fluorouracil has been researched along with Bewilderment in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To evaluate these effects, 17 patients with advanced colorectal cancer took part in a randomised, parallel group study of rIL-2 with chemotherapy (5-fluorouracil and leucovorin) versus chemotherapy alone." | 5.08 | The psychological and psychiatric effects of rIL-2 therapy: a controlled clinical trial. ( Eremin, O; Heys, SD; Lolley, J; Walker, LG; Walker, MB; Wesnes, K, 1997) |
| "Levamisole was administered to 38 patients orally three times a day for 5 days concurrently with a course of 5-FU administered daily by rapid intravenous injection for 5 days." | 2.69 | Clinical and pharmacokinetic studies of high-dose levamisole in combination with 5-fluorouracil in patients with advanced cancer. ( Bagniewski, PG; Kovach, JS; Moertel, CG; O'Connell, MJ; Reid, JM, 1998) |
| "Capecitabine is an oral fluoropyrimidine used for cancer treatment." | 1.32 | Capecitabine-related neurotoxicity presenting as trismus. ( Couch, LS; Groteluschen, DL; Mulkerin, DL; Stewart, JA, 2003) |
| "Fluorouracil can cause both acute and delayed neurotoxicity." | 1.31 | Fluorouracil-induced neurotoxicity. ( Ali, II; Dafer, RM; Pirzada, NA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, MT | 1 |
| Stoianovici, R | 1 |
| Brunetti, L | 1 |
| Pulcini, C | 1 |
| Vandenbos, F | 1 |
| Bernard, E | 1 |
| Roth, S | 1 |
| Elbeze, JP | 1 |
| Dunais, B | 1 |
| Peyrade, F | 1 |
| Dellamonica, P | 1 |
| Couch, LS | 1 |
| Groteluschen, DL | 1 |
| Stewart, JA | 1 |
| Mulkerin, DL | 1 |
| Guilloton, L | 1 |
| Michaud, A | 1 |
| Potier, V | 1 |
| Le Berre, J | 1 |
| Drouet, A | 1 |
| Felten, D | 1 |
| O'Connell, MJ | 2 |
| Moertel, CG | 2 |
| Rubin, J | 1 |
| Hahn, RG | 1 |
| Kvols, LK | 1 |
| Schutt, AJ | 1 |
| Yeh, KH | 1 |
| Cheng, AL | 1 |
| Walker, LG | 1 |
| Walker, MB | 1 |
| Heys, SD | 1 |
| Lolley, J | 1 |
| Wesnes, K | 1 |
| Eremin, O | 1 |
| Reid, JM | 1 |
| Kovach, JS | 1 |
| Bagniewski, PG | 1 |
| Pirzada, NA | 1 |
| Ali, II | 1 |
| Dafer, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of the HIV-1 DNA Vaccine VRC-HIVDNA009-00-VP (Gag-Pol-Nef-multiclade Env) With the Plasmid Cytokine Adjuvant VRC-ADJDNA004-IL2-VP (IL-2/Ig)[NCT00069030] | Phase 1 | 70 participants (Actual) | Interventional | 2003-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for fluorouracil and Bewilderment
| Article | Year |
|---|---|
The psychological and psychiatric effects of rIL-2 therapy: a controlled clinical trial.
Topics: Antimetabolites, Antineoplastic; Cognition Disorders; Colorectal Neoplasms; Combined Modality Therap | 1997 |
Clinical and pharmacokinetic studies of high-dose levamisole in combination with 5-fluorouracil in patients with advanced cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Confusion; Drug Synergism; Drug The | 1998 |
7 other studies available for fluorouracil and Bewilderment
| Article | Year |
|---|---|
Chemotherapy induced stroke mimic: 5-Fluorouracil encephalopathy fulfilling criteria for tissue plasminogen activator therapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aphasia; Brain Dise | 2017 |
[Diagnosis of a metastatic valvular tumor in a living patient].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Ischemia; Car | 2003 |
Capecitabine-related neurotoxicity presenting as trismus.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Central Nervous System; Confusion; Deoxycytidine; Dia | 2003 |
[Ataxia and confusion after treatment with 5 Fluorouracile].
Topics: Antimetabolites, Antineoplastic; Ataxia; Colonic Neoplasms; Confusion; Fluorouracil; Humans; Wernick | 2005 |
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasm | 1984 |
Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.
Topics: Acute Disease; Brain Diseases; Coma; Confusion; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 1994 |
Fluorouracil-induced neurotoxicity.
Topics: Aged; Antimetabolites, Antineoplastic; Ataxia; Confusion; Esophageal Neoplasms; Fluorouracil; Humans | 2000 |