Page last updated: 2024-10-27

fluorouracil and Burkitt Lymphoma

fluorouracil has been researched along with Burkitt Lymphoma in 7 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.

Research Excerpts

ExcerptRelevanceReference
" Similarly, constitutive hTERT expression inhibited wild-type p53-dependent apoptosis in response to mitomycin C or 5-fluorouracil in HCT116 colon carcinoma cells carrying endogenous p53."3.73hTERT antagonizes p53-induced apoptosis independently of telomerase activity. ( Latonen, L; Rahman, R; Wiman, KG, 2005)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19904 (57.14)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xiong, J1
Qin, J1
Zheng, Y1
Peng, X1
Luo, Y1
Meng, X1
Rahman, R1
Latonen, L1
Wiman, KG1
Vrba, M1
Adámek, R1
Blasko, M1
Brezina, V1
Chrz, R1
Goetz, P1
Michalová, K1
Musilová, J1
Novotná, B1
Pogosianz, HE1
Raposa, T1
Siracký, J1
Sokova, OI2
Thust, R1
Ujházy, V1
Volgareva, GM2
Feng, WH1
Israel, B1
Raab-Traub, N1
Busson, P1
Kenney, SC1
Pogosiants, EE1
Wheeler, RH1
Bull, FE1
Ruddon, RW1
Ravina, A1

Reviews

1 review available for fluorouracil and Burkitt Lymphoma

ArticleYear
[Burkitt's lymphoma and acute leukemias].
    La Presse medicale, 1969, Feb-08, Volume: 77, Issue:7

    Topics: Acute Disease; Animals; Asparaginase; Burkitt Lymphoma; Child; Cyclophosphamide; Cytarabine; Dactino

1969

Other Studies

6 other studies available for fluorouracil and Burkitt Lymphoma

ArticleYear
PEG10 promotes the migration of human Burkitt's lymphoma cells by up-regulating the expression of matrix metalloproteinase-2 and -9.
    Clinical and investigative medicine. Medecine clinique et experimentale, 2012, Jun-01, Volume: 35, Issue:3

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Burkitt Lymphoma; Cell Line, Tumor; Cel

2012
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
    Oncogene, 2005, Feb-17, Volume: 24, Issue:8

    Topics: Apoptosis; Burkitt Lymphoma; Carcinoma; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA-Bind

2005
Clastogenicity and sister chromatid exchange induction by ftorafur.
    Neoplasma, 1981, Volume: 28, Issue:4

    Topics: Animals; Burkitt Lymphoma; Cell Line; Chromosomes; Chromosomes, Human; Cricetinae; Crossing Over, Ge

1981
Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors.
    Cancer research, 2002, Mar-15, Volume: 62, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Carcinoma; Cisplatin; Dru

2002
[Effect of ftorafur on the chromosomes of human normal and tumor cells in vitro].
    Genetika, 1979, Volume: 15, Issue:1

    Topics: Burkitt Lymphoma; Cells, Cultured; Chromosomes, Human; Dose-Response Relationship, Drug; Fluorouraci

1979
The effect of heparin on the cytotoxicity and uptake of anti-neoplastic drugs in cultured Burkitt lymphoma cells.
    Cancer research, 1974, Volume: 34, Issue:12

    Topics: Burkitt Lymphoma; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Hepari

1974
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