fluorouracil has been researched along with Bile Duct Obstruction in 17 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metastatic pancreatic cancer is one of the leading causes of cancer-related deaths in North America and Europe." | 2.41 | Metastatic pancreatic cancer. ( Kulke, MH, 2002) |
| "As an outpatient without recurrence he has received oral administration of uracil plus tegafur." | 1.31 | [A patient with obstructive jaundice due to recurrence after gastric cancer surgery responding remarkably to FLP combination therapy]. ( Kawahara, M; Nashimoto, A; Yabusaki, H, 2001) |
| " There seemed to be no correlation with the total dosage of 5-FU or the number of administrations." | 1.30 | [Complication due to arterial infusion chemotherapy for liver metastasis from colorectal cancer]. ( Hamada, H; Hashimoto, M; Katsuki, Y; Kawata, S; Kon, H; Sasaki, R; Tomita, I; Tsuji, Y; Yasuda, T, 1997) |
| "A 69-year-old male patient with gastric cancer complaining severe jaundice was readmitted for the purpose of chemotherapy." | 1.30 | [A case of unresectable advanced gastric cancer with severe obstructive jaundice responding to combined chemotherapy with 5-fluorouracil and low-dose cisplatin]. ( Hoshiko, M; Iwamoto, M; Kawabata, S; Shirouzu, K; Takeda, J; Yasumoto, K, 1998) |
| "Multiple liver and lung metastasis of breast cancer were diagnosed because of high CA 15/3 serum levels and normal gastrointestinal study." | 1.30 | [Effective chemo-endocrine combination therapy for obstructive-jaundice caused by multiple liver metastasis of recurrent breast cancer--a case report]. ( Hoshino, K; Ikeda, H; Koyama, T; Morishita, Y; Nakamura, M, 1999) |
| "Excisions of metastatic liver cancer were performed in 36 patients and 23 had nonresectable metastatic liver cancer." | 1.28 | [Complications of intra-arterial infusion chemotherapy in patients with colorectal cancer with liver metastasis, with special reference to IA-5-FU induced sclerosing cholangitis]. ( Hojo, K; Moriya, Y; Sawada, T, 1989) |
| "Excisions of metastatic liver cancer were performed in 23 pts and 15 pts had nonresectable metastatic liver cancer." | 1.27 | [Results of intra-arterial infusion chemotherapy in colorectal cancer patients with metastatic liver cancer]. ( Hojo, K; Moriya, Y; Sawada, T, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, J | 1 |
| Lee, SH | 1 |
| Choi, JH | 1 |
| Paik, WH | 1 |
| Ahn, DW | 1 |
| Jeong, JB | 1 |
| Ryu, JK | 1 |
| Kim, YT | 1 |
| O'Meara, AT | 1 |
| Kulke, MH | 1 |
| Ishikawa, A | 1 |
| Matsuura, M | 1 |
| Nakajima, N | 1 |
| Ozawa, M | 1 |
| Matsuda, M | 1 |
| Ito, K | 1 |
| Suzuki, K | 1 |
| Toyama, K | 1 |
| Tsuji, Y | 1 |
| Hamada, H | 1 |
| Katsuki, Y | 1 |
| Hashimoto, M | 1 |
| Tomita, I | 1 |
| Kon, H | 1 |
| Sasaki, R | 1 |
| Kawata, S | 1 |
| Yasuda, T | 1 |
| Yasumoto, K | 1 |
| Iwamoto, M | 1 |
| Hoshiko, M | 1 |
| Kawabata, S | 1 |
| Takeda, J | 1 |
| Shirouzu, K | 1 |
| Mochizuki, F | 1 |
| Fujii, M | 1 |
| Kasakura, Y | 1 |
| Imai, S | 1 |
| Kanamori, N | 1 |
| Kasahara, M | 1 |
| Yamagata, M | 1 |
| Iwai, S | 1 |
| Hoshino, K | 1 |
| Nakamura, M | 1 |
| Ikeda, H | 1 |
| Koyama, T | 1 |
| Morishita, Y | 1 |
| Kawahara, M | 1 |
| Nashimoto, A | 1 |
| Yabusaki, H | 1 |
| Barkin, JS | 1 |
| Kalser, MH | 1 |
| Kaplan, R | 1 |
| Redlhammer, D | 1 |
| Heal, A | 1 |
| Sawada, T | 2 |
| Hojo, K | 2 |
| Moriya, Y | 2 |
| Tomita, T | 1 |
| Tajima, T | 1 |
| Ishibashi, M | 1 |
| Tagaya, N | 1 |
| Aoki, H | 1 |
| Itoh, S | 1 |
| Kadowaki, A | 1 |
| Kogure, H | 1 |
| Tajima, Y | 1 |
| Kemeny, MM | 1 |
| Goldberg, DA | 1 |
| Browning, S | 1 |
| Metter, GE | 1 |
| Miner, PJ | 1 |
| Terz, JJ | 1 |
| Bevan, PG | 1 |
| Pemberton, LB | 1 |
| Diffenbaugh, WF | 1 |
| Strohl, EL | 1 |
| Saito, T | 1 |
| Nozaki, H | 1 |
| Kanamaru, R | 1 |
| Isono, S | 1 |
| Kurobane, T | 1 |
2 reviews available for fluorouracil and Bile Duct Obstruction
| Article | Year |
|---|---|
Pancreatic cancer: evidence-based diagnosis and treatment.
Topics: Chemotherapy, Adjuvant; Cholestasis; Fluorouracil; Humans; Neoplasm Staging; Neuroendocrine Tumors; | 2002 |
Metastatic pancreatic cancer.
Topics: Antineoplastic Agents; Autonomic Nerve Block; Celiac Plexus; Cholestasis; Clinical Trials as Topic; | 2002 |
1 trial available for fluorouracil and Bile Duct Obstruction
| Article | Year |
|---|---|
Experience with continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries. A prospective randomized study.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Colonic Neoplasms; Combined Modality Therapy; F | 1985 |
14 other studies available for fluorouracil and Bile Duct Obstruction
| Article | Year |
|---|---|
Folfirinox chemotherapy prolongs stent patency in patients with malignant biliary obstruction due to unresectable pancreatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cholangiopancreatogr | 2020 |
[Advanced breast cancer with onset of multi-organ metastases successfully treated with combined loco-regional therapies: a case report].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Ch | 1993 |
[Complication due to arterial infusion chemotherapy for liver metastasis from colorectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arterial Occlusive Diseases; Choles | 1997 |
[A case of unresectable advanced gastric cancer with severe obstructive jaundice responding to combined chemotherapy with 5-fluorouracil and low-dose cisplatin].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cholestasis; Cisplatin; Drug Administration Sc | 1998 |
[Two patients with obstructive jaundice due to intra-abdominal lymph-node metastases of gastric cancer responding to combination chemotherapy with 5-FU and CDDP].
Topics: Abdomen; Aged; Antineoplastic Combined Chemotherapy Protocols; Cholestasis; Cisplatin; Drug Administ | 1998 |
[Effective chemo-endocrine combination therapy for obstructive-jaundice caused by multiple liver metastasis of recurrent breast cancer--a case report].
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neopla | 1999 |
[A patient with obstructive jaundice due to recurrence after gastric cancer surgery responding remarkably to FLP combination therapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cholestasis; Cisplatin; Drainage; Drug Adminis | 2001 |
Initial levels of CEA and their rate of change in pancreatic carcinoma following surgery chemotherapy and radiation therapy.
Topics: Alkaline Phosphatase; Carcinoembryonic Antigen; Carcinoma; Cholestasis; Fluorouracil; Humans; Neopla | 1978 |
[Complications of intra-arterial infusion chemotherapy in patients with colorectal cancer with liver metastasis, with special reference to IA-5-FU induced sclerosing cholangitis].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Catheterization; Cholangitis, Sclerosin | 1989 |
[Study on the concentrations of 5-fluorouracil (5-FU), tegafur (ET) and uracil in bile: comparison of UFT or FT].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile; Biliary Tract Neoplasms; Cholestasis; Fe | 1989 |
[Results of intra-arterial infusion chemotherapy in colorectal cancer patients with metastatic liver cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cholestasis; Colonic Neoplasms; Combined Modality Th | 1988 |
Cytotoxic perfusion of the liver via the umbilical vein for liver metastases in carcinoma of the colon.
Topics: Aged; Blood Sedimentation; Cholestasis; Colonic Neoplasms; Diarrhea; Fluorouracil; Humans; Leukocyte | 1973 |
The surgical significance of carcinoma of the gallbladder.
Topics: Appendicitis; Autopsy; Cholecystectomy; Cholecystitis; Cholelithiasis; Cholestasis; Diagnosis, Diffe | 1971 |
[Cancer and appendicitis--death due to incidental appendicitis in recurrent stomach cancer with successful chemotherapy].
Topics: Antineoplastic Agents; Appendicitis; Cholestasis; Female; Fluorouracil; Humans; Middle Aged; Mitomyc | 1968 |