fluorouracil has been researched along with Brain Injuries in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the effect of 5-fluorouracil mobilized bone marrow regenerative cells (BMRCs) transplantation on brain injury following focal cerebral ischemia and to explore the mechanisms." | 7.81 | Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats. ( Li, M; Liao, H; Liu, XL; Xiao, LH; Xu, FF; Xu, ZP; Yang, B, 2015) |
| "The aim of this study was to evaluate the effect of 5-fluorouracil mobilized bone marrow regenerative cells (BMRCs) transplantation on brain injury following focal cerebral ischemia and to explore the mechanisms." | 3.81 | Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats. ( Li, M; Liao, H; Liu, XL; Xiao, LH; Xu, FF; Xu, ZP; Yang, B, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, FF | 1 |
| Liu, XL | 1 |
| Li, M | 1 |
| Yang, B | 1 |
| Liao, H | 1 |
| Xiao, LH | 1 |
| Xu, ZP | 1 |
| Nishimura, K | 1 |
| Inoue, T | 1 |
| Yoshimoto, K | 1 |
| Taniguchi, T | 1 |
| Kitamura, Y | 1 |
| Agata, K | 1 |
2 other studies available for fluorouracil and Brain Injuries
| Article | Year |
|---|---|
Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats.
Topics: Administration, Intravenous; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain Injuries | 2015 |
Regeneration of dopaminergic neurons after 6-hydroxydopamine-induced lesion in planarian brain.
Topics: Analysis of Variance; Animals; Brain Injuries; Bromodeoxyuridine; Cell Cycle; Cell Movement; Cell Pr | 2011 |