fluorouracil has been researched along with Cancer of the Thyroid in 36 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the two antitumor drugs vinblastine and 5-fluorouracil on the growth of the human tumor cell lines U-118 MG (glioma) and HTh-7 (thyroid cancer) were analyzed." | 7.67 | Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids. ( Nederman, T, 1984) |
| "Although anaplastic thyroid carcinoma has a dismal prognosis, some patients show favorable survival following multimodal treatment with surgery, external irradiation and chemotherapy." | 6.76 | A novel chemo-radiotherapy with low-dose daily cisplatin, 5-fluorouracil and doxorubicin for anaplastic thyroid carcinoma: a preliminary report. ( Fujimoto, Y; Sugitani, I; Tanaka, K, 2011) |
| "The effects of the two antitumor drugs vinblastine and 5-fluorouracil on the growth of the human tumor cell lines U-118 MG (glioma) and HTh-7 (thyroid cancer) were analyzed." | 3.67 | Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids. ( Nederman, T, 1984) |
| "5-Fluorouracil(5-FU)is a widely used antitumor agent for treating patients with adenocarcinoma of gastroenterial tract and breast following intravenous or oral administration." | 3.67 | [5-Fluorouracil concentration in various tissues from cancer patients after oral administration of 5-fluorouracil]. ( Hashimoto, I; Kashi, Y; Mikami, J; Nakamura, T; Nakanishi, Y; Nishidai, H; Sawada, Y; Yoshimoto, M, 1984) |
| "Although anaplastic thyroid carcinoma has a dismal prognosis, some patients show favorable survival following multimodal treatment with surgery, external irradiation and chemotherapy." | 2.76 | A novel chemo-radiotherapy with low-dose daily cisplatin, 5-fluorouracil and doxorubicin for anaplastic thyroid carcinoma: a preliminary report. ( Fujimoto, Y; Sugitani, I; Tanaka, K, 2011) |
| "Finally, unlike differentiated thyroid cancer, there is no known effective systemic therapy for MTC." | 2.43 | Medullary thyroid carcinoma: including MEN 2A and MEN 2B syndromes. ( Moley, JF; Quayle, FJ, 2005) |
| "Capecitabine has not been tested against thyroid cancers, and it is not known to what extent thyroid cancers express TP, TS or DPD." | 1.32 | Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. ( Bauer, A; Francis, GL; Helms, A; Patel, A; Pluim, T; Tuttle, RM, 2004) |
| "Although rare, carcinoid tumors may present as thyroid metastatic nodules." | 1.29 | Bronchial carcinoid tumor presenting as a thyroid nodule: an unusual clinical manifestation. ( Chico, A; Ciprés, L; Matías-Guiu, X; Pallarés, MC; Puig-Domingo, M; Webb, SM, 1996) |
| "Twenty-two advanced consecutive thyroid cancer patients with varying histologies were treated with the so called BAP regime which consisted of bleomycin (B) 30 mg a day for three days, adriamycin (A) 60 mg/m2 iv in day 5, and cisplatinum (P) 60 to mg/m2 iv in day 5." | 1.28 | Combined chemotherapy with bleomycin, adriamycin, and platinum in advanced thyroid cancer. ( Busnardo, B; Casara, D; De Besi, P; Fiorentino, MV; Girelli, ME; Nacamulli, D; Simioni, N; Toso, S; Zorat, P, 1991) |
| "In case of breast cancer, it was 10 times higher than normal tissue." | 1.28 | [A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon]. ( Adachi, I; Douden, K; Hayashi, H; Hikishima, H; Iwa, T; Munemoto, Y; Okada, Y; Omura, K; Watanabe, Y, 1990) |
| "Thyroid cancer, nasal cancer and paranasal sinus cancer gave the best results." | 1.27 | [Chemotherapy with FT-207 suppository (Futraful Supo) in head and neck cancer--cooperative studies by six medical schools in Kanagawa Prefecture]. ( Hattori, Y; Horiuchi, M; Miyake, H; Murakami, T; Otake, H; Sawaki, S; Takahashi, H; Takeyama, I; Tamamushi, N; Yao, K, 1985) |
| "An unique combination treatment for cancer patients has been attempted in our department." | 1.26 | [Protective effect of CoQ 10 administration on cardial toxicity in FAC therapy]. ( Enomoto, K; Kodama, K; Okada, N; Sakurai, T; Suzuki, Y; Takimoto, M; Yokoi, H, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (33.33) | 18.7374 |
| 1990's | 9 (25.00) | 18.2507 |
| 2000's | 9 (25.00) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kucerova, L | 1 |
| Feketeova, L | 1 |
| Kozovska, Z | 1 |
| Poturnajova, M | 1 |
| Matuskova, M | 1 |
| Nencka, R | 1 |
| Babal, P | 1 |
| Wei, Y | 1 |
| Zheng, Q | 1 |
| Tang, G | 1 |
| Song, C | 1 |
| Wang, G | 1 |
| Zhang, Y | 1 |
| Xiao, Y | 1 |
| Zeng, X | 1 |
| Wang, Z | 1 |
| Xiao, J | 1 |
| Zheng, X | 1 |
| Marchand, L | 1 |
| Nozières, C | 1 |
| Walter, T | 1 |
| Descotes, F | 1 |
| Decaussin-Petrucci, M | 1 |
| Joly, MO | 1 |
| Lapras, V | 1 |
| Bournaud, C | 1 |
| Borson-Chazot, F | 1 |
| Tran, B | 1 |
| McKendrick, J | 1 |
| Tanaka, K | 1 |
| Sugitani, I | 1 |
| Fujimoto, Y | 1 |
| Rai, K | 1 |
| Fujiwara, K | 1 |
| Tsushima, M | 1 |
| Kudo, K | 1 |
| Mizuta, M | 1 |
| Matsuo, K | 1 |
| Yonei, T | 1 |
| Yamadori, I | 1 |
| Kiura, K | 1 |
| Sato, T | 1 |
| Pietras, K | 1 |
| Rubin, K | 1 |
| Sjöblom, T | 1 |
| Buchdunger, E | 1 |
| Sjöquist, M | 1 |
| Heldin, CH | 1 |
| Ostman, A | 1 |
| Misaki, T | 1 |
| Iwata, M | 1 |
| Iida, Y | 1 |
| Kasagi, K | 1 |
| Konishi, J | 1 |
| SULLIVAN, RD | 1 |
| ZUREK, WZ | 1 |
| Patel, A | 2 |
| Pluim, T | 1 |
| Helms, A | 1 |
| Bauer, A | 1 |
| Tuttle, RM | 1 |
| Francis, GL | 1 |
| Quayle, FJ | 1 |
| Moley, JF | 1 |
| Malani, AK | 1 |
| Gupta, C | 1 |
| Rangineni, S | 1 |
| Gupta, V | 1 |
| Gilliam, LK | 1 |
| Kohn, AD | 1 |
| Lalani, T | 1 |
| Swanson, PE | 1 |
| Vasko, V | 1 |
| Livingston, RB | 1 |
| Pickett, CA | 1 |
| Labidi, SI | 1 |
| Gravis, G | 1 |
| Tarpin, C | 1 |
| Brun, V | 1 |
| Viens, P | 1 |
| Paiva, CE | 1 |
| Michelin, OC | 1 |
| Nederman, T | 1 |
| Nakamura, T | 1 |
| Hashimoto, I | 1 |
| Sawada, Y | 1 |
| Mikami, J | 1 |
| Yoshimoto, M | 1 |
| Nishidai, H | 1 |
| Nakanishi, Y | 1 |
| Kashi, Y | 1 |
| Takimoto, M | 1 |
| Sakurai, T | 1 |
| Kodama, K | 1 |
| Yokoi, H | 1 |
| Suzuki, Y | 1 |
| Enomoto, K | 1 |
| Okada, N | 1 |
| Schlumberger, M | 2 |
| Abdelmoumene, N | 1 |
| Delisle, MJ | 1 |
| Couette, JE | 1 |
| Sasaki, F | 1 |
| Ishimura, H | 1 |
| Takada, N | 1 |
| Uchino, J | 1 |
| Orlandi, F | 1 |
| Caraci, P | 1 |
| Berruti, A | 1 |
| Puligheddu, B | 1 |
| Pivano, G | 1 |
| Dogliotti, L | 1 |
| Angeli, A | 1 |
| Chico, A | 1 |
| Pallarés, MC | 1 |
| Matías-Guiu, X | 1 |
| Ciprés, L | 1 |
| Puig-Domingo, M | 1 |
| Webb, SM | 1 |
| Behr, TM | 1 |
| Wulst, E | 1 |
| Radetzky, S | 1 |
| Blumenthal, RD | 1 |
| Dunn, RM | 1 |
| Gratz, S | 1 |
| Rave-Fränk, M | 1 |
| Schmidberger, H | 1 |
| Raue, F | 1 |
| Becker, W | 1 |
| Narimatsu, M | 1 |
| Nagayama, Y | 1 |
| Akino, K | 1 |
| Yasuda, M | 1 |
| Yamamoto, T | 1 |
| Yang, TT | 1 |
| Ohtsuru, A | 1 |
| Namba, H | 1 |
| Yamashita, S | 1 |
| Ayabe, H | 1 |
| Niwa, M | 1 |
| Nocera, M | 1 |
| Baudin, E | 1 |
| Pellegriti, G | 1 |
| Cailleux, AF | 1 |
| Mechelany-Corone, C | 1 |
| Okada, T | 1 |
| De Besi, P | 1 |
| Busnardo, B | 1 |
| Toso, S | 1 |
| Girelli, ME | 1 |
| Nacamulli, D | 1 |
| Simioni, N | 1 |
| Casara, D | 1 |
| Zorat, P | 1 |
| Fiorentino, MV | 1 |
| Munemoto, Y | 1 |
| Omura, K | 1 |
| Hikishima, H | 1 |
| Okada, Y | 1 |
| Hayashi, H | 1 |
| Adachi, I | 1 |
| Douden, K | 1 |
| Watanabe, Y | 1 |
| Iwa, T | 1 |
| Barth, V | 1 |
| Schönfelder, M | 1 |
| Tallroth, E | 1 |
| Wallin, G | 1 |
| Lundell, G | 1 |
| Löwhagen, T | 1 |
| Einhorn, J | 1 |
| Ayadi, A | 1 |
| Bassot, V | 1 |
| Donnadieu, S | 1 |
| Brasnu, D | 1 |
| Laccourreye, M | 1 |
| Petursson, SR | 1 |
| Sawaki, S | 1 |
| Tamamushi, N | 1 |
| Takahashi, H | 1 |
| Yao, K | 1 |
| Takeyama, I | 1 |
| Otake, H | 1 |
| Miyake, H | 1 |
| Horiuchi, M | 1 |
| Hattori, Y | 1 |
| Murakami, T | 1 |
| Mayer, M | 1 |
| Colon, J | 1 |
| Omura, GA | 1 |
| Roberts, GA | 1 |
| Wallgren, A | 1 |
| Norin, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of the Combination of Gemcitabine and Imatinib Mesylate in Pemetrexed-pretreated Patients With Malignant Pleural Mesothelioma[NCT02303899] | Phase 2 | 22 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Cancer of the Thyroid
| Article | Year |
|---|---|
Medullary thyroid carcinoma: including MEN 2A and MEN 2B syndromes.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calcitonin; Carcinoma, Medullary; Combined Modality | 2005 |
4 trials available for fluorouracil and Cancer of the Thyroid
| Article | Year |
|---|---|
A novel chemo-radiotherapy with low-dose daily cisplatin, 5-fluorouracil and doxorubicin for anaplastic thyroid carcinoma: a preliminary report.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chemotherapy, Ad | 2011 |
Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. The Groupe d'Etude des Tumeurs a Calcitonine (GETC).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Medullary; Combined Modality | 1995 |
Chemotherapy with dacarbazine and 5-fluorouracil in advanced medullary thyroid cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Medullary; Dacarbazine; Fema | 1994 |
Treatment of advanced medullary thyroid cancer with an alternating combination of doxorubicin-streptozocin and 5 FU-dacarbazine. Groupe d'Etude des Tumeurs à Calcitonine (GETC).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Medullary; Dacarbazine; Doxo | 2000 |
31 other studies available for fluorouracil and Cancer of the Thyroid
| Article | Year |
|---|---|
In vivo 5FU-exposed human medullary thyroid carcinoma cells contain a chemoresistant CD133+ tumor-initiating cell subset.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents; Apoptosis; Carcinoma, Medullary; Carcinoma, Neur | 2014 |
Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Flavones; Fluorouracil; H | 2016 |
Combination chemotherapy with 5-fluorouracil and dacarbazine in advanced medullary thyroid cancer, a possible alternative?
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Neuroendocrine; Dacarbazine; DNA Methylat | 2016 |
Metastatic urachal cancer responding to FOLFOX chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cystectom | 2010 |
A case of colorectal cancer with double-activating epidermal growth factor receptor mutations.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomark | 2011 |
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Drug Syn | 2002 |
Chemo-radionuclide therapy for thyroid cancer: initial experimental study with cultured cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Papillary; Cell Survival; Cisplatin; Dose | 2002 |
PROTRACTED AMBULATORY INFUSION CANCER CHEMOTHERAPY BY THE WATKINS CHRONOMETRIC INFUSOR.
Topics: Adenoma; Antineoplastic Agents; Breast Neoplasms; Carcinosarcoma; Colonic Neoplasms; Dermatitis, Exf | 1964 |
Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Papillary; Child; Deoxy | 2004 |
Thyroid metastasis from colorectal cancer: role of [18F]-fluoro-2-deoxy-D-glucose positron emission tomography.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colect | 2005 |
Capecitabine therapy for refractory metastatic thyroid carcinoma: a case series.
Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Carcinoembryonic Antigen; Deoxycytidine; Dihyd | 2006 |
Medullary thyroid cancer treated by capecitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Carcinoma, Medullary; Cisplati | 2007 |
Use of capecitabine in refractory metastatic medullary thyroid carcinoma.
Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Medullary; Deoxycytidine; Fluoroura | 2008 |
Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids.
Topics: Cell Division; Cell Line; Cell Survival; Culture Techniques; Drug Evaluation, Preclinical; Fluoroura | 1984 |
[5-Fluorouracil concentration in various tissues from cancer patients after oral administration of 5-fluorouracil].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Breast Neoplasms; Female; Fluorouracil; Humans; M | 1984 |
[Protective effect of CoQ 10 administration on cardial toxicity in FAC therapy].
Topics: Adult; Aged; Breast Neoplasms; Coenzymes; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; | 1982 |
[Chemosensitivity test for thyroid cancer by in vitro MTT assay].
Topics: Antineoplastic Agents; Cisplatin; Coloring Agents; Doxorubicin; Drug Screening Assays, Antitumor; Fe | 1995 |
Bronchial carcinoid tumor presenting as a thyroid nodule: an unusual clinical manifestation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bronchial Neoplasms; Carcinoid Tumor; Cisplat | 1996 |
Improved treatment of medullary thyroid cancer in a nude mouse model by combined radioimmunochemotherapy: doxorubicin potentiates the therapeutic efficacy of radiolabeled antibodies in a radioresistant tumor type.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antineoplastic Combined Chemotherapy Protocol | 1997 |
Therapeutic usefulness of wild-type p53 gene introduction in a p53-null anaplastic thyroid carcinoma cell line.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma; Cisplatin; Doxorubicin; Drug Scre | 1998 |
Anti-tumor activities of 1-Acetyl-3-o-Toluyl-5-Fu.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Female; Fluorouracil; HeLa Cells; Leiomyosarcoma; | 1979 |
Combined chemotherapy with bleomycin, adriamycin, and platinum in advanced thyroid cancer.
Topics: Adenocarcinoma; Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Betamethas | 1991 |
[A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Colonic Neoplasms; Combined Modality Therapy; F | 1990 |
[Study of procreation capacity of men after treatment of their malignant tumors (melanoblastoma, thyroid carcinoma) with ionizing radiation and cytostatic agents].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cobalt Radioisotopes; Cyclophospha | 1990 |
Multimodality treatment in anaplastic giant cell thyroid carcinoma.
Topics: Bleomycin; Carcinoma; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Fluorouracil; Humans | 1987 |
[Early death after chemotherapy via central venous catheterization in tumors of the upper respiratory and digestive tracts].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Catheterization, Central Venous; Ca | 1989 |
Metastatic medullary thyroid carcinoma. Complete response to combination chemotherapy with dacarbazine and 5-fluorouracil.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Apudoma; Carcinoma; Dacarbazine; Female; Fluo | 1988 |
[Chemotherapy with FT-207 suppository (Futraful Supo) in head and neck cancer--cooperative studies by six medical schools in Kanagawa Prefecture].
Topics: Adult; Aged; Anorexia; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Fluorouracil; | 1985 |
[Chemotherapy by intra-arterial path in cancer of the "head and neck" region].
Topics: Antineoplastic Agents; Bleomycin; Facial Neoplasms; Fluorouracil; Head; Head and Neck Neoplasms; Hum | 1971 |
Combination therapy of solid tumors using 1,3-bis(2-chloroethyl)-1-nitrosourea (NCNU), vincristine, methotrexate, and 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Carmustine; Female; Fluorouracil; Gastrointes | 1973 |
Combined chemotherapy and radiation therapy in spindle and giant cell carcinoma of the thyroid gland. Report of a case.
Topics: Aged; Carcinoma; Cobalt Isotopes; Cyclophosphamide; Female; Fluorouracil; Humans; Neoplasm Metastasi | 1973 |