fluorouracil has been researched along with Cancer of Spleen in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A case is presented of hemangiosarcoma of theliver and spleen treated effectively by hepatic artery ligation, splenectomy, and postoperative intraportal infusion of 5-fluorouracil, as indicated by the regression of hepatic tumors on postoperative scanning and arteriograpms." | 3.65 | Hemangiosarcoma of liver and spleen treated by hepatic artery ligation, intraportal infusion chemotherapy, and splenectomy. ( Inokuchi, K; Nagasue, N; Ogawa, Y, 1976) |
| "Metastatic gastric cancer is usually treated with cisplatin- and 5-FU-based chemotherapy regimens." | 2.71 | Recurrent gastric adenocarcinoma with unusual metastatic localization and excellent response to docetaxel and 5-FU continuous infusion. ( Dörken, B; Krenn, V; Kretzschmar, A; Reichardt, P; Thuss-Patience, PC, 2003) |
| "Distant metastasis still remained a major concern in pCR patients following nCRT and TME." | 1.51 | Pathological complete response may underestimate distant metastasis in locally advanced rectal cancer following neoadjuvant chemoradiotherapy and radical surgery: Incidence, metastatic pattern, and risk factors. ( Chi, P; Huang, Y; Lin, H; Lu, X; Sun, Y; Wu, X; Zhang, Y, 2019) |
| "We report a case of advanced relapsed colon cancer, which had multiple liver and spleen metastasis, controlled for about two years by capecitabine therapy." | 1.39 | [A case of relapsed colon cancer successfully treated by capecitabine]. ( Hashimoto, T; Kimura, S; Toyono, M; Usuba, O; Yokoyama, M, 2013) |
| "Basaloid squamous cell carcinoma (BSC) of the esophagus is a rare malignant disease." | 1.34 | Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin. ( Arita, S; Ariyama, H; Baba, E; Kusaba, H; Miki, R; Mitsugi, K; Nakano, S; Noshiro, H; Ogami, N; Qin, B; Shibata, Y; Yao, T, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Wu, X | 1 |
| Zhang, Y | 1 |
| Lin, H | 1 |
| Lu, X | 1 |
| Huang, Y | 1 |
| Chi, P | 1 |
| Hashimoto, T | 1 |
| Yokoyama, M | 1 |
| Kimura, S | 1 |
| Usuba, O | 1 |
| Toyono, M | 1 |
| Nasyrov, AR | 1 |
| Pirtskhalava, TL | 1 |
| Korovina, IaV | 1 |
| Shimizu, T | 1 |
| Inaba, S | 1 |
| Nakata, M | 1 |
| Matsushita, Y | 1 |
| Araki, Y | 1 |
| Koyama, H | 1 |
| Ogino, A | 1 |
| Yamada, E | 1 |
| Matsuyama, T | 1 |
| Thuss-Patience, PC | 1 |
| Kretzschmar, A | 1 |
| Krenn, V | 1 |
| Dörken, B | 1 |
| Reichardt, P | 1 |
| Cavanna, L | 1 |
| Lazzaro, A | 1 |
| Trabacchi, E | 1 |
| Anselmi, E | 1 |
| Vallisa, D | 1 |
| Foroni, RP | 1 |
| Shibata, Y | 1 |
| Baba, E | 1 |
| Ariyama, H | 1 |
| Miki, R | 1 |
| Ogami, N | 1 |
| Arita, S | 1 |
| Qin, B | 1 |
| Kusaba, H | 1 |
| Mitsugi, K | 1 |
| Noshiro, H | 1 |
| Yao, T | 1 |
| Nakano, S | 1 |
| Avninder, S | 1 |
| Bhatnagar, A | 1 |
| Agrawal, U | 1 |
| Saxena, S | 1 |
| Nagasue, N | 1 |
| Ogawa, Y | 1 |
| Inokuchi, K | 1 |
| Maruyama, Y | 1 |
| Feola, J | 1 |
| McBee, P | 1 |
| Petraiuolo, W | 1 |
| Katoh, A | 1 |
2 trials available for fluorouracil and Cancer of Spleen
| Article | Year |
|---|---|
[Chemotherapy in patients with non-resectable colorectal cancer metastases to the liver: systemic or regional?].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colore | 2011 |
Recurrent gastric adenocarcinoma with unusual metastatic localization and excellent response to docetaxel and 5-FU continuous infusion.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Cisplatin; Doc | 2003 |
9 other studies available for fluorouracil and Cancer of Spleen
| Article | Year |
|---|---|
Pathological complete response may underestimate distant metastasis in locally advanced rectal cancer following neoadjuvant chemoradiotherapy and radical surgery: Incidence, metastatic pattern, and risk factors.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain N | 2019 |
[A case of relapsed colon cancer successfully treated by capecitabine].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; Deoxycytidine; Female; Fluorouraci | 2013 |
[A case report--TS-1/CDDP combined chemotherapy found effective for metastatic recurrence after operation for colon cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colon, Sigmoid; Combined Modality T | 2003 |
Presentation of esophageal cancer with solitary splenic metastasis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy, Fine-Needle; Carcinoma, Squamous Cell; Cispl | 2005 |
Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Esophageal Neop | 2007 |
Isolated splenic metastasis from colorectal mucinous carcinoma.
Topics: Adenocarcinoma, Mucinous; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Co | 2006 |
Hemangiosarcoma of liver and spleen treated by hepatic artery ligation, intraportal infusion chemotherapy, and splenectomy.
Topics: Adult; Female; Fluorouracil; Hemangiosarcoma; Hepatic Artery; Humans; Ligation; Liver Neoplasms; Spl | 1976 |
Changes in cell age cohort composition of tumors and normal tissues by radiation and chemotherapy.
Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Fluorouracil; Hydroxyurea; Mice; Splenic Ne | 1976 |
Inhibition of liver metastases in nude mice by the combined action of 5-fluorouracil and interferon.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relatio | 1990 |