fluorouracil has been researched along with Cancer of the Thymus in 14 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors retrospectively evaluated 3 patients with progressive, metastatic neuroendocrine tumors of the thymus who were treated with a combination of capecitabine and temozolomide." | 7.79 | Treatment of metastatic neuroendocrine tumors of the thymus with capecitabine and temozolomide: a case series. ( Centeno, B; Kvols, L; Morse, B; Saranga-Perry, V; Strosberg, J, 2013) |
| "Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out." | 3.85 | The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy. ( Ishchenko, IY; Kabakov, AV; Kazakov, OV; Konenkov, VI; Michurina, SV; Poveshchenko, AF; Raiter, TV; Strunkin, DN, 2017) |
| "The authors retrospectively evaluated 3 patients with progressive, metastatic neuroendocrine tumors of the thymus who were treated with a combination of capecitabine and temozolomide." | 3.79 | Treatment of metastatic neuroendocrine tumors of the thymus with capecitabine and temozolomide: a case series. ( Centeno, B; Kvols, L; Morse, B; Saranga-Perry, V; Strosberg, J, 2013) |
| "To predict tumor sensitivity to 5-fluorouracil (5-FU) in thymoma, we investigated the mRNA levels of thymidylate synthase (TS), the key enzyme that catalyzes the methylation of deoxyuridine monophosphate, and correlates with the resistance of 5-FU and dihydropyrimidine dehydrogenase (DPD), which degrades 5-FU in thymoma." | 3.72 | Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma. ( Fujii, Y; Fukai, I; Kaji, M; Kiriyama, M; Sasaki, H; Yamakawa, Y; Yano, M, 2003) |
| "Thymic carcinomas are rare tumors for which the main treatments have been surgery, radiotherapy, or both." | 1.30 | [Thymic anaplastic carcinoma successfully controlled by combination chemotherapy]. ( Honma, S; Nakanishi, F; Sakamoto, K; Shijubo, N; Shiratori, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heine, A | 1 |
| Schmiedel, A | 1 |
| Menschik, T | 1 |
| Held, SA | 1 |
| Erdmann, C | 1 |
| Brossart, P | 1 |
| Palmieri, G | 2 |
| Buonerba, C | 1 |
| Ottaviano, M | 1 |
| Federico, P | 2 |
| Calabrese, F | 1 |
| Von Arx, C | 1 |
| De Maio, AP | 1 |
| Marino, M | 2 |
| Lalle, M | 2 |
| Montella, L | 2 |
| Merola, C | 2 |
| Milella, M | 2 |
| Bergaglio, M | 2 |
| Di Lorenzo, G | 2 |
| Damiano, V | 1 |
| Kazakov, OV | 1 |
| Kabakov, AV | 1 |
| Ishchenko, IY | 1 |
| Poveshchenko, AF | 1 |
| Raiter, TV | 1 |
| Strunkin, DN | 1 |
| Michurina, SV | 1 |
| Konenkov, VI | 1 |
| Merola, G | 1 |
| Petillo, L | 1 |
| Ceribelli, A | 1 |
| Del Prete, S | 1 |
| De Placido, S | 1 |
| Rajan, A | 1 |
| Giaccone, G | 1 |
| Saranga-Perry, V | 1 |
| Morse, B | 1 |
| Centeno, B | 1 |
| Kvols, L | 1 |
| Strosberg, J | 1 |
| Sasaki, H | 1 |
| Fukai, I | 1 |
| Kiriyama, M | 1 |
| Kaji, M | 1 |
| Yano, M | 1 |
| Yamakawa, Y | 1 |
| Fujii, Y | 1 |
| Tampellini, M | 1 |
| Alabiso, I | 1 |
| Sculli, CM | 1 |
| Barberis, M | 1 |
| Giachino, D | 1 |
| Berruti, A | 1 |
| Dogliotti, L | 1 |
| Liu, JM | 1 |
| Wang, LS | 1 |
| Huang, MH | 1 |
| Hsu, WH | 1 |
| Yen, SH | 1 |
| Shiau, CY | 1 |
| Li, AF | 1 |
| Tiu, CM | 1 |
| Tseng, SW | 1 |
| Huang, BS | 1 |
| Tanino, H | 1 |
| Miyoshi, S | 1 |
| Furukawa, T | 1 |
| Bessho, T | 1 |
| Maebeya, S | 1 |
| Suzuma, T | 1 |
| Hirai, I | 1 |
| Arimoto, J | 1 |
| Harada, N | 1 |
| Hoso, T | 1 |
| Naito, Y | 1 |
| Mori, T | 1 |
| Hongo, H | 1 |
| Kondo, K | 1 |
| Akamine, T | 1 |
| Hanada, N | 1 |
| Toyota, N | 1 |
| Yoshioka, M | 1 |
| Tabira, Y | 1 |
| Hiraoka, T | 1 |
| Kitamura, N | 1 |
| Nakanishi, F | 1 |
| Sakamoto, K | 1 |
| Shijubo, N | 1 |
| Shiratori, M | 1 |
| Honma, S | 1 |
| Donovan, PJ | 1 |
| Foley, JF | 1 |
| Sagara, N | 1 |
| Kurooka, K | 1 |
| Mori, K | 1 |
| Kayama, H | 1 |
| Haeno, Y | 1 |
| Hara, S | 1 |
| Yasutomi, M | 1 |
1 review available for fluorouracil and Cancer of the Thymus
| Article | Year |
|---|---|
Chemotherapy for thymic tumors: induction, consolidation, palliation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Clinical Trials as Topic; C | 2011 |
2 trials available for fluorouracil and Cancer of the Thymus
| Article | Year |
|---|---|
Capecitabine plus gemcitabine in thymic epithelial tumors: final analysis of a Phase II trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fluorouracil; G | 2014 |
Preliminary results of phase II study of capecitabine and gemcitabine (CAP-GEM) in patients with metastatic pretreated thymic epithelial tumors (TETs).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fl | 2010 |
11 other studies available for fluorouracil and Cancer of the Thymus
| Article | Year |
|---|---|
Regression of liver metastases after treatment with oxaliplatin/capecitabine and development of a progressive multifocal leukoencephalopathy in a patient with advanced thymoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; L | 2013 |
The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinogens; Cell Transform | 2017 |
Treatment of metastatic neuroendocrine tumors of the thymus with capecitabine and temozolomide: a case series.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Dacarbazine; Deoxycytidine; Flu | 2013 |
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); | 2003 |
Stage IB malignant thymoma in a Lynch syndrome patient with multiple cancers: response to incidental administration of oxaliplatin and 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms, Hereditary Nonpolyposis; Femal | 2006 |
Topoisomerase 2alpha plays a pivotal role in the tumor biology of stage IV thymic neoplasia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy | 2007 |
[Induction chemotherapy based on histoculture drug response assay for a patient with advanced thymic cancer--a case report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Doxorubicin; Dr | 1997 |
[Successful chemotherapy based on in vitro chemosensitivity testing in a case of recurrent thymic carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Adenosquamous; Cis | 1998 |
[Thymic anaplastic carcinoma successfully controlled by combination chemotherapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Cyclophosphamide; Doxor | 1998 |
Chemotherapy in invasive thymomas: five case reports.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dacarbazine; Doxorubicin; Female; | 1986 |
[A case of non-resectable thymoma which responded to the administration of adriamycin, vindesine and 5-FU].
Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Middle Ag | 1986 |