fluorouracil has been researched along with Brain Edema in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a multicentre trial of adjuvant chemotherapy in gastric adenocarcinoma, a number of patients developed chronic haemolysis and renal failure following long-term treatment with 5-fluorouracil and mitomycin-C." | 3.66 | Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C. ( Brookes, VS; Fielding, JW; Howell, A; Jones, BG; Newman, CE, 1980) |
| "The diagnosis of toxic encephalopathy was supported after elimination of alternative causes of the neurological dysfunction and complete resolution of clinical and imaging findings after 3 months of no further chemotherapy." | 2.50 | Subacute reversible toxic encephalopathy related to treatment with capecitabine: a case report with literature review and discussion of pathophysiology. ( Fassbender, K; Keller, I; Lyros, E; Papanagiotou, P; Walter, S, 2014) |
| "Patients with cerebrovascular accidents were excluded." | 1.35 | Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients. ( Baehring, JM; Fulbright, RK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Chiu, YW | 1 |
| Tsui, YK | 1 |
| Shen, HN | 1 |
| Lu, L | 1 |
| Sheng, Y | 1 |
| Zhang, G | 1 |
| Li, Y | 1 |
| OuYang, PY | 1 |
| Ge, Y | 1 |
| Xie, T | 1 |
| Chang, H | 1 |
| Deng, X | 1 |
| Wu, JQ | 1 |
| Lyros, E | 1 |
| Walter, S | 1 |
| Keller, I | 1 |
| Papanagiotou, P | 1 |
| Fassbender, K | 1 |
| Baehring, JM | 1 |
| Fulbright, RK | 1 |
| Ota, K | 1 |
| Kishida, S | 1 |
| Jones, BG | 1 |
| Fielding, JW | 1 |
| Newman, CE | 1 |
| Howell, A | 1 |
| Brookes, VS | 1 |
| Sutton, CH | 1 |
2 reviews available for fluorouracil and Brain Edema
| Article | Year |
|---|---|
Subacute reversible toxic encephalopathy related to treatment with capecitabine: a case report with literature review and discussion of pathophysiology.
Topics: Aged; Brain Edema; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Magnetic Resonance Imaging; Ma | 2014 |
[Drug-induced leukoencephalopathy].
Topics: Antineoplastic Agents; Brain Edema; Cisplatin; Cytarabine; Fluorouracil; Humans; Hypertensive Enceph | 2007 |
5 other studies available for fluorouracil and Brain Edema
| Article | Year |
|---|---|
Reversible cerebral edema and herniation caused by 5-fluorouracil-induced hyperammonemic encephalopathy.
Topics: Brain Edema; Fluorouracil; Humans; Hyperammonemia; Neurotoxicity Syndromes | 2023 |
Temporal lobe injury patterns following intensity modulated radiotherapy in a large cohort of nasopharyngeal carcinoma patients.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Edema; Cisplatin; Docetaxel; Female; Flu | 2018 |
Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
Topics: Adult; Aged; Antineoplastic Agents; Brain; Brain Edema; Capecitabine; Dementia, Vascular; Deoxycytid | 2008 |
Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C.
Topics: Adenocarcinoma; Adult; Anemia, Macrocytic; Brain Edema; Disseminated Intravascular Coagulation; Fema | 1980 |
Tumor hyperthermia in the treatment of malignant gliomas of the brain.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Dogs; Fluorouracil; Glioma; Hot Temperat | 1971 |