Page last updated: 2024-10-27

fluorouracil and Bone Diseases, Metabolic

fluorouracil has been researched along with Bone Diseases, Metabolic in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Bone Diseases, Metabolic: Diseases that affect the METABOLIC PROCESSES of BONE TISSUE.

Research Excerpts

ExcerptRelevanceReference
" A postmenopausal woman was treated for stage II breast cancer with a modified radical mastectomy and adjuvant cyclophosphamide, doxorubicin, and 5-flurouracil followed by tamoxifen for 5 years."3.72Raloxifene rebound regression. ( Dosik, M; Kaufman, R, 2004)
"Grade ≥ 3 neutropenia was significantly more common in patients with than without osteopenia (p = 0."1.72Impact of osteopenia and neutropenia in patients with colorectal cancer treated with FOLFOXIRI: a retrospective cohort study. ( Kashihara, H; Nakao, T; Nishi, M; Shimada, M; Takasu, C; Tokunaga, T; Wada, Y; Yamashita, S; Yoshikawa, K; Yoshimoto, T, 2022)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Nakao, T1
Shimada, M1
Yoshikawa, K1
Tokunaga, T1
Nishi, M1
Kashihara, H1
Takasu, C1
Wada, Y1
Yoshimoto, T1
Yamashita, S1
Greenbaum, AM1
Revollo, LD1
Woloszynek, JR1
Civitelli, R1
Link, DC1
Dosik, M1
Kaufman, R1

Other Studies

3 other studies available for fluorouracil and Bone Diseases, Metabolic

ArticleYear
Impact of osteopenia and neutropenia in patients with colorectal cancer treated with FOLFOXIRI: a retrospective cohort study.
    International journal of clinical oncology, 2022, Volume: 27, Issue:9

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Diseases, M

2022
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.
    Blood, 2012, Jul-12, Volume: 120, Issue:2

    Topics: Animals; Base Sequence; Bone Diseases, Metabolic; Cadherins; Cell Lineage; Female; Fluorouracil; Gra

2012
Raloxifene rebound regression.
    Cancer investigation, 2004, Volume: 22, Issue:5

    Topics: Antineoplastic Agents; Bone Diseases, Metabolic; Breast Neoplasms; Carcinoma, Ductal; Cyclophosphami

2004