fluorouracil has been researched along with Bile Duct Obstruction, Extrahepatic in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 24-year-old man with hepatocellular carcinoma presented with recurrent obstructive jaundice caused by bile duct invasion and distal migration of necrotic tumor fragments." | 1.27 | Recurrent obstructive jaundice caused by fibrolamellar hepatocellular carcinoma. ( Albaugh, JS; Keeffe, EB; Krippaehne, WW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knox, JJ | 1 |
| Hedley, D | 1 |
| Oza, A | 1 |
| Feld, R | 1 |
| Siu, LL | 1 |
| Chen, E | 1 |
| Nematollahi, M | 1 |
| Pond, GR | 1 |
| Zhang, J | 1 |
| Moore, MJ | 1 |
| Albaugh, JS | 1 |
| Keeffe, EB | 1 |
| Krippaehne, WW | 1 |
| Recchia, F | 1 |
| Recchia, G | 1 |
| Tempesti, M | 1 |
| Venditti, A | 1 |
| Lo, SS | 1 |
| Wu, CW | 1 |
| Chi, KH | 1 |
| Tseng, HS | 1 |
| Shen, KH | 1 |
| Hsieh, MC | 1 |
| Lui, WY | 1 |
2 trials available for fluorouracil and Bile Duct Obstruction, Extrahepatic
| Article | Year |
|---|---|
Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trial.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemot | 2005 |
Concomitant chemoradiation treatment in the management of patients with extrahepatic biliary tract recurrence of gastric carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Extrah | 2000 |
2 other studies available for fluorouracil and Bile Duct Obstruction, Extrahepatic
| Article | Year |
|---|---|
Recurrent obstructive jaundice caused by fibrolamellar hepatocellular carcinoma.
Topics: Adult; Carcinoma, Hepatocellular; Cholestasis, Extrahepatic; Combined Modality Therapy; Doxorubicin; | 1984 |
[Indications and technic of percutaneous external biliary drainage].
Topics: Antineoplastic Agents; Bile; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Cholestasis, | 1981 |