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fluorouracil and Biliary Tract Diseases

fluorouracil has been researched along with Biliary Tract Diseases in 5 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Biliary Tract Diseases: Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.

Research Excerpts

ExcerptRelevanceReference
"The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival."1.29Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity. ( Chase, JL; Curley, SA; Davidson, BS; DuBrow, RA; Hohn, DC; Izzo, F; Patt, Y, 1996)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miyamoto, S1
Umekita, N1
Maeshiro, T1
Awane, Y1
Davidson, BS1
Izzo, F1
Chase, JL1
DuBrow, RA1
Patt, Y1
Hohn, DC1
Curley, SA1
Bullen, BR1
Giles, GR1
Malhotra, A1
Bird, GG1
Hall, R1
Bunch, GA1
Brown, GJ1
Bateman, JR1
Pugh, RP1
Cassidy, FR1
Marshall, GJ1
Irwin, LE1
Kovalev, MM1
Tanasienko, ID1
Govdenko, PF1
Geleskul, VF1

Trials

1 trial available for fluorouracil and Biliary Tract Diseases

ArticleYear
Randomized comparison of melphalan and 5-fluorouracil in the treatment of advanced gastrointestinal cancer.
    Cancer treatment reports, 1976, Volume: 60, Issue:9

    Topics: Adult; Aged; Biliary Tract Diseases; Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; F

1976

Other Studies

4 other studies available for fluorouracil and Biliary Tract Diseases

ArticleYear
[Sclerosing cholangitis-induced biliary cyst formation: complication of hepatic artery infusion chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:11

    Topics: Adenocarcinoma; Biliary Tract Diseases; Cholangitis, Sclerosing; Cysts; Fluorouracil; Hepatic Artery

1995
Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity.
    American journal of surgery, 1996, Volume: 172, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biliar

1996
5-fluorouracil given once weekly: comparison of intravenous and oral administration.
    Cancer, 1971, Volume: 28, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Biliary Tract Diseases; Breast Neoplasms; Female; Fluorouracil

1971
[Transumbilical drug infusions in the complex treatment of patients with diseases of the abdominal organs].
    Klinicheskaia khirurgiia, 1971, Volume: 12

    Topics: Adult; Aged; Anti-Bacterial Agents; Biliary Tract Diseases; Female; Fluorouracil; Gastrointestinal D

1971