fluorouracil has been researched along with Cancer of the Vagina in 60 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty nonpregnant women with condylomata acuminata of the vagina were studied to assess the effectiveness of weekly topical 5-fluorouracil application." | 7.67 | Treatment of vaginal condylomata acuminata by weekly topical application of 5-fluorouracil. ( Krebs, HB, 1987) |
| "A patient with vaginal carcinoma in situ was treated with 5-fluorouracil in a less intensive regimen that previously recorded." | 7.66 | A new regimen for the treatment of vaginal carcinoma in situ using 5-fluorouracil. Case report. ( Hawthorne, JH; Stokes, IM; Sworn, MJ, 1980) |
| " The early diagnosis was a choriocarcinoma, and combination chemotherapy (etoposide, kengshengmycin, methotrexate, leucovorin, vincristine, and cyclophosphamide [EMACO]) was administered." | 4.98 | Postmenopausal choriocarcinoma: a rare case report and review of the literature. ( Guo, N; Li, Q; Song, L; Wang, D; Yin, R, 2018) |
| "Twenty nonpregnant women with condylomata acuminata of the vagina were studied to assess the effectiveness of weekly topical 5-fluorouracil application." | 3.67 | Treatment of vaginal condylomata acuminata by weekly topical application of 5-fluorouracil. ( Krebs, HB, 1987) |
| " Adenocarcinoma related to diethylstilbestrol exposure in utero is a recently recognized type of vaginal lesion, and melanoma and sarcoma occur rarely in the vagina." | 3.66 | Malignant tumors of the vagina. Classification and approach to treatment. ( Gerbie, MV, 1983) |
| "A patient with vaginal carcinoma in situ was treated with 5-fluorouracil in a less intensive regimen that previously recorded." | 3.66 | A new regimen for the treatment of vaginal carcinoma in situ using 5-fluorouracil. Case report. ( Hawthorne, JH; Stokes, IM; Sworn, MJ, 1980) |
| "The overall response rate in the 18 cervical cancer patients was 89% (78% complete, 11% partial)." | 2.69 | Phase I trial of concomitant chemoradiotherapy for cervical cancer and other advanced pelvic malignancies. ( Fleming, G; Mundt, AJ; Quiet, C; Rotmensch, J; Waggoner, S, 1999) |
| "5-Fluorouracil showed to be an adequate treatment." | 1.29 | [Vaginal intraepithelial carcinoma. Diagnosis and management]. ( Chávez Brambilia, J; Deolarte Melgarejo, JM; González Sanchez, JL; Menéndez Velazquez, J, 1993) |
| "Eight patients with squamous cell carcinoma in situ of the vagina were treated with monthly 5 day courses of 20% 5-fluorouracil cream applied to the vagina." | 1.26 | Postirradiation squamous cell carcinoma in situ of the vagina: treatment by topical 20 percent 5-fluorouracil cream. ( Barlow, JJ; Gamarra, M; Piver, MS; Sandecki, A; Tsukada, Y, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (65.00) | 18.7374 |
| 1990's | 9 (15.00) | 18.2507 |
| 2000's | 7 (11.67) | 29.6817 |
| 2010's | 5 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, N | 1 |
| Yin, R | 1 |
| Li, Q | 1 |
| Song, L | 1 |
| Wang, D | 1 |
| Tranoulis, A | 1 |
| Georgiou, D | 1 |
| Laios, A | 1 |
| Theophilou, G | 1 |
| Thangavelu, A | 1 |
| Hutson, RC | 1 |
| Veloz-Martínez, MG | 1 |
| Quintana-Romero, V | 1 |
| Contreras-Morales, Mdel R | 1 |
| Jiménez-Vieyra, CR | 1 |
| Laliscia, C | 1 |
| Fabrini, MG | 1 |
| Delishaj, D | 1 |
| Coraggio, G | 1 |
| Morganti, R | 1 |
| Tana, R | 1 |
| Paiar, F | 1 |
| Gadducci, A | 1 |
| Paczos, TA | 1 |
| Ackers, S | 1 |
| Odunsi, K | 1 |
| Lele, S | 1 |
| Mhawech-Fauceglia, P | 1 |
| González Sánchez, JL | 2 |
| Flores Murrieta, G | 1 |
| Chávez Brambila, J | 1 |
| Deolarte Manzano, JM | 1 |
| Andrade Manzano, AF | 1 |
| Katsumoto, Y | 1 |
| Maruyama, K | 1 |
| Furukawa, J | 1 |
| Nagai, K | 1 |
| Maruyama, N | 1 |
| Tanaka, J | 1 |
| Yokouchi, H | 1 |
| Nakaguchi, K | 1 |
| Sue, F | 1 |
| Murta, EF | 1 |
| Neves Junior, MA | 1 |
| Sempionato, LR | 1 |
| Costa, MC | 1 |
| Maluf, PJ | 1 |
| Ait Menguellet, S | 1 |
| Collinet, P | 1 |
| Houfflin Debarge, V | 1 |
| Nayama, M | 1 |
| Vinatier, D | 1 |
| Leroy, JL | 1 |
| Georgiev, D | 1 |
| Karag'ozov, I | 1 |
| Velev, M | 1 |
| Makaveeva, V | 1 |
| Abitbol, A | 1 |
| Straus, MJ | 1 |
| Sedlis, A | 2 |
| Davidian, M | 1 |
| Ferenczy, A | 1 |
| Gerbie, MV | 1 |
| Petrilli, ES | 1 |
| Townsend, DE | 1 |
| Morrow, CP | 1 |
| Nakao, CY | 1 |
| Weismann, K | 1 |
| Kassis, V | 1 |
| Pride, GL | 1 |
| Chuprevich, TW | 1 |
| Sillman, FH | 2 |
| Boyce, JG | 2 |
| Macasaet, MA | 1 |
| Nicastri, AD | 1 |
| Caglar, H | 1 |
| Hertzog, RW | 1 |
| Hreshchyshyn, MM | 1 |
| Woodruff, JD | 2 |
| Daly, JW | 1 |
| Ellis, GF | 1 |
| Stokes, IM | 1 |
| Sworn, MJ | 1 |
| Hawthorne, JH | 1 |
| Richter, P | 1 |
| Sarembe, B | 1 |
| Geissler, U | 1 |
| Chávez Brambilia, J | 1 |
| Menéndez Velazquez, J | 1 |
| Deolarte Melgarejo, JM | 1 |
| Bornstein, J | 1 |
| Sova, Y | 1 |
| Atad, J | 1 |
| Lurie, M | 1 |
| Abramovici, H | 1 |
| Surico, N | 1 |
| Ribaldone, R | 1 |
| Mundt, AJ | 1 |
| Rotmensch, J | 1 |
| Waggoner, S | 1 |
| Quiet, C | 1 |
| Fleming, G | 1 |
| Campagnutta, E | 1 |
| Parin, A | 1 |
| De Piero, G | 1 |
| Giorda, G | 1 |
| Gallo, A | 1 |
| Scarabelli, C | 1 |
| Foroudi, F | 1 |
| Bull, CA | 1 |
| Gebski, V | 1 |
| Cardosi, RJ | 1 |
| Bomalaski, JJ | 1 |
| Hoffman, MS | 3 |
| Yingna, S | 1 |
| Yang, X | 1 |
| Xiuyu, Y | 1 |
| Hongzhao, S | 1 |
| Hull, MG | 4 |
| Bowen-Simpkins, P | 4 |
| Paintin, DB | 2 |
| Guthrie, D | 1 |
| Way, S | 1 |
| Piver, MS | 2 |
| Barlow, JJ | 2 |
| Xynos, FP | 1 |
| Ballon, SC | 1 |
| Roberts, JA | 1 |
| Lagasse, LD | 1 |
| Tsukada, Y | 1 |
| Gamarra, M | 1 |
| Sandecki, A | 1 |
| Grünberger, W | 1 |
| Pantucek, F | 1 |
| Marzotko, F | 1 |
| Krafft, W | 1 |
| Preibsch, W | 1 |
| Schröder, M | 1 |
| Parmley, TH | 1 |
| Julian, CG | 1 |
| Krebs, HB | 3 |
| Roberts, WS | 2 |
| Kavanagh, JJ | 2 |
| Fiorica, JV | 1 |
| Greenberg, H | 2 |
| Finan, MA | 1 |
| Cavanagh, D | 2 |
| Goodman, A | 1 |
| Zukerberg, LR | 1 |
| Nikrui, N | 1 |
| Scully, RE | 1 |
| Silva, PD | 1 |
| Micha, JP | 1 |
| Silva, DG | 1 |
| Bryson, SC | 1 |
| LaPolla, JP | 1 |
| Townsend, PA | 1 |
| Hewitt, S | 1 |
| Evans, LS | 1 |
| Kersh, CR | 1 |
| Constable, WC | 1 |
| Taylor, PT | 1 |
| Dargent, D | 1 |
| Lathrop, JC | 1 |
| Ree, HJ | 1 |
| McDuff, HC | 1 |
| Kirwan, P | 1 |
| Naftalin, NJ | 1 |
| Gottlieb, JA | 1 |
| Luce, JK | 1 |
| Hughes, RR | 1 |
| Smith, JP | 1 |
| Rutledge, F | 1 |
| Sutow, WW | 1 |
| Lewis, GC | 1 |
| Malkasian, GD | 2 |
| Decker, DG | 2 |
| Mussey, E | 2 |
| Johnson, CE | 2 |
6 reviews available for fluorouracil and Cancer of the Vagina
| Article | Year |
|---|---|
Postmenopausal choriocarcinoma: a rare case report and review of the literature.
Topics: Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin, beta Subuni | 2018 |
5-Flouorouracil Is an Attractive Medical Treatment in Women With Vaginal Intraepithelial Neoplasia: A Meta-Analysis.
Topics: Antineoplastic Agents; Carcinoma in Situ; Female; Fluorouracil; Humans; Observational Studies as Top | 2018 |
Diagnosis and management of vulvar and vaginal intraepithelial neoplasia.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Biopsy; Carcinoma in Situ; Female; Fluorou | 2001 |
Vaginal adenosis and clear cell carcinoma after 5-fluorouracil treatment for condylomas.
Topics: Adenocarcinoma; Adult; Condylomata Acuminata; Female; Fluorouracil; Humans; Vaginal Diseases; Vagina | 1991 |
A review of lower genital intraepithelial neoplasia and the use of topical 5-fluorouracil.
Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Adult; Anal Canal; Anus Neoplasms; Carc | 1985 |
Chemotherapy of squamous cell carcinoma of the cervix, vagina, and vulva.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Female; F | 1968 |
5 trials available for fluorouracil and Cancer of the Vagina
| Article | Year |
|---|---|
Comparison of 5-fluorouracil and CO2 laser for treatment of vaginal condylomata.
Topics: Adolescent; Adult; Condylomata Acuminata; Female; Fluorouracil; Humans; Laser Therapy; Neoplasm Recu | 1984 |
[Treatment of condyloma acuminatum with 0.5% 5-fluorouracil-solution, A double-blind clinical trial].
Topics: Administration, Topical; Adolescent; Adult; Anus Neoplasms; Clinical Trials as Topic; Condylomata Ac | 1982 |
Phase I trial of concomitant chemoradiotherapy for cervical cancer and other advanced pelvic malignancies.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemoth | 1999 |
Further experience with radiation therapy and concomitant intravenous chemotherapy in advanced carcinoma of the lower female genital tract.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Carcinoma, Squamous Cell | 1991 |
Management of condyloma acuminatum.
Topics: Clinical Trials as Topic; Condylomata Acuminata; Cryosurgery; Electrocoagulation; Female; Fluorourac | 1985 |
49 other studies available for fluorouracil and Cancer of the Vagina
| Article | Year |
|---|---|
[Treatment results for different categories of vaginal intraepithelial neoplasia with electrocoagulation, 5-fluorouracil and combined treatment].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma in Situ; Carcinoma, Squam | 2015 |
Concomitant External-beam Irradiation and Chemotherapy Followed by High-dose Rate Brachytherapy Boost in the Treatment of Squamous Cell Carcinoma of the Vagina: A Single-Center Retrospective Study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brachytherapy; Carboplatin; Carcinoma, Squamo | 2016 |
Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy.
Topics: Adenocarcinoma; Biopsy; Carcinoma in Situ; DNA, Viral; Female; Fluorouracil; Histocytochemistry; Hum | 2010 |
[Topical 5-fluorouracil for treatment of vaginal intraepithelial neoplasms].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Middl | 2002 |
[A case of metastatic vaginal tumor of rectal cancer].
Topics: Adenocarcinoma; Combined Modality Therapy; Female; Fluorouracil; Humans; Hysterectomy; Middle Aged; | 2002 |
Vaginal intraepithelial neoplasia: clinical-therapeutic analysis of 33 cases.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma in Situ; Combined Modality Therapy; Female; | 2005 |
Management of multicentric lesions of the lower genital tract.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Cryosurgery; Female; Fluorouracil; Humans; | 2007 |
[Three cases of vaginal adenosis after topical 5-fluorouracil therapy for vaginal HPV-associated lesions].
Topics: Administration, Intravaginal; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Papillo | 2006 |
Multimodality treatment of adenocarcinoma of the vagina Stage IV: potential for cure.
Topics: Adenocarcinoma, Mucinous; Adult; Combined Modality Therapy; Female; Fluorouracil; Humans; Lymphatic | 1983 |
Malignant tumors of the vagina. Classification and approach to treatment.
Topics: Adenocarcinoma; Adolescent; Adult; Carcinoma in Situ; Carcinoma, Squamous Cell; Child; Diethylstilbe | 1983 |
Vaginal intraepithelial neoplasia: Biologic aspects and treatment with topical 5-fluorouracil and the carbon dioxide laser.
Topics: Adult; Aged; Carbon Dioxide; Carcinoma in Situ; Carcinoma, Squamous Cell; Female; Fluorouracil; Huma | 1980 |
Topical 5-fluorouracil treatment of transformation zone intraepithelial neoplasia of cervix and vagina.
Topics: Administration, Topical; Carcinoma in Situ; Female; Fluorouracil; Humans; Uterine Cervical Dysplasia | 1982 |
5-fluorouracil/chemosurgery for intraepithelial neoplasia of the lower genital tract.
Topics: Adult; Aged; Carcinoma in Situ; Female; Fluorouracil; Genital Neoplasms, Female; Humans; Methods; Mi | 1981 |
Topical 5-fluorouracil treatment of vaginal intraepithelial neoplasia.
Topics: Administration, Topical; Adult; Aged; Carcinoma in Situ; Drug Evaluation; Female; Fluorouracil; Huma | 1981 |
Carcinoma in situ of the vagina.
Topics: Carcinoma in Situ; Female; Fluorouracil; Humans; Vagina; Vaginal Neoplasms | 1981 |
Treatment of vaginal dysplasia and carcinoma in situ with topical 5-fluorouracil.
Topics: Adult; Aged; Carcinoma in Situ; Female; Fluorouracil; Humans; Middle Aged; Neoplasms, Multiple Prima | 1980 |
A new regimen for the treatment of vaginal carcinoma in situ using 5-fluorouracil. Case report.
Topics: Administration, Topical; Carcinoma in Situ; Female; Fluorouracil; Humans; Middle Aged; Vagina; Vagin | 1980 |
[Malignant melanoma of the vagina].
Topics: Adult; BCG Vaccine; Cyclophosphamide; Drug Therapy, Combination; Eyelid Neoplasms; Female; Fluoroura | 1980 |
[Vaginal intraepithelial carcinoma. Diagnosis and management].
Topics: Adult; Carcinoma in Situ; Colposcopy; Combined Modality Therapy; Cryosurgery; Female; Fluorouracil; | 1993 |
Development of vaginal adenosis following combined 5-fluorouracil and carbon dioxide laser treatments for diffuse vaginal condylomatosis.
Topics: Adult; Combined Modality Therapy; Condylomata Acuminata; Female; Fluorouracil; Humans; Laser Therapy | 1993 |
Topical treatment of vaginal recurrence of endometrial carcinoma with 5-fluorouracil: case-report.
Topics: Adenocarcinoma; Administration, Topical; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; B | 1997 |
Treatment of vaginal intraepithelial neoplasia (VAIN) with the carbon dioxide laser.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma in Situ; Combined Modality Therapy; Evaluati | 1999 |
Primary invasive cancer of the vagina: outcome and complications of therapy.
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Brachy | 1999 |
Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis.
Topics: Angiography; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Choriocarcinoma; Embolization, | 2002 |
Letter: 5-Fluorouracil versus immunotherapy for non-clinical vaginal cancer.
Topics: Carcinoma, Squamous Cell; Dinitrochlorobenzene; Drug Evaluation; Female; Fluorouracil; Humans; Nitro | 1976 |
Letter: 5-F.U. or D. N.C.B. for non-clinical vaginal cancer.
Topics: Dinitrochlorobenzene; Female; Fluorouracil; Humans; Nitrobenzenes; Uterine Cervical Neoplasms; Vagin | 1976 |
Letter: 5-F.U. or D.N.C.B. for non-clinical vaginal and cervical cancer.
Topics: Carcinoma, Squamous Cell; Dinitrochlorobenzene; Drug Evaluation; Female; Fluorouracil; Humans; Nitro | 1976 |
Adriamycin alone or in combination in 100 patients with carcinoma of the cervix or vagina.
Topics: Adenocarcinoma; Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Dactin | 1978 |
Topical 5-fluorouracil in the treatment of intraepithelial neoplasia of the vagina.
Topics: Administration, Topical; Carcinoma in Situ; Female; Fluorouracil; Humans; Neoplasm Recurrence, Local | 1979 |
Postirradiation squamous cell carcinoma in situ of the vagina: treatment by topical 20 percent 5-fluorouracil cream.
Topics: Administration, Topical; Adult; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Middle Aged; | 1979 |
Topical treatment of vaginal intraepithelial neoplasia.
Topics: Adult; Age Factors; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Pregnancy; Vaginal Neopl | 1977 |
[Case report of a Gartner's duct carcinoma of the vagina (author's transl)].
Topics: Adult; Antineoplastic Agents; Carcinoembryonic Antigen; Cyclophosphamide; Female; Fluorouracil; Huma | 1977 |
[In vitro testing and clinical experience with 5-fluorouracil in gynaecologic cancer (author's transl)].
Topics: Adult; Aged; Culture Techniques; Drug Evaluation; Female; Fluorouracil; Genital Neoplasms, Female; H | 1976 |
Intraepithelial vaginal neoplasia following immunosuppressive therapy treated with topical 5-Fu.
Topics: Administration, Topical; Adult; Azathioprine; Biopsy; Carcinoma, Squamous Cell; Cervix Uteri; Female | 1975 |
Topical 5-fluorouracil in the treatment of vaginal carcinoma-in-situ.
Topics: Administration, Topical; Adult; Carcinoma in Situ; Female; Fluorouracil; Humans; Middle Aged; Vagina | 1975 |
Treatment of genital condylomata with topical 5-fluorouracil.
Topics: Administration, Topical; Anus Neoplasms; Combined Modality Therapy; Condylomata Acuminata; Female; F | 1991 |
Concomitant radiation therapy and chemotherapy in the treatment of advanced squamous carcinoma of the lower female genital tract.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Carcinoma, Squamous Cell; Cisp | 1989 |
Treatment of vaginal intraepithelial neoplasia with laser and topical 5-fluorouracil.
Topics: Adult; Aged; Carcinoma in Situ; Female; Fluorouracil; Humans; Laser Therapy; Middle Aged; Vaginal Ne | 1989 |
Concomitant 5-fluorouracil, mitomycin-C, and radiotherapy for advanced gynecologic malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Th | 1988 |
[Pain following the treatment of vulvo-vaginal condylomatous lesions. Efficacy of benzydamine].
Topics: Adult; Benzydamine; Condylomata Acuminata; Female; Fluorouracil; Humans; Laser Therapy; Pain, Postop | 1988 |
Treatment of vaginal condylomata acuminata by weekly topical application of 5-fluorouracil.
Topics: Administration, Intravaginal; Adolescent; Adult; Condylomata Acuminata; Female; Fluorouracil; Follow | 1987 |
Intraepithelial neoplasia of the neovagina.
Topics: Adult; Carcinoma in Situ; Epithelium; Female; Fluorouracil; Follow-Up Studies; Humans; Middle Aged; | 1985 |
Topical 5-fluorouracil in the treatment of vaginal intraepithelial neoplasia.
Topics: Administration, Topical; Adult; Female; Fluorouracil; Humans; Middle Aged; Uterine Cervical Dysplasi | 1985 |
Cerebellar ataxia with weekly 5-fluorouracil administration.
Topics: Adenocarcinoma; Cerebellar Ataxia; Colonic Neoplasms; Female; Fluorouracil; Humans; Middle Aged; Neo | 1971 |
Early diagnosis and management of premalignant lesions and early invasive cancers of the vulva.
Topics: Adult; Aged; Carcinoma; Female; Fluorouracil; Follow-Up Studies; Humans; Middle Aged; Neoplasm Metas | 1971 |
Malignant gynecologic tumors in children: current approaches to treatment.
Topics: Age Factors; Child; Child, Preschool; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; | 1973 |
Gynecologic oncology.
Topics: Alkylating Agents; Ascites; Biopsy; Dactinomycin; Endometrium; Female; Fluorouracil; Genital Neoplas | 1973 |
Intra-epithelial carcinoma of the vagina following immunosuppression treated with topical 5-fluorouracil.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Prednisolone; Vaginal N | 1974 |
Observations on gynecologic malignancy treated with 5-fluorouracil.
Topics: Adult; Age Factors; Aged; Fallopian Tube Neoplasms; Female; Fluorouracil; Genital Neoplasms, Female; | 1968 |