fluorouracil has been researched along with Bradyarrhythmia in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) is a commonly used anti-neoplastic agent." | 6.47 | Symptomatic 5-fluorouracil-induced sinus bradycardia. ( Lee, AD; McKay, MJ, 2011) |
| "A 78-year-old man with Stage III esophageal cancer was referred to our hospital." | 5.42 | [A Case of Severe Bradycardia Induced by Combination Chemotherapy with Cisplatin and 5-Fluorouracil]. ( Kawamori, H; Kusunoki, N; Nakajima, T; Ohno, M; Takase, S; Yamazaki, Y, 2015) |
| "5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens." | 5.30 | Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998) |
| "Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) which is converted in tumor cells to 5-FU by the enzyme thymidine phosphorylase." | 2.48 | Capecitabine induced cardiotoxicity: a case report and review of literature. ( Hashmi, A; Shoaib, M; Tunio, MA, 2012) |
| "5-Fluorouracil (5-FU) is a commonly used anti-neoplastic agent." | 2.47 | Symptomatic 5-fluorouracil-induced sinus bradycardia. ( Lee, AD; McKay, MJ, 2011) |
| "A 78-year-old man with Stage III esophageal cancer was referred to our hospital." | 1.42 | [A Case of Severe Bradycardia Induced by Combination Chemotherapy with Cisplatin and 5-Fluorouracil]. ( Kawamori, H; Kusunoki, N; Nakajima, T; Ohno, M; Takase, S; Yamazaki, Y, 2015) |
| "5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens." | 1.30 | Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakajima, T | 1 |
| Kawamori, H | 1 |
| Ohno, M | 1 |
| Kusunoki, N | 1 |
| Yamazaki, Y | 1 |
| Takase, S | 1 |
| Lee, AD | 1 |
| McKay, MJ | 1 |
| Tunio, MA | 1 |
| Hashmi, A | 1 |
| Shoaib, M | 1 |
| Khan, MA | 1 |
| Masood, N | 1 |
| Husain, N | 1 |
| Ahmad, B | 1 |
| Aziz, T | 1 |
| Naeem, A | 1 |
| Aziz, SA | 1 |
| Tramboo, NA | 1 |
| Mohi-ud-Din, K | 1 |
| Iqbal, K | 1 |
| Jalal, S | 1 |
| Ahmad, M | 1 |
| Schneider, M | 1 |
| Schneider, G | 1 |
2 reviews available for fluorouracil and Bradyarrhythmia
| Article | Year |
|---|---|
Symptomatic 5-fluorouracil-induced sinus bradycardia.
Topics: Antimetabolites, Antineoplastic; Arrhythmia, Sinus; Bradycardia; Fluorouracil; Humans; Infusions, In | 2011 |
Capecitabine induced cardiotoxicity: a case report and review of literature.
Topics: Antimetabolites, Antineoplastic; Bradycardia; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Mal | 2012 |
4 other studies available for fluorouracil and Bradyarrhythmia
| Article | Year |
|---|---|
[A Case of Severe Bradycardia Induced by Combination Chemotherapy with Cisplatin and 5-Fluorouracil].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bradycardia; Cisplatin; Combined Modality Ther | 2015 |
A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bradycardia; | 2012 |
Supraventricular arrhythmia: a complication of 5-fluorouracil therapy.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atr | 1998 |
[Bradyarrhythmia after chemotherapy with 5-fluorouracil].
Topics: Aged; Antimetabolites, Antineoplastic; Bradycardia; Female; Fluorouracil; Humans; Male | 2002 |