fluorouracil has been researched along with Basal Cell Nevus Syndrome in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Basal Cell Nevus Syndrome: Hereditary disorder consisting of multiple basal cell carcinomas, odontogenic keratocysts, and multiple skeletal defects, e.g., frontal and temporoparietal bossing, bifurcated and splayed ribs, kyphoscoliosis, fusion of vertebrae, and cervicothoracic spina bifida. Genetic transmission is autosomal dominant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The case of a child with basal cell nevus syndrome whose condition was successfully managed for 10 years with a combination of topical 5-fluorouracil and tretinoin is reported." | 7.68 | Long-term management of basal cell nevus syndrome with topical tretinoin and 5-fluorouracil. ( Lang, PG; Strange, PR, 1992) |
| "A 58-year-old man with basal cell nevus syndrome had variously sized basal cell epitheliomas (BCEs), mostly of the superficial type, on his chest, back, and lumbar areas." | 5.29 | Cryosurgery and topical fluorouracil: a treatment method for widespread basal cell epithelioma in basal cell nevus syndrome. ( Nishimura, M; Otake, N; Tsuji, T, 1993) |
| "A single patient with basal cell nevus syndrome is presented." | 5.27 | Basal cell nevus syndrome. Unresponsiveness of early cutaneous lesions to topical 5-fluorouracil or dinitrochlorobenzene. ( Hazen, PG; Taub, SJ, 1984) |
| "The case of a child with basal cell nevus syndrome whose condition was successfully managed for 10 years with a combination of topical 5-fluorouracil and tretinoin is reported." | 3.68 | Long-term management of basal cell nevus syndrome with topical tretinoin and 5-fluorouracil. ( Lang, PG; Strange, PR, 1992) |
| "An updated review of management of nevoid basal cell carcinoma syndrome (NBCCS) is presented." | 2.44 | Nevoid basal cell carcinoma syndrome (Gorlin syndrome): updated review of minimally invasive treatments. ( Mitropoulos, P; Norman, R, 2008) |
| "Little guidance on management of basal cell nevus syndrome in children exists." | 1.56 | A pediatric approach to management of skin growths in basal cell nevus syndrome. ( Bartenstein, DW; Fisher, J; Hawryluk, EB; Kroshinsky, D; Lilly, E; Moustafa, D; Su, KA, 2020) |
| "A 58-year-old man with basal cell nevus syndrome had variously sized basal cell epitheliomas (BCEs), mostly of the superficial type, on his chest, back, and lumbar areas." | 1.29 | Cryosurgery and topical fluorouracil: a treatment method for widespread basal cell epithelioma in basal cell nevus syndrome. ( Nishimura, M; Otake, N; Tsuji, T, 1993) |
| "A single patient with basal cell nevus syndrome is presented." | 1.27 | Basal cell nevus syndrome. Unresponsiveness of early cutaneous lesions to topical 5-fluorouracil or dinitrochlorobenzene. ( Hazen, PG; Taub, SJ, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, Y | 1 |
| Zhang, G | 1 |
| Fu, S | 1 |
| Fisher, J | 1 |
| Moustafa, D | 1 |
| Su, KA | 1 |
| Bartenstein, DW | 1 |
| Lilly, E | 1 |
| Kroshinsky, D | 1 |
| Hawryluk, EB | 1 |
| Basset-Seguin, N | 1 |
| Lam, C | 1 |
| Ou, JC | 1 |
| Billingsley, EM | 1 |
| Beach, DF | 1 |
| Somer, R | 1 |
| Tang, JY | 1 |
| Marghoob, AA | 1 |
| van Ruth, S | 1 |
| Jansman, FG | 1 |
| Sanders, CJ | 1 |
| Mitropoulos, P | 1 |
| Norman, R | 1 |
| Cesteleyn, L | 1 |
| Akuamoa-Boateng, E | 1 |
| Hazen, PG | 1 |
| Taub, SJ | 1 |
| Casson, P | 1 |
| Tsuji, T | 1 |
| Otake, N | 1 |
| Nishimura, M | 1 |
| Strange, PR | 1 |
| Lang, PG | 1 |
3 reviews available for fluorouracil and Basal Cell Nevus Syndrome
| Article | Year |
|---|---|
Topics: Alopecia; Anilides; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Basal Cel | 2018 |
Emerging treatments and signaling pathway inhibitors.
Topics: Aminoquinolines; Anilides; Antineoplastic Agents; Basal Cell Nevus Syndrome; Benzamides; Carcinoma, | 2011 |
Nevoid basal cell carcinoma syndrome (Gorlin syndrome): updated review of minimally invasive treatments.
Topics: Aminoquinolines; Antineoplastic Agents; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Cryosurger | 2008 |
10 other studies available for fluorouracil and Basal Cell Nevus Syndrome
| Article | Year |
|---|---|
Comprehensive treatment of basal cell carcinoma in nevoid basal cell carcinoma syndrome with 5-fluorouracil and salicylic acid.
Topics: Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Fluorouracil; Humans; Salicylic Acid; Skin Neoplas | 2022 |
A pediatric approach to management of skin growths in basal cell nevus syndrome.
Topics: Aminoquinolines; Basal Cell Nevus Syndrome; Child; Child, Preschool; Fluorouracil; Humans; Imiquimod | 2020 |
"PTCH"-ing it together: a basal cell nevus syndrome review.
Topics: Anilides; Antimetabolites, Antineoplastic; Antineoplastic Agents; Basal Cell Nevus Syndrome; Combine | 2013 |
Novel approach to Gorlin syndrome: a patient treated with oral capecitabine.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Basal Cell Nevus Syndrome; Capecitabine; Deox | 2011 |
Total body topical 5-fluorouracil for extensive non-melanoma skin cancer.
Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Basal Cell Nevus Syndrome; Fluoroura | 2006 |
[Maxillofacial surgical treatment of basaliomas in the basocellular nevus syndrome].
Topics: Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Facial Neoplasms; Female; Fluorouracil; Humans; Ma | 1983 |
Basal cell nevus syndrome. Unresponsiveness of early cutaneous lesions to topical 5-fluorouracil or dinitrochlorobenzene.
Topics: Administration, Topical; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Child; Dinitrochlorobenze | 1984 |
Basal cell carcinoma.
Topics: Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Cryosurgery; Female; Fluorouracil; Humans; Male; N | 1980 |
Cryosurgery and topical fluorouracil: a treatment method for widespread basal cell epithelioma in basal cell nevus syndrome.
Topics: Administration, Topical; Back; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Combined Modality T | 1993 |
Long-term management of basal cell nevus syndrome with topical tretinoin and 5-fluorouracil.
Topics: Basal Cell Nevus Syndrome; Child, Preschool; Drug Synergism; Drug Therapy, Combination; Female; Fluo | 1992 |