fluorouracil and Burkitt Lymphoma
fluorouracil has been researched along with Burkitt Lymphoma in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" Similarly, constitutive hTERT expression inhibited wild-type p53-dependent apoptosis in response to mitomycin C or 5-fluorouracil in HCT116 colon carcinoma cells carrying endogenous p53." | 3.73 | hTERT antagonizes p53-induced apoptosis independently of telomerase activity. ( Latonen, L; Rahman, R; Wiman, KG, 2005) |
Research
Studies (7)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (57.14) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (28.57) | 29.6817 |
2010's | 1 (14.29) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Xiong, J | 1 |
Qin, J | 1 |
Zheng, Y | 1 |
Peng, X | 1 |
Luo, Y | 1 |
Meng, X | 1 |
Rahman, R | 1 |
Latonen, L | 1 |
Wiman, KG | 1 |
Vrba, M | 1 |
Adámek, R | 1 |
Blasko, M | 1 |
Brezina, V | 1 |
Chrz, R | 1 |
Goetz, P | 1 |
Michalová, K | 1 |
Musilová, J | 1 |
Novotná, B | 1 |
Pogosianz, HE | 1 |
Raposa, T | 1 |
Siracký, J | 1 |
Sokova, OI | 2 |
Thust, R | 1 |
Ujházy, V | 1 |
Volgareva, GM | 2 |
Feng, WH | 1 |
Israel, B | 1 |
Raab-Traub, N | 1 |
Busson, P | 1 |
Kenney, SC | 1 |
Pogosiants, EE | 1 |
Wheeler, RH | 1 |
Bull, FE | 1 |
Ruddon, RW | 1 |
Ravina, A | 1 |
Reviews
1 review available for fluorouracil and Burkitt Lymphoma
Article | Year |
---|---|
[Burkitt's lymphoma and acute leukemias].
Topics: Acute Disease; Animals; Asparaginase; Burkitt Lymphoma; Child; Cyclophosphamide; Cytarabine; Dactino | 1969 |
Other Studies
6 other studies available for fluorouracil and Burkitt Lymphoma
Article | Year |
---|---|
PEG10 promotes the migration of human Burkitt's lymphoma cells by up-regulating the expression of matrix metalloproteinase-2 and -9.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Burkitt Lymphoma; Cell Line, Tumor; Cel | 2012 |
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
Topics: Apoptosis; Burkitt Lymphoma; Carcinoma; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA-Bind | 2005 |
Clastogenicity and sister chromatid exchange induction by ftorafur.
Topics: Animals; Burkitt Lymphoma; Cell Line; Chromosomes; Chromosomes, Human; Cricetinae; Crossing Over, Ge | 1981 |
Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Carcinoma; Cisplatin; Dru | 2002 |
[Effect of ftorafur on the chromosomes of human normal and tumor cells in vitro].
Topics: Burkitt Lymphoma; Cells, Cultured; Chromosomes, Human; Dose-Response Relationship, Drug; Fluorouraci | 1979 |
The effect of heparin on the cytotoxicity and uptake of anti-neoplastic drugs in cultured Burkitt lymphoma cells.
Topics: Burkitt Lymphoma; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Hepari | 1974 |