Page last updated: 2024-10-27

fluorouracil and Burns

fluorouracil has been researched along with Burns in 9 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Research Excerpts

ExcerptRelevanceReference
"The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars."9.30Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019)
"TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments."9.12The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021)
"The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars."5.30Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019)
"TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments."5.12The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021)
"A review of 20 patients with postburn scar carcinoma is presented."1.28Postburn scar carcinoma. ( Aron, NK; Tajuri, S, 1989)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's1 (11.11)24.3611
2020's5 (55.56)2.80

Authors

AuthorsStudies
Artzi, O1
Koren, A1
Niv, R1
Mehrabi, JN1
Mashiah, J1
Friedman, O1
Feng, Y1
Sun, ZL2
Yuan, FL2
Wang, J1
Wu, QY1
Li, X1
Lv, GZ1
Zhuang, Z1
Li, Y1
Wei, X1
Khalid, FA2
Mehrose, MY2
Saleem, M2
Yousaf, MA1
Mujahid, AM2
Rehman, SU2
Ahmad, S2
Tarar, MN2
Amin, M1
Pereverzev, AE1
Rozanov, IuM1
Aron, NK1
Tajuri, S1
Hermann, J1
Plenert, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Post-Surgical Intralesional Injection With Triamcinolone Versus Triamcinolone Plus Fluorouracil in the Treatment of Keloids[NCT04710719]7 participants (Actual)Interventional2021-02-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for fluorouracil and Burns

ArticleYear
The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis.
    Burns : journal of the International Society for Burn Injuries, 2021, Volume: 47, Issue:5

    Topics: Atrophy; Burns; Cicatrix, Hypertrophic; Culture Media; Fluorouracil; Humans; Injections, Intralesion

2021
[Generalized candida mycoses].
    Kinderarztliche Praxis, 1974, Volume: 42, Issue:4

    Topics: Amphotericin B; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Burns; Candida albicans; Candidi

1974

Trials

1 trial available for fluorouracil and Burns

ArticleYear
Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial.
    Burns : journal of the International Society for Burn Injuries, 2019, Volume: 45, Issue:1

    Topics: Adult; Body Piercing; Burns; Cicatrix, Hypertrophic; Double-Blind Method; Drug Therapy, Combination;

2019

Other Studies

6 other studies available for fluorouracil and Burns

ArticleYear
A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery.
    Journal of cosmetic dermatology, 2020, Volume: 19, Issue:1

    Topics: Administration, Cutaneous; Age Factors; Burns; Child; Child, Preschool; Cicatrix, Hypertrophic; Comb

2020
Comments on "A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery".
    Journal of cosmetic dermatology, 2020, Volume: 19, Issue:7

    Topics: Burns; Child; Cicatrix, Hypertrophic; Fluorouracil; Humans; Keloid; Triamcinolone Acetonide

2020
Comments on"Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomisedcontrol trial".
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:2

    Topics: Burns; Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid; Triamcinolon

2020
Reply to comments on "comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial".
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:2

    Topics: Burns; Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid; Triamcinolon

2020
[The dynamic proliferative activity of mouse bone marrow cells during the suppression and recovery of hemopoiesis after 5-fluorouracil administration to the animals].
    Tsitologiia, 1993, Volume: 35, Issue:10

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Burns; Cell Division; Depression, Chemical; Flow Cytometry;

1993
Postburn scar carcinoma.
    Burns : journal of the International Society for Burn Injuries, 1989, Volume: 15, Issue:2

    Topics: Adult; Aged; Burns; Carcinoma, Squamous Cell; Cicatrix; Combined Modality Therapy; Female; Fluoroura

1989