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fluorouracil and Blood Pressure, Low

fluorouracil has been researched along with Blood Pressure, Low in 15 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"To determine whether adding bevacizumab, with or without mitomycin, to capecitabine monotherapy improves progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC) in an open-label, three-arm randomized trial."9.14Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study. ( Ackland, SP; Broad, A; Chua, Y; Cummins, MM; Cunningham, D; Forgeson, G; Ganju, V; Gebski, VJ; Price, TJ; Robinson, B; Saunders, MP; Simes, RJ; Stockler, MR; Tebbutt, NC; van Hazel, GA; Wilson, K; Zalcberg, JR; Zannino, D, 2010)
"To determine the plasma pharmacokinetics and the maximum-tolerated dose (MTD) of intravenous (IV) azidothymidine (AZT) administered 90 to 120 minutes after fluorouracil (5-FU) and leucovorin and to preliminarily evaluate the antitumor activity of this combination in metastatic colorectal cancer."9.08Intravenous azidothymidine with fluorouracil and leucovorin: a phase I-II study in previously untreated metastatic colorectal cancer patients. ( Brunetti, I; Conte, PF; Danesi, R; Dargenio, F; Del Tacca, M; Falcone, A; Nethersell, AB; Pfanner, E, 1996)
"Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU)."7.67Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil. ( Jakubowski, AA; Kemeny, N, 1988)
"Sixteen patients with metastatic colorectal cancer have been treated with a regimen involving an 120 h continuous infusion of rIL-2, 18 x 10(6) iu m-2 day followed by three injections of 5FU 600 mg m-2 at weekly intervals."6.67A phase-III study of recombinant interleukin 2 and 5-fluorouracil chemotherapy in patients with metastatic colorectal cancer. ( Franks, CR; Hamblin, TJ; Oskam, R; Palmer, P; Sadullah, S; Stevenson, J; Williamson, P, 1993)
"To determine whether adding bevacizumab, with or without mitomycin, to capecitabine monotherapy improves progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC) in an open-label, three-arm randomized trial."5.14Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study. ( Ackland, SP; Broad, A; Chua, Y; Cummins, MM; Cunningham, D; Forgeson, G; Ganju, V; Gebski, VJ; Price, TJ; Robinson, B; Saunders, MP; Simes, RJ; Stockler, MR; Tebbutt, NC; van Hazel, GA; Wilson, K; Zalcberg, JR; Zannino, D, 2010)
"To determine the plasma pharmacokinetics and the maximum-tolerated dose (MTD) of intravenous (IV) azidothymidine (AZT) administered 90 to 120 minutes after fluorouracil (5-FU) and leucovorin and to preliminarily evaluate the antitumor activity of this combination in metastatic colorectal cancer."5.08Intravenous azidothymidine with fluorouracil and leucovorin: a phase I-II study in previously untreated metastatic colorectal cancer patients. ( Brunetti, I; Conte, PF; Danesi, R; Dargenio, F; Del Tacca, M; Falcone, A; Nethersell, AB; Pfanner, E, 1996)
"Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU)."3.67Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil. ( Jakubowski, AA; Kemeny, N, 1988)
"Sixteen patients with metastatic colorectal cancer have been treated with a regimen involving an 120 h continuous infusion of rIL-2, 18 x 10(6) iu m-2 day followed by three injections of 5FU 600 mg m-2 at weekly intervals."2.67A phase-III study of recombinant interleukin 2 and 5-fluorouracil chemotherapy in patients with metastatic colorectal cancer. ( Franks, CR; Hamblin, TJ; Oskam, R; Palmer, P; Sadullah, S; Stevenson, J; Williamson, P, 1993)
"Hypotension was observed in three of five patients at the highest dose level (0."2.67A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer. ( Botet, J; Crown, J; Gasparetto, C; Gordon, M; Jakubowski, A; Kemeny, N; Meisenberg, B; Sheridan, C; Toner, G; Wong, G, 1991)
"Transient hypotension was the most common side effect occurring in association with amifostine."1.31Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study. ( Genvresse, I; Harder, H; Lange, C; Possinger, K; Schanz, J; Schweigert, M; Späth-Schwalbe, E, 2001)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's6 (40.00)18.2507
2000's5 (33.33)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tebbutt, NC1
Wilson, K1
Gebski, VJ1
Cummins, MM1
Zannino, D1
van Hazel, GA1
Robinson, B1
Broad, A1
Ganju, V1
Ackland, SP1
Forgeson, G1
Cunningham, D1
Saunders, MP1
Stockler, MR1
Chua, Y1
Zalcberg, JR1
Simes, RJ1
Price, TJ1
Pérez, J1
Rodríguez, MJ1
Campaña, O1
Veiras, S1
Lorenzo, D1
Lamas, M1
Alvarez, J1
Iqbal, K1
Chu, Q1
Mei, Q1
Chen, Y1
Niederle, N2
Kurschel, E1
Schmidt, CG1
Bounous, G1
O'Shaughnessy, JA1
Denicoff, AM1
Venzon, DJ1
Danforth, D1
Pierce, LJ1
Frame, JN1
Bastian, A1
Ghosh, B1
Goldspiel, B1
Miller, L1
Weidmann, B1
Teipel, A1
Hamblin, TJ1
Sadullah, S1
Williamson, P1
Stevenson, J1
Oskam, R1
Palmer, P1
Franks, CR1
Falcone, A1
Danesi, R1
Dargenio, F1
Pfanner, E1
Brunetti, I1
Del Tacca, M1
Nethersell, AB1
Conte, PF1
Muc, M1
Baranowski, M1
Braczkowski, R1
Zubelewicz, B1
Kozowicz, A1
Santini, D1
Tonini, G1
Salerno, A1
Vincenzi, B1
Patti, G1
Battistoni, F1
Dicuonzo, G1
Labianca, R1
Genvresse, I1
Lange, C1
Schanz, J1
Schweigert, M1
Harder, H1
Possinger, K1
Späth-Schwalbe, E1
Schüll, B1
Kornek, GV1
Scheithauer, W1
Crown, J1
Jakubowski, A1
Kemeny, N2
Gordon, M1
Gasparetto, C1
Wong, G1
Sheridan, C1
Toner, G1
Meisenberg, B1
Botet, J1
Jakubowski, AA1

Trials

6 trials available for fluorouracil and Blood Pressure, Low

ArticleYear
Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Jul-01, Volume: 28, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopl

2010
[Biological effect of recombined leukocyte alpha-2-interferon in metastasizing colorectal cancers].
    Deutsche medizinische Wochenschrift (1946), 1984, May-18, Volume: 109, Issue:20

    Topics: Adenocarcinoma; Adult; Colonic Neoplasms; Female; Fluorouracil; Herpes Labialis; Humans; Hypotension

1984
A dose intensity study of FLAC (5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide) chemotherapy and Escherichia coli-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) in advanced breast cancer patients.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1994, Volume: 5, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dox

1994
A phase-III study of recombinant interleukin 2 and 5-fluorouracil chemotherapy in patients with metastatic colorectal cancer.
    British journal of cancer, 1993, Volume: 68, Issue:6

    Topics: Abdominal Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capillary Permeabi

1993
Intravenous azidothymidine with fluorouracil and leucovorin: a phase I-II study in previously untreated metastatic colorectal cancer patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colore

1996
A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer.
    Blood, 1991, Sep-15, Volume: 78, Issue:6

    Topics: Adult; Aged; Blood Glucose; Bone Marrow; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combinati

1991

Other Studies

9 other studies available for fluorouracil and Blood Pressure, Low

ArticleYear
[Anesthetic management for scheduled peritonectomy and hyperthermic intraperitoneal chemotherapy in 20 patients].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:9

    Topics: Adult; Aged; Analgesia, Epidural; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intraveno

2006
Bevacizumab-associated reversible hypotension.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2007, Volume: 19, Issue:10

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C

2007
Protection of the gastrointestinal mucosa by elemental diets.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1980, Volume: 3, Issue:3-4

    Topics: Animals; Fluorouracil; Food, Formulated; Humans; Hypotension; Intestinal Mucosa; Radiation Injuries;

1980
The syndrome of 5-fluorouracil cardiotoxicity: an elusive cardiopathy.
    Cancer, 1994, Apr-01, Volume: 73, Issue:7

    Topics: Adenocarcinoma; Angina Pectoris; Electrocardiography; Female; Fluorouracil; Heart; Heart Diseases; H

1994
[Cardiotoxic effect of the herec-TNF alpha preparation given intravenously to patients with advanced neoplasms].
    Przeglad lekarski, 1996, Volume: 53, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Female; Fluoroura

1996
Idiosyncratic reaction after oxaliplatin infusion.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chills; Fever; Fluorouracil;

2001
Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study.
    Anti-cancer drugs, 2001, Volume: 12, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Amifostine; Antihypertensive Agents; Antineoplastic Com

2001
Idiosyncratic reaction after oxaliplatin: circumvention by use of a continuous infusional administration schedule.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:11

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colo

2001
Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil.
    Cancer, 1988, Jul-15, Volume: 62, Issue:2

    Topics: Adult; Cisplatin; Colonic Neoplasms; Echocardiography; Electrocardiography; Female; Fluorouracil; He

1988