fluorouracil has been researched along with Canine Diseases in 23 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Toxic doses can be as little as 5 mg/kg, and doses ≥40 mg/kg are reported to be uniformly fatal." | 2.48 | Accidental and experimentally induced 5-fluorouracil toxicity in dogs. ( Bailey, EM; Barr, JW; Sayre, RS, 2012) |
| "5-Fluorouracil (5-FU) cream is a common human topical chemotherapy agent with potentially fatal neurotoxic effects on dogs if accidentally ingested." | 1.72 | Transient chemotherapy-induced alopecia after successful reversal of 5-fluorouracil myelosuppression and neurotoxicosis in a 9-month-old dog. ( Goodman, IH; Immelman, LM; Keller, N, 2022) |
| "In three healthy Beagle dogs receiving 100 mg/kg of 5-fluorocytosine twice daily for 14 days by oral route, non-compartmental pharmacokinetics revealed a terminal elimination half-life of 164." | 1.62 | Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs. ( Béguin, J; Degorce, F; Erbs, P; Klonjkowski, B; Kohlhauer, M; Laloy, E; Maurey, C; Moreau, B; Quéméneur, É, 2021) |
| "Final diagnosis of a pleomorphic liposarcoma was made by the routine histology and further identified by Oil Red O stain." | 1.35 | Mesojejunoileac liposarcoma with intrahepatic metastasis in a dog. ( Chang, SC; Liao, JW, 2008) |
| "Capecitabine (CPC) was administered as an oral immunosuppressive agent." | 1.34 | Histopathologic evidence of capecitabine corneal toxicity in dogs. ( Bentley, E; Dubielzig, R; McAnulty, J; Milovancev, M; Schmiedt, C; Zarfoss, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (26.09) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 5 (21.74) | 2.80 |
| Authors | Studies |
|---|---|
| Ellis, H | 1 |
| Immelman, LM | 1 |
| Goodman, IH | 1 |
| Keller, N | 1 |
| Campbell, O | 1 |
| Gagnon, J | 1 |
| Rubin, JE | 1 |
| Ho, B | 1 |
| Bates, N | 1 |
| Edwards, N | 1 |
| Robinson, N | 1 |
| Ellison, J | 1 |
| Romans, CW | 1 |
| Day, TK | 1 |
| Smith, JJ | 1 |
| Béguin, J | 1 |
| Kohlhauer, M | 1 |
| Laloy, E | 1 |
| Degorce, F | 1 |
| Moreau, B | 1 |
| Quéméneur, É | 1 |
| Erbs, P | 1 |
| Klonjkowski, B | 1 |
| Maurey, C | 1 |
| Zhou, B | 1 |
| Zhang, D | 1 |
| Pei, SM | 1 |
| Zhang, H | 1 |
| Du, HC | 1 |
| Jin, YP | 1 |
| Lin, DG | 1 |
| Overton, TL | 1 |
| Allbaugh, RA | 1 |
| Whitley, D | 1 |
| Ben-Shlomo, G | 1 |
| Griggs, A | 1 |
| Tofflemire, KL | 1 |
| Whitley, EM | 1 |
| Chang, SC | 1 |
| Liao, JW | 1 |
| SWENSON, HM | 1 |
| MUHLER, JC | 1 |
| Snavely, NR | 1 |
| Snavely, DA | 1 |
| Wilson, BB | 1 |
| Sayre, RS | 1 |
| Barr, JW | 1 |
| Bailey, EM | 1 |
| Fry, MM | 1 |
| Forman, MA | 1 |
| Zarfoss, M | 1 |
| Bentley, E | 1 |
| Milovancev, M | 1 |
| Schmiedt, C | 1 |
| Dubielzig, R | 1 |
| McAnulty, J | 1 |
| Vinayak, VK | 1 |
| Gupta, NK | 1 |
| Chopra, AK | 1 |
| Sharma, GL | 1 |
| Kumar, A | 1 |
| Kitchell, BK | 1 |
| Orenberg, EK | 1 |
| Brown, DM | 1 |
| Hutson, C | 1 |
| Ray, K | 1 |
| Woods, L | 1 |
| Luck, E | 1 |
| Levine, RA | 1 |
| Fleischli, MA | 1 |
| Karayannopoulou, M | 1 |
| Kaldrymidou, E | 1 |
| Constantinidis, TC | 1 |
| Dessiris, A | 1 |
| Yamashita, A | 1 |
| Maruo, K | 1 |
| Suzuki, K | 1 |
| Shirota, K | 1 |
| Kobayashi, K | 1 |
| Hioki, K | 1 |
| Golubeva, VA | 1 |
| Osipov, NE | 1 |
| Bukharova, IK | 1 |
| Harvey, HJ | 1 |
| MacEwen, EG | 1 |
| Hayes, AA | 1 |
| Ndiritu, CG | 1 |
| Enos, LR | 1 |
| Henness, AM | 1 |
| Theilen, GH | 1 |
| Madewell, BR | 1 |
| Crow, SE | 1 |
1 review available for fluorouracil and Canine Diseases
| Article | Year |
|---|---|
Accidental and experimentally induced 5-fluorouracil toxicity in dogs.
Topics: Animals; Dog Diseases; Dogs; Fluorouracil; Immunosuppressive Agents | 2012 |
22 other studies available for fluorouracil and Canine Diseases
| Article | Year |
|---|---|
Management of fluorouracil toxicity in a Labrador retriever-poodle crossbred dog.
Topics: Anemia; Animals; Dog Diseases; Dogs; Fluorouracil; Male; Thrombocytopenia | 2022 |
Transient chemotherapy-induced alopecia after successful reversal of 5-fluorouracil myelosuppression and neurotoxicosis in a 9-month-old dog.
Topics: Aftercare; Alopecia Areata; Animals; Antineoplastic Agents; Dog Diseases; Dogs; Female; Fluorouracil | 2022 |
Antibacterial activity of chemotherapeutic drugs against Escherichia coli and Staphylococcus pseudintermedius.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bleomycin; Dog Diseases; Dogs; Escherichia co | 2019 |
Under-recognised effects on our canine and feline companions with 5-fluorouracil use.
Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Fluorouracil; Friends; Humans | 2020 |
Oxidative red blood cell damage associated with propofol and intravenous lipid emulsion therapy in a dog treated for 5-fluorouracil toxicosis.
Topics: Animals; Antimetabolites; Dog Diseases; Dogs; Erythrocytes; Fat Emulsions, Intravenous; Fluorouracil | 2020 |
Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Dog Diseases; Dogs; Drug Eruptions; Drug-Relat | 2021 |
Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Dog Diseases; Dogs; Drug Resistance, Neo | 2017 |
A pulse-dose topical 1% 5-fluorouracil treatment regimen in a young dog with corneal squamous cell carcinoma.
Topics: Administration, Ophthalmic; Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Corn | 2015 |
Mesojejunoileac liposarcoma with intrahepatic metastasis in a dog.
Topics: Animals; Capecitabine; Deoxycytidine; Dog Diseases; Dogs; Doxorubicin; Fatal Outcome; Fluorouracil; | 2008 |
Sodium carbonate and its relationship to fuso-spirochetal infection in dogs.
Topics: Animals; Carbonates; Dog Diseases; Dogs; Fluorouracil; Fusobacterium Infections; Gingivitis, Necroti | 1947 |
Toxic effects of fluorouracil cream ingestion on dogs and cats.
Topics: Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dog Diseases; Dogs; Dosage Forms; Fluo | 2010 |
5-fluorouracil toxicity with severe bone marrow suppression in a dog.
Topics: Animals; Antimetabolites, Antineoplastic; Ataxia; Blood Chemical Analysis; Bone Marrow; Diagnosis, D | 2004 |
Histopathologic evidence of capecitabine corneal toxicity in dogs.
Topics: Animals; Capecitabine; Cornea; Corneal Diseases; Deoxycytidine; Dog Diseases; Dogs; Female; Fluorour | 2007 |
Efficacies of vaccines against canine hookworm disease.
Topics: Ancylostoma; Ancylostomiasis; Animals; Dog Diseases; Dogs; Fluorouracil; Vaccination; Vaccines; X-Ra | 1981 |
Intralesional sustained-release chemotherapy with therapeutic implants for treatment of canine sun-induced squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Delayed-Action Preparations; Di | 1995 |
Inactivation of p53 and retinoblastoma family pathways in canine osteosarcoma cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Blotting, Northern; Blotting, Western; Bone Neoplasms; DNA | 2000 |
Adjuvant post-operative chemotherapy in bitches with mammary cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinosarcoma; Chemotherapy, Ad | 2001 |
Experimental chemotherapy against canine mammary cancer xenograft in SCID mice and its prediction of clinical effect.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisp | 2001 |
[Therapeutic effect of ftorafur].
Topics: Adenocarcinoma; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Fluorouracil; Mammary Gland | 1977 |
Neurotoxicosis associated with use of 5-fluorouracil in five dogs and one cat.
Topics: Animals; Ataxia; Blindness; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Fluorouracil; Male; Nerv | 1977 |
Adverse reactions to drugs in a veterinary hospital.
Topics: Amphotericin B; Anaphylaxis; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Chloral Hydrate; | 1977 |
Neurotoxicosis associated with use of 5-florouracil.
Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Fluorouracil; Nervous System Diseases | 1977 |