fluorouracil has been researched along with Body Weight, Fetal in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment." | 1.31 | Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data. ( Cameron, AM; Copeland, MF; Ellis, DH; Kavlock, RJ; Lau, C; Logsdon, TR; Merriman, J; Mole, ML; Rogers, JM; Setzer, RW; Shuey, DL, 2001) |
| "Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk assessments." | 1.31 | Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct. ( Copeland, MF; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lau, C | 2 |
| Mole, ML | 2 |
| Copeland, MF | 2 |
| Rogers, JM | 2 |
| Kavlock, RJ | 2 |
| Shuey, DL | 1 |
| Cameron, AM | 1 |
| Ellis, DH | 1 |
| Logsdon, TR | 1 |
| Merriman, J | 1 |
| Setzer, RW | 2 |
2 other studies available for fluorouracil and Body Weight, Fetal
| Article | Year |
|---|---|
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data.
Topics: Abnormalities, Drug-Induced; Animals; Cell Cycle; Deoxyribonucleotides; DNA; Dose-Response Relations | 2001 |
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct.
Topics: Abnormalities, Drug-Induced; Animals; Area Under Curve; Deoxyribonucleotides; Dose-Response Relation | 2001 |