.42Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas. ( Benincasa, M; Magnani, G; Mancini, S; Mariani, F; Palumbo, C; Pedroni, M; Roncucci, L; Sena, P, 2015)
"The HT-29 colorectal cancer cell line was cultured and exposed with 5-FU in three stages based on Bolus protocol."1.40Down-regulation of BAX gene during carcinogenesis and acquisition of resistance to 5-FU in colorectal cancer. ( Bandehpour, M; Karbasi, A; Kazemi, B; Manoochehri, M, 2014)
"In the cancer microenvironment, CICs/CSCs may localize in a specific area, the so-called stem cell niche, and isolation of this niche is important to elucidate the molecular mechanism of how CICs/CSCs acquire malignancy."1.39Possible role of mural cell-covered mature blood vessels in inducing drug resistance in cancer-initiating cells. ( Kanakura, Y; Kinugasa, Y; Matsui, T; Tahara, H; Takakura, N, 2013)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's50 (69.44)24.3611
2020's22 (30.56)2.80

Authors

AuthorsStudies
Xu, H2
Wong, CC3
Li, W2
Zhou, Y3
Li, Y6
Wang, L4
Liu, L2
Yu, J5
Guerra, GR1
Kong, JC1
Millen, RM1
Read, M1
Liu, DS1
Roth, S1
Sampurno, S1
Sia, J1
Bernardi, MP1
Chittleborough, TJ1
Behrenbruch, CC1
Teh, J1
Haynes, NM1
Lupat, R1
Hawkes, D1
Di Costanzo, N1
Tothill, RW1
Mitchell, C1
Ngan, SY1
Heriot, AG1
Ramsay, RG1
Phillips, WA1
Li, C2
Wang, Y3
Liu, D2
Coker, OO1
Zhang, X3
Liu, C4
Liu, Y6
Kang, W2
To, KF2
Sung, JJ1
Noel, K1
Bokhari, A'1
Bertrand, R1
Renaud, F1
Bourgoin, P1
Cohen, R1
Svrcek, M1
Joly, AC1
Duval, A1
Collura, A1
Zhao, Y3
Zhang, B2
Ma, Y1
Zhao, F2
Chen, J4
Wang, B2
Jin, H1
Zhou, F1
Guan, J1
Zhao, Q1
Wang, H2
Liu, Q2
Wang, X2
Wang, MQ2
Chen, YR2
Xu, HW2
Zhan, JR2
Suo, DQ2
Wang, JJ2
Ma, YZ2
Guan, XY2
Zhu, SL2
Lu, K1
Yang, C2
Du, W1
Liang, Z1
Chen, Q1
Song, H1
Wang, Z1
Xing, W1
Jin, S1
Song, X1
Yang, H2
Zhao, W1
Gong, W1
Guo, Y1
Yuan, H1
Chai, R1
Wan, Z1
Zheng, B1
Hu, X1
Chen, B1
Gao, S1
Dai, Q1
Yu, P1
Tu, S1
Xu, X1
Chen, X2
Xu, M1
Liu, X3
Pan, B1
Qin, J1
Xu, T1
Zeng, K1
Pan, Y1
He, B1
Sun, H1
Sun, L2
Wang, S1
Christensen, S1
Van der Roest, B1
Besselink, N1
Janssen, R1
Boymans, S1
Martens, JWM1
Yaspo, ML1
Priestley, P1
Kuijk, E1
Cuppen, E1
Van Hoeck, A1
Burocziova, M1
Burdova, K1
Martinikova, AS1
Kasparek, P1
Kleiblova, P1
Danielsen, SA1
Borecka, M1
Jenikova, G1
Janečková, L1
Pavel, J1
Zemankova, P1
Schneiderova, M1
Schwarzova, L1
Ticha, I1
Sun, XF2
Jiraskova, K1
Liska, V1
Vodickova, L1
Vodicka, P1
Sedlacek, R1
Kleibl, Z1
Lothe, RA1
Korinek, V1
Macurek, L1
Khattar, E1
Maung, KZY1
Chew, CL1
Ghosh, A1
Mok, MMH1
Lee, P1
Zhang, J2
Chor, WHJ1
Cildir, G1
Wang, CQ1
Mohd-Ismail, NK1
Chin, DWL1
Lee, SC1
Shin, YJ1
Nam, DH1
Chen, L1
Kumar, AP1
Deng, LW1
Ikawa, M1
Gunaratne, J1
Osato, M1
Tergaonkar, V1
Tamjidifar, R1
Akbari, M1
Tarzi, S1
Sadeghzadeh, M1
Abolghasemi, M1
Poursaei, E1
Shomali, N1
Mahdavi, F1
Chen, CH1
Hsieh, YC1
Yang, PM1
Liu, YR1
Cho, EC1
Hong, E1
Park, S1
Ooshima, A1
Hong, CP1
Park, J1
Heo, JS1
Lee, S1
An, H1
Kang, JM1
Park, SH1
Park, JO1
Kim, SJ1
Ren, TJ1
Hou, JF1
Shan, FX1
Mendoza-Rodríguez, MG1
Sánchez-Barrera, CÁ1
Callejas, BE1
García-Castillo, V1
Beristain-Terrazas, DL1
Delgado-Buenrostro, NL1
Chirino, YI1
León-Cabrera, SA1
Rodríguez-Sosa, M1
Gutierrez-Cirlos, EB1
Pérez-Plasencia, C1
Vaca-Paniagua, F1
Meraz-Ríos, MA1
Terrazas, LI1
Cornejo, CM1
Jambusaria-Pahlajani, A1
Willenbrink, TJ1
Schmults, CD1
Arron, ST1
Ruiz, ES1
Chung, HH1
Lee, CT1
Hu, JM1
Chou, YC1
Lin, YW1
Shih, YL1
Permpoon, U1
Khan, F1
Vadevoo, SMP1
Gurung, S1
Gunassekaran, GR1
Kim, MJ1
Kim, SH1
Thuwajit, P1
Lee, B1
Chen, R1
Masuo, K1
Yogo, A1
Yokoyama, S1
Sugiyama, A1
Seno, H1
Yoshizawa, A1
Takaishi, S1
Huang, T1
Chan, RCK1
Dong, Y1
Wu, F1
Wu, WKK1
Chan, MWY1
Cheng, ASL1
Wong, N1
Lo, KW1
He, Z1
Chen, D2
Wu, J2
Sui, C1
Deng, X1
Zhang, P2
Chen, Z1
Shi, J1
Li, G1
Yao, X2
Malvi, P1
Janostiak, R1
Nagarajan, A1
Wajapeyee, N1
Elbadawy, M1
Hayashi, K1
Ayame, H1
Ishihara, Y1
Abugomaa, A1
Shibutani, M1
Hayashi, SM1
Hazama, S1
Takenouchi, H1
Nakajima, M1
Tsunedomi, R1
Suzuki, N1
Nagano, H1
Shinohara, Y1
Kaneda, M1
Yamawaki, H1
Usui, T1
Sasaki, K1
Shi, CS1
Li, JM1
Chin, CC1
Kuo, YH1
Lee, YR1
Huang, YC1
Jiao, T1
Gao, T1
Zhang, Y5
Feng, M1
Liu, M1
Zhou, H2
Sun, M1
Fan, L1
Niu, Y1
Mian, W1
Zhang, F2
Xie, M1
Sun, Y1
Mei, Q1
Abedi-Valugerdi, M1
Zheng, W1
Benkessou, F1
Hassan, M1
Jiang, C1
Xu, C1
Xue, H1
Gu, L1
Xu, Q1
Hwang, J1
Soung, NK1
Han, HJ1
Lee, Y1
Choi, TW1
Mun, J1
Cha-Molstad, H1
Lee, KH1
Kim, HJ2
Lee, HG1
Hong, JT1
Ahn, JS1
Kwon, YT1
Kim, BY1
Kuang, YS1
Ding, LD1
Yang, L1
Liu, SH1
Zhu, BT1
Wang, XN1
Liu, HY1
Li, J3
Chang, ZJ1
Wang, YY1
Jia, BQ1
Jia, QA1
Kadel, D1
Zhang, XF1
Zhang, QB1
Wu, GJ1
Pen, J1
Huang, Y1
An, S1
Yang, Y2
Hao, Q1
Guo, XX1
Xu, TR1
Jeong, SI1
Kim, JW1
Ko, KP1
Ryu, BK1
Lee, MG1
Chi, SG1
Zhang, Z1
Feng, L1
Liu, P1
Duan, W1
Ou, J1
Peng, Y2
Yang, W1
Hao, J1
Li, F1
Chen, Y2
Xie, X1
Wu, S1
Zha, L1
Luo, X1
Xie, G1
Sun, W1
Zhou, Q1
Liang, H1
Li, K1
Li, M2
Zhou, R1
Xu, L1
Zhao, L1
Spartalis, C1
Schmidt, EM1
Elmasry, M1
Schulz, GB1
Kirchner, T1
Horst, D1
Ren, T1
Hou, J1
Shan, F1
Xiong, X1
Qin, A1
Ren, W1
Song, L1
Liu, H2
Lin, JA1
Fang, SU1
Su, CL1
Hsiao, CJ1
Chang, CC1
Lin, YF1
Cheng, CW1
Matsui, T1
Kinugasa, Y1
Tahara, H1
Kanakura, Y1
Takakura, N1
Geng, ZM1
Zhang, M1
Pan, XT1
Hoshiba, T1
Tanaka, M1
Fan, CW1
Chen, T1
Shang, YN1
Gu, YZ1
Zhang, SL1
Lu, R1
OuYang, SR1
Zhou, X2
Meng, WT1
Hu, JK1
Lu, Y1
Bu, H1
Zhou, ZG1
Mo, XM1
Manoochehri, M1
Karbasi, A1
Bandehpour, M1
Kazemi, B1
Yang, CZ1
Ma, J1
Zhu, DW1
Montgomery, B1
Wang, LZ1
Zhang, ZY1
Zhang, CP1
Zhong, LP1
Wang, J4
Kai, C1
Shi, F1
Dou, J1
Yu, D1
Yang, J2
Jin, C1
Zhao, X1
Cheng, J1
Qi, X1
Wang, K1
Kim, MK1
Di Caro, G1
Wong, J1
Shalapour, S1
Wan, J1
Zhang, W1
Zhong, Z1
Sanchez-Lopez, E1
Wu, LW1
Taniguchi, K1
Feng, Y1
Fearon, E1
Grivennikov, SI1
Karin, M1
Kugimiya, N1
Nishimoto, A1
Hosoyama, T1
Ueno, K1
Enoki, T1
Li, TS1
Hamano, K1
Vanden Heuvel, JP1
Thompson, JT1
Albrecht, P1
Mandetta, D1
Kamerow, H1
Ford, JP1
He, S1
Zhao, Z1
O'Connell, D1
Oh, S1
Ma, B1
Lee, JH1
Zhang, T1
Varghese, B1
Yip, J1
Dolatshahi Pirooz, S1
Li, GM1
Ellen Martin, S1
Machida, K1
Liang, C1
Sena, P1
Mariani, F1
Mancini, S1
Benincasa, M1
Magnani, G1
Pedroni, M1
Palumbo, C1
Roncucci, L1
Cutler, MJ1
Lowthers, EL1
Richard, CL1
Hajducek, DM1
Spagnuolo, PA1
Blay, J1
Jian, B1
Li, Z1
Xiao, D1
He, G1
Bai, L1
Yang, Q1
Liu, S2
Guo, C1
Qi, H1
Sun, MZ1
Gao, D1
Herman, JG1
Guo, M1
Wu, WR1
Zhang, R1
Shi, XD1
Yi, C1
Xu, LB1
Huynh, N1
Shulkes, A1
Baldwin, G1
He, H1
Kensara, OA1
El-Shemi, AG1
Mohamed, AM1
Refaat, B1
Idris, S1
Ahmad, J1
Tarpgaard, LS1
Ørum-Madsen, MS1
Christensen, IJ1
Nordgaard, C1
Noer, J1
Guren, TK1
Glimelius, B1
Sorbye, H1
Ikdahl, T1
Kure, EH1
Tveit, KM1
Nielsen, HJ1
Pfeiffer, P1
Brünner, N1
Moreira, JM1
Wen, S1
Yang, M1
Yang, K1
Huang, J1
Feng, D1
Wu, Y1
Xie, R1
Tang, W1
Wu, M1
Ba, Y1
Zhao, J1
Li, A1
Nan, Q1
Xing, X1
Zhang, S1
Wang, C1
Li, L1
Ji, Q1
Cheng, Y1
Yang, B1
Xi, Y1
Huang, KC1
Ng, MC1
Ng, SK1
Welch, WR1
Muto, MG1
Berkowitz, RS1
Ng, SW1
Song, KH1
Woo, SR1
Chung, JY1
Lee, HJ1
Oh, SJ1
Hong, SO1
Shim, J1
Kim, YN1
Rho, SB1
Hong, SM1
Cho, H1
Hibi, M1
Bae, DJ1
Kim, SY1
Kim, MG1
Kim, TW1
Bae, YK1
Bommer, UA1
Vine, KL1
Puri, P1
Engel, M1
Belfiore, L1
Fildes, K1
Batterham, M1
Lochhead, A1
Aghmesheh, M1
Kazakov, OV1
Kabakov, AV1
Ishchenko, IY1
Poveshchenko, AF1
Raiter, TV1
Strunkin, DN1
Michurina, SV1
Konenkov, VI1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study of TPF (Docetaxel, Cisplatin, 5-fluorouracil) Induction Chemotherapy Followed by Surgery and Radiotherapy in Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma[NCT01542931]Phase 2/Phase 3256 participants (Actual)Interventional2008-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for fluorouracil and Carcinogenesis

ArticleYear
Field cancerization: Treatment.
    Journal of the American Academy of Dermatology, 2020, Volume: 83, Issue:3

    Topics: Administration, Cutaneous; Antineoplastic Combined Chemotherapy Protocols; Calcitriol; Carcinogenesi

2020
The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer.
    Oncotarget, 2016, Jun-14, Volume: 7, Issue:24

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Carcinogenesis; CpG Islands; Decita

2016

Trials

2 trials available for fluorouracil and Carcinogenesis

ArticleYear
GDF15 is a potential predictive biomarker for TPF induction chemotherapy and promotes tumorigenesis and progression in oral squamous cell carcinoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2014, Volume: 25, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinogenesis; Carc

2014
TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: a potential novel approach to the treatment of metastatic colorectal cancer.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Line, Tumor; Cell Movemen

2016

Other Studies

68 other studies available for fluorouracil and Carcinogenesis

ArticleYear
RING-finger protein 6 promotes colorectal tumorigenesis by transcriptionally activating SF3B2.
    Oncogene, 2021, Volume: 40, Issue:47

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Case-Control

2021
Molecular and genomic characterisation of a panel of human anal cancer cell lines.
    Cell death & disease, 2021, 10-18, Volume: 12, Issue:11

    Topics: Animals; Anus Neoplasms; B7-H1 Antigen; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor;

2021
Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
    Gut, 2022, Volume: 71, Issue:11

    Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogenesis; Cell Proliferation; Cholesterol; Colore

2022
Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice.
    Cellular and molecular life sciences : CMLS, 2022, Jun-01, Volume: 79, Issue:6

    Topics: Animals; Carcinogenesis; Fluorouracil; HSP110 Heat-Shock Proteins; Mice; Microsatellite Instability;

2022
Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022, Volume: 9, Issue:22

    Topics: Carcinogenesis; Colorectal Neoplasms; Fluorouracil; Humans; Organoids

2022
HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer.
    Cancer science, 2023, Volume: 114, Issue:4

    Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Drug Resis

2023
HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer.
    Cancer science, 2023, Volume: 114, Issue:4

    Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Drug Resis

2023
HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer.
    Cancer science, 2023, Volume: 114, Issue:4

    Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Drug Resis

2023
HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer.
    Cancer science, 2023, Volume: 114, Issue:4

    Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Drug Resis

2023
EIF3D promotes resistance to 5-fluorouracil in colorectal cancer through upregulating RUVBL1.
    Journal of clinical laboratory analysis, 2023, Volume: 37, Issue:2

    Topics: Animals; Apoptosis; ATPases Associated with Diverse Cellular Activities; bcl-2-Associated X Protein;

2023
The Gut Microbiota Metabolite Urolithin B Prevents Colorectal Carcinogenesis by Remodeling Microbiota and PD-L1/HLA-B.
    Oxidative medicine and cellular longevity, 2023, Volume: 2023

    Topics: Animals; B7-H1 Antigen; Carcinogenesis; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Gastr

2023
Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
    Cancer gene therapy, 2023, Volume: 30, Issue:6

    Topics: Cancer-Associated Fibroblasts; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transforma

2023
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
    Aging, 2019, 09-22, Volume: 11, Issue:18

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Carcinogenesis; Cell Line, Tumor; Cell

2019
5-Fluorouracil treatment induces characteristic T>G mutations in human cancer.
    Nature communications, 2019, 10-08, Volume: 10, Issue:1

    Topics: Adult; Age of Onset; Aged; Biopsy; Carcinogenesis; Cell Culture Techniques; Cell Line; Clinical Tria

2019
Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.
    Cell death & disease, 2019, 10-28, Volume: 10, Issue:11

    Topics: Adenomatous Polyposis Coli Protein; Animals; Carcinogenesis; Cell Cycle Checkpoints; Cell Proliferat

2019
Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
    Nature communications, 2019, 12-13, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinogenesis; Cell Line; Cell Survival; DNA Damage; DNA Ligase ATP

2019
Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations.
    Journal of gastrointestinal cancer, 2021, Volume: 52, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Chemotherap

2021
Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer.
    Biochemical and biophysical research communications, 2020, 04-16, Volume: 524, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferatio

2020
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.
    Scientific reports, 2020, 02-19, Volume: 10, Issue:1

    Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Lin

2020
CircDDX17 reduces 5-fluorouracil resistance and hinders tumorigenesis in colorectal cancer by regulating miR-31-5p/KANK1 axis.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Carcinogenesis; Cell

2020
Use of STAT6 Phosphorylation Inhibitor and Trimethylglycine as New Adjuvant Therapies for 5-Fluorouracil in Colitis-Associated Tumorigenesis.
    International journal of molecular sciences, 2020, Mar-20, Volume: 21, Issue:6

    Topics: Adjuvants, Pharmaceutic; Animals; Apoptosis; beta Catenin; Cadherins; Carcinogenesis; Cell Adhesion

2020
NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer.
    International journal of molecular sciences, 2020, Jul-19, Volume: 21, Issue:14

    Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Transformation, Ne

2020
Inhibition of Tumor Growth against Chemoresistant Cholangiocarcinoma by a Proapoptotic Peptide Targeting Interleukin-4 Receptor.
    Molecular pharmaceutics, 2020, 11-02, Volume: 17, Issue:11

    Topics: Animals; Apoptosis; Bile Duct Neoplasms; Carcinogenesis; Cell Line, Tumor; Cholangiocarcinoma; Drug

2020
SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.
    Carcinogenesis, 2021, 02-25, Volume: 42, Issue:2

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neo

2021
NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway.
    Oncogene, 2021, Volume: 40, Issue:9

    Topics: Apoptosis; Carcinogenesis; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Ci

2021
Yes associated protein 1 promotes resistance to 5-fluorouracil in gastric cancer by regulating GLUT3-dependent glycometabolism reprogramming of tumor-associated macrophages.
    Archives of biochemistry and biophysics, 2021, 05-15, Volume: 702

    Topics: Adaptor Proteins, Signal Transducing; Carcinogenesis; Cell Line, Tumor; Drug Resistance, Neoplasm; F

2021
N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production.
    Molecular metabolism, 2021, Volume: 48

    Topics: Acid Ceramidase; Animals; Carcinogenesis; Cell Line, Tumor; Ceramides; E2F1 Transcription Factor; Fl

2021
Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 142

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Cell Cycle; Cell Proliferation; Cell Surv

2021
Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells.
    Anticancer research, 2017, Volume: 37, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogenesis; Carcinoma; Cell Cycle; Cell Division;

2017
MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:3

    Topics: Adult; Aged; Apoptosis; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Cyclin

2017
An apple oligogalactan enhances the growth inhibitory effect of 5-fluorouracil on colorectal cancer.
    European journal of pharmacology, 2017, Jun-05, Volume: 804

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Drug

2017
Differential effects of low-dose fludarabine or 5-fluorouracil on the tumor growth and myeloid derived immunosuppression status of tumor-bearing mice.
    International immunopharmacology, 2017, Volume: 47

    Topics: Animals; Antineoplastic Agents; Carcinogenesis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocyt

2017
Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway.
    Oncotarget, 2017, Apr-25, Volume: 8, Issue:17

    Topics: Adult; Aged; Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Movement;

2017
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
    Experimental dermatology, 2018, Volume: 27, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Benzofurans; Carcinogene

2018
Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil.
    World journal of gastroenterology, 2018, Jan-28, Volume: 24, Issue:4

    Topics: Adenoma; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Cell Cycle;

2018
Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC).
    Medical science monitor : international medical journal of experimental and clinical research, 2018, May-03, Volume: 24

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinogenesis; Carcinoma, Hepatoc

2018
KAP1 inhibits the Raf-MEK-ERK pathway to promote tumorigenesis in A549 lung cancer cells.
    Molecular carcinogenesis, 2018, Volume: 57, Issue:10

    Topics: A549 Cells; Antimetabolites, Antineoplastic; Carcinogenesis; Extracellular Signal-Regulated MAP Kina

2018
XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis.
    Cell death & disease, 2018, 07-24, Volume: 9, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinogene

2018
ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer.
    Bioscience reports, 2018, 12-21, Volume: 38, Issue:6

    Topics: Apoptosis; Carcinogenesis; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Drug Resistance,

2018
ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield.
    Nature communications, 2019, 03-06, Volume: 10, Issue:1

    Topics: 1-Acylglycerol-3-Phosphate O-Acyltransferase; Animals; Antimetabolites, Antineoplastic; Autophagy; B

2019
A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer.
    EBioMedicine, 2019, Volume: 44

    Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation;

2019
In vivo effects of chemotherapy on oncogenic pathways in colorectal cancer.
    Cancer science, 2019, Volume: 110, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Proliferation; Colorec

2019
The long non-coding RNA HOTAIRM1 suppresses cell progression via sponging endogenous miR-17-5p/ B-cell translocation gene 3 (BTG3) axis in 5-fluorouracil resistant colorectal cancer cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 117

    Topics: Animals; Base Sequence; Carcinogenesis; Cell Cycle Proteins; Cell Line, Tumor; Colorectal Neoplasms;

2019
Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Ce

2019
Silencing glucose-regulated protein 78 induced renal cell carcinoma cell line G1 cell-cycle arrest and resistance to conventional chemotherapy.
    Urologic oncology, 2014, Volume: 32, Issue:1

    Topics: Antineoplastic Agents; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation;

2014
Possible role of mural cell-covered mature blood vessels in inducing drug resistance in cancer-initiating cells.
    The American journal of pathology, 2013, Volume: 182, Issue:5

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding

2013
Bcl-2 gene silencing by RNA interference inhibits the growth of the human gallbladder carcinoma cell line GBC-SD in vitro and in vivo.
    Oncology reports, 2013, Volume: 30, Issue:2

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Growth Processes; Cell Line, Tumor; Fluorouracil; Gallbladd

2013
Breast cancer cell behaviors on staged tumorigenesis-mimicking matrices derived from tumor cells at various malignant stages.
    Biochemical and biophysical research communications, 2013, Sep-20, Volume: 439, Issue:2

    Topics: Antimetabolites, Antineoplastic; Breast; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Pr

2013
Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies.
    Cell death & disease, 2013, Oct-03, Volume: 4

    Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Pro

2013
Down-regulation of BAX gene during carcinogenesis and acquisition of resistance to 5-FU in colorectal cancer.
    Pathology oncology research : POR, 2014, Volume: 20, Issue:2

    Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carcinogenesis;

2014
Observation of ovarian cancer stem cell behavior and investigation of potential mechanisms of drug resistance in three-dimensional cell culture.
    Journal of bioscience and bioengineering, 2014, Volume: 118, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carboplatin; Carcinogenesis; Carcinoma, Ovarian Epithelia

2014
Clinical implications of BMI-1 in cancer stem cells of laryngeal carcinoma.
    Cell biochemistry and biophysics, 2015, Volume: 71, Issue:1

    Topics: AC133 Antigen; Animals; Antigens, CD; Carboplatin; Carcinogenesis; Cell Line, Tumor; Docetaxel; Drug

2015
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
    Immunity, 2014, Dec-18, Volume: 41, Issue:6

    Topics: Aberrant Crypt Foci; Animals; Antibodies, Blocking; Antineoplastic Combined Chemotherapy Protocols;

2014
The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells.
    Journal of cellular and molecular medicine, 2015, Volume: 19, Issue:7

    Topics: Aged; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subf

2015
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis.
    Investigational new drugs, 2015, Volume: 33, Issue:5

    Topics: Adenine; Carcinogenesis; Cell Line, Tumor; DNA Replication; Epithelial Cells; Esophagus; Fluorouraci

2015
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.
    Nature communications, 2015, Aug-03, Volume: 6

    Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Autophagy; Carcinogenesis; Cell Line, Tumor;

2015
Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas.
    Oncology reports, 2015, Volume: 34, Issue:6

    Topics: Apoptosis; Autophagy; Bevacizumab; Carcinogenesis; Chloroquine; Colorectal Neoplasms; Fluorouracil;

2015
Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26.
    BMC cancer, 2015, Nov-10, Volume: 15

    Topics: Animals; Camptothecin; Carcinogenesis; Cell Lineage; Cell Movement; Chemokine CXCL12; Colonic Neopla

2015
Downregulation of microRNA-193-3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:7

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Drug

2016
ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun.
    Oncotarget, 2016, Mar-29, Volume: 7, Issue:13

    Topics: Animals; Annexins; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumo

2016
Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells.
    Oncology reports, 2016, Volume: 36, Issue:1

    Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor;

2016
Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer.
    Cancer biology & therapy, 2016, 08-02, Volume: 17, Issue:8

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluorour

2016
Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats.
    Drug design, development and therapy, 2016, Volume: 10

    Topics: Animals; Anticarcinogenic Agents; Benzoquinones; Carcinogenesis; Cell Proliferation; Colonic Neoplas

2016
Increased NEK2 in hepatocellular carcinoma promotes cancer progression and drug resistance by promoting PP1/Akt and Wnt activation.
    Oncology reports, 2016, Volume: 36, Issue:4

    Topics: Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Drug Resistance, Neoplasm; Fluorourac

2016
Knockdown of FOXK1 alone or in combination with apoptosis-inducing 5-FU inhibits cell growth in colorectal cancer.
    Oncology reports, 2016, Volume: 36, Issue:4

    Topics: Animals; Apoptosis; Carcinogenesis; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Fluorourac

2016
Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways.
    Oncology reports, 2016, Volume: 36, Issue:5

    Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Co

2016
RAD51B as a potential biomarker for early detection and poor prognostic evaluation contributes to tumorigenesis of gastric cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Aneuploidy; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Carc

2016
Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 67

    Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Carcinogenesis; Cell Line, Tumor; Cell Prolife

2016
REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival.
    Cell death & disease, 2017, 01-05, Volume: 8, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Sur

2017
Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin.
    Cell communication and signaling : CCS, 2017, Feb-01, Volume: 15, Issue:1

    Topics: Biomarkers, Tumor; Carcinogenesis; Cell Death; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluo

2017
The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
    Bulletin of experimental biology and medicine, 2017, Volume: 162, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinogens; Cell Transform

2017