fluorouracil has been researched along with Burns in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars." | 9.30 | Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019) |
| "TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments." | 9.12 | The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021) |
| "The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars." | 5.30 | Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019) |
| "TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments." | 5.12 | The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021) |
| "A review of 20 patients with postburn scar carcinoma is presented." | 1.28 | Postburn scar carcinoma. ( Aron, NK; Tajuri, S, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 5 (55.56) | 2.80 |
| Authors | Studies |
|---|---|
| Artzi, O | 1 |
| Koren, A | 1 |
| Niv, R | 1 |
| Mehrabi, JN | 1 |
| Mashiah, J | 1 |
| Friedman, O | 1 |
| Feng, Y | 1 |
| Sun, ZL | 2 |
| Yuan, FL | 2 |
| Wang, J | 1 |
| Wu, QY | 1 |
| Li, X | 1 |
| Lv, GZ | 1 |
| Zhuang, Z | 1 |
| Li, Y | 1 |
| Wei, X | 1 |
| Khalid, FA | 2 |
| Mehrose, MY | 2 |
| Saleem, M | 2 |
| Yousaf, MA | 1 |
| Mujahid, AM | 2 |
| Rehman, SU | 2 |
| Ahmad, S | 2 |
| Tarar, MN | 2 |
| Amin, M | 1 |
| Pereverzev, AE | 1 |
| Rozanov, IuM | 1 |
| Aron, NK | 1 |
| Tajuri, S | 1 |
| Hermann, J | 1 |
| Plenert, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Post-Surgical Intralesional Injection With Triamcinolone Versus Triamcinolone Plus Fluorouracil in the Treatment of Keloids[NCT04710719] | 7 participants (Actual) | Interventional | 2021-02-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Burns
| Article | Year |
|---|---|
The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis.
Topics: Atrophy; Burns; Cicatrix, Hypertrophic; Culture Media; Fluorouracil; Humans; Injections, Intralesion | 2021 |
[Generalized candida mycoses].
Topics: Amphotericin B; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Burns; Candida albicans; Candidi | 1974 |
1 trial available for fluorouracil and Burns
| Article | Year |
|---|---|
Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial.
Topics: Adult; Body Piercing; Burns; Cicatrix, Hypertrophic; Double-Blind Method; Drug Therapy, Combination; | 2019 |
6 other studies available for fluorouracil and Burns
| Article | Year |
|---|---|
A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery.
Topics: Administration, Cutaneous; Age Factors; Burns; Child; Child, Preschool; Cicatrix, Hypertrophic; Comb | 2020 |
Comments on "A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery".
Topics: Burns; Child; Cicatrix, Hypertrophic; Fluorouracil; Humans; Keloid; Triamcinolone Acetonide | 2020 |
Comments on"Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomisedcontrol trial".
Topics: Burns; Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid; Triamcinolon | 2020 |
Reply to comments on "comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial".
Topics: Burns; Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid; Triamcinolon | 2020 |
[The dynamic proliferative activity of mouse bone marrow cells during the suppression and recovery of hemopoiesis after 5-fluorouracil administration to the animals].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Burns; Cell Division; Depression, Chemical; Flow Cytometry; | 1993 |
Postburn scar carcinoma.
Topics: Adult; Aged; Burns; Carcinoma, Squamous Cell; Cicatrix; Combined Modality Therapy; Female; Fluoroura | 1989 |