fluorouracil has been researched along with Bone Marrow Neoplasms in 21 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "MAI (≥ 10) was strongly associated with breast cancer-related death in lymph node (LN)-negative patients (hazard ratio (HR): 7." | 2.76 | Mitotic activity and bone marrow micrometastases have independent prognostic value in node positive breast cancer patients. ( Baak, JP; Gilje, B; Janssen, EA; Nordgård, O; Smaaland, R; Søiland, H; Tjensvoll, K, 2011) |
| "Febrile neutropenia was observed in 10% of patients and 2." | 2.70 | Docetaxel, 5-fluorouracil, and leucovorin as treatment for advanced gastric cancer: results of a phase II study. ( Campos, B; Carrete, N; Constenla, M; Garcia-Arroyo, R; Lorenzo, I; Palacios, P, 2002) |
| "Women with resected T1-3N1,2 primary breast cancer and > or = 10 positive axillary lymph nodes referred for possible trial participation were evaluated for this report." | 2.68 | Outcome of extensive evaluation before adjuvant therapy in women with breast cancer and 10 or more positive axillary lymph nodes. ( Crump, M; Girouard, C; Goss, PE; Prince, M, 1996) |
| "Moreover, circulating tumor cells were demonstrated by flow cytometry." | 1.38 | [Severe hemorrhage in a patient with metastatic colorectal cancer - case 8/2012]. ( Horger, M; Jaschonek, K; Kanz, L; Kopp, HG; Kurth, R; Mayer, F; Orgel, M, 2012) |
| "Brain MRI revealed a subdural hematoma, and he was transferred to the Department of Neurosurgery of our hospital." | 1.37 | [A case of gastric cancer accompanied by disseminated carcinomatosis of bone marrow with DIC, and subdural hematoma successfully treated with sequential methotrexate and 5-fluorouracil therapy]. ( Dairaku, N; Iwahashi, S; Maejima, R; Narisawa, A; Shimada, N; Yamagiwa, T, 2011) |
| "It is said that disseminated carcinomatosis of the bone marrow has a poor prognosis, but we were able to obtain a good response in this case by chemotherapy." | 1.37 | [Successful chemotherapy of carcinomatosis of the bone marrow with disseminated intravascular coagulation from a rectal carcinoma found by eosinophilia]. ( Abiko, S; Gotoh, J; Higashiyama, A; Kawamura, A; Kawamura, N; Kudo, M; Meguro, J; Nagasako, T; Takano, M; Tamaki, T; Tanino, M; Yamamoto, Y; Yonekawa, M, 2011) |
| "Blood test showed severe disseminated intravascular coagulation (DIC)." | 1.36 | [mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report]. ( Doi, M; Okamoto, Y; Shinozaki, K; Yamauchi, M, 2010) |
| "Endoscopy revealed gastric cancer with pyloric stenosis and MRI showed multiple metastasis of thoracic vertebral body." | 1.35 | [A case of gastric cancer accompanied by disseminated carcinomatosis of bone marrow with DIC recovered by sequential therapy consisting of MTX and 5-FU]. ( Akazai, Y; Kimura, T; Seita, M; Takahata, T; Yasuda, K, 2008) |
| "Final diagnosis stated a multilocular metastasising gastric cancer with infiltration of bone, peritoneum and dura and signet-cell infiltration of the bone marrow." | 1.31 | [Hemorrhagic diathesis as initial symptom of stomach carcinoma]. ( Dempke, W; Kellner, O; Schmoll, HJ; von Poblozki, A; Wolf, HH, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Xiaohui, Z | 1 |
| Shanshan, L | 1 |
| Taiyuan, C | 1 |
| Ge, D | 1 |
| Hongen, Y | 1 |
| Lishuo, S | 1 |
| Xiaoru, L | 1 |
| Wanjia, H | 1 |
| Jian, X | 1 |
| Yamazaki, K | 1 |
| Katsumura, N | 1 |
| Ozawa, N | 1 |
| Ogiso, H | 1 |
| Hanai, Y | 1 |
| Otsuji, K | 1 |
| Toda, K | 1 |
| Morino, K | 1 |
| Mori, Y | 1 |
| Araki, H | 1 |
| Moriwaki, H | 1 |
| Amano, K | 1 |
| Nakata, K | 1 |
| Tsujie, M | 1 |
| Sasamatsu, S | 1 |
| Nishi, H | 1 |
| Hiraki, Y | 1 |
| Shimizu, K | 1 |
| Ebihara, T | 1 |
| Kato, F | 1 |
| Hoshino, H | 1 |
| Mikami, J | 1 |
| Usui, A | 1 |
| Yamamoto, T | 1 |
| Ikeda, N | 1 |
| Kimura, Y | 1 |
| Yasuda, K | 1 |
| Kimura, T | 1 |
| Seita, M | 1 |
| Takahata, T | 1 |
| Akazai, Y | 1 |
| Kadikoylu, G | 1 |
| Barutca, S | 1 |
| Tataroglu, C | 1 |
| Kafkas, S | 1 |
| Erpek, H | 1 |
| Meydan, N | 1 |
| Yavasoglu, I | 1 |
| Bolaman, Z | 1 |
| Nonaka, K | 2 |
| Sha, S | 1 |
| Ito, M | 1 |
| Yamanaka, N | 1 |
| Yamauchi, M | 1 |
| Okamoto, Y | 1 |
| Doi, M | 1 |
| Shinozaki, K | 1 |
| Gilje, B | 1 |
| Nordgård, O | 1 |
| Tjensvoll, K | 1 |
| Janssen, EA | 1 |
| Søiland, H | 1 |
| Smaaland, R | 1 |
| Baak, JP | 1 |
| Takai, H | 1 |
| Kondoh, E | 1 |
| Sato, Y | 1 |
| Kakui, K | 1 |
| Tatsumi, K | 1 |
| Konishi, I | 1 |
| Yamagiwa, T | 1 |
| Maejima, R | 1 |
| Shimada, N | 1 |
| Dairaku, N | 1 |
| Narisawa, A | 1 |
| Iwahashi, S | 1 |
| Higashiyama, A | 1 |
| Kudo, M | 1 |
| Nagasako, T | 1 |
| Kawamura, N | 1 |
| Abiko, S | 1 |
| Yamamoto, Y | 1 |
| Takano, M | 1 |
| Gotoh, J | 1 |
| Tamaki, T | 1 |
| Meguro, J | 1 |
| Yonekawa, M | 1 |
| Kawamura, A | 1 |
| Tanino, M | 1 |
| Isozaki, Y | 1 |
| Yamanishi, M | 1 |
| Utsunomiya, S | 1 |
| Yamaguchi, S | 1 |
| Okita, M | 1 |
| Matsumoto, N | 1 |
| Nagao, Y | 1 |
| Oyamada, H | 1 |
| Kokura, S | 1 |
| Naito, Y | 1 |
| Yoshikawa, T | 1 |
| Ferrand, FR | 1 |
| Gontier, E | 1 |
| Guymar, S | 1 |
| Fagot, T | 1 |
| Ceccaldi, B | 1 |
| Malfuson, JV | 1 |
| de Revel, T | 1 |
| Orgel, M | 1 |
| Horger, M | 1 |
| Kurth, R | 1 |
| Kanz, L | 1 |
| Jaschonek, K | 1 |
| Mayer, F | 1 |
| Kopp, HG | 1 |
| Constenla, M | 1 |
| Garcia-Arroyo, R | 1 |
| Lorenzo, I | 1 |
| Carrete, N | 1 |
| Campos, B | 1 |
| Palacios, P | 1 |
| Nabeshima, S | 1 |
| Kishihara, Y | 1 |
| Nabeshima, A | 1 |
| Yamaga, S | 1 |
| Kinjo, M | 1 |
| Kashiwagi, S | 1 |
| Hayashi, J | 1 |
| Satoh, D | 1 |
| Ninomiya, M | 1 |
| Umeoka, T | 1 |
| Harano, M | 1 |
| Sasaki, H | 1 |
| Aoki, H | 1 |
| Onoda, T | 1 |
| Shiozaki, Y | 1 |
| Ohno, S | 1 |
| Higaki, K | 1 |
| Takakura, N | 1 |
| Tokar, M | 1 |
| Bobilev, D | 1 |
| Ariad, S | 1 |
| Geffen, DB | 1 |
| Crump, M | 1 |
| Goss, PE | 1 |
| Prince, M | 1 |
| Girouard, C | 1 |
| Noda, N | 1 |
| Sano, T | 1 |
| Shirao, K | 1 |
| Ono, H | 1 |
| Katai, H | 1 |
| Sasako, M | 1 |
| Maruyama, K | 1 |
| Dempke, W | 1 |
| von Poblozki, A | 1 |
| Kellner, O | 1 |
| Wolf, HH | 1 |
| Schmoll, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Infusional Fluorouracil and Weekly Docetaxel as First-line Therapy for Gastric Cancer With Bone Marrow Metastasis and Disseminated Intravascular Coagulation: a Multi-center, Phase II Trail[NCT04547153] | Phase 2 | 24 participants (Actual) | Interventional | 2021-01-15 | Completed | ||
| A Randomized Phase II Study of Capecitabine and Cisplatin (XP) +/- Sorafenib (Nexavar®) in Patients With Advanced Gastric Cancer[NCT01187212] | Phase 2 | 195 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and Bone Marrow Neoplasms
| Article | Year |
|---|---|
Docetaxel and fluorouracil as first-line therapy for gastric cancer with bone marrow metastasis and disseminated intravascular coagulation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Clinical Trials as Topic; Dis | 2022 |
[A case of mucinous adenocarcinoma of the sigmoid colon with disseminated carcinomatosis of the bone marrow successfully treated with FOLFOX4/bevacizumab].
Topics: Adenocarcinoma, Mucinous; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemother | 2013 |
[A case of poorly differentiated adenocarcinoma of the rectum with disseminated carcinomatosis of the bone marrow successfully treated with mFOLFOX-6/bevacizumab].
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C | 2010 |
3 trials available for fluorouracil and Bone Marrow Neoplasms
| Article | Year |
|---|---|
Mitotic activity and bone marrow micrometastases have independent prognostic value in node positive breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasm | 2011 |
Docetaxel, 5-fluorouracil, and leucovorin as treatment for advanced gastric cancer: results of a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Disease Progress | 2002 |
Outcome of extensive evaluation before adjuvant therapy in women with breast cancer and 10 or more positive axillary lymph nodes.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow Neoplasms; Bone Marrow Tr | 1996 |
15 other studies available for fluorouracil and Bone Marrow Neoplasms
| Article | Year |
|---|---|
[A Case of Disseminated Carcinomatosis of the Bone Marrow with Disseminated Intravascular Coagulation Caused by Cecal Cancer Successfully Treated with mFOLFOX6].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Bone Marrow Neoplasms; | 2015 |
[A case of gastric cancer accompanied by disseminated carcinomatosis of bone marrow with DIC recovered by sequential therapy consisting of MTX and 5-FU].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow Neoplasms; Carcinoembryoni | 2008 |
Thrombotic thrombocytopenic purpura as the first manifestation of metastatic adenocarcinoma in a young woman.
Topics: Abdomen, Acute; Adenocarcinoma, Mucinous; Adult; Antineoplastic Combined Chemotherapy Protocols; Bio | 2010 |
[mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Bone Marrow Ne | 2010 |
Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Carcinoma, Signet Ring | 2011 |
[A case of gastric cancer accompanied by disseminated carcinomatosis of bone marrow with DIC, and subdural hematoma successfully treated with sequential methotrexate and 5-fluorouracil therapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Disseminated Intravasc | 2011 |
[Successful chemotherapy of carcinomatosis of the bone marrow with disseminated intravascular coagulation from a rectal carcinoma found by eosinophilia].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Carcino | 2011 |
[A case of disseminated carcinomatosis of bone marrow with disseminated intravascular coagulation caused by advanced colon cancer treated by mFOLFOX6].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Colonic Neoplasms; Disseminat | 2011 |
Effectiveness and safe use of modified FOLFOX-6 for metastatic gastric cancer with signet ring cell components complicated by disseminated intravascular coagulation and diffuse bone marrow carcinomatosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Carcinoma; Carcinoma, Signet | 2012 |
[Severe hemorrhage in a patient with metastatic colorectal cancer - case 8/2012].
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherap | 2012 |
Poorly differentiated adenocarcinoma with signet-ring cells of the Vater's ampulla, without jaundice but with disseminated carcinomatosis.
Topics: Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Carcinoma, | 2003 |
[A case of progressive gastric carcinoma accompanied by disseminated carcinomatosis of bone marrow due to bone metastasis with DIC recovery by joint administration of 5-FU and paclitaxel].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Bo | 2006 |
Disseminated intravascular coagulation at presentation of advanced gastric cancer.
Topics: Acute Disease; Adult; Antimetabolites, Antineoplastic; Bone Marrow Neoplasms; Cisplatin; Disease Pro | 2006 |
A case of bone marrow recurrence from gastric carcinoma after a nine-year disease-free interval.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Carcinoma, Signet Ring Cell; | 1996 |
[Hemorrhagic diathesis as initial symptom of stomach carcinoma].
Topics: Algorithms; Anemia, Hemolytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplasti | 2000 |