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fluorouracil and Cancer of Salivary Gland

fluorouracil has been researched along with Cancer of Salivary Gland in 23 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"The growth inhibitory effects of 5-fluorouracil (5-Fu) and the combination of 5-Fu and human leukocyte interferon (HuIFN-alpha) on the human salivary gland adenocarcinoma cell line HSG in culture were examined by measuring colony formation in the semi-solid agar medium and cell proliferation in the monolayer culture."7.67Effects of 5-fluorouracil and the combination of 5-fluorouracil and human leukocyte interferon on human salivary gland adenocarcinoma cell line in culture. ( Hayashi, Y; Kobayashi, S; Nitta, T; Sato, M; Urata, M; Yanagawa, T; Yoshida, H; Yura, Y, 1984)
"Nine patients (5 males, 4 females; median age, 62 years) with recurrent high-grade malignancies of major (7 cases) and minor (2 cases) salivary gland origin (4 adenoid cystic carcinomas, 2 adenocarcinomas, 2 poorly differentiated carcinomas, 1 mixed malignant tumor) were treated with cisplatin (60 mg/m2), epirubicin (50 mg/m2) and 5-fluorouracil (600 mg/m2) (CEF) by intravenous injections on the first day of a 21-day regimen."7.67Cisplatin, epirubicin and 5-fluorouracil combination chemotherapy for recurrent carcinoma of the salivary gland. ( Airoldi, M; Brando, V; Gabriele, P; Giordano, C; Pedani, F, 1989)
"The growth inhibitory effects of 5-fluorouracil (5-Fu) and the combination of 5-Fu and human leukocyte interferon (HuIFN-alpha) on the human salivary gland adenocarcinoma cell line HSG in culture were examined by measuring colony formation in the semi-solid agar medium and cell proliferation in the monolayer culture."3.67Effects of 5-fluorouracil and the combination of 5-fluorouracil and human leukocyte interferon on human salivary gland adenocarcinoma cell line in culture. ( Hayashi, Y; Kobayashi, S; Nitta, T; Sato, M; Urata, M; Yanagawa, T; Yoshida, H; Yura, Y, 1984)
"Nine patients (5 males, 4 females; median age, 62 years) with recurrent high-grade malignancies of major (7 cases) and minor (2 cases) salivary gland origin (4 adenoid cystic carcinomas, 2 adenocarcinomas, 2 poorly differentiated carcinomas, 1 mixed malignant tumor) were treated with cisplatin (60 mg/m2), epirubicin (50 mg/m2) and 5-fluorouracil (600 mg/m2) (CEF) by intravenous injections on the first day of a 21-day regimen."3.67Cisplatin, epirubicin and 5-fluorouracil combination chemotherapy for recurrent carcinoma of the salivary gland. ( Airoldi, M; Brando, V; Gabriele, P; Giordano, C; Pedani, F, 1989)
"Adenoid cystic carcinoma is a relatively rare tumour which arises in the parotid and submandibular salivary glands."2.68Cisplatin and 5-fluorouracil for symptom control in advanced salivary adenoid cystic carcinoma. ( A'Hern, RP; Archer, D; Breach, N; Constenla, DO; Gore, ME; Henk, JM; Hill, ME; Rhys-Evans, P, 1997)
"From 09/1991 - 06/2007, 24 high-risk salivary gland cancer patients were treated with surgery, followed by adjuvant chemoradiotherapy for high-risk pathologic features including, perineural involvement, nodal involvement, positive margins, or T3/T4 tumors."1.37Adjuvant chemoradiotherapy for locoregionally advanced and high-risk salivary gland malignancies. ( Blair, EA; Cohen, EE; Haraf, DJ; Pederson, AW; Portugal, L; Salama, JK; Seiwert, T; Stenson, KM; Villaflor, VM; Vokes, EE; Witt, ME, 2011)
"Carcinoma ex pleomorphic adenoma is a rare histologic subtype of salivary gland cancer with an overall poor prognosis."1.36Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine. ( Kelly, RJ; Sharon, E; Szabo, E, 2010)
"We found that upon treatment of a human salivary gland cancer cell line (cl-1) with 5-FU, the NF-kappaB activity was suppressed in a time-dependent manner."1.315-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. ( Aota, K; Azuma, M; Hayashi, Y; Ishimaru, N; Motegi, K; Sato, M; Tamatani, T; Yamashita, T, 2000)
"Fifteen patients with squamous cell carcinoma arising in the gingiva (8), tongue (3), floor of the mouth (1), or maxillary sinus (3) were enrolled."1.30Intranodal injection of anticancer drugs into fixed cervical metastatic lymph nodes. ( Osaki, T; Ueta, E; Yamamoto, T; Yoneda, K, 1997)
"Chemosensitivity of salivary gland and oral cancer cell lines to 14 antitumor drugs was tested using a tetrazolium-based colorimetric assay and the relative antitumor activity (RAA) of the drugs was compared."1.28Chemosensitivity of salivary gland and oral cancer cell lines. ( Chen, JY; Liu, B; Situ, ZQ; Wang, W; Wu, JZ, 1992)
"A total of 77 patients with cancer of the head and neck area were treated with five different drug combination regimens."1.26Combination chemotherapy of head and neck cancer. ( Byers, RM; Gard, DA; Goepfert, H; Guillamondegui, OM; Holoye, PY; Jesse, RH, 1978)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's6 (26.09)18.2507
2000's7 (30.43)29.6817
2010's4 (17.39)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Yamanaka, S1
Suzuki, S1
Ito, H1
Sivasundaram, K1
Hanamura, I1
Okubo, I1
Yoshikawa, K1
Ono, S1
Takahara, T1
Satou, A1
Tsuzuki, T1
Ueda, R1
Ogawa, T1
Fujimoto, Y1
Wang, XF1
Wu, DM1
Li, BX1
Lu, YJ1
Yang, BF1
Ross, PJ1
Teoh, EM1
A'hern, RP2
Rhys-Evans, PH1
Harrington, KJ1
Nutting, CM1
Gore, ME2
Sharon, E1
Kelly, RJ1
Szabo, E1
Pederson, AW1
Salama, JK1
Haraf, DJ1
Witt, ME1
Stenson, KM1
Portugal, L1
Seiwert, T1
Villaflor, VM1
Cohen, EE1
Vokes, EE1
Blair, EA1
Cai, BL1
Xu, XF1
Fu, SM1
Shen, LL1
Zhang, J1
Guan, SM1
Wu, JZ2
Rosenberg, L1
Weissler, M1
Hayes, DN1
Shockley, W1
Zanation, A1
Rosenman, J1
Chera, B1
White, JD1
Junor, EJ1
McGarva, J1
McManners, J1
Holland, IS1
Sato, M6
Yoshida, H4
Urata, M1
Yanagawa, T1
Yura, Y1
Nitta, T1
Kobayashi, S1
Hayashi, Y2
Jones, AS1
Phillips, DE1
Cook, JA1
Helliwell, TR1
Hill, ME1
Constenla, DO1
Henk, JM1
Rhys-Evans, P1
Breach, N1
Archer, D1
Osaki, T1
Ueta, E1
Yoneda, K1
Yamamoto, T1
Okamoto, M1
Kasetani, H1
Kaji, R1
Goda, H1
Ohe, G1
Uchida, D2
Kawamata, H2
Omotehara, F2
Miwa, Y1
Hino, S2
Begum, NM2
Aota, K2
Azuma, M2
Yamashita, T2
Tamatani, T2
Motegi, K1
Ishimaru, N1
Hoque, MO1
Nakashiro, KI1
Shinagawa, Y1
Fujimori, T1
Holoye, PY1
Byers, RM1
Gard, DA1
Goepfert, H1
Guillamondegui, OM1
Jesse, RH1
Situ, ZQ1
Chen, JY1
Liu, B1
Wang, W1
Nielsen, LL1
Gurnani, M1
Tyler, RD1
Airoldi, M1
Pedani, F1
Brando, V1
Gabriele, P1
Giordano, C1
Venook, AP1
Tseng, A1
Meyers, FJ1
Silverberg, I1
Boles, R1
Fu, KK1
Jacobs, CD1
Mayer, M1
Colon, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Combined Treatment of Adenoid Cystic Carcinoma With Cetuximab and IMRT Plus C12 Heavy Ion Boost - ACCEPT - (ACC, Erbitux, and Particle Therapy); Phase I/II Feasibility Study[NCT01192087]Phase 1/Phase 249 participants (Anticipated)Interventional2012-06-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for fluorouracil and Cancer of Salivary Gland

ArticleYear
A randomised phase II trial of epirubicin and 5-fluorouracil versus cisplatinum in the palliation of advanced and recurrent malignant tumour of the salivary glands.
    British journal of cancer, 1993, Volume: 67, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Epirubicin; Female; Fluorouracil; Humans;

1993
Cisplatin and 5-fluorouracil for symptom control in advanced salivary adenoid cystic carcinoma.
    Oral oncology, 1997, Volume: 33, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Adenoid Cystic; Cisplatin; F

1997

Other Studies

21 other studies available for fluorouracil and Cancer of Salivary Gland

ArticleYear
Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens.
    International journal of molecular sciences, 2023, Jan-15, Volume: 24, Issue:2

    Topics: Biopsy; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Cisplatin; DNA-Binding Proteins; Fluorouracil;

2023
Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma.
    Phytotherapy research : PTR, 2009, Volume: 23, Issue:3

    Topics: Anticarcinogenic Agents; Antimetabolites, Antineoplastic; Carcinoma, Adenoid Cystic; Cell Line, Tumo

2009
Epirubicin, cisplatin and protracted venous infusion 5-Fluorouracil chemotherapy for advanced salivary adenoid cystic carcinoma.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2009, Volume: 21, Issue:4

    Topics: Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth

2009
Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine.
    Head & neck oncology, 2010, May-26, Volume: 2

    Topics: Adenoma, Pleomorphic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Comb

2010
Adjuvant chemoradiotherapy for locoregionally advanced and high-risk salivary gland malignancies.
    Head & neck oncology, 2011, Jul-26, Volume: 3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Adjuvant; Female; Fl

2011
Nuclear translocation of MRP1 contributes to multidrug resistance of mucoepidermoid carcinoma.
    Oral oncology, 2011, Volume: 47, Issue:12

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cas

2011
Concurrent chemoradiotherapy for locoregionally advanced salivary gland malignancies.
    Head & neck, 2012, Volume: 34, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Carboplatin; Carcinoma; Chemoradiotherapy; Cisplatin; Female; Fl

2012
Adenocarcinoma of the salivary gland? A chemo-sensitive disease.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2004, Volume: 16, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Epirubicin; Fluorouracil;

2004
Effects of 5-fluorouracil and the combination of 5-fluorouracil and human leukocyte interferon on human salivary gland adenocarcinoma cell line in culture.
    International journal of oral surgery, 1984, Volume: 13, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; C

1984
Intranodal injection of anticancer drugs into fixed cervical metastatic lymph nodes.
    Oral diseases, 1997, Volume: 3, Issue:4

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; C

1997
cis-Diamminedichloroplatinum and 5-fluorouracil are potent inducers of the cytokines and natural killer cell activity in vivo and in vitro.
    Cancer immunology, immunotherapy : CII, 1998, Volume: 47, Issue:4

    Topics: Adenocarcinoma; Animals; Antibodies; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cisplat

1998
Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line.
    Laboratory investigation; a journal of technical methods and pathology, 2000, Volume: 80, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Survival; Chromatin; Cisplatin;

2000
5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells.
    Biochemical and biophysical research communications, 2000, Jul-14, Volume: 273, Issue:3

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Division

2000
5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary gland cancer cells.
    Biochemical and biophysical research communications, 2001, Mar-23, Volume: 282, Issue:1

    Topics: Fluorouracil; Humans; Hydrolysis; I-kappa B Kinase; MAP Kinase Kinase Kinase 1; NF-kappa B; NF-kappa

2001
Dihydropyrimidine dehydrogenase mRNA level correlates with the response to 5-fluorouracil-based chemo-immuno-radiation therapy in human oral squamous cell cancer.
    International journal of oncology, 2001, Volume: 19, Issue:5

    Topics: Antimetabolites, Antineoplastic; Biopsy; Carcinoma, Squamous Cell; Cobalt Radioisotopes; Combined Mo

2001
Combination chemotherapy of head and neck cancer.
    Cancer, 1978, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bleomycin; Bone Marrow; Carcinoma, Squamous Cell; Cy

1978
Chemosensitivity of salivary gland and oral cancer cell lines.
    Chinese medical journal, 1992, Volume: 105, Issue:12

    Topics: Cantharidin; Doxorubicin; Fluorouracil; Humans; Methotrexate; Mouth Neoplasms; Salivary Gland Neopla

1992
Evaluation of the wap-ras transgenic mouse as a model system for testing anticancer drugs.
    Cancer research, 1992, Jul-01, Volume: 52, Issue:13

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Disease Models, Animal; Fluorouracil; Genes, ras;

1992
Cisplatin, epirubicin and 5-fluorouracil combination chemotherapy for recurrent carcinoma of the salivary gland.
    Tumori, 1989, Jun-30, Volume: 75, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinoma, A

1989
Cisplatin, doxorubicin, and 5-fluorouracil chemotherapy for salivary gland malignancies: a pilot study of the Northern California Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; D

1987
[Chemotherapy by intra-arterial path in cancer of the "head and neck" region].
    Acta chirurgica Belgica, 1971, Volume: 70, Issue:4

    Topics: Antineoplastic Agents; Bleomycin; Facial Neoplasms; Fluorouracil; Head; Head and Neck Neoplasms; Hum

1971