fluorouracil has been researched along with Cancer of Endometrium in 32 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-three patients with advanced or recurrent endometrial carcinoma entered a prospective study of chemotherapy which consisted of carboplatin (300 mg/m2), methotrexate (30 mg/m2), and 5-fluoruracil (500 mg/m2) given on day 1, in a 3-weekly schedule, in combination with medroxyprogesterone acetate (MPA): 300 mg daily, p." | 9.09 | Carboplatin, methotrexate and 5-fluorouracil in combination with medroxyprogesterone acetate (JMF-M) in the treatment of advanced or recurrent endometrial carcinoma: A Hellenic cooperative oncology group study. ( Aravantinos, G; Bafaloukos, D; Bakoyiannis, C; Katsifis, G; Kosmidis, P; Samonis, G; Skarlos, D, 1999) |
| "A recent study showed that both 5-fluorouracil (5FU)-stimulated apoptosis and Fas-mediated apoptosis in human endometrial adenocarcinoma cells are enhanced by targeted knockdown of endogenous death-associated protein kinase (DAPK) with DAPK small-interfering RNAs." | 7.78 | Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells. ( Bai, T; Tanaka, J; Tanaka, T; Toujima, S; Utsunomiya, H; Utsunomiya, T; Yukawa, K, 2012) |
| "To investigate anticancer effects of 5-fluorouracil (5-FU) combined with CL, extract of Rosa roxburghii Tratt on human endometrial adenocarcinoma cell line (JEC)." | 7.77 | [Anticancer effect of 5-fluorouracil combined with extract of Rosa roxburghii Tratt on human endometrial adenocarcinoma]. ( Dai, ZK; Yang, XS; Yu, LM, 2011) |
| "To investigate acquired 5-fluorouracil (5FU)-resistance in cancer cells, we established four monoclonal 5FU-resistant cell lines from human endometrial adenocarcinoma cells by long-term 5FU-exposure cultures and limiting dilution cultures." | 7.76 | Establishment and characterization of monoclonal 5-fluorouracil-resistant cell lines derived from human endometrial adenocarcinoma. ( Bai, T; Tanaka, T; Toujima, S, 2010) |
| "Twenty-three patients with advanced or recurrent endometrial carcinoma entered a prospective study of chemotherapy which consisted of carboplatin (300 mg/m2), methotrexate (30 mg/m2), and 5-fluoruracil (500 mg/m2) given on day 1, in a 3-weekly schedule, in combination with medroxyprogesterone acetate (MPA): 300 mg daily, p." | 5.09 | Carboplatin, methotrexate and 5-fluorouracil in combination with medroxyprogesterone acetate (JMF-M) in the treatment of advanced or recurrent endometrial carcinoma: A Hellenic cooperative oncology group study. ( Aravantinos, G; Bafaloukos, D; Bakoyiannis, C; Katsifis, G; Kosmidis, P; Samonis, G; Skarlos, D, 1999) |
| "At this juncture in the development of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ), knowledge about the agent's pharmacologic behavior and clinical antitumor activity in less common neoplasms is being elucidated." | 4.79 | Paclitaxel pharmacology and other tumor types. ( Rowinsky, EK, 1997) |
| "A recent study showed that both 5-fluorouracil (5FU)-stimulated apoptosis and Fas-mediated apoptosis in human endometrial adenocarcinoma cells are enhanced by targeted knockdown of endogenous death-associated protein kinase (DAPK) with DAPK small-interfering RNAs." | 3.78 | Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells. ( Bai, T; Tanaka, J; Tanaka, T; Toujima, S; Utsunomiya, H; Utsunomiya, T; Yukawa, K, 2012) |
| "To investigate anticancer effects of 5-fluorouracil (5-FU) combined with CL, extract of Rosa roxburghii Tratt on human endometrial adenocarcinoma cell line (JEC)." | 3.77 | [Anticancer effect of 5-fluorouracil combined with extract of Rosa roxburghii Tratt on human endometrial adenocarcinoma]. ( Dai, ZK; Yang, XS; Yu, LM, 2011) |
| " Using multiparameter cytometry we explored the effects of doxorubicin (DOX), cisplatin (CDDP) and 5-fluorouracil (5-FU) on four types of endometrioid adenocarcinoma cell lines (HEC-1A, HEC-1B, Ishikawa, KLE) correlating the drug-induced increases in phosphorylated H2AX (gammaH2AX) with cell cycle phase, induction of apoptosis and induction of cell senescence, the latter detected by analysis of beta-galactosidase." | 3.76 | DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines. ( Darzynkiewicz, Z; Ikeda, M; Kurose, A; Sawai, T; Sugiyama, T; Takatori, E; Traganos, F, 2010) |
| "To investigate acquired 5-fluorouracil (5FU)-resistance in cancer cells, we established four monoclonal 5FU-resistant cell lines from human endometrial adenocarcinoma cells by long-term 5FU-exposure cultures and limiting dilution cultures." | 3.76 | Establishment and characterization of monoclonal 5-fluorouracil-resistant cell lines derived from human endometrial adenocarcinoma. ( Bai, T; Tanaka, T; Toujima, S, 2010) |
| "Lymphatic metastasis is one of the most important problems in the treatment of gynecologic malignancy." | 2.68 | [Chemotherapy against lymphatic metastases of gynecologic cancer via pelvic retroperitoneal cannulation: a preliminary report]. ( Cao, Z; You, Z; Zhou, S, 1995) |
| "Case 2 was a 68-yo-female with an endometrial cancer recurrence." | 2.40 | [Anticancer drug-induced colitis--case report and review of the literature]. ( Abe, H; Ishiguro, K; Mitani, I; Tsunaga, N; Yamashita, S, 1997) |
| "MMR-D pancreatic cancer have been reported to respond to checkpoint inhibitor therapy." | 1.48 | Acquired resistance to immunotherapy in MMR-D pancreatic cancer. ( Diaz, LA; Hellmann, MD; Hu, ZI; O'Reilly, EM; Shia, J; Stadler, ZK; Vyas, M; Wolchok, JD, 2018) |
| "Endometrial cancer is the most common gynecologic malignancy in women worldwide." | 1.42 | Additional effects of engineered stem cells expressing a therapeutic gene and interferon-β in a xenograft mouse model of endometrial cancer. ( Choi, KC; Kim, SU; Yi, BR, 2015) |
| "A complete remission of anal cancer was achieved in both patients with minimal acute and late toxicities." | 1.31 | Successful chemoradiotherapy for anal cancer despite previous radical radiotherapy for gynaecological malignancy. ( Arnott, SJ; Leslie, MD; Subramaniam, R, 2002) |
| "Endometrial carcinoma is the commonest female genital tract malignancy in the south of Israel." | 1.30 | Endometrial carcinoma in the south of Israel: study of 231 cases. ( Bar-Dayan, A; Cohen, Y; Glezerman, M; Piura, B; Yanai-Inbar, I, 1997) |
| "Fluorouracil (5-FU) was repeatedly injected into the pelvic retroperitoneal space of 43 patients and the abdominal cavity of 11 patients." | 1.30 | [The contrast between chemotherapy via pelvic retroperitoneal cannulation and intraperitoneal chemotherapy in gynecological malignancies cancers with lymph node metastases]. ( Cao, Z; Peng, Z; Zhang, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (43.75) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 12 (37.50) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, X | 1 |
| Wu, Z | 1 |
| Xiao, C | 1 |
| Chen, XI | 1 |
| Bruckner, HW | 1 |
| Gurell, D | 1 |
| Hirschfeld, A | 1 |
| Hu, ZI | 1 |
| Hellmann, MD | 1 |
| Wolchok, JD | 1 |
| Vyas, M | 1 |
| Shia, J | 1 |
| Stadler, ZK | 1 |
| Diaz, LA | 1 |
| O'Reilly, EM | 1 |
| Matsuzaki, S | 1 |
| Enomoto, T | 1 |
| Serada, S | 1 |
| Yoshino, K | 1 |
| Nagamori, S | 1 |
| Morimoto, A | 1 |
| Yokoyama, T | 1 |
| Kim, A | 1 |
| Kimura, T | 2 |
| Ueda, Y | 1 |
| Fujita, M | 1 |
| Fujimoto, M | 1 |
| Kanai, Y | 1 |
| Naka, T | 1 |
| Carmona, R | 1 |
| Pritz, J | 1 |
| Bydder, M | 1 |
| Gulaya, S | 1 |
| Zhu, H | 1 |
| Williamson, CW | 1 |
| Welch, CS | 1 |
| Vaida, F | 1 |
| Bydder, G | 1 |
| Mell, LK | 1 |
| Yi, BR | 1 |
| Kim, SU | 1 |
| Choi, KC | 1 |
| Fleming, GF | 1 |
| Ikeda, M | 1 |
| Kurose, A | 1 |
| Takatori, E | 1 |
| Sugiyama, T | 1 |
| Traganos, F | 1 |
| Darzynkiewicz, Z | 1 |
| Sawai, T | 1 |
| Tanaka, T | 3 |
| Bai, T | 3 |
| Toujima, S | 2 |
| Yukawa, K | 2 |
| Dai, ZK | 1 |
| Yang, XS | 1 |
| Yu, LM | 1 |
| Utsunomiya, T | 1 |
| Utsunomiya, H | 1 |
| Tanaka, J | 1 |
| Peled, Y | 1 |
| Levavi, H | 1 |
| Krissi, H | 1 |
| Weill, Y | 1 |
| Sabah, G | 1 |
| Eitan, R | 1 |
| Subramaniam, R | 1 |
| Arnott, SJ | 1 |
| Leslie, MD | 1 |
| O'Toole, SA | 1 |
| Sheppard, BL | 1 |
| McGuinness, EP | 1 |
| Gleeson, NC | 1 |
| Yoneda, M | 1 |
| Bonnar, J | 1 |
| Kaneyasu, Y | 1 |
| Okawa, T | 1 |
| Yajima, M | 1 |
| Saito, R | 1 |
| Nakabayashi, M | 1 |
| Seshimo, A | 1 |
| Kameoka, S | 1 |
| Aomi, S | 1 |
| Nishikawa, T | 1 |
| Sawada, T | 1 |
| Mitsuhashi, N | 1 |
| Semiglazov, VF | 1 |
| Maksimov, SIa | 1 |
| Semiglazov, VV | 1 |
| Kosnikov, AG | 1 |
| Sheng, XG | 1 |
| Tang, L | 1 |
| Li, DP | 1 |
| Li, HQ | 1 |
| Song, XR | 1 |
| Lu, CH | 1 |
| Wang, XW | 1 |
| Li, QS | 1 |
| Cornelison, TL | 1 |
| Baker, TR | 1 |
| Piver, MS | 1 |
| Driscoll, DL | 1 |
| Cao, Z | 3 |
| You, Z | 1 |
| Zhou, S | 1 |
| Goff, BA | 1 |
| Goodman, A | 1 |
| Muntz, HG | 1 |
| Fuller, AF | 1 |
| Nikrui, N | 1 |
| Rice, LW | 1 |
| Pierga, JY | 2 |
| Dieras, V | 2 |
| Paraiso, D | 1 |
| Dorval, T | 2 |
| Palangie, T | 2 |
| Beuzeboc, P | 2 |
| Jouve, M | 2 |
| Scholl, SM | 2 |
| Garcia-Giralt, E | 2 |
| Pouillart, P | 2 |
| Abe, H | 1 |
| Tsunaga, N | 1 |
| Yamashita, S | 1 |
| Ishiguro, K | 1 |
| Mitani, I | 1 |
| Piura, B | 1 |
| Bar-Dayan, A | 1 |
| Cohen, Y | 1 |
| Yanai-Inbar, I | 1 |
| Glezerman, M | 1 |
| Rowinsky, EK | 1 |
| Surico, N | 1 |
| Ribaldone, R | 1 |
| Zhang, D | 2 |
| Peng, Z | 2 |
| Aebi, S | 1 |
| Fink, D | 1 |
| Gordon, R | 1 |
| Kim, HK | 1 |
| Zheng, H | 1 |
| Fink, JL | 1 |
| Howell, SB | 1 |
| Bafaloukos, D | 1 |
| Aravantinos, G | 1 |
| Samonis, G | 1 |
| Katsifis, G | 1 |
| Bakoyiannis, C | 1 |
| Skarlos, D | 1 |
| Kosmidis, P | 1 |
| Vering, A | 1 |
| Michel, RT | 1 |
| Mitze, M | 1 |
| Stegmüller, M | 1 |
| Bender, HG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Label, Non-Randomized Multisite Phase II Trial Combining Bevacizumab, Atezolizumab and Rucaparib for the Treatment of Previously Treated Recurrent and Progressive Endometrial Carcinoma[NCT03694262] | Phase 2 | 30 participants (Actual) | Interventional | 2019-07-19 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and Cancer of Endometrium
| Article | Year |
|---|---|
Second-Line Therapy for Endometrial Cancer: The Need for Better Options.
Topics: Adenocarcinoma; Amines; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Clinical Trials | 2015 |
[Anticancer drug-induced colitis--case report and review of the literature].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colitis; Colonoscopy; Drug A | 1997 |
Paclitaxel pharmacology and other tumor types.
Topics: Alkylating Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols | 1997 |
6 trials available for fluorouracil and Cancer of Endometrium
| Article | Year |
|---|---|
[The modern organ- and function-sparing surgical treatment in oncology].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carci | 2003 |
Cisplatin, adriamycin, etoposide, megestrol acetate versus melphalan, 5-fluorouracil, medroxyprogesterone acetate in the treatment of endometrial carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Endometrial Neoplasms; | 1995 |
[Chemotherapy against lymphatic metastases of gynecologic cancer via pelvic retroperitoneal cannulation: a preliminary report].
Topics: Adenocarcinoma; Adult; Aged; Animals; Catheterization; Endometrial Neoplasms; Female; Fluorouracil; | 1995 |
Treatment of advanced or recurrent endometrial carcinoma with combination of etoposide, cisplatin, and 5-fluorouracil: a phase II study.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 1996 |
Phase II trial of doxorubicin, 5-fluorouracil, etoposide, and cisplatin in advanced or recurrent endometrial carcinoma.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineopla | 1997 |
Carboplatin, methotrexate and 5-fluorouracil in combination with medroxyprogesterone acetate (JMF-M) in the treatment of advanced or recurrent endometrial carcinoma: A Hellenic cooperative oncology group study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma; Drug Synergism; | 1999 |
23 other studies available for fluorouracil and Cancer of Endometrium
| Article | Year |
|---|---|
E2F7/RAD51AP1 Axis Inhibits Endometrial Cancer Sensitivity to 5-FU
Topics: DNA-Binding Proteins; E2F7 Transcription Factor; Endometrial Neoplasms; Fatty Acids; Female; Fluorou | 2023 |
Bevacizumab Added to Moderate-dose Chemotherapy for Refractory Uterine Cancer.
Topics: Adenocarcinoma; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols | 2018 |
Acquired resistance to immunotherapy in MMR-D pancreatic cancer.
Topics: Adenocarcinoma; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols | 2018 |
Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A.
Topics: Adenosine Triphosphatases; Animals; Annexin A4; Antineoplastic Agents; Biological Transport; Carbopl | 2014 |
Fat composition changes in bone marrow during chemotherapy and radiation therapy.
Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Co | 2014 |
Additional effects of engineered stem cells expressing a therapeutic gene and interferon-β in a xenograft mouse model of endometrial cancer.
Topics: Animals; Cell Line, Tumor; Combined Modality Therapy; Cytosine Deaminase; Endometrial Neoplasms; Fem | 2015 |
DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines.
Topics: Adenocarcinoma; Apoptosis; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Cisplatin; DNA Damage; | 2010 |
Establishment and characterization of monoclonal 5-fluorouracil-resistant cell lines derived from human endometrial adenocarcinoma.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Resistance, Neoplasm; Endome | 2010 |
Suppressed protein expression of the death-associated protein kinase enhances 5-fluorouracil-sensitivity but not etoposide-sensitivity in human endometrial adenocarcinoma cells.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis Regula | 2010 |
[Anticancer effect of 5-fluorouracil combined with extract of Rosa roxburghii Tratt on human endometrial adenocarcinoma].
Topics: Adenocarcinoma; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; F | 2011 |
Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Calcium-C | 2012 |
The use of Fluorouracil (5-FU) and leucovorin in women with heavily pretreated advanced ovarian carcinoma.
Topics: Adenocarcinoma, Mucinous; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Papillary | 2013 |
Successful chemoradiotherapy for anal cancer despite previous radical radiotherapy for gynaecological malignancy.
Topics: Adult; Aged; Anus Neoplasms; Carcinoma, Squamous Cell; Combined Modality Therapy; Endometrial Neopla | 2002 |
The MTS assay as an indicator of chemosensitivity/resistance in malignant gynaecological tumours.
Topics: Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Drug Resistance, Neoplasm; Drug Sc | 2003 |
Stage IVB uterine endometrial cancer successfully salvaged by chemoradiotherapy and surgery.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Endometrial Neoplasms; | 2003 |
[Experimental study of sensitivity to chemotherapeutic agents for human endometrial carcinoma cell line].
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carboplat | 2004 |
Surgical stage IV endometrial carcinoma: a study of 47 cases.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Cyclo | 1994 |
Endometrial carcinoma in the south of Israel: study of 231 cases.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined | 1997 |
Topical treatment of vaginal recurrence of endometrial carcinoma with 5-fluorouracil: case-report.
Topics: Adenocarcinoma; Administration, Topical; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; B | 1997 |
[Chemotherapy repeated injection via pelvic retroperitoneal cannulation].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Catheters, Indwelling; Dogs; Endometrial Ne | 1997 |
Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Antineoplastic Agents; Carboplatin; Carrier Pr | 1997 |
[The contrast between chemotherapy via pelvic retroperitoneal cannulation and intraperitoneal chemotherapy in gynecological malignancies cancers with lymph node metastases].
Topics: Antimetabolites, Antineoplastic; Endometrial Neoplasms; Female; Fluorouracil; Humans; Injections, In | 1999 |
Influence of chemotherapy on hormone receptor concentration in a xenotransplanted endometrial cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bleomycin; Carboplatin; Cyclophosphamide; Endometria | 1992 |