fluorouracil has been researched along with Cancer of the Urethra in 38 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) cream was compared with podophyllin 25 percent in alcohol for treating genital and urethral condylomata acuminata." | 7.65 | 5-Fluorouracil in the treatment of penile and urethral condylomata acuminata. ( Wallin, J, 1977) |
| "From January 1991 to December 2006, 18 patients with invasive carcinoma of the male urethra referred to our institution were treated with a chemoradiation therapy protocol, consisting of 2 cycles of 5-fluorouracil (1,000 mg/m(2)) on days 1 to 4 and days 29 to 32, and mitomycin-C (10 mg/m(2)) on days 1 and 29 with concurrent external beam radiation therapy (45 to 55 Gy in 25 fractions during 5 weeks) to the genitalia, perineum, and inguinal and external iliac lymph nodes." | 3.74 | Coordinated chemoradiation therapy with genital preservation for the treatment of primary invasive carcinoma of the male urethra. ( Billmeyer, B; Cohen, MS; Girshovich, L; Hanley, RS; Oberfield, RA; Shuster, T; Triaca, V; Zinman, L, 2008) |
| "5-Fluorouracil (5-FU) cream was compared with podophyllin 25 percent in alcohol for treating genital and urethral condylomata acuminata." | 3.65 | 5-Fluorouracil in the treatment of penile and urethral condylomata acuminata. ( Wallin, J, 1977) |
| "Case 1 was a 61-year-old man with squamous cell carcinoma of the urethra that directly invaded into the perineal skin." | 1.40 | Docetaxel, cisplatin and 5-fluorouracil chemotherapy with concurrent radiation for unresectable advanced urethral carcinoma. ( Arai, Y; Itoh, J; Kaiho, Y; Kimura, S; Mitsuzuka, K; Saito, H; Tanaka, T; Yamada, S; Yamamuro, T; Yamashita, S, 2014) |
| "Herein, we report two cases of female urethral cancer." | 1.34 | [Two cases of primary female urethral cancer]. ( Bando, S; Inai, T; Kanda, K; Koizumi, T, 2007) |
| "Adenocarcinoma of the female urethral diverticulum is rare and has been treated by surgery and/or radiation." | 1.32 | Adenocarcinoma of the female urethral diverticulum treated by multimodality therapy. ( Awakura, Y; Fukuyama, T; Itoh, N; Maeno, A; Nonomura, M, 2003) |
| "Patients with locally advanced squamous cell carcinoma of the bulbomembranous urethra fare poorly whether they undergo surgery or primary radiotherapy." | 1.29 | Combined chemoradiotherapy for locally advanced squamous cell carcinoma of the bulbomembranous urethra: a case report. ( Huang, DT; Lutz, ST, 1995) |
| " They have provided better patient compliance and dosage monitoring, and have extended patient usefulness to male and female subjects." | 1.26 | 5-fluorouracil urethral suppositories for the eradication of condyloma accuminata. ( Culp, DA; Milleman, LA; Reiland, TL; Weimar, GW, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (55.26) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abate, D | 1 |
| Giusti, G | 1 |
| Caria, N | 1 |
| De Vita, G | 1 |
| Lucci Chiarissi, M | 1 |
| De Lisa, A | 1 |
| Itoh, J | 1 |
| Mitsuzuka, K | 1 |
| Kimura, S | 1 |
| Tanaka, T | 1 |
| Yamamuro, T | 1 |
| Yamashita, S | 1 |
| Yamada, S | 1 |
| Saito, H | 1 |
| Kaiho, Y | 1 |
| Arai, Y | 1 |
| Gakis, G | 1 |
| Morgan, TM | 1 |
| Daneshmand, S | 1 |
| Keegan, KA | 1 |
| Todenhöfer, T | 1 |
| Mischinger, J | 1 |
| Schubert, T | 1 |
| Zaid, HB | 1 |
| Hrbacek, J | 1 |
| Ali-El-Dein, B | 1 |
| Clayman, RH | 1 |
| Galland, S | 1 |
| Olugbade, K | 1 |
| Rink, M | 1 |
| Fritsche, HM | 1 |
| Burger, M | 1 |
| Chang, SS | 1 |
| Babjuk, M | 1 |
| Thalmann, GN | 1 |
| Stenzl, A | 1 |
| Efstathiou, JA | 1 |
| Quinlan, JF | 1 |
| North, J | 1 |
| Clarke, DA | 1 |
| Gwynne-Jones, DP | 1 |
| Davis, R | 1 |
| Peterson, AC | 1 |
| Lance, R | 1 |
| Awakura, Y | 1 |
| Nonomura, M | 1 |
| Itoh, N | 1 |
| Maeno, A | 1 |
| Fukuyama, T | 1 |
| Benchekroun, A | 1 |
| Nouini, Y | 1 |
| Zannoud, M | 1 |
| Kasmaoui, el H | 1 |
| Jira, H | 1 |
| el Alj, HA | 1 |
| HELSPER, JT | 1 |
| DEMOSS, EV | 1 |
| Hara, I | 1 |
| Hikosaka, S | 1 |
| Eto, H | 1 |
| Miyake, H | 1 |
| Yamada, Y | 1 |
| Soejima, T | 1 |
| Sugimura, K | 1 |
| Kamidono, S | 1 |
| Lin, CC | 1 |
| Hsu, CH | 1 |
| Huang, CY | 1 |
| Tsai, YC | 1 |
| Huang, KH | 1 |
| Cheng, AL | 1 |
| Pu, YS | 1 |
| Koizumi, T | 1 |
| Bando, S | 1 |
| Kanda, K | 1 |
| Inai, T | 1 |
| Cohen, MS | 1 |
| Triaca, V | 1 |
| Billmeyer, B | 1 |
| Hanley, RS | 1 |
| Girshovich, L | 2 |
| Shuster, T | 1 |
| Oberfield, RA | 2 |
| Zinman, L | 1 |
| Brenner, M | 1 |
| Johnson, CM | 1 |
| Nulf, TH | 1 |
| Rheinfrank, RE | 1 |
| Destito, A | 1 |
| Sasso, F | 1 |
| Vacilotto, D | 1 |
| Tomasini, L | 1 |
| Giorgi, G | 1 |
| Alcini, E | 1 |
| Cetti, NE | 1 |
| Konnak, JW | 1 |
| Weismann, K | 1 |
| Kassis, V | 1 |
| Bringel, PJ | 1 |
| de Andrade Arruda, R | 1 |
| Jensen, KS | 1 |
| Lange, P | 1 |
| Weber, M | 1 |
| Mayer, P | 1 |
| Marx, FJ | 1 |
| Leissner, KH | 1 |
| Johansson, S | 1 |
| Lutz, ST | 1 |
| Huang, DT | 1 |
| Licht, MR | 1 |
| Klein, EA | 1 |
| Bukowski, R | 1 |
| Montie, JE | 1 |
| Saxton, JP | 1 |
| Tran, LN | 1 |
| Krieg, RM | 1 |
| Szabo, RJ | 1 |
| Zinman, LN | 1 |
| Leibenhaut, M | 1 |
| Silverman, ML | 1 |
| Netto Junior, NR | 1 |
| Montellato, NI | 1 |
| Srougi, M | 1 |
| Rangel, PE | 1 |
| de Góes, GM | 1 |
| Sander, S | 1 |
| Weimar, GW | 1 |
| Milleman, LA | 1 |
| Reiland, TL | 1 |
| Culp, DA | 1 |
| Wein, AJ | 1 |
| Benson, GS | 1 |
| Wallin, J | 1 |
| Krebs, HB | 1 |
| Hussein, AM | 1 |
| Benedetto, P | 1 |
| Sridhar, KS | 1 |
| Silva, PD | 1 |
| Micha, JP | 1 |
| Silva, DG | 1 |
| Johnson, DW | 1 |
| Kessler, JF | 1 |
| Ferrigni, RG | 1 |
| Anderson, JD | 1 |
| Bernstein, G | 1 |
| Forgaard, DM | 1 |
| Miller, JE | 1 |
| Shah, AB | 1 |
| Kalra, JK | 1 |
| Silber, L | 1 |
| Molho, L | 1 |
| Buscemi, ML | 1 |
| Silber, LM | 1 |
| Hanna, MK | 1 |
| Bissada, NK | 1 |
| Redman, JF | 1 |
| Sulieman, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial of Cabazitaxel Chemotherapy in Relapsed Locally Advanced &/or Metastatic Carcinoma of the Penis[NCT03114254] | Phase 2 | 17 participants (Actual) | Interventional | 2014-12-05 | Completed | ||
| Cabozantinib in Patients With Advanced Penile Squamous Cell Carcinoma (PSCC): an Open-label, Single-center, Phase 2, Single-arm Trial (CaboPen)[NCT03943602] | Phase 2 | 37 participants (Anticipated) | Interventional | 2019-08-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Cancer of the Urethra
| Article | Year |
|---|---|
Successful treatment for squamous cell carcinoma of the female urethra with combined radio- and chemotherapy.
Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Drug Th | 2004 |
5 trials available for fluorouracil and Cancer of the Urethra
| Article | Year |
|---|---|
Prognostic factors for metastatic urothelial carcinoma treated with cisplatin and 5-fluorouracil-based regimens.
Topics: Adult; Aged; Alkaline Phosphatase; Antineoplastic Agents; Cisplatin; Female; Fluorouracil; Humans; K | 2007 |
[Treatment of condyloma acuminatum with 0.5% 5-fluorouracil-solution, A double-blind clinical trial].
Topics: Administration, Topical; Adolescent; Adult; Anus Neoplasms; Clinical Trials as Topic; Condylomata Ac | 1982 |
5-fluorouracil cream 5% in the treatment of intraurethral condylomata acuminata.
Topics: Administration, Topical; Adult; Clinical Trials as Topic; Condylomata Acuminata; Fluorouracil; Human | 1982 |
[Treatment of condylomata acuminata with 5-fluorouracil].
Topics: Clinical Trials as Topic; Condylomata Acuminata; Drug Evaluation; Fluorouracil; Humans; Male; Ointme | 1977 |
Management of condyloma acuminatum.
Topics: Clinical Trials as Topic; Condylomata Acuminata; Cryosurgery; Electrocoagulation; Female; Fluorourac | 1985 |
32 other studies available for fluorouracil and Cancer of the Urethra
| Article | Year |
|---|---|
Skin flap squamous cell carcinoma developed after urethroplasty.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; F | 2018 |
Docetaxel, cisplatin and 5-fluorouracil chemotherapy with concurrent radiation for unresectable advanced urethral carcinoma.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradio | 2014 |
Impact of perioperative chemotherapy on survival in patients with advanced primary urethral cancer: results of the international collaboration on primary urethral carcinoma.
Topics: Adenocarcinoma; Aged; Albumin-Bound Paclitaxel; Antineoplastic Combined Chemotherapy Protocols; Carb | 2015 |
Radiation-induced osteonecrosis of the hips following genital-preserving surgery and chemoradiotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Arthroplasty, Replacement, Hip; Carcinoma, Squ | 2009 |
Clear cell adenocarcinoma in a female urethral diverticulum.
Topics: Adenocarcinoma, Clear Cell; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, | 2003 |
Adenocarcinoma of the female urethral diverticulum treated by multimodality therapy.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cispla | 2003 |
[Ureteral adenocarcinoma in men: a case report].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality | 2003 |
REGIONAL INTRA-ARTERIAL INFUSION OF 5-FLUOROURACIL FOR CANCER.
Topics: Adenocarcinoma; Adenocarcinoma, Scirrhous; Carcinoma, Squamous Cell; Female; Fluorouracil; Glioblast | 1964 |
[Two cases of primary female urethral cancer].
Topics: Adenocarcinoma, Clear Cell; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamou | 2007 |
Coordinated chemoradiation therapy with genital preservation for the treatment of primary invasive carcinoma of the male urethra.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma; Cohort Studies; Combined Modality | 2008 |
Intraurethral condyloma acuminatum: current management.
Topics: Adult; Benzenesulfonates; Colchicine; Condylomata Acuminata; Female; Fluorouracil; Humans; Male; Thi | 1983 |
[Therapeutic possibilities in the treatment of condylomata of the distal urethra].
Topics: Adult; Condylomata Acuminata; Fluorouracil; Humans; Male; Ointments; Urethral Neoplasms | 1983 |
Condyloma acuminatum of the urethra: problems in eradication.
Topics: Adult; Combined Modality Therapy; Condylomata Acuminata; Electrocoagulation; Fluorouracil; Humans; M | 1984 |
Conservative management of low grade neoplasms of the male urethra: a preliminary report.
Topics: Adult; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Fluorouracil; Humans; Male; Middle Ag | 1980 |
[Effect of 5% 5-fluorouracil on intraurethral condylomata acuminata].
Topics: Adult; Condylomata Acuminata; Fluorouracil; Humans; Male; Urethral Neoplasms | 1982 |
[Local treatment of urethral condylomata by 5-fluorouracil].
Topics: Administration, Topical; Adult; Condylomata Acuminata; Fluorouracil; Gels; Humans; Male; Ointments; | 1981 |
Topical application of 5-fluorouracil cream: a therapeutic alternative in the treatment of urothelial tumours of the distal urethra. A case report.
Topics: Administration, Topical; Aged; Fluorouracil; Humans; Male; Urethral Neoplasms | 1980 |
Combined chemoradiotherapy for locally advanced squamous cell carcinoma of the bulbomembranous urethra: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; | 1995 |
Combination radiation and chemotherapy for the treatment of squamous cell carcinoma of the male and female urethra.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Moda | 1995 |
Combination chemotherapy and radiotherapy for a locally advanced squamous cell carcinoma of the urethra: a case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Th | 1995 |
Management of invasive squamous cell carcinoma of the bulbomembranous male urethra with co-ordinated chemo-radiotherapy and genital preservation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Carcinoma, Squamous Cell; Comb | 1996 |
[Condylomata acuminata in the urethra treated with 5-fluroro-uracil cream].
Topics: Adult; Condylomata Acuminata; Fluorouracil; Humans; Male; Urethral Neoplasms | 1978 |
5-fluorouracil urethral suppositories for the eradication of condyloma accuminata.
Topics: Adult; Condylomata Acuminata; Female; Fluorouracil; Humans; Male; Suppositories; Urethral Neoplasms | 1978 |
Treatment of urethral condyloma acuminatum with 5-fluorouracil cream.
Topics: Adult; Condylomata Acuminata; Endoscopy; Fluorouracil; Humans; Male; Middle Aged; Urethral Neoplasms | 1977 |
5-Fluorouracil in the treatment of penile and urethral condylomata acuminata.
Topics: Condylomata Acuminata; Fluorouracil; Humans; Male; Penile Neoplasms; Podophyllin; Urethral Neoplasms | 1977 |
Treatment of genital condylomata with topical 5-fluorouracil.
Topics: Administration, Topical; Anus Neoplasms; Combined Modality Therapy; Condylomata Acuminata; Female; F | 1991 |
Chemotherapy with cisplatin and 5-fluorouracil for penile and urethral squamous cell carcinomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 1990 |
Chemotherapy with cisplatin and 5-fluorouracil for penile and urethral squamous cell carcinomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 1990 |
Chemotherapy with cisplatin and 5-fluorouracil for penile and urethral squamous cell carcinomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 1990 |
Chemotherapy with cisplatin and 5-fluorouracil for penile and urethral squamous cell carcinomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 1990 |
Low dose combined chemotherapy/radiotherapy in the management of locally advanced urethral squamous cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cobalt Radioisotopes; Comb | 1989 |
Carcinoma in situ of the glans penis and distal urethra.
Topics: Adult; Carcinoma in Situ; Carcinoma, Squamous Cell; Combined Modality Therapy; Fluorouracil; Humans; | 1986 |
Squamous cell cancer of female urethra. Successful treatment with chemoradiotherapy.
Topics: Aged; Biopsy; Carcinoma, Squamous Cell; Cobalt Radioisotopes; Combined Modality Therapy; Female; Flu | 1985 |
Intraurethral condylomas acuminata in previous hypospadias repair.
Topics: Adult; Condylomata Acuminata; Fluorouracil; Homosexuality; Humans; Hypospadias; Male; Postoperative | 1985 |
Condyloma acuminatum of male urethra. Successful management with 5-fluorouracil.
Topics: Adult; Condylomata Acuminata; Diverticulum; Fistula; Fluorouracil; Humans; Male; Neoplasm Recurrence | 1974 |