fluorouracil has been researched along with Bone Loss, Osteoclastic in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osteoporosis is of concern in breast cancer patients who are undergoing chemotherapy." | 2.75 | Combination of radiological and biochemical methods to assess bone mineral density of mandible in fully edentulous patients after chemotherapy: a 5-year prospective study. ( Cheung, MN; Chow, LW; Jin, LJ; Loo, WT; Wang, M, 2010) |
| "45 premenopausal women with early stage breast cancer were treated with adjuvant chemotherapy." | 2.71 | Short-term intermittent intravenous clodronate in the prevention of bone loss related to chemotherapy-induced ovarian failure. ( Blomqvist, C; Elomaa, I; Risteli, J; Risteli, L; Saarto, T; Vehmanen, L, 2004) |
| "77." | 1.33 | Osteoprotegerin and bone mass in squamous cell head and neck cancer patients. ( Hernández, JL; Macías, JG; Olmos, JM; Rivera, F; Valero, C; Vega, ME, 2006) |
| "Measuring a bone resorption marker, ICTP, allows clinicians to monitor patients' responses to CAF therapy and may prevent prolonged ineffective therapy or unnecessary changes in therapy as a result of the flare phenomenon." | 1.30 | Bone metabolic markers in the evaluation of bone scan flare phenomenon in bone metastases of breast cancer. ( Koizumi, M; Matsumoto, S; Ogata, E; Takahashi, S; Yamashita, T, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tabuchi, Y | 1 |
| Ando, Y | 1 |
| Kanemura, H | 1 |
| Kawasaki, I | 1 |
| Ohishi, T | 1 |
| Koida, M | 1 |
| Fukuyama, R | 1 |
| Nakamuta, H | 1 |
| Ohta, S | 1 |
| Nishide, K | 1 |
| Ohishi, Y | 1 |
| Song, D | 1 |
| Meng, T | 1 |
| Xu, W | 1 |
| Hou, T | 1 |
| Lin, Z | 1 |
| Yin, H | 1 |
| Li, B | 1 |
| Zhou, L | 1 |
| Wang, T | 1 |
| Han, S | 1 |
| Fan, T | 1 |
| Miao, W | 1 |
| Liu, M | 1 |
| Luo, J | 1 |
| Zhou, W | 1 |
| Li, Z | 1 |
| Xiao, J | 1 |
| Schem, C | 1 |
| Tower, RJ | 1 |
| Kneissl, P | 1 |
| Rambow, AC | 1 |
| Campbell, GM | 1 |
| Desel, C | 1 |
| Damm, T | 1 |
| Heilmann, T | 1 |
| Fuchs, S | 1 |
| Zuhayra, M | 1 |
| Trauzold, A | 1 |
| Glüer, CC | 1 |
| Schott, S | 1 |
| Tiwari, S | 1 |
| Loo, WT | 1 |
| Jin, LJ | 1 |
| Cheung, MN | 1 |
| Chow, LW | 1 |
| Wang, M | 1 |
| Raghu Nadhanan, R | 1 |
| Abimosleh, SM | 1 |
| Su, YW | 1 |
| Scherer, MA | 1 |
| Howarth, GS | 1 |
| Xian, CJ | 1 |
| Vehmanen, L | 1 |
| Saarto, T | 1 |
| Risteli, J | 1 |
| Risteli, L | 1 |
| Blomqvist, C | 1 |
| Elomaa, I | 1 |
| Valero, C | 1 |
| Olmos, JM | 1 |
| Rivera, F | 1 |
| Hernández, JL | 1 |
| Vega, ME | 1 |
| Macías, JG | 1 |
| Body, JJ | 1 |
| Koizumi, M | 1 |
| Matsumoto, S | 1 |
| Takahashi, S | 1 |
| Yamashita, T | 1 |
| Ogata, E | 1 |
| Mochizuki, H | 1 |
| Hakeda, Y | 1 |
| Wakatsuki, N | 1 |
| Usui, N | 1 |
| Akashi, S | 1 |
| Sato, T | 1 |
| Tanaka, K | 1 |
| Kumegawa, M | 1 |
2 trials available for fluorouracil and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Combination of radiological and biochemical methods to assess bone mineral density of mandible in fully edentulous patients after chemotherapy: a 5-year prospective study.
Topics: Absorptiometry, Photon; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Bone Res | 2010 |
Short-term intermittent intravenous clodronate in the prevention of bone loss related to chemotherapy-induced ovarian failure.
Topics: Adult; Antimetabolites; Antineoplastic Combined Chemotherapy Protocols; Bone Resorption; Breast Neop | 2004 |
8 other studies available for fluorouracil and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Preparation of novel (Z)-4-ylidenebenzo[b]furo[3,2-d][1,3]oxazines and their biological activity.
Topics: Animals; Antineoplastic Agents; Bone Resorption; Breast Neoplasms; Cell Line, Tumor; Cell Proliferat | 2009 |
5-Fluoruracil blocked giant cell tumor progression by suppressing osteoclastogenesis through NF-kappaB signals and blocking angiogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Resorption; Cell Differentiation; Cell Lineage; Chemo | 2015 |
Pharmacologically Inactive Bisphosphonates as an Alternative Strategy for Targeting Osteoclasts: In Vivo Assessment of 5-Fluorodeoxyuridine-Alendronate in a Preclinical Model of Breast Cancer Bone Metastases.
Topics: Alendronate; Animals; Apoptosis; Biomarkers, Tumor; Bone Neoplasms; Bone Resorption; Caspases; Cell | 2017 |
Dietary emu oil supplementation suppresses 5-fluorouracil chemotherapy-induced inflammation, osteoclast formation, and bone loss.
Topics: Animals; Antimetabolites, Antineoplastic; Bone and Bones; Bone Resorption; Caseins; Diet; Dietary Fa | 2012 |
Osteoprotegerin and bone mass in squamous cell head and neck cancer patients.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bone Density; Bone Matrix; Bone Remode | 2006 |
Low-dose prednisone and increased risk of development of bone metastases.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Bon | 1996 |
Bone metabolic markers in the evaluation of bone scan flare phenomenon in bone metastases of breast cancer.
Topics: Adult; Alkaline Phosphatase; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineopl | 1999 |
Insulin-like growth factor-I supports formation and activation of osteoclasts.
Topics: Animals; Bone Resorption; Calcitriol; Cell Survival; Cells, Cultured; Dose-Response Relationship, Dr | 1992 |