fluorouracil has been researched along with Cancer of Eye in 38 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of mitomycin-C (MMC) and 5-fluorouracil (5-FU) on the viability, proliferation, and migratory capacity of cultured ocular adnexal sebaceous carcinoma (SC) cells." | 8.12 | Effects of Mitomycin-C and 5-Fluorouracil on Ocular Adnexal Sebaceous Carcinoma Cells. ( Gallo, RA; Gomez, A; Lang, SH; Pelaez, D; Rong, AJ; Sabater, AL; Tse, DT, 2022) |
| "A 26-year-old, wild caught, male Malayan tapir at the Miami Metrozoo with bilateral corneal papillomas was serially immobilized and given subconjunctival injections of fluorouracil." | 7.71 | Fluorouracil as a treatment for corneal papilloma in a Malayan tapir. ( Karpinski, LG; Miller, CL, 2002) |
| "Harmaline and 5-FU were incubated with human retinoblastoma (Rb) cell line SO-Rb50 for 72 hours separately before subjected to sampling, viable cell counting and inhibition rate (IR) calculation." | 7.68 | [Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50]. ( Jin, YJ, 1990) |
| " Ocular discomfort occurred in 43 of 49 patients in the fluorouracil group versus 36 of 49 in the placebo group, epiphora occurred in 24 versus five, and eyelid skin inflammation occurred in seven versus none." | 5.22 | Topical fluorouracil after surgery for ocular surface squamous neoplasia in Kenya: a randomised, double-blind, placebo-controlled trial. ( Burton, MJ; Gichuhi, S; Kabiru, J; Macharia, E; Maina, J; Munene, R; Ollando, E; Onyuma, T; Rono, H; Sagoo, MS; Wachira, J; Weiss, HA; Zindamoyen, AM, 2016) |
| "To investigate the effects of mitomycin-C (MMC) and 5-fluorouracil (5-FU) on the viability, proliferation, and migratory capacity of cultured ocular adnexal sebaceous carcinoma (SC) cells." | 4.12 | Effects of Mitomycin-C and 5-Fluorouracil on Ocular Adnexal Sebaceous Carcinoma Cells. ( Gallo, RA; Gomez, A; Lang, SH; Pelaez, D; Rong, AJ; Sabater, AL; Tse, DT, 2022) |
| "A 26-year-old, wild caught, male Malayan tapir at the Miami Metrozoo with bilateral corneal papillomas was serially immobilized and given subconjunctival injections of fluorouracil." | 3.71 | Fluorouracil as a treatment for corneal papilloma in a Malayan tapir. ( Karpinski, LG; Miller, CL, 2002) |
| "A treatment schedule for primary intraocular lymphoma consisting of methotrexate intravitreal injections every 48 to 72 hours provides therapeutic drug concentrations in the vitreous and, in combination with fluorouracil and dexamethasone, appears to be safe in the rabbit eye." | 3.71 | Pharmacokinetics and toxicity of intravitreal chemotherapy for primary intraocular lymphoma. ( Chan, CC; Nussenblatt, RB; Reed, GF; Robinson, MR; Sung, C; Tansey, G; Velez, G; Yuan, P, 2001) |
| "Harmaline and 5-FU were incubated with human retinoblastoma (Rb) cell line SO-Rb50 for 72 hours separately before subjected to sampling, viable cell counting and inhibition rate (IR) calculation." | 3.68 | [Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50]. ( Jin, YJ, 1990) |
| "Subconjunctival/perilesional 5-fluorouracil injections are an effective and safe treatment for OSSN." | 1.56 | Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia. ( Hua, R; Sun, Y, 2020) |
| "To evaluate the efficacy of pulse dosing of topical 5-fluorouracil (5-FU) in the treatment of conjunctival and corneal intraepithelial neoplasia." | 1.31 | 5-Fluorouracil for the treatment of intraepithelial neoplasia of the conjunctiva and cornea. ( Curry, CD; Engelbrecht, NE; Ford, JG; Walter, KA; Yeatts, RP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (23.68) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 11 (28.95) | 24.3611 |
| 2020's | 8 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Gallo, RA | 1 |
| Lang, SH | 1 |
| Gomez, A | 1 |
| Sabater, AL | 1 |
| Tse, DT | 1 |
| Pelaez, D | 1 |
| Rong, AJ | 1 |
| Kozma, K | 1 |
| Dömötör, ZR | 1 |
| Csutak, A | 1 |
| Szabó, L | 1 |
| Hegyi, P | 1 |
| Erőss, B | 1 |
| Helyes, Z | 1 |
| Molnár, Z | 1 |
| Dembrovszky, F | 1 |
| Szalai, E | 1 |
| Wylegala, A | 2 |
| Sripawadkul, W | 2 |
| Zein, M | 2 |
| Alvarez, OP | 2 |
| Al Bayyat, G | 2 |
| Galor, A | 6 |
| Karp, CL | 7 |
| Monroy, D | 1 |
| Serrano, A | 1 |
| Agarwal, A | 1 |
| Kaliki, S | 1 |
| Murthy, SI | 1 |
| Hӧllhumer, R | 2 |
| Williams, S | 2 |
| Michelow, P | 2 |
| Sun, Y | 1 |
| Hua, R | 1 |
| Chaugule, SS | 1 |
| Park, J | 1 |
| Finger, PT | 1 |
| Polski, A | 1 |
| Sibug Saber, M | 1 |
| Kim, JW | 1 |
| Berry, JL | 1 |
| Venkateswaran, N | 1 |
| Mercado, C | 1 |
| Overton, TL | 1 |
| Allbaugh, RA | 1 |
| Whitley, D | 1 |
| Ben-Shlomo, G | 1 |
| Griggs, A | 1 |
| Tofflemire, KL | 1 |
| Whitley, EM | 1 |
| Gichuhi, S | 1 |
| Macharia, E | 1 |
| Kabiru, J | 1 |
| Zindamoyen, AM | 1 |
| Rono, H | 1 |
| Ollando, E | 1 |
| Wachira, J | 1 |
| Munene, R | 1 |
| Maina, J | 1 |
| Onyuma, T | 1 |
| Sagoo, MS | 1 |
| Weiss, HA | 1 |
| Burton, MJ | 1 |
| Parrozzani, R | 1 |
| Frizziero, L | 1 |
| Trainiti, S | 1 |
| Testi, I | 1 |
| Miglionico, G | 1 |
| Pilotto, E | 1 |
| Blandamura, S | 1 |
| Fassina, A | 1 |
| Midena, E | 2 |
| Ashkenazy, N | 1 |
| Wang, G | 1 |
| Acosta, CM | 1 |
| Sepulveda, R | 1 |
| Pe'er, J | 1 |
| Seregard, S | 1 |
| Dua, HS | 1 |
| Singh, AD | 1 |
| Rudkin, AK | 1 |
| Muecke, JS | 1 |
| Shousha, MA | 1 |
| Perez, VL | 1 |
| Hoffmann, R | 1 |
| Ventura, R | 1 |
| Chang, V | 1 |
| Dubovy, SR | 2 |
| Wang, J | 1 |
| Oellers, P | 1 |
| Kao, AA | 1 |
| Abdelaziz, A | 1 |
| Feuer, W | 1 |
| Karpinski, LG | 1 |
| Miller, CL | 1 |
| Schechter, BA | 2 |
| Nagler, RS | 2 |
| NEWELL, FW | 1 |
| Thavaraj, V | 1 |
| Sridhar, MR | 1 |
| Sethi, A | 1 |
| Arya, LS | 1 |
| Stone, DU | 1 |
| Butt, AL | 1 |
| Chodosh, J | 1 |
| Abraham, LM | 1 |
| Selva, D | 1 |
| Casson, R | 1 |
| Leibovitch, I | 1 |
| Kiribuchi, M | 2 |
| Yeatts, RP | 2 |
| Ford, JG | 2 |
| Stanton, CA | 1 |
| Reed, JW | 1 |
| Engelbrecht, NE | 1 |
| Curry, CD | 1 |
| Walter, KA | 1 |
| Velez, G | 1 |
| Yuan, P | 1 |
| Sung, C | 1 |
| Tansey, G | 1 |
| Reed, GF | 1 |
| Chan, CC | 1 |
| Nussenblatt, RB | 1 |
| Robinson, MR | 1 |
| Kaneko, A | 1 |
| Kimball, JC | 1 |
| Cangir, A | 1 |
| Jin, YJ | 1 |
| Blumenkranz, MS | 1 |
| Hartzer, MK | 1 |
| Hajek, AS | 1 |
| Olsen, KR | 1 |
| Blumenkranz, M | 1 |
| Hernandez, E | 1 |
| Hajek, A | 1 |
| Hartzer, M | 1 |
| Donegan, WL | 1 |
| Harris, HS | 1 |
| Aasved, H | 1 |
| Seim, V | 1 |
| Hasegawa, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open, Single-centre Non-randomized Phase II Clinical Trial on Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage[NCT01393769] | Phase 2 | 5 participants (Actual) | Interventional | 2009-11-30 | Terminated (stopped due to Only 5 subjects could be enrolled. Sample of 25 pat. not be achieved (rare disease).) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for fluorouracil and Cancer of Eye
| Article | Year |
|---|---|
Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis.
Topics: Administration, Topical; Carcinoma, Squamous Cell; Conjunctival Neoplasms; Eye Neoplasms; Fluorourac | 2022 |
Medical treatment for ocular surface squamous neoplasia.
Topics: Carcinoma, Squamous Cell; Conjunctival Neoplasms; Eye Neoplasms; Fluorouracil; Humans; Interferon al | 2023 |
Ocular surface squamous neoplasia: management and outcomes.
Topics: Carcinoma, Squamous Cell; Conjunctival Neoplasms; Eye Neoplasms; Fluorouracil; Humans; Neoplasm Recu | 2021 |
Topical chemotherapy for ocular surface squamous neoplasia: current status.
Topics: Administration, Topical; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplasti | 2010 |
The clinical applications of fluorouracil in ophthalmic practice.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Cell Proliferation; Eye Diseases; Eye Neop | 2007 |
1 trial available for fluorouracil and Cancer of Eye
| Article | Year |
|---|---|
Topical fluorouracil after surgery for ocular surface squamous neoplasia in Kenya: a randomised, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Antimetabolites, Antineoplastic; Carcinoma; Double-Blind Method; Eye | 2016 |
32 other studies available for fluorouracil and Cancer of Eye
| Article | Year |
|---|---|
Effects of Mitomycin-C and 5-Fluorouracil on Ocular Adnexal Sebaceous Carcinoma Cells.
Topics: Carcinoma; Cell Survival; Cells, Cultured; Eye Neoplasms; Fluorouracil; Humans; Mitomycin | 2022 |
Topical 1% 5-fluorouracil eye drops as primary treatment for ocular surface squamous neoplasia: Long-term follow-up study.
Topics: Carcinoma, Squamous Cell; Conjunctival Neoplasms; Eye Neoplasms; Female; Fluorouracil; Follow-Up Stu | 2023 |
Topical 1% 5-fluorouracil eye drops as primary treatment for ocular surface squamous neoplasia: Long-term follow-up study.
Topics: Carcinoma, Squamous Cell; Conjunctival Neoplasms; Eye Neoplasms; Female; Fluorouracil; Follow-Up Stu | 2023 |
Topical 1% 5-fluorouracil eye drops as primary treatment for ocular surface squamous neoplasia: Long-term follow-up study.
Topics: Carcinoma, Squamous Cell; Conjunctival Neoplasms; Eye Neoplasms; Female; Fluorouracil; Follow-Up Stu | 2023 |
Topical 1% 5-fluorouracil eye drops as primary treatment for ocular surface squamous neoplasia: Long-term follow-up study.
Topics: Carcinoma, Squamous Cell; Conjunctival Neoplasms; Eye Neoplasms; Female; Fluorouracil; Follow-Up Stu | 2023 |
Corneal squamous neoplasia: masquerades and management outcomes at a rural eyecare centre.
Topics: Carcinoma, Squamous Cell; Conjunctival Neoplasms; Corneal Diseases; Eye Neoplasms; Fluorouracil; Hum | 2023 |
Observational study of ocular surface squamous neoplasia: Risk factors, diagnosis, management and outcomes at a tertiary eye hospital in South Africa.
Topics: Adult; Antineoplastic Agents; Area Under Curve; Carcinoma, Squamous Cell; Eye Neoplasms; Female; Flu | 2020 |
Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia.
Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Conjunctiva; Eye Neoplasms; Female; | 2020 |
Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, | 2018 |
Extending far and wide: the role of biopsy and staging in the management of ocular surface squamous neoplasia.
Topics: Aged; Antineoplastic Agents; Biopsy; Carcinoma, Squamous Cell; Conjunctival Neoplasms; Corneal Disea | 2019 |
Comparison of Topical 5-Fluorouracil and Interferon Alfa-2b as Primary Treatment Modalities for Ocular Surface Squamous Neoplasia.
Topics: Administration, Ophthalmic; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic | 2019 |
A pulse-dose topical 1% 5-fluorouracil treatment regimen in a young dog with corneal squamous cell carcinoma.
Topics: Administration, Ophthalmic; Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Corn | 2015 |
Topical 1% 5-fluoruracil as a sole treatment of corneoconjunctival ocular surface squamous neoplasia: long-term study.
Topics: Administration, Topical; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Squamo | 2017 |
Immunosuppression as a Possible Risk Factor for Interferon Nonresponse in Ocular Surface Squamous Neoplasia.
Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Conjunctiv | 2017 |
Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia.
Topics: Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Eye Neoplasms; Female; Fluorouracil; Humans; Ma | 2011 |
Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography.
Topics: Administration, Topical; Aged; Aged, 80 and over; Biopsy; Carcinoma in Situ; Conjunctival Neoplasms; | 2011 |
Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma in Situ; Carcinoma, Squamous Cell; Conjunctival Neoplasms; | 2012 |
Fluorouracil as a treatment for corneal papilloma in a Malayan tapir.
Topics: Animals; Animals, Zoo; Antimetabolites, Antineoplastic; Conjunctiva; Corneal Diseases; Diagnosis, Di | 2002 |
Successful treatment with 5-Fu.
Topics: Administration, Topical; Aged; Antineoplastic Agents; Carcinoma in Situ; Conjunctival Neoplasms; Cor | 2003 |
Successful treatment with 5-Fu.
Topics: Administration, Topical; Aged; Antineoplastic Agents; Carcinoma in Situ; Conjunctival Neoplasms; Cor | 2003 |
ANTICANCER AGENTS.
Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cor | 1964 |
Adenoid cystic carcinoma of the lacrimal gland.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Adenoid Cystic; Child; Combi | 2003 |
Ocular surface squamous neoplasia: a standard of care survey.
Topics: Administration, Topical; Antineoplastic Agents; Biopsy; Combined Modality Therapy; Conjunctival Neop | 2005 |
[Retrograde infusion of anti-cancer drugs to ophthalmic artery for intraocular malignant tumors].
Topics: Eye Neoplasms; Female; Fluorouracil; Humans; Infant; Infusions, Parenteral; Lung Neoplasms; Male; Mi | 1966 |
Topical 5-fluorouracil in treating epithelial neoplasia of the conjunctiva and cornea.
Topics: Administration, Topical; Adult; Aged; Antimetabolites, Antineoplastic; Biopsy; Carcinoma in Situ; Ch | 1995 |
5-Fluorouracil for the treatment of intraepithelial neoplasia of the conjunctiva and cornea.
Topics: Administration, Topical; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma in Situ | 2000 |
Pharmacokinetics and toxicity of intravitreal chemotherapy for primary intraocular lymphoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Chromatography, Hi | 2001 |
[Drug therapy of retinoblastoma. The first report. Distribution of 5-fluorouracil and bleomycin in retinoblastoma and aqueous humor (author's transl)].
Topics: Aqueous Humor; Bleomycin; Child, Preschool; Eye Neoplasms; Fluorouracil; Humans; Infant; Retinoblast | 1977 |
Occurrence of testicular metastasis in a child with bilateral retinoblastoma.
Topics: Antineoplastic Agents; Child, Preschool; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, | 1979 |
[Effects of harmaline and fluorouracil (5-FU) on human retinoblastoma cell line SO-Rb 50].
Topics: Cell Division; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Eye Neoplasms; Fl | 1990 |
Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Division; Cell Line; Cells, Cultured; Dose-Response Rel | 1987 |
Fluorouracil therapy of intraocular Greene melanoma in the rabbit.
Topics: Animals; Eye Neoplasms; Fluorouracil; Melanoma, Experimental; Rabbits | 1988 |
Factors influencing the success of arterial infusion chemotherapy for cancer of the head and neck.
Topics: Age Factors; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell | 1972 |
Chemotherapy in intraocular metastasis from carcinoma of the breast.
Topics: Breast Neoplasms; Cell Division; Cyclophosphamide; Diethylstilbestrol; DNA; Eye Neoplasms; Female; F | 1974 |
[Retrograde infusion of anti-cancer drugs to the ophthalmic artery for intra ocular malignant tumors].
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Dogs; Eye Neoplasms; Female; Fluorouracil; Humans | 1968 |