Page last updated: 2024-10-27

fluorouracil and Brain Diseases

fluorouracil has been researched along with Brain Diseases in 43 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Research Excerpts

ExcerptRelevanceReference
"Hyperammonemia or hyperammonemic leukoencephalopathy sometimes occurs as an adverse event after 5-fluorouracil (5-FU) chemotherapy."7.74The aggravating factors of hyperammonemia related to 5-fluorouracil infusion--a report of two cases. ( Asakage, T; Kikuta, S; Kubota, A; Nakao, K; Sugasawa, M, 2008)
"We observed leukoencephalopathy in 1 patient, and progressive dementia in another, during the administration of 5-fluorouracil (5-FU) and levamisole."7.69Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases. ( Dobranowski, J; Fawcet, SE; Figueredo, AT; Molloy, DW; Paulseth, JE, 1995)
"Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients."5.30Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999)
"We report a patient who developed multifocal cerebral demyelination with the use of 5-fluorouracil, levamisole, and leucovorin as adjuvant treatment for intestinal adenocarcinoma."4.79Cerebral demyelination with 5-fluorouracil and levamisole. ( Fassas, AB; Gattani, AM; Morgello, S, 1994)
"Hyperammonemia or hyperammonemic leukoencephalopathy sometimes occurs as an adverse event after 5-fluorouracil (5-FU) chemotherapy."3.74The aggravating factors of hyperammonemia related to 5-fluorouracil infusion--a report of two cases. ( Asakage, T; Kikuta, S; Kubota, A; Nakao, K; Sugasawa, M, 2008)
"Carmofur (1-hexylcarbamyl-5-fluorouracil), a derivative of 5-fluorouracil (5-FU), has been widely used in Japan as a postoperative adjuvant chemotherapy agent for colorectal and breast cancer."3.71Diffusion-weighted MR imaging of Carmofur-induced leukoencephalopathy. ( Fujikawa, A; Hachiya, J; Katase, S; Kurosaki, Y; Tsuchiya, K, 2001)
"We observed leukoencephalopathy in 1 patient, and progressive dementia in another, during the administration of 5-fluorouracil (5-FU) and levamisole."3.69Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases. ( Dobranowski, J; Fawcet, SE; Figueredo, AT; Molloy, DW; Paulseth, JE, 1995)
"The use of 5-fluorouracil (5-FU) and levamisole in patients with Stage III adenocarcinoma of the colon has now become standard."3.69Cerebral demyelination syndrome in a patient treated with 5-fluorouracil and levamisole. The use of thallium SPECT imaging to assist in noninvasive diagnosis--a case report. ( Gordon, J; Licho, R; Litofsky, NS; Ragland, R; Recht, L; Savarese, DM; Smith, TW, 1996)
" Hyperammonemia induced by 5-FU is relatively rare, with a reported incidence of 5-9%; however, caution is required with high dosage regimens of 5-FU that are currently recommended for colorectal cancer therapy because hyperammonemia is an important side effect."2.58[A Case of Recurrent Hyperammonemic Encephalopathy during Adjuvant Chemotherapy(Modified FOLFOX6)for Colorectal Cancer]. ( Funahashi, K; Kagami, S; Tamura, A; Yoshino, Y, 2018)
"Leucoencephalopathy caused by antineoplastic drugs was reviewed."2.44[Leukoencephalopathy caused by antineoplastic drugs]. ( Mizutani, T, 2008)
" Each chemotherapeutic drug has the potential to induce various adverse events in the patients receiving chemotherapy."2.41[Prevention and treatment for adverse events induced by chemotherapy]. ( Tsukuda, M, 2002)
"Because recurrent gastric cancer is often a progressive condition, post-treatment might be promptly transferred to the other posterior regimen without 5-FU as required."1.72[Hyperammonemic encephalopathy after treatment with modified FOLFOX6 regimen for recurrent gastric cancer:a case report]. ( Hirano, S; Ichinokawa, M; Kumagai, K; Kuwabara, S; Matsumoto, J; Murakawa, K; Ono, K; Takeuchi, Y; Wada, H, 2022)
"Idiopathic hyperammonemic encephalopathy is a rare complication of chemotherapy, which has previously mainly been associated with L-asparaginase, cytarabine and 5-FU."1.72Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment. ( Huitema, ADR; Otten, HM; Verkerk, K, 2022)
"Following the diagnosis of RS rectal cancer with muc, pT4a, N3(14/15), M1c, P1, pStage Ⅳc, RAS/BRAF: wild type, treatment was initiated with mFOLFOX6 plus panitumumab(Pmab)."1.62[A Case of Hyperammonemic Encephalopathy following mFOLFOX6 plus Panitumumab Therapy for Rectal Cancer]. ( Eguchi, S; Fukuoka, T; Iseki, Y; Lee, S; Miki, Y; Muguruma, K; Nagahara, H; Ohira, M; Shibutani, M; Tamura, T; Tanaka, H; Toyokawa, T; Tsujio, G; Yashiro, M; Yoshii, M, 2021)
"5-FU-induced hyperammonaemic encephalopathy started 2 [1-4] days after 5-FU infusion onset."1.565-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey. ( Boige, V; Boilève, A; Chouchana, L; Ducreux, M; Gaboriau, L; Hillaire-Buys, D; Hollebecque, A; Jozwiak, M; Lillo-Le Louët, A; Malka, D; Thomas, L, 2020)
"Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging."1.38Atypical diffusion-restricted lesion in 5-Fluorouracil encephalopathy. ( Kim, JS; Kwon, HM; Lee, WW; Son, KR, 2012)
"Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) chemotherapy and is licensed for the treatment of breast and gastrointestinal cancers."1.35Encephalopathy secondary to capecitabine chemotherapy: a case report and discussion. ( Kolluri, RB; Raouf, S; Tipples, K, 2009)
"First, the patient developed severe encephalopathy following a high-dose chemotherapy protocol commonly used in the treatment of metastatic breast carcinoma and second, the encephalopathy involved primarily deep gray matter structures rather than white matter."1.32Fatal chemotherapy-induced encephalopathy following high-dose therapy for metastatic breast cancer: a case report and review of the literature. ( Cossaart, N; Johnson, P; Preston, D; SantaCruz, KS; Skikne, BS, 2003)
"Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients."1.30Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999)
"Patients with decreased dihydropyrimidine dehydrogenase (DPD) activity are at increased risk for experiencing serious adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy."1.29Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. ( Allegra, CJ; Cantilena, LR; Chu, E; Diasio, RB; Grem, JL; Larson, LV; Liang, MD; Lu, ZH; Takimoto, CH; Zhang, R, 1996)
" Even so, HCFU should be dosed when needed in spite of this risk."1.27[A case of leukoencephalopathy caused by HCFU]. ( Abe, S; Kamata, H; Kisida, S; Miyagawa, N; Murakami, A; Nagano, H; Ueda, K; Yasui, H, 1988)
"A case of toxic leucoencephalopathy induced by 5 FU derivatives is reported."1.27[A case of toxic leucoencephalopathy induced by 5FU derivatives]. ( Ishijima, B; Mizutani, T; Morimatsu, Y; Sato, J; Yasue, M, 1985)
" Gastrointestinal and hematologic toxic effects were mild and infrequent."1.26High-dose allopurinol modulation of 5-FU toxicity: phase I trial of an outpatient dose schedule. ( Campbell, TN; House, BA; Howell, SB; Pfeifle, C, 1982)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19909 (20.93)18.7374
1990's11 (25.58)18.2507
2000's10 (23.26)29.6817
2010's7 (16.28)24.3611
2020's6 (13.95)2.80

Authors

AuthorsStudies
Kuwabara, S1
Murakawa, K1
Kumagai, K1
Takeuchi, Y1
Wada, H1
Ichinokawa, M1
Matsumoto, J1
Ono, K1
Hirano, S1
Tsujio, G1
Muguruma, K1
Eguchi, S1
Iseki, Y1
Miki, Y1
Yoshii, M1
Fukuoka, T1
Tamura, T1
Shibutani, M1
Nagahara, H1
Toyokawa, T1
Tanaka, H1
Lee, S1
Yashiro, M1
Ohira, M1
Furuyama, T1
Enjoji, M1
Yamato, M1
Kondo, I1
Hinokida, M1
Tatsutomi, Y1
Nakazawa, K1
Nagayama, K1
Ushirokoji, Y1
Verkerk, K1
Otten, HM1
Huitema, ADR1
Boilève, A2
Thomas, L1
Lillo-Le Louët, A1
Gaboriau, L1
Chouchana, L1
Ducreux, M2
Malka, D2
Boige, V1
Hollebecque, A2
Hillaire-Buys, D1
Jozwiak, M2
Yano, Y1
Kuriyama, A1
Miaris, N1
Sgouros, J1
Gerolympou, M1
Spyropoulos, B1
Drakopoulos, D1
Gkoura, S1
Res, H1
Samantas, E1
Nguyen, MT1
Stoianovici, R1
Brunetti, L1
Yoshino, Y1
Tamura, A1
Kagami, S1
Funahashi, K1
Wicker, C1
Verret, B1
Leroy, F1
Pontoizeau, C1
Ottolenghi, C1
De Lonlay, P1
Nakagami, R1
Yamaguchi, M1
Ezawa, K1
Kimura, S1
Hamamichi, S1
Sekine, N1
Furukawa, A1
Niitsu, M1
Fujii, H1
Tipples, K1
Kolluri, RB1
Raouf, S1
Advani, PP1
Fakih, MG1
Lee, WW1
Kim, JS1
Son, KR1
Kwon, HM1
Tsukuda, M1
Cossaart, N1
SantaCruz, KS1
Preston, D1
Johnson, P1
Skikne, BS1
Ishibashi, S1
Nishimura, H1
Mizusawa, H1
Lukaschek, J1
Nufer, M1
Maurer, D1
Asanger, M1
Honegger, H1
Widmer, L1
Malet-Martino, M1
Legay, R1
Martino, R1
Mémain, N1
Angellier, JF1
Obadia, E1
Angellier, E1
Chelha, R1
Couprie, R1
Kikuta, S1
Asakage, T1
Nakao, K1
Sugasawa, M1
Kubota, A1
Mizutani, T2
Maisin, H1
Anckaert, MA1
De Coster, BM1
Bertino, JR1
Campbell, TN1
Howell, SB1
Pfeifle, C1
House, BA1
Stéphan, F1
Etienne, MC1
Wallays, C1
Milano, G1
Clergue, F1
Figueredo, AT1
Fawcet, SE1
Molloy, DW1
Dobranowski, J1
Paulseth, JE1
Enterline, DS1
Davey, NC1
Tien, RD1
Yeh, KH2
Cheng, AL2
Fassas, AB1
Gattani, AM1
Morgello, S1
Savarese, DM1
Gordon, J1
Smith, TW1
Litofsky, NS1
Licho, R1
Ragland, R1
Recht, L1
Valik, D1
Takimoto, CH1
Lu, ZH1
Zhang, R1
Liang, MD1
Larson, LV1
Cantilena, LR1
Grem, JL1
Allegra, CJ1
Diasio, RB1
Chu, E1
Liaw, CC1
Wang, HM1
Wang, CH1
Yang, TS1
Chen, JS1
Chang, HK1
Lin, YC1
Liaw, SJ1
Yeh, CT1
Osako, Y1
Fujikawa, A1
Tsuchiya, K1
Katase, S1
Kurosaki, Y1
Hachiya, J1
Yamada, T1
Okamura, S1
Okazaki, T1
Ushiroyama, T1
Yanagawa, Y1
Ueki, M1
Sugimoto, O1
Yamazaki, H1
Sugino, M1
Masui, Y1
Fosså, SD1
Dahl, O1
Hoel, R1
Heier, M1
Loeb, M1
Kamata, H1
Murakami, A1
Miyagawa, N1
Yasui, H1
Nagano, H1
Abe, S1
Ueda, K1
Kisida, S1
Yasue, M1
Ishijima, B1
Sato, J1
Morimatsu, Y1
Weiss, HD1
Walker, MD1
Wiernik, PH1
Diem, E1
Fritsch, P1

Reviews

6 reviews available for fluorouracil and Brain Diseases

ArticleYear
[A Case of Recurrent Hyperammonemic Encephalopathy during Adjuvant Chemotherapy(Modified FOLFOX6)for Colorectal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2018, Volume: 45, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Chemotherapy, Adjuvant; Colon, Ascen

2018
[Prevention and treatment for adverse events induced by chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:7

    Topics: Anaphylaxis; Antineoplastic Agents; Brain Diseases; Cisplatin; Docetaxel; Fluorouracil; Humans; Neop

2002
[Leukoencephalopathy caused by antineoplastic drugs].
    Brain and nerve = Shinkei kenkyu no shinpo, 2008, Volume: 60, Issue:2

    Topics: Antineoplastic Agents; Brain Diseases; Fluorouracil

2008
Cerebral demyelination with 5-fluorouracil and levamisole.
    Cancer investigation, 1994, Volume: 12, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Colorec

1994
Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature.
    Asia-Oceania journal of obstetrics and gynaecology, 1989, Volume: 15, Issue:2

    Topics: Antineoplastic Agents; Brain Diseases; Female; Fluorouracil; Humans; Japan; Middle Aged

1989
Neurotoxicity of commonly used antineoplastic agents (first of two parts).
    The New England journal of medicine, 1974, 07-11, Volume: 291, Issue:2

    Topics: Animals; Antineoplastic Agents; Asparaginase; Brain; Brain Diseases; Fluorouracil; Humans; Leukemia;

1974

Other Studies

37 other studies available for fluorouracil and Brain Diseases

ArticleYear
[Hyperammonemic encephalopathy after treatment with modified FOLFOX6 regimen for recurrent gastric cancer:a case report].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2022, Volume: 119, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Female; Fluorouracil; Humans; Hypera

2022
[A Case of Hyperammonemic Encephalopathy following mFOLFOX6 plus Panitumumab Therapy for Rectal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2021, Volume: 48, Issue:13

    Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Fluorouracil; Hum

2021
[A Case of Severe Hyperammonemic Encephalopathy in a Dialysis Patient Following mFOLFOX6 Therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2021, Volume: 48, Issue:13

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Fluorouracil; Humans; Hyperamm

2021
Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment.
    Cancer chemotherapy and pharmacology, 2022, Volume: 90, Issue:5

    Topics: Antineoplastic Agents; Asparaginase; Brain Diseases; Cisplatin; Cytarabine; Deoxycytidine; Fluoroura

2022
5-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey.
    European journal of cancer (Oxford, England : 1990), 2020, Volume: 129

    Topics: Aged; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Citric Acid Cycle; Dose-Response Rel

2020
5-Fluorouracil-induced encephalopathy.
    Cleveland Clinic journal of medicine, 2020, Aug-31, Volume: 87, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Female; Fluorouracil; Humans;

2020
Posterior Reversible Encephalopathy Syndrome During Treatment with Aflibercept, 5-Fluorouracil, Leucovorin, and Irinotecan for Metastatic Colorectal Cancer.
    Journal of gastrointestinal cancer, 2019, Volume: 50, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Colorectal Neoplasms; Female; Fluoro

2019
Chemotherapy induced stroke mimic: 5-Fluorouracil encephalopathy fulfilling criteria for tissue plasminogen activator therapy.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aphasia; Brain Dise

2017
5-Fluorouracil rechallenge after 5-fluorouracil-induced hyperammonemic encephalopathy.
    Anti-cancer drugs, 2019, Volume: 30, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Diseases; Female; Fluorour

2019
Recovery correction technique for NMR spectroscopy of perchloric acid extracts using DL-valine-2,3-d2: validation and application to 5-fluorouracil-induced brain damage.
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2014, Volume: 13, Issue:3

    Topics: Animals; Brain; Brain Diseases; Creatine; Fluorouracil; Magnetic Resonance Spectroscopy; Perchlorate

2014
Encephalopathy secondary to capecitabine chemotherapy: a case report and discussion.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2009, Volume: 15, Issue:4

    Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents;

2009
5-FU-induced hyperammonemic encephalopathy in a case of metastatic rectal adenocarcinoid successfully rechallenged with the fluoropyrimidine analog, capecitabine.
    Anticancer research, 2011, Volume: 31, Issue:1

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Brain Diseases; Capecitabine; Deoxycytidine;

2011
Atypical diffusion-restricted lesion in 5-Fluorouracil encephalopathy.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:7

    Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases; Diffusion Magnetic Resonance Imaging; Fluoro

2012
Fatal chemotherapy-induced encephalopathy following high-dose therapy for metastatic breast cancer: a case report and review of the literature.
    Bone marrow transplantation, 2003, Volume: 31, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain; Brain Diseases; Breast Neoplas

2003
5-FU-induced acute leukoencephalopathy.
    Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:10

    Topics: Acute Disease; Adenocarcinoma; Antimetabolites, Antineoplastic; Brain Diseases; Colonic Neoplasms; F

2004
Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Dec-15, Volume: 22, Issue:24

    Topics: Acetaldehyde; Aged; Antimetabolites, Antineoplastic; Brain Diseases; Carcinoma; Chemistry, Pharmaceu

2004
[Fatal acute encephalopathy due to 5-fluorouracil treatment].
    Presse medicale (Paris, France : 1983), 2005, Dec-03, Volume: 34, Issue:21

    Topics: Acute Disease; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brai

2005
The aggravating factors of hyperammonemia related to 5-fluorouracil infusion--a report of two cases.
    Auris, nasus, larynx, 2008, Volume: 35, Issue:2

    Topics: Brain Diseases; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Fluorouracil; Humans; Hypera

2008
[Combination chemotherapy and radiotherapy. Differential effect, on the medullary syndrome, of fractionated irradiation with fractionated drug administration].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1982, Volume: 176, Issue:1

    Topics: Animals; Brain Diseases; Disease Models, Animal; Drug Administration Schedule; Female; Fluorouracil;

1982
Clinical use of methotrexate--with emphasis on use of high doses.
    Cancer treatment reports, 1981, Volume: 65 Suppl 1

    Topics: Animals; Asparaginase; Brain Diseases; Child, Preschool; Cisplatin; Cytarabine; Drug Administration

1981
High-dose allopurinol modulation of 5-FU toxicity: phase I trial of an outpatient dose schedule.
    Cancer treatment reports, 1982, Volume: 66, Issue:9

    Topics: Adenocarcinoma; Aged; Allopurinol; Brain Diseases; Drug Administration Schedule; Drug Evaluation; Dr

1982
Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities.
    The American journal of medicine, 1995, Volume: 99, Issue:6

    Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Brain Diseases; Cecal Neoplasms; Dihydrourac

1995
Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases.
    Cancer investigation, 1995, Volume: 13, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Diseases; Chemoth

1995
Neuroradiology case of the day. Multifocal inflammatory leukoencephalopathy due to treatment with 5-fluorouracil and levamisole.
    AJR. American journal of roentgenology, 1995, Volume: 165, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Colonic Neoplasms; Demyelinating Dis

1995
Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 1994, Volume: 93, Issue:8

    Topics: Acute Disease; Brain Diseases; Coma; Confusion; Fluorouracil; Humans; Leucovorin; Male; Middle Aged

1994
Cerebral demyelination syndrome in a patient treated with 5-fluorouracil and levamisole. The use of thallium SPECT imaging to assist in noninvasive diagnosis--a case report.
    Cancer, 1996, Jan-15, Volume: 77, Issue:2

    Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Brain Diseases; Colonic Neoplasms; Demyelinati

1996
High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy.
    British journal of cancer, 1997, Volume: 75, Issue:3

    Topics: Acidosis; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Coma; Diagnosis, Differential; E

1997
Encephalopathy, lactic acidosis, hyperammonaemia and 5-fluorouracil toxicity.
    British journal of cancer, 1998, Volume: 77, Issue:10

    Topics: Acidosis, Lactic; Ammonia; Brain Diseases; Chemical and Drug Induced Liver Injury; Citric Acid Cycle

1998
Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:3

    Topics: Brain Diseases; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Male; Middle Aged; Oxidore

1996
Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.
    Anti-cancer drugs, 1999, Volume: 10, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Bacterial Infections; Brain Diseases; Dehydration; Fem

1999
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1999. Neurologic disorder in a 65-year-old man after treatment of colon cancer.
    The New England journal of medicine, 1999, Aug-12, Volume: 341, Issue:7

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Diseases; Cogniti

1999
[A case of reversible carmofur-induced leukoencephalopathy].
    No to shinkei = Brain and nerve, 2001, Volume: 53, Issue:10

    Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Breast Neoplasms; Female; Fluorouracil; Humans;

2001
Diffusion-weighted MR imaging of Carmofur-induced leukoencephalopathy.
    European radiology, 2001, Volume: 11, Issue:12

    Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Breast Neoplasms; Carcinoma, Ductal, Breast; Ch

2001
Doxifluridine (5'-dFUrd) in patients with advanced colorectal carcinoma. A phase II study.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: Angina Pectoris; Brain Diseases; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Evaluation; Elect

1985
[A case of leukoencephalopathy caused by HCFU].
    Gan no rinsho. Japan journal of cancer clinics, 1988, Volume: 34, Issue:6

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; B

1988
[A case of toxic leucoencephalopathy induced by 5FU derivatives].
    No shinkei geka. Neurological surgery, 1985, Volume: 13, Issue:11

    Topics: Antineoplastic Agents; Brain; Brain Diseases; Breast Neoplasms; Female; Fluorouracil; Humans; Middle

1985
[Xeroderma pigmentosum, universal alopecia and associated neuro-ocular symptoms].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:5

    Topics: Administration, Topical; Alopecia; Brain Diseases; Fluorouracil; Glaucoma; Humans; Male; Middle Aged

1973