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fluorouracil and Cancer of the Thymus

fluorouracil has been researched along with Cancer of the Thymus in 14 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"The authors retrospectively evaluated 3 patients with progressive, metastatic neuroendocrine tumors of the thymus who were treated with a combination of capecitabine and temozolomide."7.79Treatment of metastatic neuroendocrine tumors of the thymus with capecitabine and temozolomide: a case series. ( Centeno, B; Kvols, L; Morse, B; Saranga-Perry, V; Strosberg, J, 2013)
"Histological study of structural transformations in the thymus of Wistar females in induced carcinogenesis (N-methyl-N-nitrosourea injection in the right 2-nd mamma) and polychemotherapy (6 months after tumor growth initiation; cyclophosphamide, methotrexate, and 5-fluorouracyl) was carried out."3.85The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy. ( Ishchenko, IY; Kabakov, AV; Kazakov, OV; Konenkov, VI; Michurina, SV; Poveshchenko, AF; Raiter, TV; Strunkin, DN, 2017)
"The authors retrospectively evaluated 3 patients with progressive, metastatic neuroendocrine tumors of the thymus who were treated with a combination of capecitabine and temozolomide."3.79Treatment of metastatic neuroendocrine tumors of the thymus with capecitabine and temozolomide: a case series. ( Centeno, B; Kvols, L; Morse, B; Saranga-Perry, V; Strosberg, J, 2013)
"To predict tumor sensitivity to 5-fluorouracil (5-FU) in thymoma, we investigated the mRNA levels of thymidylate synthase (TS), the key enzyme that catalyzes the methylation of deoxyuridine monophosphate, and correlates with the resistance of 5-FU and dihydropyrimidine dehydrogenase (DPD), which degrades 5-FU in thymoma."3.72Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma. ( Fujii, Y; Fukai, I; Kaji, M; Kiriyama, M; Sasaki, H; Yamakawa, Y; Yano, M, 2003)
"Thymic carcinomas are rare tumors for which the main treatments have been surgery, radiotherapy, or both."1.30[Thymic anaplastic carcinoma successfully controlled by combination chemotherapy]. ( Honma, S; Nakanishi, F; Sakamoto, K; Shijubo, N; Shiratori, M, 1998)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19902 (14.29)18.7374
1990's3 (21.43)18.2507
2000's3 (21.43)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heine, A1
Schmiedel, A1
Menschik, T1
Held, SA1
Erdmann, C1
Brossart, P1
Palmieri, G2
Buonerba, C1
Ottaviano, M1
Federico, P2
Calabrese, F1
Von Arx, C1
De Maio, AP1
Marino, M2
Lalle, M2
Montella, L2
Merola, C2
Milella, M2
Bergaglio, M2
Di Lorenzo, G2
Damiano, V1
Kazakov, OV1
Kabakov, AV1
Ishchenko, IY1
Poveshchenko, AF1
Raiter, TV1
Strunkin, DN1
Michurina, SV1
Konenkov, VI1
Merola, G1
Petillo, L1
Ceribelli, A1
Del Prete, S1
De Placido, S1
Rajan, A1
Giaccone, G1
Saranga-Perry, V1
Morse, B1
Centeno, B1
Kvols, L1
Strosberg, J1
Sasaki, H1
Fukai, I1
Kiriyama, M1
Kaji, M1
Yano, M1
Yamakawa, Y1
Fujii, Y1
Tampellini, M1
Alabiso, I1
Sculli, CM1
Barberis, M1
Giachino, D1
Berruti, A1
Dogliotti, L1
Liu, JM1
Wang, LS1
Huang, MH1
Hsu, WH1
Yen, SH1
Shiau, CY1
Li, AF1
Tiu, CM1
Tseng, SW1
Huang, BS1
Tanino, H1
Miyoshi, S1
Furukawa, T1
Bessho, T1
Maebeya, S1
Suzuma, T1
Hirai, I1
Arimoto, J1
Harada, N1
Hoso, T1
Naito, Y1
Mori, T1
Hongo, H1
Kondo, K1
Akamine, T1
Hanada, N1
Toyota, N1
Yoshioka, M1
Tabira, Y1
Hiraoka, T1
Kitamura, N1
Nakanishi, F1
Sakamoto, K1
Shijubo, N1
Shiratori, M1
Honma, S1
Donovan, PJ1
Foley, JF1
Sagara, N1
Kurooka, K1
Mori, K1
Kayama, H1
Haeno, Y1
Hara, S1
Yasutomi, M1

Reviews

1 review available for fluorouracil and Cancer of the Thymus

ArticleYear
Chemotherapy for thymic tumors: induction, consolidation, palliation.
    Thoracic surgery clinics, 2011, Volume: 21, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Clinical Trials as Topic; C

2011

Trials

2 trials available for fluorouracil and Cancer of the Thymus

ArticleYear
Capecitabine plus gemcitabine in thymic epithelial tumors: final analysis of a Phase II trial.
    Future oncology (London, England), 2014, Volume: 10, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fluorouracil; G

2014
Preliminary results of phase II study of capecitabine and gemcitabine (CAP-GEM) in patients with metastatic pretreated thymic epithelial tumors (TETs).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2010, Volume: 21, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Female; Fl

2010

Other Studies

11 other studies available for fluorouracil and Cancer of the Thymus

ArticleYear
Regression of liver metastases after treatment with oxaliplatin/capecitabine and development of a progressive multifocal leukoencephalopathy in a patient with advanced thymoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-20, Volume: 31, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; L

2013
The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
    Bulletin of experimental biology and medicine, 2017, Volume: 162, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinogens; Cell Transform

2017
Treatment of metastatic neuroendocrine tumors of the thymus with capecitabine and temozolomide: a case series.
    Neuroendocrinology, 2013, Volume: 97, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Dacarbazine; Deoxycytidine; Flu

2013
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma.
    Surgery today, 2003, Volume: 33, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP);

2003
Stage IB malignant thymoma in a Lynch syndrome patient with multiple cancers: response to incidental administration of oxaliplatin and 5-fluorouracil.
    Journal of chemotherapy (Florence, Italy), 2006, Volume: 18, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms, Hereditary Nonpolyposis; Femal

2006
Topoisomerase 2alpha plays a pivotal role in the tumor biology of stage IV thymic neoplasia.
    Cancer, 2007, Feb-01, Volume: 109, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy

2007
[Induction chemotherapy based on histoculture drug response assay for a patient with advanced thymic cancer--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Doxorubicin; Dr

1997
[Successful chemotherapy based on in vitro chemosensitivity testing in a case of recurrent thymic carcinoma].
    Kyobu geka. The Japanese journal of thoracic surgery, 1998, Volume: 51, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Adenosquamous; Cis

1998
[Thymic anaplastic carcinoma successfully controlled by combination chemotherapy].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 1998, Volume: 36, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Cyclophosphamide; Doxor

1998
Chemotherapy in invasive thymomas: five case reports.
    Journal of surgical oncology, 1986, Volume: 33, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dacarbazine; Doxorubicin; Female;

1986
[A case of non-resectable thymoma which responded to the administration of adriamycin, vindesine and 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Middle Ag

1986